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Gene: Sesn2 (sestrin 2) Ictidomys tridecemlineatus

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Symbol:

Sesn2

Name:

sestrin 2

RGD ID:

12645361

Description:

ENCODES a protein that exhibits protein-containing complex binding (ortholog); sulfiredoxin activity (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); cellular oxidant detoxification (ortholog); regulation of protein phosphorylation (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); Hepatomegaly (ortholog); FOUND IN nucleotide-activated protein kinase complex (ortholog); TORC2 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sestrin 2, transcript variant X1; sestrin 2, transcript variant X2; sestrin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SESN2 (sestrin 2)	NCBI	Ortholog
Mus musculus (house mouse):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SESN2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sesn2 (sestrin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	46,591,898 - 46,611,063 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	12,416,652 - 12,436,814 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	12,416,652 - 12,436,799 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

Colorectal Neoplasms (ISO)

Hepatomegaly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase activity (ISO)

cellular oxidant detoxification (IEA,ISO)

cellular response to amino acid starvation (IEA)

cellular response to amino acid stimulus (IEA)

cellular response to glucose starvation (IEA)

cellular response to L-leucine (IEA)

cellular response to leucine starvation (IEA)

cellular response to oxidative stress (IEA)

D-glucose import (IEA)

DNA damage response, signal transduction by p53 class mediator (IEA)

fatty acid beta-oxidation (IEA)

glucose homeostasis (IEA)

mitochondrial DNA metabolic process (IEA)

mitochondrion organization (IEA)

negative regulation of cell growth (IEA)

negative regulation of TORC1 signaling (IEA)

negative regulation of translation in response to endoplasmic reticulum stress (IEA)

positive regulation of lipophagy (IEA)

positive regulation of macroautophagy (IEA)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

positive regulation of protein localization to nucleus (IEA)

positive regulation of TORC1 signaling (IEA)

reactive oxygen species metabolic process (IEA)

regulation of cAMP/PKA signal transduction (IEA)

regulation of gluconeogenesis (IEA)

regulation of protein phosphorylation (ISO)

regulation of response to reactive oxygen species (IEA)

regulation of TORC1 signaling (IEA)

response to glucose (IEA)

response to insulin (IEA)

triglyceride homeostasis (IEA)

Cellular Component

Atg1/ULK1 kinase complex (IEA)

cytoplasm (IEA)

lysosomal membrane (IEA)

mitochondrion (IEA)

nucleotide-activated protein kinase complex (IEA,ISO)

nucleus (IEA)

TORC2 complex (IEA,ISO)

Molecular Function

GDP-dissociation inhibitor activity (IEA)

L-leucine binding (IEA)

oxidoreductase activity, acting on peroxide as acceptor (IEA)

peroxidase activity (IEA)

PH domain binding (IEA)

protein binding (ISO)

protein sequestering activity (IEA)

protein-containing complex binding (IEA,ISO)

sulfiredoxin activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sesn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	46,591,898 - 46,611,063 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	12,416,652 - 12,436,814 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	12,416,652 - 12,436,799 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SESN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	28,259,518 - 28,282,491 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	28,259,518 - 28,282,491 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	28,586,029 - 28,609,002 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	28,458,593 - 28,481,589 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	28,270,147 - 28,293,143	NCBI
Celera	1	26,981,763 - 27,004,758 (+)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	26,842,331 - 26,865,372 (+)	NCBI		HuRef
CHM1_1	1	28,701,469 - 28,724,501 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	28,101,353 - 28,124,325 (+)	NCBI		T2T-CHM13v2.0

Sesn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	132,220,115 - 132,237,767 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	132,219,343 - 132,237,812 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	132,492,804 - 132,510,456 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	132,492,032 - 132,510,501 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	132,048,719 - 132,066,371 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	131,764,880 - 131,782,532 (-)	NCBI		MGSCv36	mm8
Celera	4	130,652,973 - 130,670,713 (-)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	65.45	NCBI

Sesn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	149,986,304 - 150,005,255 (-)	NCBI		GRCr8
mRatBN7.2	5	144,702,287 - 144,721,241 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,701,530 - 144,721,260 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,402,085 - 147,420,950 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,171,647 - 149,190,510 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	149,160,251 - 149,179,202 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,684,891 - 150,703,846 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,684,133 - 150,704,117 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,351,297 - 154,370,252 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	152,639,951 - 152,655,828 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	143,128,904 - 143,147,855 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Sesn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	7,393,007 - 7,417,304 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	7,392,644 - 7,417,204 (+)	NCBI	ChiLan1.0	ChiLan1.0

SESN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	198,572,508 - 198,596,064 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	197,689,417 - 197,712,997 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	27,518,248 - 27,541,264 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	28,555,072 - 28,577,931 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	28,555,072 - 28,577,931 (+)	Ensembl	panpan1.1		panPan2

SESN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	72,151,464 - 72,168,861 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	72,151,868 - 72,168,492 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	68,729,379 - 68,746,724 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	72,711,672 - 72,729,070 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	72,712,076 - 72,729,237 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	69,539,438 - 69,556,777 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	70,549,353 - 70,566,759 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	71,546,019 - 71,563,428 (-)	NCBI		UU_Cfam_GSD_1.0

SESN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	85,324,228 - 85,348,032 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	85,321,982 - 85,348,044 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	79,065,763 - 79,087,496 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SESN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	104,521,131 - 104,544,161 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	104,521,132 - 104,544,001 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	11,936,607 - 11,959,826 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sesn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	12,087,858 - 12,120,914 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	12,087,901 - 12,135,145 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005317684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021734701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009292 ⟹ ENSSTOP00000008338

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936474	12,416,652 - 12,436,814 (+)	Ensembl

RefSeq Acc Id:

XM_005317684 ⟹ XP_005317741

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	46,591,948 - 46,611,063 (+)	NCBI
SpeTri2.0	NW_004936474	12,416,652 - 12,436,799 (+)	NCBI

Sequence:

show sequence

TTTGTGTCCCCGCCCTCCCCCGGGGACCGCAGCGAGCTGAGAGGCGCTGCTGGTGTCAGAGCCA
GACGAGCGCTTGCAGTTCCGCGGAGGGGATGCTGAGGAGCGCTGGGTCCGCGAGCAGCGCTGGC
TATTGCGGACTTCCGAGGCACCTCAGGCCGTGAGAACCCCTGCGTCTCGACCAAATCCAGGGCC
CCAAGGCCATTCACTGTTCCAGAAGCCAGTCTGGGAGAAGAGTCCAGCACAGCAGTAGCCGTCT
CCGGATCCTGAGCGTTCTGGAACCCCGAGAGACACCCTGGGGTTCTCGAACCTCCCCCAGCAAC
TCCCAGCTCCAGCTTCCTGCGTGCGTCCGTCCGTCCGTCCGAGACACCCCACCCGTGCTCTAAT
CTCGGCGAGCCGCGACTGAGTGCTGGTGCACACACCATGATCGTTGCGGACACCGAGTGCCGCG
CGGAGCTCCAGGGCTATCTGCCGTTCTCCCGGGGCGGCGTAGGCGCCCCTGGGACCGGAGAGGA
ACAGAAGGAGAGCCGGTCTCGTCGAGGCCGAGGACCCAGCGCCTTCATCCCAGTGGAGGAGGTT
CTTCGGGAGGGGGCTGAGAGCCTTGAGCAGCACCTGGGACTGGAGGCGCTGATGTCCTCAGGGC
GGGTGGATAACCTTGCCGTGGTGATGGGCCTGCACCCTGACTACCTCAGCAGCTTTTGGCGCTT
ACACTATCTGCTGCTGCACACAGATGGGCCCCTGGCCAGTTCCTGGCGCCACTACATTGCCATC
ATGGCTGCTGCTCGCCACCAGTGTTCTTACCTGGTGGGCTCCCACATGGCTGAATTTCTGCAGA
CTGGTGGTGACCCTGAGTGGCTGCTGGGTCTCCATCGGGCCCCGGAGAAGCTGCGAAAACTTAG
CGAAATCAACAAGTTACTGGCACATCGGCCGTGGCTCATCACCAAGGAGCACATCCAGGCCTTG
CTGAAGACTGGGGAACATAGCTGGTCTCTGGCCGAACTCATCCAAGCCTTGGTCCTCCTCACTC
ACTGCCACTCACTGGCCTCTTTCGTGTTTGGCTGTGGCATCCTTCCTGAGGGAGATCCAGAGGG
AAGTCCTGCCCCTCAGGCACCATCACCCCCCAGTGAGCAAAGCAGTCCTCCAAGTGGGGACCCA
CTGAACAATTCTGGGGGTTTTGAGTCTGCCCGGGATGTGGAAGCTCTAATGGAACGCATGAGGC
AGCTGCAGGAGAGCCTGTTGCGGGATGAAGGAGCCTCCCAGGAGGAGATGGAGAGCCGTTTTGA
GCTGGAGAAGTCGGAAAGCCTGCTGGTGACTCCCTCAGCTGACATCCTGGAGCCCTCTCCGCAC
CCAGACATGCTGTGCTTTGTGGAAGACCCCACTTTTGGATATGAAGACTTCACTCGGCGAGGGG
CTCAGGCCCCACCCACCTTCCGTGCTCAGGATTATACCTGGGAAGACCATGGCTACTCACTGAT
CCAGCGGCTGTATCCTGAGGGTGGGCAGCTGCTGGATGAGAAGTTCCAGGCAGCCTATAGCCTC
ACCTACAACACCATCGCCATGCACAGTGGCGTGGACACCTCCATGCTCCGCAGGGCCATCTGGA
ACTACATCCACTGCGTCTTTGGCATCAGATATGATGATTATGATTATGGGGAGGTGAACCAGCT
CCTGGAACGGAACCTCAAGGTCTATATCAAGACAGTAGCCTGCTACCCAGAGAAGACCACCCGA
AGAATGTACAACCACTTCTGGAGGCACTTCCGCCACTCAGAGAAGGTACATGTGAACTTGCTAC
TCCTGGAGGCCCGTATGCAAGCTGCCCTGCTGTACGCCCTCCGTGCCATCACCCGCTACATGAC
CTGACTCCCTCCCACGTAGGAACCATACCTGGAGCAGCTGATCCTGGGGATACCCTCCTCCCTG
GAAGAATTCCATCTGGAGACAGATCTGGGACCCTTTCAGTTCCATGCCCATCCCCACCCTGCTG
TGGGTGGGCTTGTGTGATGTGCAGCCCCCGAGCCACACCCTCTTTTTTTCTCACTGGAATGGAC
AGGATCACTGCACTGACTCTGGGATCTCAGCTCTGTCCCTGGGAACTGGAAGAGGATTAGGAGA
TCCCAAGGGGCTATGCATTTTTCCTTCCCCTGCCCCCCAGAGGCAGAGGGCATAGAAGGGAAAT
GTGCCAACCTCGGACTTGTGTGCCAGCAGGCTGAGCCCCAGGCACCACAAGTGCTGTGGCCTTC
CTGGACTGGGAAGTCCCTGGCTAGCCCCTGTGAGAGAGGGCCAAAGACCTCCGGGGACTAACAC
TCCAGGCAGCTTTGCCTTCTCTCCCCCATCATTCTCAGAGTTCATTACCTCCCACTTGAACACC
CATTAATGTGAAAGCCAGGGTCACAGCTGGCCTGTATGCCCTGTTCCCCAAAAGCCTTTTCTGT
TGGGCAGAATGGAGACCCCTGGTACCCTCGTTGCCTGAATCCTAGTTTAGTTCTCTTACCTTCT
TTGCCCTTGTATGCCTTTCTCCGATGATTTGAGGTGGGAGACCCCAGGAGAGAGGCCAGACCGA
ACCTTTTGGATGTGAACTGTTTCTGGAGATTTGGAGCCACTGTTGGTCACTTTGCCTTCCGAAG
AAGAAGTATTTGATGATAGATTCTCTGTGTTTGGGTCCTTTGTAGTTGAGGTCAGTCCTCTTCT
CGGCCTCCCCCTTGGAGCCACAGTTGATACCTGGGAGGAGCAGAGGGAGCCTCTTCACTCTAGG
CTGTGCTGCCTGTAGAGGCTGGAGCTCTGCCAAGGATATTTGCCAAAAAGCGGGGCCTTTCTAG
GTGGCTGAGGTGGCACTGAGACTCAGTAAGAGAGGCAGACACCAGGGCTCTTGTTTGGGCCCTA
CCACTGATTGGGTGACCATGCCACATTGCCAGGCCACCTTGACCACCACAGTTGCAGACGGAGG
GGTGGGTTGGAGTTTCCCCAGTGTCTGAGGCTGTGCCCTGGGATCTCAGGCCAACCTGTCAACA
GCAAGCTGATTTTTCTTAAAAGATCTTACGAAGTCCTCTGGGGACCCCCATTCCTGTAATTGTT
TTTTCCTGGCTGCCTTCCAAGGACCCTCACCCCCATCCTGGCGTCTCATCTGTCCCCTCTCCTA
GATTTTAGGTTTGCTTGGAGGCAGAAGCAGCCAAGGACTAATCCCAGGCACTTTCTGTAGCAAA
CAACTGTGAATTATGGCTTCTCTTGCCCTTCTTAGCAGTAGGTGCCTCCTCTTGATCCAGTTTG
GAGGTACCTGAGAAAGGCAGGGGCCACCATGCTGCTGCTTCTGACCCTCCTCCCTGGGGCAGGG
CAGGAGAGAAGCCTGCCAGTGTGCCACATTTCATACCCGTGCAGGCACGGGAAAGCGACTGGGC
ACCCCCTAAGGCCTGAAAGCCCTCCCCACAAAGAAGGGGGGCCAGAGGGAAAGGGGCCCAGCAT
GGGGGTTTGAGTTCTAGAGGGGACATGATGCCTCTGTTATTGTCTCCTGGGTTGGGTGGGAAGG
GTATCCAGTGTTCAAGTGCAGAAATCTTTGACCTTGTTAACAGTTACATATGATAAGAAATAAA
AGTTCACCAAGG

