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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sesn2increases expressionISOSesn2 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SESN2 proteinPMID:25637945
Sesn2increases ubiquitinationISOSesn2 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 proteinPMID:25637945
Sesn2multiple interactionsISOSesn2 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of SESN2 protein]; Lipopolysaccharides inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 protein]PMID:25637945
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