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Gene: Csmd2 (CUB and Sushi multiple domains 2) Rattus norvegicus

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Symbol:

Csmd2

Name:

CUB and Sushi multiple domains 2

RGD ID:

1565728

Description:

Predicted to be involved in maintenance of postsynaptic density structure and postsynaptic density assembly. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human CSMD2 (CUB and Sushi multiple domains 2); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; atrazine; methoxychlor.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

CUB and sushi domain-containing protein 2; LOC313040; RGD1565728; similar to CUB and Sushi multiple domains 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CSMD2 (CUB and Sushi multiple domains 2)	HGNC	Ensembl, HomoloGene, NCBI
Mus musculus (house mouse):	Csmd2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Csmd2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CSMD2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CSMD2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Csmd2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CSMD2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CSMD2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Csmd2 (CUB and Sushi multiple domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CSMD2 (CUB and Sushi multiple domains 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Csmd2 (CUB and Sushi multiple domains 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	csmd2 (CUB and Sushi multiple domains 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	csmd2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	145,626,823 - 146,196,815 (+)	NCBI		GRCr8
mRatBN7.2	5	140,342,352 - 140,912,422 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	140,342,376 - 140,912,234 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	146,091,167 - 146,743,436 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	146,383,942 - 146,739,418 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	150,125,998 - 150,480,769 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	147,393,098 - 147,789,300 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	138,832,888 - 139,396,715 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Csmd2	Rat	attention deficit hyperactivity disorder		ISO	CSMD2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Attention deficit hyperactivity disorder	ClinVar	PMID:28332277
Csmd2	Rat	autistic disorder		ISO	CSMD2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar
Csmd2	Rat	Charcot-Marie-Tooth disease dominant intermediate C		ISO	CSMD2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate C	ClinVar	PMID:28492532
Csmd2	Rat	prostate cancer		ISO	CSMD2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Malignant tumor of prostate	ClinVar	PMID:23265383