hide sequence

RefSeq Acc Id:

XM_021734701 ⟹ XP_021590376

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	46,591,898 - 46,611,063 (+)	NCBI
SpeTri2.0	NW_004936474	12,416,719 - 12,436,799 (+)	NCBI

Sequence:

show sequence

GAGCGCTTGCAGTTCCGCGGAGGGGATGCTGAGGAGCGCTGGGTCCGCGAGCAGCGCTGGCTAT
TGCGGACTTCCGAGGCACCTCAGGCCGTGAGAACCCCTGCGTCTCGACCAAATCCAGGGCCCCA
AGGCCATTCACTGTTCCAGAAGCCAGTCTGGGAGAAGAGTCCAGCACAGCAGTAGCCGTCTCCG
GATCCTGAGCGTTCTGGAACCCCGAGAGACACCCTGGGGTTCTCGAACCTCCCCCAGCAACTCC
CAGCTCCAGCTTCCTGCGTGCGTCCGTCCGTCCGTCCGAGACACCCCACCCGTGCTCTAATCTC
GGCGAGCCGCGACTGAGTGCTGGTGCACACACCATGATCGTTGCGGACACCGAGTGCCGCGCGG
AGCTCCAGGGCTATCTGCCGTTCTCCCGGGGCGGCGTAGGCGCCCCTGGGACCGGAGAGGAACA
GAAGGAGAGCCGGTCTCGTCGAGGCCGAGGACCCAGCGCCTTCATCCCAGTGGAGGAGGTTCTT
CGGGAGGGGGCTGAGAGCCTTGAGCAGCACCTGGGACTGGAGGCGCTGATGTCCTCAGGGCGGG
TGGATAACCTTGCCGTGGTGATGGGCCTGCACCCTGACTACCTCAGCAGCTTTTGGCGCTTACA
CTATCTGCTGCTGCACACAGATGGGCCCCTGGCCAGTTCCTGGCGCCACTACATTGCCATCATG
GCTGCTGCTCGCCACCAGTGTTCTTACCTGGTGGGCTCCCACATGGCTGAATTTCTGCAGACTG
GTGGTGACCCTGAGTGGCTGCTGGGTCTCCATCGGGCCCCGGAGAAGCTGCGAAAACTTAGCGA
AATCAACAAGTTACTGGCACATCGGCCGTGGCTCATCACCAAGGAGCACATCCAGGCCTTGCTG
AAGACTGGGGAACATAGCTGGTCTCTGGCCGAACTCATCCAAGCCTTGGTCCTCCTCACTCACT
GCCACTCACTGGCCTCTTTCGTGTTTGGCTGTGGCATCCTTCCTGAGGGAGATCCAGAGGGAAG
TCCTGCCCCTCAGGCACCATCACCCCCCAGTGAGCAAAGCAGTCCTCCAAGTGGGGACCCACTG
AACAATTCTGGGGGTTTTGAGTCTGCCCGGGATGTGGAAGCTCTAATGGAACGCATGAGGCAGC
TGCAGGAGAGCCTGTTGCGGGATGAAGGAGCCTCCCAGGAGGAGATGGAGAGCCGTTTTGAGCT
GGAGAAGTCGGAAAGCCTGCTGGTGACTCCCTCAGGCCTGGCTCCAGCTGAAGTCCTGCTCCCA
CTCACTAGCGACGGACTCTCTCTGGCTCTCTGCTCTGCCTCCCCATGCCCCCCTTTGATGATTA
ATCAGGAGTGGAGCCCTTTGTGCTCCATGTCTCGACCTCACGGTGACCTCTTTCTGACATGGTC
CTCAGCTGACATCCTGGAGCCCTCTCCGCACCCAGACATGCTGTGCTTTGTGGAAGACCCCACT
TTTGGATATGAAGACTTCACTCGGCGAGGGGCTCAGGCCCCACCCACCTTCCGTGCTCAGGATT
ATACCTGGGAAGACCATGGCTACTCACTGATCCAGCGGCTGTATCCTGAGGGTGGGCAGCTGCT
GGATGAGAAGTTCCAGGCAGCCTATAGCCTCACCTACAACACCATCGCCATGCACAGTGGCGTG
GACACCTCCATGCTCCGCAGGGCCATCTGGAACTACATCCACTGCGTCTTTGGCATCAGATATG
ATGATTATGATTATGGGGAGGTGAACCAGCTCCTGGAACGGAACCTCAAGGTCTATATCAAGAC
AGTAGCCTGCTACCCAGAGAAGACCACCCGAAGAATGTACAACCACTTCTGGAGGCACTTCCGC
CACTCAGAGAAGGTACATGTGAACTTGCTACTCCTGGAGGCCCGTATGCAAGCTGCCCTGCTGT
ACGCCCTCCGTGCCATCACCCGCTACATGACCTGACTCCCTCCCACGTAGGAACCATACCTGGA
GCAGCTGATCCTGGGGATACCCTCCTCCCTGGAAGAATTCCATCTGGAGACAGATCTGGGACCC
TTTCAGTTCCATGCCCATCCCCACCCTGCTGTGGGTGGGCTTGTGTGATGTGCAGCCCCCGAGC
CACACCCTCTTTTTTTCTCACTGGAATGGACAGGATCACTGCACTGACTCTGGGATCTCAGCTC
TGTCCCTGGGAACTGGAAGAGGATTAGGAGATCCCAAGGGGCTATGCATTTTTCCTTCCCCTGC
CCCCCAGAGGCAGAGGGCATAGAAGGGAAATGTGCCAACCTCGGACTTGTGTGCCAGCAGGCTG
AGCCCCAGGCACCACAAGTGCTGTGGCCTTCCTGGACTGGGAAGTCCCTGGCTAGCCCCTGTGA
GAGAGGGCCAAAGACCTCCGGGGACTAACACTCCAGGCAGCTTTGCCTTCTCTCCCCCATCATT
CTCAGAGTTCATTACCTCCCACTTGAACACCCATTAATGTGAAAGCCAGGGTCACAGCTGGCCT
GTATGCCCTGTTCCCCAAAAGCCTTTTCTGTTGGGCAGAATGGAGACCCCTGGTACCCTCGTTG
CCTGAATCCTAGTTTAGTTCTCTTACCTTCTTTGCCCTTGTATGCCTTTCTCCGATGATTTGAG
GTGGGAGACCCCAGGAGAGAGGCCAGACCGAACCTTTTGGATGTGAACTGTTTCTGGAGATTTG
GAGCCACTGTTGGTCACTTTGCCTTCCGAAGAAGAAGTATTTGATGATAGATTCTCTGTGTTTG
GGTCCTTTGTAGTTGAGGTCAGTCCTCTTCTCGGCCTCCCCCTTGGAGCCACAGTTGATACCTG
GGAGGAGCAGAGGGAGCCTCTTCACTCTAGGCTGTGCTGCCTGTAGAGGCTGGAGCTCTGCCAA
GGATATTTGCCAAAAAGCGGGGCCTTTCTAGGTGGCTGAGGTGGCACTGAGACTCAGTAAGAGA
GGCAGACACCAGGGCTCTTGTTTGGGCCCTACCACTGATTGGGTGACCATGCCACATTGCCAGG
CCACCTTGACCACCACAGTTGCAGACGGAGGGGTGGGTTGGAGTTTCCCCAGTGTCTGAGGCTG
TGCCCTGGGATCTCAGGCCAACCTGTCAACAGCAAGCTGATTTTTCTTAAAAGATCTTACGAAG
TCCTCTGGGGACCCCCATTCCTGTAATTGTTTTTTCCTGGCTGCCTTCCAAGGACCCTCACCCC
CATCCTGGCGTCTCATCTGTCCCCTCTCCTAGATTTTAGGTTTGCTTGGAGGCAGAAGCAGCCA
AGGACTAATCCCAGGCACTTTCTGTAGCAAACAACTGTGAATTATGGCTTCTCTTGCCCTTCTT
AGCAGTAGGTGCCTCCTCTTGATCCAGTTTGGAGGTACCTGAGAAAGGCAGGGGCCACCATGCT
GCTGCTTCTGACCCTCCTCCCTGGGGCAGGGCAGGAGAGAAGCCTGCCAGTGTGCCACATTTCA
TACCCGTGCAGGCACGGGAAAGCGACTGGGCACCCCCTAAGGCCTGAAAGCCCTCCCCACAAAG
AAGGGGGGCCAGAGGGAAAGGGGCCCAGCATGGGGGTTTGAGTTCTAGAGGGGACATGATGCCT
CTGTTATTGTCTCCTGGGTTGGGTGGGAAGGGTATCCAGTGTTCAAGTGCAGAAATCTTTGACC
TTGTTAACAGTTACATATGATAAGAAATAAAAGTTCACCAAGG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005317741	(Get FASTA)	NCBI Sequence Viewer
	XP_021590376	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008338.2
GenBank Protein	KAG3282548	(Get FASTA)	NCBI Sequence Viewer
	KAG3282549	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005317741 ⟸ XM_005317684
- Peptide Label:	isoform X2
- UniProtKB:	I3MDA5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIVADTECRAELQGYLPFSRGGVGAPGTGEEQKESRSRRGRGPSAFIPVEEVLREGAESLEQHL GLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLV GSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHSWSLAE LIQALVLLTHCHSLASFVFGCGILPEGDPEGSPAPQAPSPPSEQSSPPSGDPLNNSGGFESARD VEALMERMRQLQESLLRDEGASQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTF GYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVD TSMLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNHFWRHFRH SEKVHVNLLLLEARMQAALLYALRAITRYMT hide sequence

RefSeq Acc Id:

XP_021590376 ⟸ XM_021734701

- Peptide Label:

isoform X1

- Sequence:

show sequence

MIVADTECRAELQGYLPFSRGGVGAPGTGEEQKESRSRRGRGPSAFIPVEEVLREGAESLEQHL
GLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLV
GSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHSWSLAE
LIQALVLLTHCHSLASFVFGCGILPEGDPEGSPAPQAPSPPSEQSSPPSGDPLNNSGGFESARD
VEALMERMRQLQESLLRDEGASQEEMESRFELEKSESLLVTPSGLAPAEVLLPLTSDGLSLALC
SASPCPPLMINQEWSPLCSMSRPHGDLFLTWSSADILEPSPHPDMLCFVEDPTFGYEDFTRRGA
QAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSMLRRAIWN
YIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNHFWRHFRHSEKVHVNLLL
LEARMQAALLYALRAITRYMT

hide sequence

Ensembl Acc Id:

ENSSTOP00000008338 ⟸ ENSSTOT00000009292

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009293	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009292.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1290.10	UniProtKB/TrEMBL
InterPro	AhpD-like	UniProtKB/TrEMBL
	Sestrin	UniProtKB/TrEMBL
NCBI Gene	Sesn2	ENTREZGENE
PANTHER	PTHR12474	UniProtKB/TrEMBL
	SESTRIN-2	UniProtKB/TrEMBL
Pfam	PA26	UniProtKB/TrEMBL
Superfamily-SCOP	SSF69118	UniProtKB/TrEMBL
UniProt	I3MDA5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations