Srsf4 (serine and arginine rich splicing factor 4)

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Gene: Srsf4 (serine and arginine rich splicing factor 4) Rattus norvegicus

Analyze

Symbol:

Srsf4

Name:

serine and arginine rich splicing factor 4

RGD ID:

1561347

Description:

Exhibits sequence-specific mRNA binding activity. Involved in response to insulin. Localizes to nucleus. Orthologous to human SRSF4 (serine and arginine rich splicing factor 4); PARTICIPATES IN spliceosome pathway; INTERACTS WITH bisphenol A; buspirone; flutamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

LOC362612; RGD1561347; serine/arginine-rich splicing factor 4; Sfrs4; similar to Sfrs4 protein; splicing factor, arginine/serine-rich 4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	144,060,981 - 144,090,798 (+)	NCBI
Rnor_6.0 Ensembl	5	150,032,999 - 150,060,765 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	5	150,032,999 - 150,060,769 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	5	153,711,721 - 153,739,491 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	150,731,169 - 150,758,934 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	5	142,505,197 - 142,532,845 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

clear cell renal cell carcinoma (ISO)

colon adenocarcinoma (ISO)

Down syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

buspirone (EXP)

butanal (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dihydroartemisinin (ISO)

dorsomorphin (ISO)

flutamide (EXP)

furan (EXP)

GSK690693 (ISO)

leflunomide (EXP)

methylmercury chloride (ISO)

nefazodone (EXP)

nimesulide (EXP)

paraquat (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

thimerosal (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hematopoietic progenitor cell differentiation (ISO)

mRNA cis splicing, via spliceosome (IBA)

mRNA splicing, via spliceosome (IBA)

negative regulation of mRNA splicing, via spliceosome (ISO)

regulation of alternative mRNA splicing, via spliceosome (IBA)

response to insulin (IEP)

Cellular Component

nuclear speck (IBA,ISO)

nucleus (IDA)

Molecular Function

mRNA binding (IBA)

protein binding (ISO)

RNA binding (IBA)

sequence-specific mRNA binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

References - curated


1.	Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24.
4.	Liu J, etal., Onkologie. 2012;35(6):335-40. doi: 10.1159/000338941. Epub 2012 May 22.
5.	Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30.
6.	Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
7.	RGD automated data pipeline
8.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	RGD automated import pipeline for gene-chemical interactions
10.	Tsangaris GT, etal., Proteomics. 2006 Aug;6(15):4410-9.
11.	Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
12.	Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11.

Additional References at PubMed

PMID:12477932	PMID:15009664	PMID:21073651	PMID:22658674	PMID:22681889	PMID:24029230	PMID:25002582	PMID:25931508

Genomics

Comparative Map Data

Srsf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	144,060,981 - 144,090,798 (+)	NCBI
Rnor_6.0 Ensembl	5	150,032,999 - 150,060,765 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	5	150,032,999 - 150,060,769 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	5	153,711,721 - 153,739,491 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	150,731,169 - 150,758,934 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	5	142,505,197 - 142,532,845 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

SRSF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	29,147,743 - 29,181,900 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	29,147,743 - 29,181,900 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	29,474,255 - 29,508,412 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	29,346,946 - 29,380,948 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	29,294,980 - 29,328,977	NCBI
Celera	1	27,870,392 - 27,904,789 (-)	NCBI
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	27,726,138 - 27,760,578 (-)	NCBI		HuRef
CHM1_1	1	29,589,632 - 29,624,036 (-)	NCBI		CHM1_1

Srsf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	131,600,841 - 131,629,036 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	4	131,600,928 - 131,629,017 (+)	Ensembl
GRCm38	4	131,873,530 - 131,901,725 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	131,873,617 - 131,901,706 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	131,429,554 - 131,457,640 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	4	131,169,807 - 131,173,781 (+)	NCBI			mm8
Celera	4	130,034,138 - 130,062,224 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI

Srsf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	8,142,500 - 8,174,869 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	8,143,850 - 8,174,830 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRSF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	29,444,263 - 29,490,360 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	29,444,269 - 29,478,035 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	28,418,297 - 28,452,595 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SRSF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	2	71,394,037 - 71,471,997 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	2	71,418,626 - 71,434,140 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Srsf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936474	13,113,191 - 13,140,956 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRSF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	85,891,364 - 86,131,682 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	86,064,776 - 86,092,769 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	79,952,072 - 79,979,921 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRSF4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	103,641,650 - 103,674,066 (+)	NCBI
ChlSab1.1 Ensembl	20	103,642,150 - 103,673,391 (+)	Ensembl

Srsf4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624764	12,916,857 - 12,945,861 (-)	NCBI

Position Markers

AW550192

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	5	150,060,182 - 150,060,320	NCBI	Rnor6.0
Rnor_5.0	5	153,738,904 - 153,739,042	UniSTS	Rnor5.0
RGSC_v3.4	5	150,758,353 - 150,758,491	UniSTS	RGSC3.4
Celera	5	142,532,258 - 142,532,396	UniSTS
Cytogenetic Map	5	q36	UniSTS

