RGD Reference Report - Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor. - Rat Genome Database

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Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor.

Authors: Kalashikam, RR  Battula, KK  Kirlampalli, V  Friedman, JM  Nappanveettil, G 
Citation: Kalashikam RR, etal., PLoS One. 2013 Oct 21;8(10):e77679. doi: 10.1371/journal.pone.0077679. eCollection 2013.
RGD ID: 8657042
Pubmed: PMID:24204914   (View Abstract at PubMed)
PMCID: PMC3804619   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0077679   (Journal Full-text)

WNIN/Obese (WNIN/Ob) rat a new mutant model of metabolic syndrome was identified in 1996 from an inbred Wistar rat strain, WNIN. So far several papers are published on this model highlighting its physical, biochemical and metabolic traits. WNIN/Ob is leptin resistant with unaltered leptin or its receptor coding sequences--the two well-known candidate genes for obesity. Genotyping analysis of F2 progeny (raised from WNIN/Ob x Fisher--344) in the present study localized the mutation to a recombinant region of 14.15cM on chromosome 5. This was further corroborated by QTL analysis for body weight, which narrowed this region to 4.43 cM with flanking markers D5Rat256 & D5Wox37. Interval mapping of body weight QTL shows that the LOD score peak maps upstream of leptin receptor and shows an additive effect suggesting this as a novel mutation and signifying the model as a valuable resource for studies on obesity and metabolic syndrome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw146Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw146RatWeight Gain  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw146Ratincreased body weight  IDA  RGD 
Objects Annotated

QTLs
Bw146  (Body weight QTL 146)

Strains
F344/Nin  (NA)
W-LeprfaNin  (NA)


Additional Information