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Csmd2	Rat	(+)-catechin	multiple interactions	ISO	CSMD2 (Homo sapiens)	6480464	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CSMD2 mRNA	CTD	PMID:24763279
Csmd2	Rat	17beta-estradiol	multiple interactions	ISO	CSMD2 (Homo sapiens)	6480464	[Estradiol co-treated with Progesterone] results in increased expression of CSMD2 mRNA	CTD	PMID:21453500
Csmd2	Rat	2,2',5,5'-tetrachlorobiphenyl	increases expression	ISO	CSMD2 (Homo sapiens)	6480464	2 more ...	CTD	PMID:36804509
Csmd2	Rat	2-palmitoylglycerol	increases expression	ISO	CSMD2 (Homo sapiens)	6480464	2-palmitoylglycerol results in increased expression of CSMD2 mRNA	CTD	PMID:37199045
Csmd2	Rat	3,3',4,4',5-pentachlorobiphenyl	decreases expression	EXP		6480464	3 more ...	CTD	PMID:32119087
Csmd2	Rat	4,4'-sulfonyldiphenol	affects methylation	ISO	Csmd2 (Mus musculus)	6480464	bisphenol S affects the methylation of CSMD2 exon and bisphenol S affects the methylation of CSMD2 gene	CTD	PMID:31683443 and PMID:33297965
Csmd2	Rat	aflatoxin B1	decreases methylation	ISO	CSMD2 (Homo sapiens)	6480464	Aflatoxin B1 results in decreased methylation of CSMD2 intron	CTD	PMID:30157460
Csmd2	Rat	Aflatoxin B2 alpha	increases methylation	ISO	CSMD2 (Homo sapiens)	6480464	aflatoxin B2 results in increased methylation of CSMD2 intron	CTD	PMID:30157460
Csmd2	Rat	atrazine	decreases expression	ISO	CSMD2 (Homo sapiens)	6480464	Atrazine results in decreased expression of CSMD2 mRNA	CTD	PMID:22378314
Csmd2	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of CSMD2 gene	CTD	PMID:35440735
Csmd2	Rat	benzo[a]pyrene	increases mutagenesis	ISO	CSMD2 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased mutagenesis of CSMD2 gene	CTD	PMID:25435355
Csmd2	Rat	benzo[a]pyrene	affects methylation	ISO	CSMD2 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of CSMD2 exon and Benzo(a)pyrene affects the methylation of CSMD2 intron	CTD	PMID:30157460
Csmd2	Rat	benzo[a]pyrene	increases methylation	ISO	CSMD2 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of CSMD2 promoter	CTD	PMID:27901495
Csmd2	Rat	benzo[a]pyrene	decreases methylation	ISO	CSMD2 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of CSMD2 exon	CTD	PMID:27901495
Csmd2	Rat	benzo[e]pyrene	increases methylation	ISO	CSMD2 (Homo sapiens)	6480464	benzo(e)pyrene results in increased methylation of CSMD2 intron	CTD	PMID:30157460
Csmd2	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	CSMD2 (Homo sapiens)	6480464	Diethylhexyl Phthalate results in decreased expression of CSMD2 mRNA	CTD	PMID:31163220
Csmd2	Rat	bisphenol A	decreases expression	ISO	Csmd2 (Mus musculus)	6480464	bisphenol A results in decreased expression of CSMD2 mRNA	CTD	PMID:30951980 and PMID:32156529
Csmd2	Rat	bisphenol A	multiple interactions	ISO	CSMD2 (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] affects the methylation of CSMD2 gene	CTD	PMID:31601247
Csmd2	Rat	bisphenol F	decreases expression	ISO	Csmd2 (Mus musculus)	6480464	bisphenol F results in decreased expression of CSMD2 mRNA	CTD	PMID:30951980
Csmd2	Rat	calcitriol	increases expression	ISO	CSMD2 (Homo sapiens)	6480464	Calcitriol results in increased expression of CSMD2 mRNA	CTD	PMID:16002434
Csmd2	Rat	CGP 52608	multiple interactions	ISO	CSMD2 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to CSMD2 gene]	CTD	PMID:28238834
Csmd2	Rat	doxorubicin	increases expression	ISO	CSMD2 (Homo sapiens)	6480464	Doxorubicin results in increased expression of CSMD2 mRNA	CTD	PMID:30031762
Csmd2	Rat	fulvestrant	increases methylation	ISO	CSMD2 (Homo sapiens)	6480464	Fulvestrant results in increased methylation of CSMD2 gene	CTD	PMID:31601247
Csmd2	Rat	fulvestrant	multiple interactions	ISO	CSMD2 (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] affects the methylation of CSMD2 gene	CTD	PMID:31601247
Csmd2	Rat	methapyrilene	increases methylation	ISO	CSMD2 (Homo sapiens)	6480464	Methapyrilene results in increased methylation of CSMD2 intron	CTD	PMID:30157460
Csmd2	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of CSMD2 gene	CTD	PMID:35440735
Csmd2	Rat	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] results in decreased methylation of CSMD2 gene	CTD	PMID:33148267
Csmd2	Rat	paracetamol	decreases expression	ISO	CSMD2 (Homo sapiens)	6480464	Acetaminophen results in decreased expression of CSMD2 mRNA	CTD	PMID:26690555
Csmd2	Rat	permethrin	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] results in decreased methylation of CSMD2 gene	CTD	PMID:33148267
Csmd2	Rat	progesterone	multiple interactions	ISO	CSMD2 (Homo sapiens)	6480464	[Estradiol co-treated with Progesterone] results in increased expression of CSMD2 mRNA	CTD	PMID:21453500
Csmd2	Rat	tebuconazole	decreases expression	ISO	CSMD2 (Homo sapiens)	6480464	tebuconazole results in decreased expression of CSMD2 mRNA	CTD	PMID:30458266
Csmd2	Rat	temozolomide	decreases expression	ISO	CSMD2 (Homo sapiens)	6480464	Temozolomide results in decreased expression of CSMD2 mRNA	CTD	PMID:31758290
Csmd2	Rat	triclosan	increases expression	ISO	CSMD2 (Homo sapiens)	6480464	Triclosan results in increased expression of CSMD2 mRNA	CTD	PMID:30510588
Csmd2	Rat	valproic acid	increases methylation	ISO	CSMD2 (Homo sapiens)	6480464	Valproic Acid results in increased methylation of CSMD2 gene	CTD	PMID:28853863 and PMID:29201983
Csmd2	Rat	valproic acid	affects expression	ISO	Csmd2 (Mus musculus)	6480464	Valproic Acid affects the expression of CSMD2 mRNA	CTD	PMID:17963808
Csmd2	Rat	valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of CSMD2 mRNA	CTD	PMID:29427782

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Csmd2	Rat	maintenance of postsynaptic density structure	involved_in	ISO	Csmd2 (Mus musculus)	1624291	PMID:31068362	RGD	PMID:31068362
Csmd2	Rat	postsynaptic density assembly	involved_in	ISO	Csmd2 (Mus musculus)	1624291	PMID:31068362	RGD	PMID:31068362

