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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2994
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lck
Name: LCK proto-oncogene, Src family tyrosine kinase
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lckmultiple interactionsISOLCK (Homo sapiens)6480464CTD[[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of LCK mRNA; Ascorbic Acid inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein]PMID:14572611 PMID:34480604
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