RGD Reference Report - Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. - Rat Genome Database

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Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot.

Authors: Goberdhan, DC  Wilson, C  Harris, AL 
Citation: Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
RGD ID: 11535042
Pubmed: PMID:27076075   (View Abstract at PubMed)
PMCID: PMC5067300   (View Article at PubMed Central)
DOI: DOI:10.1016/j.cmet.2016.03.013   (Journal Full-text)

Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments activate different mTORC1 complexes, which may have distinct drug sensitivities and functions. We will discuss the implications of this for mTORC1 function in health and disease.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Flcn  (folliculin)
Fnip1  (folliculin interacting protein 1)
Fnip2  (folliculin interacting protein 2)
Sesn2  (sestrin 2)

Genes (Mus musculus)
Flcn  (folliculin)
Fnip1  (folliculin interacting protein 1)
Fnip2  (folliculin interacting protein 2)
Sesn2  (sestrin 2)

Genes (Homo sapiens)
FLCN  (folliculin)
FNIP1  (folliculin interacting protein 1)
FNIP2  (folliculin interacting protein 2)
SESN2  (sestrin 2)


Additional Information