Sesn2 (sestrin 2) - Rat Genome Database

Name: Sesn2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Sesn2 (sestrin 2) Rattus norvegicus

Analyze

Symbol:

Sesn2

Name:

sestrin 2

RGD ID:

1566319

Description:

Predicted to enable several functions, including PH domain binding activity; leucine binding activity; and protein sequestering activity. Predicted to be involved in several processes, including cellular response to leucine; cellular response to starvation; and regulation of macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including positive regulation of lipophagy; protein kinase B signaling; and regulation of protein kinase activity. Predicted to be located in mitochondrion. Predicted to be part of Atg1/ULK1 kinase complex; TORC2 complex; and nucleotide-activated protein kinase complex. Orthologous to human SESN2 (sestrin 2); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; azoxystrobin.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC502988; LOC502988; RGD1566319; sestrin-2; similar to Sestrin 2 (Hi95); uncharacterized protein LOC502988

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SESN2 (sestrin 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SESN2 (sestrin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sesn2 (sestrin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sesn2 (sestrin 2)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sesn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sesn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	144,702,287 - 144,721,241 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,701,530 - 144,721,260 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,402,085 - 147,420,950 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,171,647 - 149,190,510 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	149,160,251 - 149,179,202 (-)	NCBI	Rnor_WKY
Rnor_6.0	5	150,684,891 - 150,703,846 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,684,133 - 150,704,117 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,351,297 - 154,370,252 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	152,639,951 - 152,655,828 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	143,128,904 - 143,147,855 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

Colorectal Neoplasms (ISO)

Hepatomegaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

(E)-thiamethoxam (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (ISO)

2-amino-2-deoxy-D-galactopyranose (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

4-phenylbutyric acid (ISO)

5-fluorouracil (ISO)

acrylamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alternariol (ISO)

AM-251 (ISO)

amino acid (ISO)

amiodarone (ISO)

antimycin A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

azathioprine (ISO)

azoxystrobin (EXP)

benzalkonium chloride (ISO)

benzene (ISO)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

butylated hydroxyanisole (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

cannabidiol (ISO)

carbamazepine (ISO)

chloroprene (ISO)

chlorpyrifos (EXP,ISO)

chrysene (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cycloheximide (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

deguelin (ISO)

desferrioxamine B (ISO)

diallyl disulfide (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibenziodolium (ISO)

dichloromethane (ISO)

Didecyldimethylammonium (ISO)

dioxygen (EXP,ISO)

disodium selenite (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

erastin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

ethylbenzene (ISO)

fenamidone (ISO)

fenpyroximate (ISO)

ferrostatin-1 (ISO)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP,ISO)

gamma-hexachlorocyclohexane (ISO)

genistein (ISO)

gentamycin (EXP)

glutathione (EXP,ISO)

glyphosate (EXP)

hemin (ISO)

hydrogen peroxide (EXP,ISO)

hydroquinone (ISO)

imidacloprid (EXP)

indole-3-methanol (EXP)

indoline (EXP)

irinotecan (ISO)

isorhamnetin (ISO)

L-ascorbic acid (ISO)

leflunomide (ISO)

levofloxacin (EXP)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

luteolin (ISO)

manganese(II) chloride (EXP)

mercury dibromide (ISO)

metformin (EXP,ISO)

methamphetamine (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

motexafin gadolinium (ISO)

N-acetyl-L-cysteine (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (ISO)

nefazodone (EXP)

nimesulide (EXP)

Nutlin-3 (ISO)

o-xylene (ISO)

ochratoxin A (ISO)

oxaliplatin (EXP)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

peptidoglycan (ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phenylhydrazine (ISO)

phenylmercury acetate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

poly(I:C) (ISO)

progesterone (ISO)

propanal (ISO)

pterostilbene (ISO)

pyrimidifen (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (ISO)

