Ythdf2 (YTH N6-methyladenosine RNA binding protein F2)

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Gene: Ythdf2 (YTH N6-methyladenosine RNA binding protein F2) Rattus norvegicus

Analyze

Symbol:

Ythdf2

Name:

YTH N6-methyladenosine RNA binding protein F2 (Ensembl:YTH N(6)-methyladenosine RNA binding protein 2)

RGD ID:

1311321

Description:

Predicted to enable C5-methylcytidine-containing RNA reader activity and N6-methyladenosine-containing RNA reader activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; regulation of gene expression; and regulation of stem cell differentiation. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic ribonucleoprotein granule; and cytosol. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein F2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC313053; YTH domain family 2; YTH domain family protein 2; YTH domain family, member 2; YTH domain-containing family protein 2; YTH N(6)-methyladenosine RNA binding protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	144,381,426 - 144,407,126 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,381,431 - 144,408,144 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,080,642 - 147,105,456 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	148,850,486 - 148,875,300 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	148,839,793 - 148,864,300 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,364,490 - 150,390,173 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,365,101 - 150,390,099 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,037,607 - 154,063,041 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	151,063,958 - 151,089,250 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	151,073,989 - 151,099,406 (-)	NCBI
Celera	5	142,815,747 - 142,839,776 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1,4-benzoquinone (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-phenylbutyric acid (ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

chlordecone (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

ethanol (ISO)

flutamide (EXP)

fulvestrant (ISO)

fumonisin B1 (ISO)

gentamycin (EXP)

indometacin (ISO)

ivermectin (ISO)

lead(0) (ISO)

methimazole (EXP)

methotrexate (ISO)

N(6)-methyladenosine (ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

propiconazole (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

triadimefon (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

gamete generation (ISO)

hematopoietic stem cell proliferation (ISO)

mRNA catabolic process (ISO)

mRNA destabilization (IBA,ISO)

negative regulation of stem cell differentiation (ISO)

negative regulation of type I interferon-mediated signaling pathway (ISO)

oocyte maturation (ISO)

organelle assembly (ISO)

positive regulation of cap-independent translational initiation (ISO)

positive regulation of translational initiation (ISO)

regulation of cell adhesion (ISO)

regulation of hematopoietic stem cell differentiation (ISO)

regulation of meiotic cell cycle process involved in oocyte maturation (ISO)

regulation of mRNA stability (ISO)

regulation of neurogenesis (ISO)

regulation of rRNA processing (ISO)

spermatogonial cell division (ISO)

stress granule assembly (ISO)

Cellular Component

centriolar satellite (IEA,ISO)

cytoplasm (IBA,ISO)

cytoplasmic ribonucleoprotein granule (ISO)

cytoplasmic stress granule (ISO)

cytosol (ISO)

nucleus (ISO)

P-body (ISO)

Molecular Function

C5-methylcytidine-containing RNA reader activity (ISO)

mRNA binding (IBA)

N6-methyladenosine-containing RNA reader activity (IBA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22575960	PMID:22658674	PMID:22681889	PMID:24284625	PMID:25412658	PMID:25412661	PMID:26046440	PMID:26318451	PMID:26458103	PMID:27558897	PMID:28106072
PMID:28867294	PMID:29855337	PMID:30065315	PMID:30150673	PMID:30559377	PMID:30930054	PMID:35985997	PMID:36747144

Genomics

Comparative Map Data

Ythdf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	144,381,426 - 144,407,126 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,381,431 - 144,408,144 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,080,642 - 147,105,456 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	148,850,486 - 148,875,300 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	148,839,793 - 148,864,300 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,364,490 - 150,390,173 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,365,101 - 150,390,099 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,037,607 - 154,063,041 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	151,063,958 - 151,089,250 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	151,073,989 - 151,099,406 (-)	NCBI
Celera	5	142,815,747 - 142,839,776 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

YTHDF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	28,736,624 - 28,769,775 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	28,736,621 - 28,769,775 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	29,063,136 - 29,096,287 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	28,935,723 - 28,968,874 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	28,884,098 - 28,916,902	NCBI
Celera	1	27,459,395 - 27,492,550 (+)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	27,315,797 - 27,348,923 (+)	NCBI		HuRef
CHM1_1	1	29,178,454 - 29,211,612 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	28,578,615 - 28,611,771 (+)	NCBI		T2T-CHM13v2.0

Ythdf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	131,912,227 - 131,939,567 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	131,912,223 - 131,939,614 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	132,184,916 - 132,212,256 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	132,184,912 - 132,212,303 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	131,740,831 - 131,768,171 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	131,458,133 - 131,484,332 (-)	NCBI		MGSCv36	mm8
Celera	4	130,346,178 - 130,373,501 (-)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	64.92	NCBI

Ythdf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955452	7,783,398 - 7,815,468 (+)	NCBI	ChiLan1.0	ChiLan1.0

YTHDF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	197,191,694 - 197,225,390 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	28,007,592 - 28,041,179 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	29,038,751 - 29,070,533 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	29,038,831 - 29,070,533 (+)	Ensembl	panpan1.1		panPan2

YTHDF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	71,760,232 - 71,791,420 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	71,760,312 - 71,792,527 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	68,336,008 - 68,368,586 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	72,319,158 - 72,351,686 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	72,319,154 - 72,351,626 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	69,147,969 - 69,180,375 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	70,155,530 - 70,188,135 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	71,153,556 - 71,186,141 (-)	NCBI		UU_Cfam_GSD_1.0

Ythdf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	46,966,462 - 47,003,229 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	12,791,073 - 12,827,122 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	12,791,121 - 12,827,122 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

YTHDF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	85,716,983 - 85,726,473 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	85,717,147 - 85,756,750 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	79,553,445 - 79,583,689 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

YTHDF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	104,041,657 - 104,078,705 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	104,040,679 - 104,078,484 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	12,443,353 - 12,479,983 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ythdf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	12,533,257 - 12,567,514 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	12,533,317 - 12,567,514 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ythdf2
106 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	14
Count of miRNA genes:	13
Interacting mature miRNAs:	14
Transcripts:	ENSRNOT00000014479
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat

Markers in Region

A001V19

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	144,381,904 - 144,382,069 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	150,364,964 - 150,365,127	NCBI	Rnor6.0
Rnor_5.0	5	154,038,081 - 154,038,244	UniSTS	Rnor5.0
RGSC_v3.4	5	151,064,432 - 151,064,595	UniSTS	RGSC3.4
Celera	5	142,816,221 - 142,816,388	UniSTS
Cytogenetic Map	5	q36	UniSTS

D14S811E

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	144,381,912 - 144,382,021 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	150,364,972 - 150,365,079	NCBI	Rnor6.0
Rnor_5.0	5	154,038,089 - 154,038,196	UniSTS	Rnor5.0
RGSC_v3.4	5	151,064,440 - 151,064,547	UniSTS	RGSC3.4
Celera	5	142,816,229 - 142,816,341	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	37	57	41	19	41	8	11	74	35	41	11	8
Low		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001047099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB259152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF473850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000014479 ⟹ ENSRNOP00000014479

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,397,710 - 144,408,144 (-)	Ensembl
Rnor_6.0 Ensembl	5	150,365,101 - 150,390,099 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103612 ⟹ ENSRNOP00000087650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,381,431 - 144,402,381 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110798 ⟹ ENSRNOP00000091769

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,381,434 - 144,408,144 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111641 ⟹ ENSRNOP00000090745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	144,381,431 - 144,408,144 (-)	Ensembl

RefSeq Acc Id:

NM_001047099 ⟹ NP_001040564

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	144,381,431 - 144,406,028 (-)	NCBI
Rnor_6.0	5	150,364,490 - 150,390,173 (-)	NCBI
Rnor_5.0	5	154,037,607 - 154,063,041 (-)	NCBI
RGSC_v3.4	5	151,063,958 - 151,089,250 (-)	RGD
Celera	5	142,815,747 - 142,839,776 (-)	RGD

Sequence:

show sequence

GTTGAGCTGTCCGGCTAGAGCGTCGCTGAATCGGAGCCGGAGCCCGAGCCGCGCGCTGTGTCTC
CGCTGCGTCCGCCGAGGCTCCGAGTGTCAGGGACAAAAGCCGCCGCCGTGCTGACGAGGAGTCC
GCCACCGACGTTACCAGTGAGGATCCGAGAGCCATGTCGGCCAGCAGCCTCTTGGAGCAGAGAC
CAAAAGGTCAAGGAAACAAAGTACAAAATGGTTCTGTGCATCAAAAGGATGGTCTAAATGATGA
TGATTTCGAACCTTACTTGAGCCCACAGGCAAGGCCGAATAATGCATATACTGCCATGTCAGAC
TCCTACTTACCCAGTTACTACAGCCCCTCTATTGGCTTTTCCTATTCTTTGGGTGAAGCTGCTT
GGTCTACTGGAGGTGACACAGCCATGCCCTATCTAACTTCTTATGGACAACTGAGCAACGGAGA
GCCCCACTTTCTACCAGATGCAATGTTTGGGCAACCAGGAGCCCTAGGTAGCACTCCATTTCTT
GGTCAGCATGGTTTTAATTTTTTTCCCAGTGGGATTGACTTCTCAGCATGGGGAAATAACAGTT
CTCAGGGACAGTCTACTCAAAGCTCTGGATATAGTAGCAATTATGCTTATGCACCCAGCTCCTT
AGGTGGAGCCATGATTGATGGACAGTCAGCTTTTGCCAATGAGACCCTCAATAAAGCTCCTGGC
ATGAATACTATAGACCAAGGGATGGCAGCACTGAAACTAGGTAGCACAGAAGTTGCGAGCAGTG
TTCCCAAAGTTGTAGGCTCTGCTGTTGGTAGTGGGTCCATCACTAGTAACATTGTGGCTTCTAG
CAGTTTGCCTCCAGCTACTATTGCTCCTCCAAAACCAGCATCTTGGGCTGATATTGCTAGCAAA
CCTGCAAAACAACAACCTAAGCTGAAGACCAAGAATGGCATTGCAGGATCAAGTCTTCCACCGC
CCCCAATAAAGCATAACATGGATATTGGAACTTGGGATAACAAGGGTCCTGTGGCAAAAGCCCC
CTCACAGGCTTTGGTTCAAAATATAGGTCAGCCAACCCAGGGATCTCCTCAGCCTGTAGGACAG
CAGGCCAATAATAGCCCACCAGTGACTCAGACATCAGTAGGGCAACAGACACAGCCATTGCCTC
CACCTCCACCACAGCCTGCTCAGCTCTCAGTCCAGCAGCAGGCAGCTCAGCCAACTCGCTGGGT
AGCACCTCGGAACCGTGGCAGTGGGTTCGGTCATAATGGGGTGGATGGTAATGGAGTAGGACAG
TCTCAGGCGGGTTCTGGATCTACTCCTTCAGAGCCTCACCCAGTGTTGGAGAAACTTCGGTCCA
TTAATAACTATAACCCTAAAGATTTCGACTGGAATCTGAAACACGGCCGGGTTTTCATCATTAA
GAGCTACTCTGAGGACGATATCCACCGTTCCATTAAGTATAATATCTGGTGCAGCACAGAGCAT
GGTAACAAGAGACTGGATGCCGCCTATCGTTCCATGAACGGGAAGGGTCCCGTGTACTTACTTT
TCAGTGTCAACGGCAGTGGACACTTCTGTGGAGTTGCAGAGATGAAATCTGCTGTGGACTACAA
CACATGTGCAGGTGTGTGGTCCCAGGACAAATGGAAGGGTCGTTTTGACGTCAGATGGATTTTT
GTGAAGGACGTTCCCAATAGCCAACTGCGACACATTCGTCTAGAGAACAACGAGAATAAACCAG
TGACCAACTCTAGGGACACTCAGGAAGTGCCTCTGGAAAAAGCTAAGCAGGTGTTGAAAATCAT
AGCCAGCTACAAGCACACCACTTCCATTTTTGATGACTTCTCACACTATGAGAAACGCCAAGAG
GAAGAAGAAAGTTTAAAAAGGAACGTCAAGGCCGTGGGAAATAAAAAGCGGTTCTGCATAGACT
GCAGCAACGGTTGCGTCTGCTTATCCTAAGAGGACACGATGACCTGCAAGAAAATTAGGACTTT
TTTTCTTAATTTCATTGACTTCAGAGACAATTGCAAACTTGCAGTTTAAGTATTGGAATTTCAC
AAAAGACATAGGACTTAACTGGAAAATGGGGAAAAAAAAAAAGGAAAAAAGAAAAACCTAAACA
AAAATTCCCTCTAGGTAGTTTAGGTAAAAAAAAAAAATGTCCCTTTTATTTTGGCTTTGGTTGT
GATTCAGAGCATAATGCTTTGGGTTGGTTTTTTTTTTTTTTTTTTTTTTTTTGTCTTTTTACTA
TATTTTTCGGATTTTTAAGTCCGTAAGTGCATACAATTTTCTCTAATTTTTAAACCCTTTCCTC
CTCCCATTTTGACATTTGCACTTGGAGAACACTTGAGTTGCGCAGATTTTGGGTGTCCACCCCA
GAAAGTGGGAATTTGATTTTTCCCTTCCGAACTGGAAGAAAATTTTTATGAAGAATTTTTGTCT
AGGAAAGTTTAATAACAGTGTTAGCCAAGGTTGAGTCTGTAAGGGTGGTTCATTTCTCTGACCC
TTTGTTACTCAAAGTAAAGTGCTCGGAGTCCTAAGAAATGTTCTGTTCTTGTGTATTATACTGA
TTAAGTCAGGATTAATTTGATTTCAAAGCTAAGAACAGTGGTAAAAACTTGTTTTCAGAAATGC
ATTTTGGAAGAGAAAATATTGTAAACATGTAGTGAATGTTTCTTCAGTTTCTTGTTCAGCCAAT
GAGGAAAGGGCATTGCCTTTCTTTTTACCATTAATCACTTCTCAATAAACGTGAGATCCTGTTG
AGCATCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039109798 ⟹ XP_038965726

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	144,381,426 - 144,407,126 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001040564	(Get FASTA)	NCBI Sequence Viewer
	XP_038965726	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66407	(Get FASTA)	NCBI Sequence Viewer
	BAE94259	(Get FASTA)	NCBI Sequence Viewer
	EDL80618	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014479.8
	ENSRNOP00000087650.1
	ENSRNOP00000090745
	ENSRNOP00000090745.1
	ENSRNOP00000091769.1

RefSeq Acc Id:

NP_001040564 ⟸ NM_001047099

- UniProtKB:

B2GUU1 (UniProtKB/TrEMBL), E9PU11 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARPNNAYTAMSDSYLPSYYSPSI
GFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPDAMFGQPGALGSTPFLGQHGFNFFPSG
IDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSLGGAMIDGQSAFANETLNKAPGMNTIDQGMAAL
KLGSTEVASSVPKVVGSAVGSGSITSNIVASSSLPPATIAPPKPASWADIASKPAKQQPKLKTK
NGIAGSSLPPPPIKHNMDIGTWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVTQT
SVGQQTQPLPPPPPQPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSE
PHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRS
MNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRH
IRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESLKRNVKA
VGNKKRFCIDCSNGCVCLS

hide sequence

RefSeq Acc Id:

ENSRNOP00000014479 ⟸ ENSRNOT00000014479

RefSeq Acc Id:	XP_038965726 ⟸ XM_039109798
- Peptide Label:	isoform X2
- UniProtKB:	Q1JU70 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000090745 ⟸ ENSRNOT00000111641

RefSeq Acc Id:

ENSRNOP00000091769 ⟸ ENSRNOT00000110798

RefSeq Acc Id:

ENSRNOP00000087650 ⟸ ENSRNOT00000103612

Protein Domains

YTH

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694091

Promoter ID:

EPDNEW_R4616

Type:

initiation region

Name:

Ythdf2_1

Description:

YTH N-methyladenosine RNA binding protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	150,390,146 - 150,390,206	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311321	AgrOrtholog
BioCyc Gene	G2FUF-39715	BioCyc
Ensembl Genes	ENSRNOG00000010892	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014479.8	UniProtKB/TrEMBL
	ENSRNOT00000103612.1	UniProtKB/TrEMBL
	ENSRNOT00000110798.1	UniProtKB/TrEMBL
	ENSRNOT00000111641	ENTREZGENE
	ENSRNOT00000111641.1	UniProtKB/TrEMBL
Gene3D-CATH	ph1033 like domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7453874	IMAGE-MGC_LOAD
InterPro	YTH_domain	UniProtKB/TrEMBL
	YTH_prot	UniProtKB/TrEMBL
KEGG Report	rno:313053	UniProtKB/TrEMBL
MGC_CLONE	MGC:187247	IMAGE-MGC_LOAD
NCBI Gene	313053	ENTREZGENE
PANTHER	PTHR12357	UniProtKB/TrEMBL
	YTH DOMAIN-CONTAINING FAMILY PROTEIN 2	UniProtKB/TrEMBL
Pfam	YTH	UniProtKB/TrEMBL
PhenoGen	Ythdf2	PhenoGen
PROSITE	YTH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010892	RatGTEx
UniProt	A0A8I6A4K2_RAT	UniProtKB/TrEMBL
	A0A8I6ABJ9_RAT	UniProtKB/TrEMBL
	A0A8I6ATW9_RAT	UniProtKB/TrEMBL
	B2GUU1	ENTREZGENE, UniProtKB/TrEMBL
	E9PU11	ENTREZGENE, UniProtKB/TrEMBL
	Q1JU70	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-03-09	Ythdf2	YTH N6-methyladenosine RNA binding protein F2	Ythdf2	YTH N(6)-methyladenosine RNA binding protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-12-01	Ythdf2	YTH N(6)-methyladenosine RNA binding protein 2	Ythdf2	YTH domain family, member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Ythdf2	YTH domain family, member 2	Ythdf2	YTH domain family 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ythdf2	YTH domain family 2	Ythdf2_predicted	YTH domain family 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ythdf2_predicted	YTH domain family 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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