Sesn2 (sestrin 2) - Rat Genome Database

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Gene: Sesn2 (sestrin 2) Mus musculus
Analyze
Symbol: Sesn2
Name: sestrin 2
RGD ID: 1618969
MGI Page MGI
Description: Enables GDP-dissociation inhibitor activity and PH domain binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including glucose import; positive regulation of lipophagy; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HI95; MGC11758; Ses2; SEST2; sestrin-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,220,115 - 132,237,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,219,343 - 132,237,812 (-)EnsemblGRCm39 Ensembl
GRCm384132,492,804 - 132,510,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,492,032 - 132,510,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv374132,048,719 - 132,066,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,764,880 - 131,782,532 (-)NCBIMGSCv36mm8
Celera4130,652,973 - 130,670,713 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(E)-thiamethoxam  (EXP)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alternariol  (EXP)
AM-251  (ISO)
amino acid  (EXP)
amiodarone  (ISO)
amitrole  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (ISO)
dichloromethane  (ISO)
Didecyldimethylammonium  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
erastin  (EXP,ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
fenamidone  (EXP)
fenpyroximate  (ISO)
ferrostatin-1  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
hemin  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
imidacloprid  (ISO)
indole-3-methanol  (ISO)
indoline  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isorhamnetin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP,ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nimesulide  (ISO)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
peptidoglycan  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pifithrin-?  (EXP,ISO)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
progesterone  (ISO)
propanal  (ISO)
pterostilbene  (EXP,ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sinapic acid  (EXP)
sirolimus  (ISO)
sorafenib  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thiabendazole  (ISO)
thiamethoxam  (EXP)
thiazoles  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:17032746   PMID:18344994   PMID:18692468   PMID:18799693   PMID:19273598   PMID:19805316   PMID:19822145   PMID:20106877   PMID:20203043   PMID:21677750  
PMID:21873635   PMID:22173065   PMID:22560297   PMID:22958918   PMID:23274085   PMID:23495831   PMID:24005285   PMID:24046361   PMID:24055102   PMID:24947615   PMID:25024286   PMID:25040165  
PMID:25259925   PMID:25366347   PMID:25377878   PMID:25457612   PMID:25637945   PMID:25819761   PMID:26496610   PMID:26745185   PMID:26913956   PMID:26932729   PMID:26980623   PMID:27337507  
PMID:27454290   PMID:27645114   PMID:27733322   PMID:28215577   PMID:28300563   PMID:28433684   PMID:28592638   PMID:28729213   PMID:28818524   PMID:28981119   PMID:29273527   PMID:29325933  
PMID:30116150   PMID:30522100   PMID:31026186   PMID:31749402   PMID:31857853   PMID:31868937   PMID:31915252   PMID:31929512   PMID:32234722   PMID:32358171   PMID:32363721   PMID:32528056  
PMID:32740777   PMID:32863202   PMID:33430391   PMID:33842470   PMID:34038646   PMID:34048907   PMID:34242585   PMID:34482365   PMID:34741186   PMID:34995401   PMID:35260799   PMID:35771919  
PMID:35798554   PMID:35908070   PMID:35945510   PMID:36154620   PMID:36306010   PMID:36539111   PMID:36632468   PMID:36761756   PMID:36963287   PMID:37225009   PMID:37336368   PMID:37709247  
PMID:38109473   PMID:38163459   PMID:38165565   PMID:38331008  


Genomics

Comparative Map Data
Sesn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,220,115 - 132,237,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,219,343 - 132,237,812 (-)EnsemblGRCm39 Ensembl
GRCm384132,492,804 - 132,510,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,492,032 - 132,510,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv374132,048,719 - 132,066,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,764,880 - 131,782,532 (-)NCBIMGSCv36mm8
Celera4130,652,973 - 130,670,713 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.45NCBI
SESN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,259,518 - 28,282,491 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,259,518 - 28,282,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37128,586,029 - 28,609,002 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,458,593 - 28,481,589 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,270,147 - 28,293,143NCBI
Celera126,981,763 - 27,004,758 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,842,331 - 26,865,372 (+)NCBIHuRef
CHM1_1128,701,469 - 28,724,501 (+)NCBICHM1_1
T2T-CHM13v2.0128,101,353 - 28,124,325 (+)NCBIT2T-CHM13v2.0
Sesn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,986,304 - 150,005,255 (-)NCBIGRCr8
mRatBN7.25144,702,287 - 144,721,241 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,701,530 - 144,721,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,402,085 - 147,420,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,171,647 - 149,190,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,160,251 - 149,179,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,684,891 - 150,703,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,684,133 - 150,704,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,351,297 - 154,370,252 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,639,951 - 152,655,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5143,128,904 - 143,147,855 (-)NCBICelera
Cytogenetic Map5q36NCBI
Sesn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,393,007 - 7,417,304 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,392,644 - 7,417,204 (+)NCBIChiLan1.0ChiLan1.0
SESN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,572,508 - 198,596,064 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,689,417 - 197,712,997 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,518,248 - 27,541,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,555,072 - 28,577,931 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,555,072 - 28,577,931 (+)Ensemblpanpan1.1panPan2
SESN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,151,464 - 72,168,861 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,151,868 - 72,168,492 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,729,379 - 68,746,724 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,711,672 - 72,729,070 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,712,076 - 72,729,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,539,438 - 69,556,777 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,549,353 - 70,566,759 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,546,019 - 71,563,428 (-)NCBIUU_Cfam_GSD_1.0
Sesn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,591,898 - 46,611,063 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,416,652 - 12,436,814 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,416,652 - 12,436,799 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SESN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,324,228 - 85,348,032 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,321,982 - 85,348,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,065,763 - 79,087,496 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SESN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,521,131 - 104,544,161 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,521,132 - 104,544,001 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,936,607 - 11,959,826 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sesn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,087,858 - 12,120,914 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,087,901 - 12,135,145 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sesn2
470 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:647
Count of miRNA genes:405
Interacting mature miRNAs:461
Transcripts:ENSMUST00000030724
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129465811136864536Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
25394568Skmw56_mskeletal muscle weight 56, EDL (mouse)4129859344133710576Mouse
12904009Cfq9_mconditioned fear QTL 9 (mouse)4130036287133772722Mouse
25394567Skmw55_mskeletal muscle weight 55, gastroc (mouse)4131437804133710576Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131650724140879275Mouse
14696808Rbcn1_mrod bipolar cell number 1 (mouse)4131947311134047311Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_144907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK143788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL805897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000030724   ⟹   ENSMUSP00000030724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4132,219,343 - 132,237,812 (-)Ensembl
GRCm38.p6 Ensembl4132,492,032 - 132,510,501 (-)Ensembl
RefSeq Acc Id: NM_144907   ⟹   NP_659156
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394132,220,115 - 132,237,767 (-)NCBI
GRCm384132,492,804 - 132,510,456 (-)ENTREZGENE
MGSCv374132,048,719 - 132,066,371 (-)RGD
Celera4130,652,973 - 130,670,713 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_659156 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH05672 (Get FASTA)   NCBI Sequence Viewer  
  BAE41648 (Get FASTA)   NCBI Sequence Viewer  
  BAE41872 (Get FASTA)   NCBI Sequence Viewer  
  EDL30102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030724
  ENSMUSP00000030724.9
GenBank Protein P58043 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_659156   ⟸   NM_144907
- UniProtKB: P58043 (UniProtKB/Swiss-Prot),   Q3TCT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000030724   ⟸   ENSMUST00000030724

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58043-F1-model_v2 AlphaFold P58043 1-480 view protein structure

Promoters
RGD ID:6834828
Promoter ID:MM_KWN:39957
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000022319,   OTTMUST00000022320,   UC008VBK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364132,065,581 - 132,066,482 (-)MPROMDB
RGD ID:6884896
Promoter ID:EPDNEW_M5899
Type:initiation region
Name:Sesn2_1
Description:Mus musculus sestrin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384132,510,468 - 132,510,528EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2651874 AgrOrtholog
Ensembl Genes ENSMUSG00000028893 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030724 ENTREZGENE
  ENSMUST00000030724.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AhpD-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sestrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:230784 UniProtKB/Swiss-Prot
MGD MGI:2651874 ENTREZGENE
NCBI Gene 230784 ENTREZGENE
PANTHER PTHR12474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SESTRIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PA26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sesn2 PhenoGen
Superfamily-SCOP SSF69118 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P58043 ENTREZGENE
  Q3TCT3 ENTREZGENE, UniProtKB/TrEMBL
  Q3TDF4_MOUSE UniProtKB/TrEMBL
  SESN2_MOUSE UniProtKB/Swiss-Prot