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Gene: Ptprf (protein tyrosine phosphatase, receptor type, F) Rattus norvegicus
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Symbol: Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Description: Exhibits phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Localizes to several cellular components, including the growth cone; integral component of postsynaptic density membrane; and neuronal cell body. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LAR; LARFN5C; leukocyte antigen-related (LAR) PTP receptor; leukocyte common antigen related; protein tyrosine phosphatase receptor-type F; receptor-type tyrosine-protein phosphatase F
Orthologs:
Homo sapiens (human) : PTPRF (protein tyrosine phosphatase receptor type F)  HGNC  Alliance
Mus musculus (house mouse) : Ptprf (protein tyrosine phosphatase, receptor type, F)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprf (protein tyrosine phosphatase receptor type F)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRF (protein tyrosine phosphatase receptor type F)
Canis lupus familiaris (dog) : PTPRF (protein tyrosine phosphatase receptor type F)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprf (protein tyrosine phosphatase receptor type F)
Sus scrofa (pig) : PTPRF (protein tyrosine phosphatase receptor type F)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05137,036,936 - 137,112,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,036,935 - 137,112,927 (-)Ensembl
Rnor_5.05140,825,315 - 140,901,672 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,671,725 - 138,739,002 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15138,676,940 - 138,744,228 (-)NCBI
Celera5130,289,962 - 130,357,275 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ptprf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3453
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.