Gene: Ptprf (protein tyrosine phosphatase, receptor type, F) Rattus norvegicus
Analyze
Symbol:
Ptprf
Name:
protein tyrosine phosphatase, receptor type, F
Description:
Exhibits phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Localizes to several cellular components, including the growth cone; integral component of postsynaptic density membrane; and neuronal cell body. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LAR; LARFN5C; leukocyte antigen-related (LAR) PTP receptor; leukocyte common antigen related; protein tyrosine phosphatase receptor-type F; receptor-type tyrosine-protein phosphatase F
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PTPRF (protein tyrosine phosphatase receptor type F) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Ptprf (protein tyrosine phosphatase, receptor type, F) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ptprf (protein tyrosine phosphatase receptor type F) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PTPRF (protein tyrosine phosphatase receptor type F) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PTPRF (protein tyrosine phosphatase receptor type F) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ptprf (protein tyrosine phosphatase receptor type F) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PTPRF (protein tyrosine phosphatase receptor type F) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PTPRD (protein tyrosine phosphatase receptor type D) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
PTPRS (protein tyrosine phosphatase receptor type S) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
PTPRF (protein tyrosine phosphatase receptor type F)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Ptprf (protein tyrosine phosphatase, receptor type, F)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ptprfa (protein tyrosine phosphatase, receptor type, f, a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
ptprfb (protein tyrosine phosphatase, receptor type, f, b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
ptp-3
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Drosophila melanogaster (fruit fly):
Lar
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 137,036,936 - 137,112,930 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 137,036,935 - 137,112,927 (-) Ensembl Rnor_5.0 5 140,825,315 - 140,901,672 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 138,671,725 - 138,739,002 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 138,676,940 - 138,744,228 (-) NCBI Celera 5 130,289,962 - 130,357,275 (-) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Charcot-Marie-Tooth disease dominant intermediate C ISO RGD:734202 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth disease, dominant intermediate C ClinVar PMID:28492532
Imported Annotations - CTD
Disease Progression ISO RGD:734202 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21364753 malignant mesothelioma ISO RGD:734202 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25756049 Stomach Neoplasms ISO RGD:734202 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21364753 Imported Annotations - OMIM
Breasts and/or Nipples, Aplasia or Hypoplasia of, 2 ISO RGD:734202 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTPRF mRNA] CTD PMID:31150632 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PTPRF mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression EXP 6480464 Topotecan results in increased expression of PTPRF mRNA CTD PMID:25729387 1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of PTPRF mRNA CTD PMID:21983209 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTPRF mRNA CTD PMID:20959002 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:737214 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTPRF mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:737214 6480464 Tetrachlorodibenzodioxin affects the expression of PTPRF mRNA CTD PMID:24680724 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:20959002 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:734202 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide increases expression ISO RGD:737214 6480464 Fenretinide results in increased expression of PTPRF mRNA CTD PMID:28973697 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of PTPRF mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of PTPRF mRNA CTD PMID:19483382 8-bromo-3',5'-cyclic AMP decreases expression ISO RGD:734202 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PTPRF mRNA CTD PMID:22079614 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of PTPRF mRNA CTD PMID:28959563 aflatoxin B1 increases methylation ISO RGD:734202 6480464 Aflatoxin B1 results in increased methylation of PTPRF gene CTD PMID:27153756 aflatoxin B1 affects methylation ISO RGD:734202 6480464 Aflatoxin B1 affects the methylation of PTPRF intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:734202 6480464 aflatoxin B2 results in increased methylation of PTPRF intron CTD PMID:30157460 aldrin increases expression ISO RGD:737214 6480464 Aldrin results in increased expression of PTPRF mRNA CTD PMID:18579281 all-trans-retinoic acid decreases expression ISO RGD:734202 6480464 Tretinoin results in decreased expression of PTPRF mRNA CTD PMID:15498508 , PMID:23724009 amiodarone increases expression ISO RGD:734202 6480464 Amiodarone results in increased expression of PTPRF mRNA CTD PMID:19774075 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of PTPRF mRNA CTD PMID:19483382 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PTPRF mRNA CTD PMID:16483693 arsenite(3-) increases expression ISO RGD:737214 6480464 arsenite results in increased expression of PTPRF mRNA CTD PMID:18191166 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of PTPRF mRNA CTD PMID:19483382 benzene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNA CTD PMID:17905399 benzo[a]pyrene decreases expression ISO RGD:737214 6480464 Benzo(a)pyrene results in decreased expression of PTPRF mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:734202 6480464 Benzo(a)pyrene affects the methylation of PTPRF intron CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:734202 6480464 benzo(e)pyrene results in increased methylation of PTPRF intron CTD PMID:30157460 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PTPRF mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PTPRF gene CTD PMID:28505145 bisphenol A decreases methylation ISO RGD:737214 6480464 bisphenol A results in decreased methylation of PTPRF promoter CTD PMID:27312807 bisphenol F multiple interactions ISO RGD:734202 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA CTD PMID:28628672 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of PTPRF mRNA CTD PMID:24136188 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of PTPRF mRNA CTD PMID:19010381 calcitriol increases expression ISO RGD:734202 6480464 Calcitriol results in increased expression of PTPRF mRNA CTD PMID:26485663 carbamazepine affects expression ISO RGD:734202 6480464 Carbamazepine affects the expression of PTPRF mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:737214 6480464 Nanotubes, Carbon analog results in decreased expression of PTPRF mRNA, Nanotubes, Carbon results in decreased expression of PTPRF mRNA CTD PMID:25620056 casticin decreases expression ISO RGD:737214 6480464 casticin results in decreased expression of PTPRF mRNA CTD PMID:28444820 chloropicrin decreases expression ISO RGD:734202 6480464 chloropicrin results in decreased expression of PTPRF mRNA CTD PMID:26352163 , PMID:28476498 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of PTPRF mRNA CTD PMID:18668222 choline multiple interactions ISO RGD:737214 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRF mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPRF gene CTD PMID:20938992 chromium(6+) affects expression ISO RGD:737214 6480464 chromium hexavalent ion affects the expression of PTPRF mRNA CTD PMID:28472532 cisplatin multiple interactions ISO RGD:734202 6480464 [Cisplatin co-treated with panobinostat] affects the expression of PTPRF mRNA CTD PMID:21791302 cisplatin decreases expression ISO RGD:734202 6480464 Cisplatin results in decreased expression of PTPRF mRNA CTD PMID:27392435 , PMID:27594783 clobetasol decreases expression ISO RGD:737214 6480464 Clobetasol results in decreased expression of PTPRF mRNA CTD PMID:27462272 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of PTPRF mRNA CTD PMID:19483382 clofibrate decreases expression ISO RGD:737214 6480464 Clofibrate results in decreased expression of PTPRF mRNA CTD PMID:23811191 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRF mRNA CTD PMID:17602206 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of PTPRF mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO RGD:734202 6480464 cobaltous chloride results in decreased expression of PTPRF mRNA CTD PMID:19320972 , PMID:19376846 coumestrol multiple interactions ISO RGD:734202 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of PTPRF mRNA CTD PMID:19167446 coumestrol decreases expression ISO RGD:734202 6480464 Coumestrol results in decreased expression of PTPRF mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:734202 6480464 Cyclosporine results in decreased expression of PTPRF mRNA CTD PMID:20106945 , PMID:27989131 dexamethasone multiple interactions ISO RGD:734202 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA CTD PMID:28628672 dicrotophos increases expression ISO RGD:734202 6480464 dicrotophos results in increased expression of PTPRF mRNA CTD PMID:28302478 doxorubicin increases expression ISO RGD:737214 6480464 Doxorubicin results in increased expression of PTPRF mRNA CTD PMID:25896364 doxorubicin decreases expression ISO RGD:734202 6480464 Doxorubicin results in decreased expression of PTPRF mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of PTPRF mRNA CTD PMID:29391264 ethanol affects splicing ISO RGD:737214 6480464 Ethanol affects the splicing of PTPRF mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:737214 6480464 Ethanol results in increased expression of PTPRF mRNA CTD PMID:30319688 fenofibrate affects expression EXP 6480464 Fenofibrate affects the expression of PTPRF mRNA CTD PMID:20801182 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of PTPRF mRNA CTD PMID:18035473 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of PTPRF mRNA CTD PMID:24136188 , PMID:24793618 folic acid multiple interactions ISO RGD:737214 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRF mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPRF gene CTD PMID:20938992 fonofos increases methylation ISO RGD:734202 6480464 Fonofos results in increased methylation of PTPRF promoter CTD PMID:22847954 formaldehyde decreases expression ISO RGD:734202 6480464 Formaldehyde results in decreased expression of PTPRF mRNA CTD PMID:20655997 glutathione decreases expression EXP 6480464 Glutathione deficiency results in decreased expression of PTPRF mRNA CTD PMID:20621112 graphite affects expression EXP 6480464 Graphite affects the expression of PTPRF mRNA CTD PMID:29933104 indometacin multiple interactions ISO RGD:734202 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA CTD PMID:28628672 isoprenaline increases expression ISO RGD:737214 6480464 Isoproterenol results in increased expression of PTPRF mRNA CTD PMID:20003209 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of PTPRF mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:737214 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRF mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPRF gene CTD PMID:20938992 lead(0) affects expression ISO RGD:734202 6480464 Lead affects the expression of PTPRF mRNA CTD PMID:28903495 lead(0) affects splicing ISO RGD:734202 6480464 Lead affects the splicing of PTPRF mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:734202 6480464 Lead affects the expression of PTPRF mRNA CTD PMID:28903495 lead(2+) affects splicing ISO RGD:734202 6480464 Lead affects the splicing of PTPRF mRNA CTD PMID:28903495 methapyrilene increases methylation ISO RGD:734202 6480464 Methapyrilene results in increased methylation of PTPRF intron CTD PMID:30157460 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of PTPRF mRNA CTD PMID:30467583 methylmercury(1+) multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNA CTD PMID:17905399 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRF mRNA CTD PMID:17602206 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of PTPRF mRNA CTD PMID:24136188 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of PTPRF mRNA CTD PMID:24136188 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of PTPRF mRNA CTD PMID:19483382 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PTPRF mRNA CTD PMID:25729387 panobinostat multiple interactions ISO RGD:734202 6480464 [Cisplatin co-treated with panobinostat] affects the expression of PTPRF mRNA CTD PMID:21791302 paracetamol affects expression ISO RGD:737214 6480464 Acetaminophen affects the expression of PTPRF mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:734202 6480464 Acetaminophen results in decreased expression of PTPRF mRNA CTD PMID:21420995 parathion increases methylation ISO RGD:734202 6480464 Parathion results in increased methylation of PTPRF promoter CTD PMID:22847954 perfluorooctane-1-sulfonic acid affects expression ISO RGD:737214 6480464 perfluorooctane sulfonic acid affects the expression of PTPRF mRNA CTD PMID:19429403 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of PTPRF mRNA CTD PMID:19162173 perfluorooctanoic acid affects expression ISO RGD:737214 6480464 perfluorooctanoic acid affects the expression of PTPRF mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of PTPRF mRNA CTD PMID:19162173 phenobarbital affects expression ISO RGD:737214 6480464 Phenobarbital affects the expression of PTPRF mRNA CTD PMID:23091169 phenylephrine decreases expression EXP 6480464 Phenylephrine results in decreased expression of PTPRF mRNA CTD PMID:18158353 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of PTPRF mRNA CTD PMID:19483382 pirinixic acid decreases expression ISO RGD:737214 6480464 pirinixic acid results in decreased expression of PTPRF mRNA CTD PMID:17426115 more ... pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PTPRF mRNA CTD PMID:19162173 , PMID:22484513 potassium dichromate increases expression ISO RGD:734202 6480464 Potassium Dichromate results in increased expression of PTPRF protein CTD PMID:23718831 propiconazole decreases expression ISO RGD:737214 6480464 propiconazole results in decreased expression of PTPRF mRNA CTD PMID:21278054 resveratrol multiple interactions ISO RGD:734202 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of PTPRF mRNA CTD PMID:19167446 sodium arsenite decreases expression ISO RGD:734202 6480464 sodium arsenite results in decreased expression of PTPRF mRNA CTD PMID:12377979 sodium dichromate decreases expression ISO RGD:737214 6480464 sodium bichromate results in decreased expression of PTPRF mRNA CTD PMID:22155349 sodium fluoride increases expression ISO RGD:737214 6480464 Sodium Fluoride results in increased expression of PTPRF protein CTD PMID:28918527 Soman increases expression EXP 6480464 Soman results in increased expression of PTPRF mRNA CTD PMID:19281266 sulindac sulfide decreases expression ISO RGD:734202 6480464 sulindac sulfide results in decreased expression of PTPRF mRNA CTD PMID:16184548 tamibarotene decreases expression ISO RGD:734202 6480464 tamibarotene results in decreased expression of PTPRF mRNA CTD PMID:15498508 terbufos increases methylation ISO RGD:734202 6480464 terbufos results in increased methylation of PTPRF promoter CTD PMID:22847954 tetrachloromethane affects expression ISO RGD:737214 6480464 Carbon Tetrachloride affects the expression of PTPRF mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTPRF mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PTPRF mRNA CTD PMID:31150632 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of PTPRF mRNA CTD PMID:19483382 titanium dioxide increases expression ISO RGD:737214 6480464 titanium dioxide results in increased expression of PTPRF mRNA CTD PMID:27760801 topotecan increases expression EXP 6480464 Topotecan results in increased expression of PTPRF mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PTPRF mRNA CTD PMID:25729387 trichloroethene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNA CTD PMID:17905399 trichostatin A increases expression ISO RGD:734202 6480464 trichostatin A results in increased expression of PTPRF mRNA CTD PMID:26705709 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of PTPRF mRNA CTD PMID:23639586 troglitazone decreases expression ISO RGD:737214 6480464 troglitazone results in decreased expression of PTPRF mRNA CTD PMID:28973697 tunicamycin decreases expression ISO RGD:737214 6480464 Tunicamycin results in decreased expression of PTPRF mRNA CTD PMID:17127020 valproic acid affects expression ISO RGD:734202 6480464 Valproic Acid affects the expression of PTPRF mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:734202 6480464 Valproic Acid results in increased expression of PTPRF mRNA CTD PMID:19101580 more ... vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of PTPRF mRNA CTD PMID:19015723 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PTPRF mRNA CTD PMID:23034163
Biological Process cell migration ISO RGD:734202 1624291 (PMID:23358419) RGD PMID:23358419 cell migration ISS UniProtKB:P10586 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell migration IEA UniProtKB:P10586 , ensembl:ENSP000003530301600115 GO_REF:0000107 Ensembl GO_REF:0000107 homophilic cell adhesion via plasma membrane adhesion molecules IDA 633826 RGD negative regulation of cell population proliferation IMP 1642742 contact inhibition of confluent hepatocytes RGD negative regulation of cell projection organization IMP 1642748 NGF stimulated neurite outgrowth in PC12 cells RGD negative regulation of cytokine-mediated signaling pathway IMP 1642742 hepatocyte growth factor/Met signaling RGD negative regulation of epidermal growth factor receptor signaling pathway IMP 1642757 RGD negative regulation of insulin receptor signaling pathway IMP 1642757 RGD negative regulation of neurotrophin TRK receptor signaling pathway IMP 1642748 NGF stimulated neurite outgrowth in PC12 cells RGD negative regulation of receptor binding ISO RGD:734202 1624291 (PMID:23358419) RGD PMID:23358419 negative regulation of receptor binding ISS UniProtKB:P10586 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of receptor binding IEA UniProtKB:P10586 , ensembl:ENSP000003530301600115 GO_REF:0000107 Ensembl GO_REF:0000107 nervous system development IDA 633826 RGD neuron projection regeneration ISO RGD:737214 1624291 MGI:MGI:2156205 (MGI:MGI:3777720 , PMID:11438588) RGD MGI:MGI:3777720 , PMID:11438588 neuron projection regeneration IEA UniProtKB:A2A8L5 , ensembl:ENSMUSP000000393681600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine dephosphorylation ISO RGD:734202 1624291 (PMID:23358419) RGD PMID:23358419 peptidyl-tyrosine dephosphorylation IBA PANTHER:PTN002709358 , UniProtKB:P10586 13792537 PMID:21873635 GO_Central peptidyl-tyrosine dephosphorylation IEA UniProtKB:P10586 , ensembl:ENSP000003530301600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine dephosphorylation IEA GO:0004725 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of apoptotic process IDA 1642754 RGD positive regulation of dendrite morphogenesis IMP 1642736 RGD positive regulation of neuron apoptotic process IMP 1642748 RGD protein dephosphorylation IDA 69951 insulin receptor, EGF receptor RGD protein dephosphorylation IBA FB:FBgn0000464 more ... 13792537 PMID:21873635 GO_Central protein dephosphorylation IDA 2293185 RGD regulation of axon regeneration ISO RGD:737214 1624291 (MGI:MGI:5294249, PMID:21976490) RGD MGI:MGI:5294249 , PMID:21976490 regulation of axon regeneration IEA UniProtKB:A2A8L5 , ensembl:ENSMUSP000000393681600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of neuron projection development ISO RGD:737214 1624291 MGI:MGI:2156205 (MGI:MGI:5294249 , PMID:21976490) RGD MGI:MGI:5294249 , PMID:21976490 regulation of postsynapse organization IDA 1642736 PMID:15750591 SynGO regulation of postsynapse organization IMP 1642736 PMID:15750591 SynGO regulation of synapse structure or activity IMP 1642736 RGD synaptic membrane adhesion IDA 13702345 PMID:20139422 SynGO synaptic membrane adhesion IMP 13702436 PMID:27225731 SynGO synaptic membrane adhesion IMP 13702345 PMID:20139422 SynGO synaptic membrane adhesion IBA PANTHER:PTN000760418 more ... 13792537 PMID:21873635 GO_Central synaptic membrane adhesion ISO RGD:734202 1624291 (PMID:26321637) RGD PMID:26321637 synaptic membrane adhesion IEA UniProtKB:P10586 , ensembl:ENSP000003530301600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptic membrane adhesion IDA 13702436 PMID:27225731 SynGO Cellular Component endosome IDA 1642745 RGD excitatory synapse IDA 1642736 RGD growth cone IDA 1642752 RGD integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 integral component of postsynaptic density membrane IDA 1642736 PMID:15750591 SynGO intracellular membrane-bounded organelle IDA 1642747 "heavy" microsomes RGD membrane IDA 1642746 RGD neuron projection IDA 1642751 alternatively spliced LASE-c containing molecules only RGD neuron projection IEA UniProtKB:A2A8L5 , ensembl:ENSMUSP000000393681600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection ISO RGD:737214 1624291 (MGI:MGI:3777720 more ... RGD MGI:MGI:3777720 more ... neuronal cell body IDA 1642751 alternatively spliced LASE-a and LASE-c containing molecules RGD neuronal cell body IEA UniProtKB:A2A8L5 , ensembl:ENSMUSP000000393681600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuronal cell body ISO RGD:737214 1624291 (MGI:MGI:5294249, PMID:21976490) RGD MGI:MGI:5294249 , PMID:21976490 plasma membrane IDA 1642747 RGD Molecular Function cell adhesion molecule binding IEA UniProtKB:P10586 , ensembl:ENSP000003530301600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell adhesion molecule binding ISO RGD:734202 1624291 UniProtKB:Q9HCJ2 (PMID:23986473) RGD PMID:23986473 chondroitin sulfate proteoglycan binding ISO RGD:737214 1624291 UniProtKB:Q62059 (MGI:MGI:5294249 , PMID:21976490) RGD MGI:MGI:5294249 , PMID:21976490 chondroitin sulfate proteoglycan binding IEA UniProtKB:A2A8L5 , ensembl:ENSMUSP000000393681600115 GO_REF:0000107 Ensembl GO_REF:0000107 heparin binding IEA UniProtKB-KW:KW-0358 1600115 GO_REF:0000037 UniProt GO_REF:0000037 insulin receptor binding IDA 2293185 RGD phosphate ion binding IDA 633829 forms a phosphoenzyme intermediate RGD protein tyrosine phosphatase activity IDA 69951 RGD protein tyrosine phosphatase activity IBA FB:FBgn0000464 more ... 13792537 PMID:21873635 GO_Central protein tyrosine phosphatase activity IEA EC:3.1.3.48 1600115 GO_REF:0000003 UniProt GO_REF:0000003 protein tyrosine phosphatase activity ISS UniProtKB:P10586 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein tyrosine phosphatase activity ISO RGD:734202 1624291 (PMID:10338209), (PMID:23358419) RGD PMID:10338209 , PMID:23358419 protein-containing complex binding ISO RGD:737214 1624291 (MGI:MGI:5515279, PMID:23791195) RGD MGI:MGI:5515279 , PMID:23791195 protein-containing complex binding IEA UniProtKB:A2A8L5 , ensembl:ENSMUSP000000393681600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor tyrosine kinase binding IPI RGD:3082 1642742 RGD transmembrane receptor protein tyrosine phosphatase activity IDA 2293185 RGD
Gene-Chemical Interaction Annotations