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Csmd2	Rat	glutamatergic synapse	is_active_in	ISO	Csmd2 (Mus musculus)	1624291	PMID:31068362	RGD	PMID:31068362
Csmd2	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Csmd2	Rat	postsynaptic density membrane	is_active_in	ISO	Csmd2 (Mus musculus)	1624291	PMID:31068362	RGD	PMID:31068362

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Csmd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	145,626,823 - 146,196,815 (+)	NCBI		GRCr8
mRatBN7.2	5	140,342,352 - 140,912,422 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	140,342,376 - 140,912,234 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	146,091,167 - 146,743,436 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	146,383,942 - 146,739,418 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	150,125,998 - 150,480,769 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	147,393,098 - 147,789,300 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	138,832,888 - 139,396,715 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

CSMD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	33,513,998 - 34,165,842 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	33,513,998 - 34,165,842 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	33,979,598 - 34,631,443 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	33,752,196 - 34,404,030 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	33,648,701 - 34,300,536	NCBI
Celera	1	32,251,406 - 32,903,645 (-)	NCBI		Celera
Cytogenetic Map	1	p35.1	NCBI
HuRef	1	32,095,768 - 32,747,734 (-)	NCBI		HuRef
CHM1_1	1	34,095,005 - 34,746,840 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	33,375,608 - 34,027,570 (-)	NCBI		T2T-CHM13v2.0

Csmd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	127,880,310 - 128,461,459 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	127,881,650 - 128,461,449 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	127,986,505 - 128,567,660 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	127,987,857 - 128,567,656 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	127,665,294 - 128,245,100 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	4	126,322,889 - 126,895,394 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	61.65	NCBI

Csmd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	11,695,182 - 12,274,450 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	11,695,182 - 12,274,450 (-)	NCBI	ChiLan1.0	ChiLan1.0

CSMD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	192,669,104 - 193,312,556 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	191,791,148 - 192,434,700 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	32,800,267 - 33,443,599 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	33,984,656 - 34,625,977 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	33,989,876 - 34,625,977 (-)	Ensembl	panpan1.1		panPan2

CSMD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	7,753,901 - 8,191,506 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	7,997,160 - 8,382,285 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	7,899,049 - 8,343,901 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	7,888,699 - 8,343,903 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	7,905,652 - 8,116,554 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	7,815,247 - 8,253,359 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	7,830,746 - 8,268,735 (+)	NCBI		UU_Cfam_GSD_1.0

Csmd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	50,498,763 - 50,982,232 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	16,326,666 - 16,866,720 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	16,323,899 - 16,607,712 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CSMD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	89,778,338 - 90,424,979 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	83,782,065 - 83,802,730 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CSMD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	98,708,384 - 99,358,093 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	98,936,373 - 99,352,601 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	17,336,998 - 18,008,225 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Csmd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	16,600,854 - 17,179,612 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	16,597,719 - 17,179,729 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Csmd2
4013 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	43
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000036029
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	129132428	143070159	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	120740824	143608494	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

D5Rat171

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	145,922,755 - 145,922,980 (+)	Marker Load Pipeline
mRatBN7.2	5	140,638,332 - 140,638,557 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	146,468,558 - 146,468,782	NCBI	Rnor6.0
Rnor_5.0	5	150,208,216 - 150,208,440	UniSTS	Rnor5.0
RGSC_v3.4	5	147,509,594 - 147,509,819	RGD	RGSC3.4
RGSC_v3.4	5	147,509,595 - 147,509,819	UniSTS	RGSC3.4
RGSC_v3.1	5	147,519,472 - 147,519,873	RGD
Celera	5	139,124,533 - 139,124,757	UniSTS
SHRSP x BN Map	5	78.5399	UniSTS
SHRSP x BN Map	5	78.5399	RGD
Cytogenetic Map	5	q36	UniSTS

D5Got81

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	145,629,083 - 145,629,322 (+)	Marker Load Pipeline
mRatBN7.2	5	140,344,611 - 140,344,850 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	146,092,488 - 146,092,730	NCBI	Rnor6.0
Rnor_6.0	5	146,086,033 - 146,086,275	NCBI	Rnor6.0
Rnor_5.0	5	149,843,442 - 149,843,684	UniSTS	Rnor5.0
Rnor_5.0	5	149,838,030 - 149,838,272	UniSTS	Rnor5.0
Celera	5	138,835,105 - 138,835,347	UniSTS
RH 3.4 Map	5	948.5	RGD
RH 3.4 Map	5	948.5	UniSTS
RH 2.0 Map	5	154.8	RGD
Cytogenetic Map	5	q36	UniSTS

BF399094

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	140,735,719 - 140,735,913 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	146,566,750 - 146,566,943	NCBI	Rnor6.0
Rnor_5.0	5	150,305,702 - 150,305,895	UniSTS	Rnor5.0
RGSC_v3.4	5	147,608,974 - 147,609,167	UniSTS	RGSC3.4
Celera	5	139,221,138 - 139,221,331	UniSTS
RH 3.4 Map	5	944.3	UniSTS
Cytogenetic Map	5	q36	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
6	9	47	113	81	80	49	20	49	6	183	88	93	32	60	31


RefSeq Transcripts	XM_006225533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000036029 ⟹ ENSRNOP00000030107

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	146,656,049 - 146,674,056 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078588 ⟹ ENSRNOP00000073789

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	140,342,376 - 140,912,234 (+)	Ensembl
Rnor_6.0 Ensembl	5	146,383,942 - 146,739,418 (+)	Ensembl

RefSeq Acc Id:

XM_063288624 ⟹ XP_063144694

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,827 - 146,196,815 (+)	NCBI

RefSeq Acc Id:

XR_010066640

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,827 - 146,196,815 (+)	NCBI

RefSeq Acc Id:

XR_010066641

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,827 - 146,196,815 (+)	NCBI

RefSeq Acc Id:

XR_010066642

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,829 - 146,196,815 (+)	NCBI

RefSeq Acc Id:

XR_010066643

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,829 - 146,196,815 (+)	NCBI

RefSeq Acc Id:

XR_010066644

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,829 - 146,196,815 (+)	NCBI

RefSeq Acc Id:

XR_010066645

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	145,626,823 - 146,168,215 (+)	NCBI


Protein RefSeqs	XP_063144694	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073789.2
	ENSRNOP00000105641

Ensembl Acc Id:

ENSRNOP00000030107 ⟸ ENSRNOT00000036029

Ensembl Acc Id:

ENSRNOP00000073789 ⟸ ENSRNOT00000078588

RefSeq Acc Id:	XP_063144694 ⟸ XM_063288624
- UniProtKB:	A0A0G2K6F2 (UniProtKB/TrEMBL)

Protein Domains

CUB Sushi

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-39843	BioCyc
Ensembl Genes	ENSRNOG00000007057	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078588	ENTREZGENE
	ENSRNOT00000078588.2	UniProtKB/TrEMBL
	ENSRNOT00000136888	ENTREZGENE
	ENSRNOT00000139049	ENTREZGENE
Gene3D-CATH	2.60.120.290	UniProtKB/TrEMBL
	Complement Module, domain 1	UniProtKB/TrEMBL
InterPro	CUB	UniProtKB/TrEMBL
	SEZ6_CSMD_C4BPB_Regulators	UniProtKB/TrEMBL
	sperma_CUB_dom	UniProtKB/TrEMBL
	Sushi/SCR/CCP_sf	UniProtKB/TrEMBL
	Sushi_SCR_CCP	UniProtKB/TrEMBL
NCBI Gene	313040	ENTREZGENE
PANTHER	PROTEIN CBR-CLEC-78	UniProtKB/TrEMBL
	PROTEIN CBR-CLEC-78	UniProtKB/TrEMBL
Pfam	CUB	UniProtKB/TrEMBL
	Sushi	UniProtKB/TrEMBL
PhenoGen	Csmd2	PhenoGen
PROSITE	CUB	UniProtKB/TrEMBL
	SUSHI	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007057	RatGTEx
SMART	CCP	UniProtKB/TrEMBL
	CUB	UniProtKB/TrEMBL
Superfamily-SCOP	Complement_control_module	UniProtKB/TrEMBL
	CUB	UniProtKB/TrEMBL
UniProt	A0A0G2K6F2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-12	Csmd2	CUB and Sushi multiple domains 2	RGD1565728	similar to CUB and Sushi multiple domains 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1565728	similar to CUB and Sushi multiple domains 2	RGD1565728_predicted	similar to CUB and Sushi multiple domains 2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1565728_predicted	similar to CUB and Sushi multiple domains 2 (predicted)	LOC313040	similar to CUB and Sushi multiple domains 2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC313040	similar to CUB and Sushi multiple domains 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar