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Gene: PTPRF (protein tyrosine phosphatase receptor type F) Homo sapiens
Symbol: PTPRF
Name: protein tyrosine phosphatase receptor type F
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BNAH2; FLJ43335; FLJ45062; FLJ45567; LAR; LCA-homolog; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; leukocyte common antigen related; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; receptor-type tyrosine-protein phosphatase F
Mus musculus (house mouse) : Ptprf (protein tyrosine phosphatase, receptor type, F)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptprf (protein tyrosine phosphatase, receptor type, F)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprf (protein tyrosine phosphatase receptor type F)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRF (protein tyrosine phosphatase receptor type F)
Canis lupus familiaris (dog) : PTPRF (protein tyrosine phosphatase receptor type F)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprf (protein tyrosine phosphatase receptor type F)
Sus scrofa (pig) : PTPRF (protein tyrosine phosphatase receptor type F)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38143,522,238 - 43,623,672 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37143,991,708 - 44,089,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,769,134 - 43,861,930 (+)NCBINCBI36hg18NCBI36
Build 34143,665,639 - 43,758,427NCBI
Celera142,278,501 - 42,371,223 (+)NCBI
Cytogenetic Map1p34.2NCBI
HuRef142,115,737 - 42,210,000 (+)NCBIHuRef
CHM1_1144,112,964 - 44,205,662 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPRF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734202
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.