BF394391

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	5	150,039,209 - 150,039,298	NCBI	Rnor6.0
Rnor_5.0	5	153,717,931 - 153,718,020	UniSTS	Rnor5.0
RGSC_v3.4	5	151,146,572 - 151,146,661	UniSTS	RGSC3.4
RGSC_v3.4	5	150,737,379 - 150,737,468	UniSTS	RGSC3.4
Celera	5	142,511,407 - 142,511,496	UniSTS
RH 3.4 Map	5	988.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40777918	154732375	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	47745646	167946134	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	61612600	168109659	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	71552569	157225114	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	84963058	173504662	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	100723739	153577831	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	102945579	154732228	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	107119214	152119214	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111278451	156278451	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112279412	157279412	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112279412	157279412	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112279412	157279412	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112279412	157279412	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112279412	157279412	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114140832	159140832	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114140832	159140832	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116767924	161767924	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116767924	161767924	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116767924	161767924	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116767924	161767924	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125455818	157225114	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	128687766	173687766	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	131077716	173707219	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132551937	173707219	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133943857	173707219	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133943857	173707219	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	134197905	173707219	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134502140	157212422	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	134712342	173707219	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	134712342	173707219	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	136354114	173707219	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136640731	173707219	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138154677	172402610	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	142307322	173707219	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	142309061	173707219	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149029982	173687766	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	149568588	167739697	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149832180	164807402	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	68
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000013301
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	57	41	19	41	1	4	74	34	41	11	1
Low		7					7	7		1			7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC160850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013301 ⟹ ENSRNOP00000013301

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	150,032,999 - 150,060,765 (+)	Ensembl

RefSeq Acc Id:

NM_001108685 ⟹ NP_001102155

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	144,061,463 - 144,089,235 (+)	NCBI
Rnor_6.0	5	150,032,999 - 150,060,769 (+)	NCBI
Rnor_5.0	5	153,711,721 - 153,739,491 (+)	NCBI
RGSC_v3.4	5	150,731,169 - 150,758,934 (+)	RGD
Celera	5	142,505,197 - 142,532,845 (+)	NCBI

Sequence:

show sequence

CGCCGGGCTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTACCGCCGCCGCCGCCGCGCTTTCC
CTTCGCCGGCCGCCGCCTGAGGGGGGCCGGGGCCAGCCGCCGCCGGAATGCCGCGCGTGTACAT
CGGCCGCCTGAGCTACCAGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAG
ATCCTGGAGGTGGATCTGAAGAACGGGTATGGTTTTGTGGAGTTTGATGATCTGCGTGATGCAG
ATGATGCTGTTTATGAACTGAATGGCAAAGACCTCTGTGGTGAACGAGTCATTGTTGAGCATGC
CCGAGGCCCACGTCGGGACGGCAGTTACGGTTCTGGACGCAGTGGATATGGTTATCGAAGAAGT
GGCCGAGATAAATATGGTCCTCCTACTCGCACAGAGTACAGACTTATTGTGGAGAATCTGTCAA
GTCGATGCAGCTGGCAAGATCTAAAGGATTATATGCGTCAGGCAGGAGAAGTGACGTATGCAGA
TGCTCACAAGGGACGCAAAAACGAAGGAGTGATTGAATTTGTGTCTTACTCTGATATGAAAAGA
GCTTTGGAAAAGTTGGATGGAACTGAAGTCAACGGCAGAAAAATCAGATTAGTTGAAGACAAGC
CAGGTTCTAGACGGCGCCGGTCTTACTCCAGAAGCCGGAGTCACTCAAGGTCTCGCTCTCGAAG
CAGACATTCTCGGAAGAGCAGAAGCCGAAGTGGTAGCAGTAAAAGCAGCCATTCAAAGAGCCGC
TCTCGATCCAGGTCGGGTTCCCACTCCCGCAGCAAGAGCCGCAGCCGCAGCCAGAGCCGCAGTC
GCAGTAAGAAGGAGAAAAGCCGGAGCCCCAGCAAAGACAACAAGAGCCGCAGTCGCAGCCGCAG
CCCCGACAAGAGCCGAAGCAAAAGTAAAGACCATGCAGAGGACAAGCTCCAGAACAACGACAGC
GCTGGCAAAGCCAAGAGCCACAGCCCCAGCCGCCATGACAGTAAAAGTCGGAGCAGGAGCCAGG
AGAGGAGAGCAGAGGAGGAGAGGAGAAGCAGCACGAGCAGGGGTCACAGCCAGGAGAAGAGCCT
GCTTAAGAGCCGCAGCCGCAGCCGCAGCAAAGTGGGCAGCCGCAGCCGCAGCCGCAGCAAAAGC
AAGGACAAGCGGAAGGGCCGGAAGAGAAGCAGGGAAGAAAGTCGAAGCCGGAGCCGCAGCAAGA
GCGAGCGCAGCCGGAAGCATAGCAGCAAGCGGGACAGCAAAGTCAGCAGCAGCAGCAGCAAGAA
GAAGAAGGGAGACACCGACCACTCCCGGTCACCGTCCCGCTCAGTGTCAAAGGAGCGGGAACAT
GCCACGGCAGAGCCTGGCCAGAGGGAAAGCCGGGCTGAGGGTGAGAGCGAGGGTCCCAATCCAG
AGCCCCGGGCCAGGTCAAGATCCACTTCCAAATCCAAACCTAGTCTCCCGGCAGAGTCCCGCTC
CAGGTCAAAGTCAGCTTCAAAAACGCGCTCTCGGTCCAAGTCTCCATCCAGGTCTGCTTCCAGG
TCGCCCTCCCGGTCTAGATCCAGGTCCCACTCAAGGTCCTAACTGGCCATGCTGCGCTGGAACT
GCCGAGAAGTTTTTGTACATTTGGTAGCCGTAGCACAGGAGTGAAGTAGAACACCCGTCACTGC
TGTACATTAACTCCCCAAAGGTGTGTCTCAGTTGTTCAATCTCAGTGCTTCCTCGGTACCGCCT
CCCGGCGCCAGGCCTTCCCGCTCCACTGAAAAGCAGCTCCTCAAACTCCCTGTACTCACAGTAG
GACACCCAACGCCTTGGCTTTCAGGCCTGGCCACGGCTACAGGGAGCTCGGCACCTGGACGGCT
TCTCAGGCTGGAGTGATGGCGTAGGTAGGTGTGGTGAGCTCAGCCGTTTGCCCTTGAATTGATG
CCCTTTGATGTGTGCCACGTAGTGAAAGTGCAAGTCTTCAGTCTCCCACCACTTCGGTTTCCTG
TTTCTGGACTTAACAACCTTGTGAATAGCACAGTCAAGAGAAATGGATACCTGCATAGCCCATA
GGAAGTAACACTGTAGAGCTCCATATTCTGGTATTGTGATTATATTGTTTTATATTAAAAAAGG
AAAGAATTTTTTTTAATTTTATTTTTCCCCGTCTTGCAAAGTATAGTGGCCCCTGTTTCCATTA
AATTTGAATAAAGACTATTTTTGCTTGACAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039110382 ⟹ XP_038966310

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	144,060,981 - 144,090,798 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102155	(Get FASTA)	NCBI Sequence Viewer
	XP_038966310	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI60850	(Get FASTA)	NCBI Sequence Viewer
	EDL80612	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102155 ⟸ NM_001108685

- UniProtKB:

G3V798 (UniProtKB/TrEMBL), B1H240 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGER
VIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAG
EVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHS
RSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSHSRSKSRSRSQSRSRSKKEKSRSPSKDNKS
RSRSRSPDKSRSKSKDHAEDKLQNNDSAGKAKSHSPSRHDSKSRSRSQERRAEEERRSSTSRGH
SQEKSLLKSRSRSRSKVGSRSRSRSKSKDKRKGRKRSREESRSRSRSKSERSRKHSSKRDSKVS
SSSSKKKKGDTDHSRSPSRSVSKEREHATAEPGQRESRAEGESEGPNPEPRARSRSTSKSKPSL
PAESRSRSKSASKTRSRSKSPSRSASRSPSRSRSRSHSRS

hide sequence

RefSeq Acc Id:

ENSRNOP00000013301 ⟸ ENSRNOT00000013301

RefSeq Acc Id:	XP_038966310 ⟸ XM_039110382
- Peptide Label:	isoform X1

Protein Domains

RRM

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694090

Promoter ID:

EPDNEW_R4614

Type:

initiation region

Name:

Srsf4_1

Description:

serine and arginine rich splicing factor 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	150,032,983 - 150,033,043	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561347	AgrOrtholog
Ensembl Genes	ENSRNOG00000010007	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013301	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013301	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8363821	IMAGE-MGC_LOAD
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM1_SRSF4-like	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
KEGG Report	rno:362612	UniProtKB/TrEMBL
MGC_CLONE	MGC:187592	IMAGE-MGC_LOAD
NCBI Gene	362612	ENTREZGENE
Pfam	RRM_1	UniProtKB/TrEMBL
PhenoGen	Srsf4	PhenoGen
PROSITE	RRM	UniProtKB/TrEMBL
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	B1H240	ENTREZGENE, UniProtKB/TrEMBL
	G3V798	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Srsf4	serine and arginine rich splicing factor 4	Srsf4	serine/arginine-rich splicing factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-01	Srsf4	serine/arginine-rich splicing factor 4	Sfrs4	splicing factor, arginine/serine-rich 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-22	Sfrs4	splicing factor, arginine/serine-rich 4	Srsf4	serine/arginine-rich splicing factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-13	Srsf4	serine/arginine-rich splicing factor 4	Sfrs4	splicing factor, arginine/serine-rich 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Sfrs4	splicing factor, arginine/serine-rich 4	RGD1561347	similar to Sfrs4 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1561347	similar to Sfrs4 protein	RGD1561347_predicted	similar to Sfrs4 protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1561347_predicted	similar to Sfrs4 protein (predicted)	LOC362612	similar to Sfrs4 protein	Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations