Git1 (GIT ArfGAP 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Git1 (GIT ArfGAP 1) Rattus norvegicus
Analyze
Symbol: Git1
Name: GIT ArfGAP 1
RGD ID: 69331
Description: Enables several functions, including GTPase activator activity; enzyme binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic specialization. Involved in several processes, including cellular response to epidermal growth factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of signal transduction. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in several cellular components, including excitatory synapse; growth cone; and inhibitory synapse. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1); PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; endocytosis pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1); G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GRK-interactor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21062,342,082 - 62,356,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,342,299 - 62,356,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1066,992,057 - 67,006,179 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01066,497,543 - 66,511,665 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,970,798 - 61,984,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,656,000 - 62,664,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,656,000 - 62,664,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01062,352,883 - 62,362,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41066,610,282 - 66,618,919 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11066,623,904 - 66,632,546 (-)NCBI
Celera1061,351,008 - 61,359,475 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
calyx of Held  (IEA,ISO)
centrosome  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO,TAS)
dendrite  (IDA)
endosome  (IDA)
excitatory synapse  (IDA)
focal adhesion  (IEA,ISO,TAS)
GABA-ergic synapse  (IDA,IMP)
glutamatergic synapse  (IDA)
growth cone  (IDA)
inhibitory synapse  (IDA)
lamellipodium  (IEA)
mitochondrion  (IEA,ISO)
mitotic spindle pole  (IEA,ISO,ISS)
neuron projection  (IBA,IEA)
postsynapse  (IBA,IDA,IEA,ISO,ISS)
postsynaptic density  (IEA)
synapse  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. Cavet ME, etal., FASEB J. 2008 Oct;22(10):3607-16. doi: 10.1096/fj.07-094086. Epub 2008 Jun 3.
2. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Fiuza M, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12. doi: 10.1073/pnas.1312211110. Epub 2013 Dec 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Goehler H, etal., Mol Cell 2004 Sep 24;15(6):853-65.
6. N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Hua KT, etal., Cancer Cell. 2011 Feb 15;19(2):218-31. doi: 10.1016/j.ccr.2010.11.010. Epub 2011 Feb 3.
7. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
8. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
9. Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. Meyer MZ, etal., J Biol Chem. 2006 Mar 24;281(12):7919-26. Epub 2006 Jan 26.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Premont RT, etal., Cell Signal 2004 Sep;16(9):1001-11.
15. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Premont RT, etal., Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14082-7.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, etal., Nat Neurosci. 2007 Mar;10(3):301-10. Epub 2007 Feb 18.
19. GIT1 and ßPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Smith KR, etal., Cell Rep. 2014 Oct 9;9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. Epub 2014 Oct 2.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Won H, etal., Nat Med. 2011 May;17(5):566-72. doi: 10.1038/nm.2330. Epub 2011 Apr 17.
Additional References at PubMed
PMID:10938112   PMID:12153727   PMID:12695502   PMID:14523024   PMID:18292392   PMID:19136011   PMID:19912111   PMID:19946888   PMID:20689073   PMID:21423176   PMID:22294688   PMID:22797318  
PMID:23108400   PMID:23352984   PMID:24764294   PMID:25017023   PMID:25175053   PMID:25715677   PMID:26637799   PMID:29191942   PMID:30053369   PMID:32223487   PMID:34002676   PMID:34154701  
PMID:36044673  


Genomics

Comparative Map Data
Git1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21062,342,082 - 62,356,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,342,299 - 62,356,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1066,992,057 - 67,006,179 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01066,497,543 - 66,511,665 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,970,798 - 61,984,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,656,000 - 62,664,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,656,000 - 62,664,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01062,352,883 - 62,362,201 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41066,610,282 - 66,618,919 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11066,623,904 - 66,632,546 (-)NCBI
Celera1061,351,008 - 61,359,475 (+)NCBICelera
Cytogenetic Map10q24NCBI
GIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381729,573,475 - 29,589,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1729,573,475 - 29,594,054 (-)EnsemblGRCh38hg38GRCh38
GRCh371727,900,493 - 27,916,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,924,613 - 24,940,736 (-)NCBINCBI36Build 36hg18NCBI36
Build 341724,924,619 - 24,940,735NCBI
Celera1724,761,352 - 24,777,476 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1724,109,826 - 24,125,786 (-)NCBIHuRef
CHM1_11727,963,149 - 27,983,295 (-)NCBICHM1_1
T2T-CHM13v2.01730,516,351 - 30,532,526 (-)NCBIT2T-CHM13v2.0
Git1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,384,114 - 77,398,600 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1177,384,388 - 77,398,612 (+)EnsemblGRCm39 Ensembl
GRCm381177,493,288 - 77,507,774 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,493,562 - 77,507,786 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,306,914 - 77,321,276 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,309,607 - 77,323,969 (+)NCBIMGSCv36mm8
Celera1184,991,973 - 85,006,335 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.61NCBI
Git1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554813,670,111 - 3,685,051 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554813,671,728 - 3,681,279 (+)NCBIChiLan1.0ChiLan1.0
GIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11736,748,981 - 36,765,176 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01727,185,025 - 27,201,146 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11727,707,452 - 27,717,857 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1727,706,776 - 27,717,857 (+)Ensemblpanpan1.1panPan2
GIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1943,676,707 - 43,686,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl943,677,899 - 43,693,177 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha942,829,811 - 42,846,296 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0944,492,902 - 44,509,385 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl944,492,901 - 44,508,582 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1943,277,271 - 43,293,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0943,567,974 - 43,584,445 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0943,648,051 - 43,664,538 (-)NCBIUU_Cfam_GSD_1.0
Git1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,806,717 - 42,827,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365385,684,644 - 5,695,043 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365385,684,660 - 5,694,779 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,768,176 - 45,783,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11245,768,172 - 45,783,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,719,221 - 47,730,533 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11623,313,629 - 23,329,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1623,315,439 - 23,329,469 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660756,742,731 - 6,758,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Git1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247862,071,382 - 2,086,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247862,071,376 - 2,086,929 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Git1
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:155
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000056112
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106134541366743655Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat

Markers in Region
RH128287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,356,158 - 62,356,348 (-)MAPPERmRatBN7.2
Rnor_6.01062,655,702 - 62,655,891NCBIRnor6.0
Rnor_5.01062,352,585 - 62,352,774UniSTSRnor5.0
RGSC_v3.41066,609,984 - 66,610,173UniSTSRGSC3.4
Celera1061,359,584 - 61,359,773UniSTS
Cytogenetic Map10q26UniSTS
GIT1_9564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,355,753 - 62,356,330 (-)MAPPERmRatBN7.2
Rnor_6.01062,655,720 - 62,656,296NCBIRnor6.0
Rnor_5.01062,352,603 - 62,353,179UniSTSRnor5.0
RGSC_v3.41066,610,002 - 66,610,578UniSTSRGSC3.4
Celera1061,359,179 - 61,359,755UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 3 43 49 33 19 33 8 11 74 35 37 11 8
Low 8 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000078730   ⟹   ENSRNOP00000073267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,342,299 - 62,356,373 (+)Ensembl
Rnor_6.0 Ensembl1062,656,000 - 62,664,466 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101598   ⟹   ENSRNOP00000090288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,345,194 - 62,356,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114941   ⟹   ENSRNOP00000091910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1062,345,194 - 62,356,050 (+)Ensembl
RefSeq Acc Id: NM_031814   ⟹   NP_114002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21062,342,265 - 62,356,379 (+)NCBI
Rnor_6.01062,656,000 - 62,664,467 (-)NCBI
Rnor_5.01062,352,883 - 62,362,201 (-)NCBI
RGSC_v3.41066,610,282 - 66,618,919 (-)RGD
Celera1061,351,008 - 61,359,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086946   ⟹   XP_038942874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21062,342,082 - 62,356,379 (+)NCBI
RefSeq Acc Id: XM_039086947   ⟹   XP_038942875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21062,342,083 - 62,356,379 (+)NCBI
RefSeq Acc Id: XM_039086948   ⟹   XP_038942876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21062,347,885 - 62,356,379 (+)NCBI
RefSeq Acc Id: NP_114002   ⟸   NM_031814
- UniProtKB: Q9Z272 (UniProtKB/Swiss-Prot),   A0A8I6AGH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073267   ⟸   ENSRNOT00000078730
RefSeq Acc Id: XP_038942874   ⟸   XM_039086946
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942875   ⟸   XM_039086947
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942876   ⟸   XM_039086948
- Peptide Label: isoform X3
- UniProtKB: A6HGY0 (UniProtKB/TrEMBL),   A0A8I6AGH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090288   ⟸   ENSRNOT00000101598
RefSeq Acc Id: ENSRNOP00000091910   ⟸   ENSRNOT00000114941
Protein Domains
Arf-GAP   GIT Spa2 homology (SHD)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z272-F1-model_v2 AlphaFold Q9Z272 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697428
Promoter ID:EPDNEW_R7952
Type:single initiation site
Name:Git1_1
Description:GIT ArfGAP 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01062,664,455 - 62,664,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69331 AgrOrtholog
BioCyc Gene G2FUF-24125 BioCyc
Ensembl Genes ENSRNOG00000061270 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055026761 UniProtKB/Swiss-Prot
  ENSRNOG00060029464 UniProtKB/Swiss-Prot
  ENSRNOG00065019852 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078730 ENTREZGENE
  ENSRNOT00000078730.2 UniProtKB/TrEMBL
  ENSRNOT00000101598 ENTREZGENE
  ENSRNOT00000101598.1 UniProtKB/TrEMBL
  ENSRNOT00000114941 ENTREZGENE
  ENSRNOT00000114941.1 UniProtKB/TrEMBL
  ENSRNOT00055046345 UniProtKB/Swiss-Prot
  ENSRNOT00060051210 UniProtKB/Swiss-Prot
  ENSRNOT00065033521 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT1/2_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT_SHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83709 UniProtKB/Swiss-Prot
NCBI Gene 83709 ENTREZGENE
PANTHER ARF GTPASE-ACTIVATING PROTEIN GIT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT_SHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Git1 PhenoGen
PRINTS REVINTRACTNG UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARFGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061270 RatGTEx
  ENSRNOG00055026761 RatGTEx
  ENSRNOG00060029464 RatGTEx
  ENSRNOG00065019852 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57863 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204831
UniProt A0A0G2K527_RAT UniProtKB/TrEMBL
  A0A8I6AGH2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GI27_RAT UniProtKB/TrEMBL
  A6HGY0 ENTREZGENE, UniProtKB/TrEMBL
  A6HGY1_RAT UniProtKB/TrEMBL
  A6HGY2_RAT UniProtKB/TrEMBL
  GIT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Git1  GIT ArfGAP 1  Git1  G protein-coupled receptor kinase interacting ArfGAP 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Git1  G protein-coupled receptor kinase interacting ArfGAP 1  Git1  G protein-coupled receptor kinase interactor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Git1  G protein-coupled receptor kinase interactor 1    G protein-coupled receptor kinase-interactor 1  Name updated 1299863 APPROVED
2002-06-10 Git1  G protein-coupled receptor kinase-interactor 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process GTPase-activating protein (GAP) for the ADP ribosylation factor (ARF) family of small GTP-binding proteins 68782
gene_product member of G protein-coupled receptor kinase-interacting protein 68782