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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2994
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lck
Name: LCK proto-oncogene, Src family tyrosine kinase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lckaffects expressionEXP 6480464CTDbisphenol A affects the expression of LCK mRNAPMID:25181051
Lckdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LCK mRNAPMID:34947998
Lckincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LCK mRNAPMID:18180321
Lckdecreases methylationISOLck (Mus musculus)6480464CTDbisphenol A results in decreased methylation of LCK promoterPMID:27312807
Lckincreases expressionISOLck (Mus musculus)6480464CTDbisphenol A results in increased expression of LCK mRNAPMID:35752395
Lckincreases phosphorylationISOLck (Mus musculus)6480464CTDbisphenol A results in increased phosphorylation of LCK proteinPMID:35752395
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