LCK (LCK proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

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Gene: LCK (LCK proto-oncogene, Src family tyrosine kinase) Pan paniscus
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Symbol: LCK
Name: LCK proto-oncogene, Src family tyrosine kinase
RGD ID: 11823360
Description: ENCODES a protein that exhibits antigen binding (ortholog); ATPase binding (ortholog); CD4 receptor binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); aging (ortholog); apoptotic process (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH allergic conjunctivitis (ortholog); dilated cardiomyopathy (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN cell-cell junction (ortholog); endocytic vesicle (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1132,567,712 - 32,579,923 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,565,739 - 32,579,923 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0131,560,229 - 31,572,391 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
LCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1132,567,712 - 32,579,923 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,565,739 - 32,579,923 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0131,560,229 - 31,572,391 (+)NCBIMhudiblu_PPA_v0panPan3
LCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl132,251,239 - 32,286,165 (+)EnsemblGRCh38hg38GRCh38
GRCh38132,251,265 - 32,286,165 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,716,866 - 32,751,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,489,427 - 32,524,353 (+)NCBINCBI36hg18NCBI36
Build 34132,386,024 - 32,420,854NCBI
Celera130,987,010 - 31,022,233 (+)NCBI
Cytogenetic Map1p35.2NCBI
HuRef130,833,080 - 30,867,241 (+)NCBIHuRef
CHM1_1132,832,435 - 32,867,211 (+)NCBICHM1_1
Lck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,442,137 - 129,467,434 (-)NCBIGRCm39mm39
GRCm39 Ensembl4129,442,137 - 129,467,434 (-)Ensembl
GRCm384129,548,344 - 129,573,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,548,344 - 129,573,641 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,225,588 - 129,250,885 (-)NCBIGRCm37mm9NCBIm37
MGSCv364129,050,662 - 129,060,676 (-)NCBImm8
Celera4127,881,707 - 127,907,449 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
Lck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25141,888,319 - 141,916,992 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5141,888,326 - 141,903,794 (-)Ensembl
Rnor_6.05147,750,976 - 147,779,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,750,973 - 147,761,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,480,214 - 151,509,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,707,505 - 148,718,296 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5140,363,592 - 140,374,224 (-)NCBICelera
Cytogenetic Map5q36NCBI
Lck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,608,318 - 10,632,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,608,317 - 10,632,310 (+)NCBIChiLan1.0ChiLan1.0
LCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,940,816 - 68,964,585 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,941,249 - 68,964,567 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,521,599 - 65,545,402 (-)NCBI
ROS_Cfam_1.0269,507,326 - 69,531,453 (-)NCBI
UMICH_Zoey_3.1266,344,251 - 66,368,026 (-)NCBI
UNSW_CanFamBas_1.0267,339,915 - 67,363,766 (-)NCBI
UU_Cfam_GSD_1.0268,338,870 - 68,362,999 (-)NCBI
Lck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,480,227 - 49,489,329 (+)NCBI
SpeTri2.0NW_00493647415,293,115 - 15,314,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl688,720,176 - 88,745,917 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,719,886 - 88,745,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,843,255 - 82,852,667 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,582,718 - 100,618,041 (-)NCBI
Vero_WHO_p1.0NW_02366603316,070,565 - 16,104,978 (+)NCBI
Lck
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476415,469,582 - 15,495,351 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000038839   ⟹   ENSPPAP00000016146
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl132,565,739 - 32,579,472 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000038843   ⟹   ENSPPAP00000016150
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl132,567,716 - 32,579,923 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000038853   ⟹   ENSPPAP00000016160
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl132,567,729 - 32,579,923 (+)Ensembl
RefSeq Acc Id: XM_003828150   ⟹   XP_003828198
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1132,567,716 - 32,579,923 (+)NCBI
Mhudiblu_PPA_v0131,560,237 - 31,572,391 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008953504   ⟹   XP_008951752
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1132,567,729 - 32,579,923 (+)NCBI
Mhudiblu_PPA_v0131,560,229 - 31,572,391 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008953505   ⟹   XP_008951753
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1132,567,727 - 32,579,923 (+)NCBI
Mhudiblu_PPA_v0131,560,241 - 31,572,391 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003828198 (Get FASTA)   NCBI Sequence Viewer  
  XP_008951752 (Get FASTA)   NCBI Sequence Viewer  
  XP_008951753 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003828198   ⟸   XM_003828150
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008951753   ⟸   XM_008953505
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008951752   ⟸   XM_008953504
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000016160   ⟸   ENSPPAT00000038853
RefSeq Acc Id: ENSPPAP00000016150   ⟸   ENSPPAT00000038843
RefSeq Acc Id: ENSPPAP00000016146   ⟸   ENSPPAT00000038839


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031166 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000016150 ENTREZGENE
  ENSPPAP00000016160 ENTREZGENE
NCBI Gene LCK ENTREZGENE