Cdc20 (cell division cycle 20) - Rat Genome Database

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Gene: Cdc20 (cell division cycle 20) Rattus norvegicus
Analyze
Symbol: Cdc20
Name: cell division cycle 20
RGD ID: 620477
Description: Enables histone deacetylase binding activity. Involved in positive regulation of cell population proliferation and regulation of dendrite development. Located in centrosome and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human CDC20 (cell division cycle 20); PARTICIPATES IN cell cycle pathway, mitotic; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell cycle protein p55CDC; cell division cycle 20 homolog; cell division cycle 20 homolog (S. cerevisiae); cell division cycle protein 20 homolog; MGC93111; p55cdc
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,251,596 - 137,255,799 (-)NCBIGRCr8
mRatBN7.25131,966,203 - 131,970,406 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5131,966,215 - 131,970,512 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5134,673,439 - 134,677,645 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05136,428,076 - 136,432,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05136,450,474 - 136,454,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05137,260,728 - 137,264,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,260,739 - 137,265,015 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,050,192 - 141,054,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,913,180 - 138,916,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,918,405 - 138,921,970 (-)NCBI
Celera5130,511,685 - 130,515,888 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
flavonoids  (EXP)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
geraniol  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (EXP,ISO)
isobutanol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP)
lidocaine  (EXP)
lucanthone  (ISO)
malathion  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nimesulide  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
oxcarbazepine  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell-cycle-dependent PC-PLC regulation by APC/C(Cdc20)-mediated ubiquitin-proteasome pathway. Fu D, etal., J Cell Biochem. 2009 Jul 1;107(4):686-96.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Kim AH, etal., Cell. 2009 Jan 23;136(2):322-36.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. Weinstein J, etal., Mol Cell Biol 1994 May;14(5):3350-63.
11. Genomic organization, 5' flanking enhancer region, and chromosomal assignment of the cell cycle gene, p55Cdc. Weinstein J, etal., Mol Genet Metab 1998 May;64(1):52-7.
Additional References at PubMed
PMID:10700282   PMID:11459825   PMID:11459826   PMID:12477932   PMID:16456547   PMID:17325031   PMID:17443180   PMID:18753608   PMID:19900895   PMID:20517887   PMID:21725312   PMID:22045811  
PMID:35621027   PMID:36764621  


Genomics

Comparative Map Data
Cdc20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,251,596 - 137,255,799 (-)NCBIGRCr8
mRatBN7.25131,966,203 - 131,970,406 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5131,966,215 - 131,970,512 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5134,673,439 - 134,677,645 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05136,428,076 - 136,432,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05136,450,474 - 136,454,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05137,260,728 - 137,264,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,260,739 - 137,265,015 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,050,192 - 141,054,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,913,180 - 138,916,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,918,405 - 138,921,970 (-)NCBI
Celera5130,511,685 - 130,515,888 (-)NCBICelera
Cytogenetic Map5q36NCBI
CDC20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38143,358,981 - 43,363,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl143,358,981 - 43,363,203 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,824,652 - 43,828,874 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,597,213 - 43,601,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 34143,493,720 - 43,497,964NCBI
Celera142,106,780 - 42,111,028 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,944,368 - 41,948,616 (+)NCBIHuRef
CHM1_1143,941,085 - 43,945,333 (+)NCBICHM1_1
T2T-CHM13v2.0143,229,529 - 43,233,751 (+)NCBIT2T-CHM13v2.0
Cdc20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,290,098 - 118,294,540 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,290,098 - 118,294,549 (-)EnsemblGRCm39 Ensembl
GRCm384118,432,901 - 118,437,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4118,432,901 - 118,437,352 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,105,506 - 118,109,948 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364117,930,833 - 117,935,181 (-)NCBIMGSCv36mm8
Celera4117,158,439 - 117,162,881 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map454.61NCBI
Cdc20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,941,265 - 2,945,158 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,941,265 - 2,945,158 (+)NCBIChiLan1.0ChiLan1.0
CDC20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,446,843 - 183,454,742 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,588,226 - 182,592,803 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,660,338 - 42,664,618 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1144,039,971 - 44,044,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl144,039,971 - 44,044,497 (+)Ensemblpanpan1.1panPan2
CDC20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11516,803,204 - 16,806,935 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1516,803,204 - 16,806,919 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1516,930,216 - 16,933,933 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01516,969,931 - 16,973,648 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1516,969,932 - 16,981,515 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11516,762,404 - 16,766,121 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01516,831,404 - 16,835,121 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01516,904,979 - 16,908,696 (-)NCBIUU_Cfam_GSD_1.0
Cdc20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,928,248 - 58,940,284 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,760,298 - 24,767,725 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,760,258 - 24,765,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6167,886,270 - 167,890,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16167,886,266 - 167,890,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26155,341,127 - 155,345,061 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,449,008 - 89,453,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2089,444,165 - 89,453,044 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603327,468,097 - 27,472,613 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,675,754 - 2,679,793 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,675,980 - 2,679,709 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdc20
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000036151
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
D5Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25131,965,869 - 131,966,040 (+)MAPPERmRatBN7.2
Rnor_6.05137,260,395 - 137,260,565NCBIRnor6.0
Rnor_5.05141,049,859 - 141,050,029UniSTSRnor5.0
Celera5130,511,352 - 130,511,522UniSTS
Cytogenetic Map5q36UniSTS
BB151133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25131,965,773 - 131,965,865 (+)MAPPERmRatBN7.2
Rnor_6.05137,260,299 - 137,260,390NCBIRnor6.0
Rnor_5.05141,049,763 - 141,049,854UniSTSRnor5.0
Celera5130,511,256 - 130,511,347UniSTS
Cytogenetic Map5q36UniSTS
BF387216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25131,971,506 - 131,971,675 (+)MAPPERmRatBN7.2
Rnor_6.05137,266,032 - 137,266,200NCBIRnor6.0
Rnor_5.05141,055,496 - 141,055,664UniSTSRnor5.0
RGSC_v3.45138,917,862 - 138,918,030UniSTSRGSC3.4
Celera5130,516,989 - 130,517,157UniSTS
RH 3.4 Map5853.4UniSTS
Cytogenetic Map5q36UniSTS
AA963388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25131,965,784 - 131,965,938 (+)MAPPERmRatBN7.2
Rnor_6.05137,260,310 - 137,260,463NCBIRnor6.0
Rnor_5.05141,049,774 - 141,049,927UniSTSRnor5.0
Celera5130,511,267 - 130,511,420UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:496549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25131,966,929 - 131,967,934 (+)MAPPERmRatBN7.2
Rnor_6.05137,261,455 - 137,262,459NCBIRnor6.0
Rnor_5.05141,050,919 - 141,051,923UniSTSRnor5.0
RGSC_v3.45138,913,268 - 138,914,272UniSTSRGSC3.4
Celera5130,512,412 - 130,513,416UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000036151   ⟹   ENSRNOP00000037772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5131,966,215 - 131,970,512 (-)Ensembl
Rnor_6.0 Ensembl5137,260,739 - 137,265,015 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5137,260,739 - 137,261,332 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099282   ⟹   ENSRNOP00000082901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5131,966,217 - 131,970,377 (-)Ensembl
RefSeq Acc Id: NM_171993   ⟹   NP_741990
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,251,596 - 137,255,799 (-)NCBI
mRatBN7.25131,966,203 - 131,970,406 (-)NCBI
Rnor_6.05137,260,728 - 137,264,931 (-)NCBI
Rnor_5.05141,050,192 - 141,054,395 (-)NCBI
RGSC_v3.45138,913,180 - 138,916,744 (-)RGD
Celera5130,511,685 - 130,515,888 (-)RGD
Sequence:
RefSeq Acc Id: NP_741990   ⟸   NM_171993
- UniProtKB: O70380 (UniProtKB/Swiss-Prot),   Q5U360 (UniProtKB/Swiss-Prot),   Q62623 (UniProtKB/Swiss-Prot),   A6JZI4 (UniProtKB/TrEMBL),   A0A8L2UL78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037772   ⟸   ENSRNOT00000036151
Ensembl Acc Id: ENSRNOP00000082901   ⟸   ENSRNOT00000099282
Protein Domains
Anaphase-promoting complex subunit 4-like WD40

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62623-F1-model_v2 AlphaFold Q62623 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693966
Promoter ID:EPDNEW_R4490
Type:initiation region
Name:Cdc20_1
Description:cell division cycle 20
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05137,264,912 - 137,264,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620477 AgrOrtholog
BioCyc Gene G2FUF-40155 BioCyc
Ensembl Genes ENSRNOG00000028415 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055012949 UniProtKB/Swiss-Prot
  ENSRNOG00060014125 UniProtKB/Swiss-Prot
  ENSRNOG00065017386 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036151.5 UniProtKB/TrEMBL
  ENSRNOT00000099282.1 UniProtKB/TrEMBL
  ENSRNOT00055022186 UniProtKB/Swiss-Prot
  ENSRNOT00060024164 UniProtKB/Swiss-Prot
  ENSRNOT00065029026 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134739 IMAGE-MGC_LOAD
InterPro Apc4_WD40_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cdc20/Fizzy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64515 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93111 IMAGE-MGC_LOAD
NCBI Gene 64515 ENTREZGENE
PANTHER CELL DIVISION CYCLE PROTEIN 20 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19918 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANAPC4_WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CDC20 RGD
PhenoGen Cdc20 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028415 RatGTEx
  ENSRNOG00055012949 RatGTEx
  ENSRNOG00060014125 RatGTEx
  ENSRNOG00065017386 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZW38_RAT UniProtKB/TrEMBL
  A0A8L2UL78 ENTREZGENE, UniProtKB/TrEMBL
  A6JZI4 ENTREZGENE, UniProtKB/TrEMBL
  CDC20_RAT UniProtKB/Swiss-Prot
  O70380 ENTREZGENE
  Q5U360 ENTREZGENE
  Q62623 ENTREZGENE
UniProt Secondary O70380 UniProtKB/Swiss-Prot
  Q5U360 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc20  cell division cycle 20  Cdc20  cell division cycle 20 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Cdc20  cell division cycle 20 homolog (S. cerevisiae)    cell cycle protein p55CDC  Name updated 1299863 APPROVED
2002-08-07 Cdc20  cell cycle protein p55CDC      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains seven repeats homologous to the beta subunit of G proteins 632471
gene_transcript contains ten exons 632470