SB 203580 (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (ISO)

sirolimus (ISO)

sorafenib (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (EXP,ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

thapsigargin (ISO)

thiabendazole (EXP)

thiamethoxam (ISO)

thiazoles (EXP)

thifluzamide (ISO)

thioacetamide (EXP)

toluene (ISO)

topotecan (EXP)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

tunicamycin (EXP,ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vincristine (ISO)

zinc acetate (ISO)

zinc atom (ISO)

zinc sulfate (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase activity (ISO)

cellular oxidant detoxification (ISO)

cellular response to amino acid starvation (ISO)

cellular response to amino acid stimulus (ISO)

cellular response to glucose starvation (ISO)

cellular response to leucine (IBA,ISO)

cellular response to leucine starvation (IBA,ISO)

cellular response to oxidative stress (ISO)

DNA damage response, signal transduction by p53 class mediator (ISO)

fatty acid beta-oxidation (ISO)

glucose homeostasis (ISO)

glucose import (ISO)

mitochondrial DNA metabolic process (ISO)

mitochondrion organization (ISO)

negative regulation of cell growth (ISO)

negative regulation of TORC1 signaling (IBA,ISO)

negative regulation of translation in response to endoplasmic reticulum stress (ISO)

positive regulation of lipophagy (ISO)

positive regulation of macroautophagy (IBA,ISO)

positive regulation of protein localization to nucleus (ISO)

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress (ISO)

protein kinase B signaling (ISO)

reactive oxygen species metabolic process (ISO)

regulation of cAMP-dependent protein kinase activity (ISO)

regulation of gluconeogenesis (ISO)

regulation of protein phosphorylation (ISO)

regulation of response to reactive oxygen species (IEA)

response to glucose (ISO)

response to insulin (ISO)

triglyceride homeostasis (ISO)

Cellular Component

Atg1/ULK1 kinase complex (ISO)

cytoplasm (ISO)

mitochondrion (ISO)

nucleotide-activated protein kinase complex (ISO)

nucleus (IEA)

TORC2 complex (ISO)

Molecular Function

GDP-dissociation inhibitor activity (ISO)

leucine binding (IBA,ISO)

oxidoreductase activity, acting on peroxide as acceptor (IBA,ISO)

peroxidase activity (ISO)

PH domain binding (ISO)

protein binding (ISO)

protein sequestering activity (ISO)

protein-containing complex binding (ISO)

sulfiredoxin activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot.	Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15105503	PMID:18692468	PMID:19113821	PMID:19430206	PMID:20203043	PMID:22958918	PMID:23274085	PMID:23698117	PMID:23816887	PMID:24368194	PMID:24947615
PMID:25040165	PMID:25056347	PMID:25259925	PMID:25263562	PMID:25377878	PMID:25457612	PMID:26031332	PMID:26208700	PMID:26449471	PMID:26556340	PMID:26586190	PMID:26612684
PMID:27453548	PMID:28497371	PMID:29917204	PMID:30116150	PMID:30522100	PMID:30835510	PMID:31085280	PMID:31199952	PMID:32275923	PMID:32526292

Genomics

Comparative Map Data

Sesn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	144,702,287 - 144,721,241 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,701,530 - 144,721,260 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,402,085 - 147,420,950 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,171,647 - 149,190,510 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	149,160,251 - 149,179,202 (-)	NCBI	Rnor_WKY
Rnor_6.0	5	150,684,891 - 150,703,846 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,684,133 - 150,704,117 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,351,297 - 154,370,252 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	152,639,951 - 152,655,828 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	143,128,904 - 143,147,855 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

SESN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	28,259,518 - 28,282,491 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	28,259,518 - 28,282,491 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	28,586,029 - 28,609,002 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	28,458,593 - 28,481,589 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	28,270,147 - 28,293,143	NCBI
Celera	1	26,981,763 - 27,004,758 (+)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	26,842,331 - 26,865,372 (+)	NCBI		HuRef
CHM1_1	1	28,701,469 - 28,724,501 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	28,101,353 - 28,124,325 (+)	NCBI		T2T-CHM13v2.0

Sesn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	132,220,115 - 132,237,767 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	132,219,343 - 132,237,812 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	132,492,804 - 132,510,456 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	132,492,032 - 132,510,501 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	132,048,719 - 132,066,371 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	131,764,880 - 131,782,532 (-)	NCBI		MGSCv36	mm8
Celera	4	130,652,973 - 130,670,713 (-)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI

Sesn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	7,393,007 - 7,417,304 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	7,392,644 - 7,417,204 (+)	NCBI	ChiLan1.0	ChiLan1.0

SESN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	28,555,072 - 28,577,931 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	28,555,072 - 28,577,931 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	27,518,248 - 27,541,264 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SESN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	72,151,464 - 72,168,861 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	72,151,868 - 72,168,492 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	68,729,379 - 68,746,724 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	72,711,672 - 72,729,070 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	72,712,076 - 72,729,237 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	69,539,438 - 69,556,777 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	70,549,353 - 70,566,759 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	71,546,019 - 71,563,428 (-)	NCBI		UU_Cfam_GSD_1.0

Sesn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	46,591,898 - 46,611,063 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	12,416,652 - 12,436,814 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936474	12,416,652 - 12,436,799 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SESN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	85,324,228 - 85,348,032 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	85,321,982 - 85,348,044 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	79,065,763 - 79,087,496 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SESN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	104,521,131 - 104,544,161 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	104,521,132 - 104,544,001 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	11,936,607 - 11,959,826 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sesn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	12,087,858 - 12,120,914 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	12,087,901 - 12,135,145 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sesn2
93 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	77
Count of miRNA genes:	69
Interacting mature miRNAs:	72
Transcripts:	ENSRNOT00000067455
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat

Markers in Region

RH141763

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	144,715,624 - 144,715,831 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	150,698,231 - 150,698,437	NCBI	Rnor6.0
Rnor_5.0	5	154,364,637 - 154,364,843	UniSTS	Rnor5.0
RGSC_v3.4	5	152,645,360 - 152,645,566	UniSTS	RGSC3.4
Celera	5	143,142,240 - 143,142,446	UniSTS
RH 3.4 Map	5	965.9	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	12	27	23	8	23			19	35	34	11
Low		31	30	18	11	18	8	11	55		7		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000067455 ⟹ ENSRNOP00000062295

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,701,530 - 144,721,251 (-)	Ensembl
Rnor_6.0 Ensembl	5	150,684,133 - 150,704,117 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103737 ⟹ ENSRNOP00000077718

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,702,290 - 144,721,260 (-)	Ensembl

RefSeq Acc Id:

NM_001109358 ⟹ NP_001102828

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	144,702,287 - 144,721,241 (-)	NCBI
Rnor_6.0	5	150,684,891 - 150,703,846 (-)	NCBI
Rnor_5.0	5	154,351,297 - 154,370,252 (-)	NCBI
RGSC_v3.4	5	152,639,951 - 152,655,828 (+)	RGD
Celera	5	143,128,904 - 143,147,855 (-)	RGD

Sequence:

show sequence

TGGTGAGGAGCGCCGGCTTCGCGAGCAGCGCTGGCCACTGCGGACTTCCGAGGCACTCCGGGCC
GTGAAAACCTCTGCGCCGCGGCCAATCTCAGGCCTCCAAGGCCGGCCACAGTTCTCCAAGCTGG
GCTGGAAGGAGTGTCCAGCGCGGTATCGCCAGTTCTCCTCGTTCGGAGAGATACCCCGGGGATC
TCGAGCTTCCCCGGCGACCCCTAGTCCGGGCCTCCTTTGCGCGCCCGCCTCAGACCCCCACGGG
TGCCCGGGGCGCTGACGAGCCGCGGCCGGGTCCTGGCGCACACCATGATCGTAGCCGACTCCGA
GTGCCATGGGGAGATCAAGGGCTACCTGCCGTTCACCAGGGGCGGTGTGGCCGGCCCCGGGACC
CGAGAGGAGCATCGGGAGGGCCAGGCGCGGCGAGGCCCTCGAGGACCCAGCGCCTTCATCCCAG
TGGAGGAGATCCTTCGGGAAGGAGCTGAGAGCCTGGAGCAGCACCTGGGGCTCGAGGCTCTGAT
GTCTTCAGGGCGGGTGGACAACCTGGCGGTGGTGATGGGCCTACACCCCGACTACCTTAGCAGC
TTCTGGCGCCTCCACTACCTGCTGCTGCACACGGATGGGCCCCTGGCCAGCTCCTGGCGCCACT
ACATTGCCATCATGGCTGCTGCCCGCCACCAGTGTTCTTACCTGGTGGGTTCCCACATGACCGA
GTTCCTGCAGACCGGCGGTGACCCCGAGTGGCTGCTGGGCCTCCATCGCGCCCCTGAAAAGCTC
CGCAAGCTCAGCGAGATCAACAAATTACTGGCACATCGGCCATGGCTTATCACCAAGGAGCATA
TTCAGGCCTTGCTGAAGACTGGAGAGCACAGCTGGTCCCTGGCTGAGCTCATCCAAGCGCTGGT
CCTGCTCACCCACTGCCACTGTCTGGCCTCCTTTGTGTTTGGCTGTGGGATACTTCCTGAGGGA
GACGCTGAGGGCAGCCCTGCCTCACAGGCACCTTCGCCACCCAGTGAGCAAGGCGGCCCCCCAA
GCAGAGACCCATTGAACAACTCGGGGGGCTTTGAAGCCGCCCGTGACATAGAAGCTCTGATGGA
ACGCATGAGGCAGCTTCAGGAGAGCCTCCTGCGGGATGAGGGGGCTTCCCAGGAGGAAATGGAG
AACCGTTTTGAGCTGGAGAAGACGGAAAGCCTGCTGGTGACCCCCTCAGCGGATATTCTGGAGC
CCTCTCCACACCCAGACATCCTATGCTTTGTAGAGGACCCCACGTTTGGATATGAAGACTTCAC
TCGTCGAGGGACTCAGGCCCCCCCAACCTTTCGTGCCCAGGATTATACCTGGGAAGACCATGGC
TACTCGCTGATCCAGCGGCTCTACCCCGAGGGAGGGCAGCTGCTGGATGAGAAGTTTCAGGTAG
CCTACAGCCTCACCTATAACACCATCGCCATGCACAGTGGCGTAGACACCTCCATGCTCCGCAG
AGCCGTCTGGAACTACATCCACTGCGTCTTTGGTATCAGATATGATGACTATGATTATGGAGAG
GTAAACCAGCTCCTGGAAAGGAACCTCAAGATCTATATCAAGACGGTTGCCTGCTACCCGGAGA
AGACGACCCGCAGAATGTACAACCTCTTTTGGAGGCACTTCCGCCACTCAGAGAAGGTTCACGT
GAACTTGCTGCTCCTCGAAGCCCGCATGCAAGCAGCTTTGCTCTATGCCCTCCGCGCCATCACC
CGCTACATGACCTGATTACCTGGCACACAGGAATGGCACCTGGAACAGCTGACCCTGGGCCACT
GTCCTCCGTGCAAGGACTTCTGTGTCTGGAGACAGATCCAGGACCCTTTCCGTCTCATGTCCAT
CCACCAAATGCCAGGGATGAGCATGCGTATGGCCATGCACAGCCCCCGAGGCAAGCCACACCTT
CCTTTTCCTCACTGGACTGAACAGGATCGTTGCACTGACTTTGGGGGTCTTGGCTCTGTCCCTA
GAGCTGGAAGATTAGGAAAACCCAAAGGCTCCGCCCCCTTTTCTTTCCTTGCTCCTTAAAGCAG
AGGAAGTCTACAGAGCTAAAGTCCGGCTTACGAGCCAGCAGGCTGGACCCCAGGCACAAATGCT
GCCTTCCTGGACTGGGAAGCCCCTGGCTGCCCATGTGGGAAAAAAGCAGGGACTAACACTCCAG
AAAGCTTGCCTTCCCTAGTTCCTCATTCACAAGTGTCATCACACACACACACACACACACACAC
ACACACACACCCACCCGCCTTCCACCCATCAATGTGAAAGTTGGACTCACAGCTGGCCTGTGTG
CCCAGTTCCCCCTAAGCCTGTTCTGTCGGGCAGCCTGTTCCTTGGTTACCTGAATATTGGTTCA
GTCCTTTTGTCTCCTTTCCCCTTACACCCTTTTCTCCCATGCCTGGTGGTGTGGGGCCTGGGAG
AGCGGCCAAACACATCCAAAGAACACACTGTCTCTGGAGAGTTGGAGCCCACGGTGGTCTCTCT
GCTGTCTGAAGAGTAAGGAATGGGTGCTGACGAACTCTGCATTTGGGTCTTGAGGCTGAGGTCT
GGTCTCTTGAGGACCTCACCATGGAACCAGAGTCAAAGCCTAGGAGGGAGTTGACACTGTTCTT
CTAGGTTGTATTGCCACACAGAGGCTGGCGTCCCATTCTCCTCATCCCTTGGGTTCTGCCTAGA
GTGCTTGCCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102828	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66423	(Get FASTA)	NCBI Sequence Viewer
	EDL80638	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102828 ⟸ NM_001109358

- UniProtKB:

B2GUV6 (UniProtKB/TrEMBL), D3ZFT9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIVADSECHGEIKGYLPFTRGGVAGPGTREEHREGQARRGPRGPSAFIPVEEILREGAESLEQH
LGLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYL
VGSHMTEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHSWSLA
ELIQALVLLTHCHCLASFVFGCGILPEGDAEGSPASQAPSPPSEQGGPPSRDPLNNSGGFEAAR
DIEALMERMRQLQESLLRDEGASQEEMENRFELEKTESLLVTPSADILEPSPHPDILCFVEDPT
FGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVAYSLTYNTIAMHSGV
DTSMLRRAVWNYIHCVFGIRYDDYDYGEVNQLLERNLKIYIKTVACYPEKTTRRMYNLFWRHFR
HSEKVHVNLLLLEARMQAALLYALRAITRYMT

hide sequence

RefSeq Acc Id:

ENSRNOP00000062295 ⟸ ENSRNOT00000067455

RefSeq Acc Id:

ENSRNOP00000077718 ⟸ ENSRNOT00000103737

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUV6-F1-model_v2	AlphaFold	B2GUV6	1-480	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694097

Promoter ID:

EPDNEW_R4621

Type:

initiation region

Name:

Sesn2_1

Description:

sestrin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	150,703,862 - 150,703,922	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566319	AgrOrtholog
BioCyc Gene	G2FUF-39685	BioCyc
Ensembl Genes	ENSRNOG00000042785	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000062295.3	UniProtKB/TrEMBL
	ENSRNOP00000077718	ENTREZGENE
	ENSRNOP00000077718.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067455.4	UniProtKB/TrEMBL
	ENSRNOT00000103737	ENTREZGENE
	ENSRNOT00000103737.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1290.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7096599	IMAGE-MGC_LOAD
InterPro	AhpD-like	UniProtKB/TrEMBL
	PA26	UniProtKB/TrEMBL
KEGG Report	rno:502988	UniProtKB/TrEMBL
MGC_CLONE	MGC:187396	IMAGE-MGC_LOAD
NCBI Gene	502988	ENTREZGENE
PANTHER	PTHR12474	UniProtKB/TrEMBL
Pfam	PA26	UniProtKB/TrEMBL
PhenoGen	Sesn2	PhenoGen
Superfamily-SCOP	SSF69118	UniProtKB/TrEMBL
UniProt	A0A8J8YB21_RAT	UniProtKB/TrEMBL
	B2GUV6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZFT9	ENTREZGENE
UniProt Secondary	D3ZFT9	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-12	Sesn2	sestrin 2	RGD1566319	similar to Sestrin 2 (Hi95)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1566319	similar to Sestrin 2 (Hi95)	RGD1566319_predicted	similar to Sestrin 2 (Hi95) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1566319_predicted	similar to Sestrin 2 (Hi95) (predicted)	LOC502988	similar to Sestrin 2 (Hi95)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502988	similar to Sestrin 2 (Hi95)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations