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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2994
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lck
Name: LCK proto-oncogene, Src family tyrosine kinase
Acc ID: CHEBI:75295
Term: compound 48/80
Definition: R1, R2 = H or CH2OH; n is normally between 1 and 10. An alternating copolymer resulting from the condensation of N,O-dimethyltyramine with formaldehyde. It is a potent histamine releasing agent, primarily from mast cells, with subsequent depletion of tissue histamine.
Chemical ID: MESH:D003189
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lckincreases activityEXP 6480464CTDp-Methoxy-N-methylphenethylamine results in increased activity of LCK protein

PMID:27553716
Lckmultiple interactionsEXP 6480464CTDatractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein], damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein], pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]

PMID:27553716
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.