Ece1 (endothelin converting enzyme 1) - Rat Genome Database

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Gene: Ece1 (endothelin converting enzyme 1) Rattus norvegicus
Symbol: Ece1
Name: endothelin converting enzyme 1
RGD ID: 620293
Description: Enables identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Located in early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
Previously known as: Ece; ECE-1; Endothelin-converting enzyme; endothelin-converting enzyme 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Mcs33
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85155,361,031 - 155,462,723 (+)NCBIGRCr8
mRatBN7.25150,077,679 - 150,179,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,077,644 - 150,179,371 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,773,465 - 152,873,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,547,754 - 154,648,239 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,529,783 - 154,630,269 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,215,469 - 156,318,652 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,215,417 - 156,318,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,968,604 - 160,075,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,635,656 - 156,735,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,645,659 - 156,747,472 (+)NCBI
Celera5148,472,086 - 148,571,980 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methylphenanthrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
ceftriaxone  (EXP)
chlordecone  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
glycidol  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
L-mimosine  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury(1+)  (EXP)
metoprolol  (ISO)
nickel sulfate  (ISO)
oroxylin A  (EXP)
ouabain  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosphoramidon  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
quartz  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sorafenib  (EXP)
stilbene-4,4'-diol  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
torcetrapib  (ISO)
trans-stilbene-4,4'-diol  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Renal endothelin-converting enzyme in rats with congestive heart failure. Abassi Z, etal., J Cardiovasc Pharmacol. 1998;31 Suppl 1:S31-4.
2. Endothelin-converting enzyme: ultrastructural localization and its recycling from the cell surface. Barnes K, etal., Hypertension. 1998 Jan;31(1):3-9.
3. Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats. Battistini B, etal., Clin Sci (Lond). 2002 Aug;103 Suppl 48:363S-366S.
4. Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease. Bohnemeier H, etal., Clin Exp Hypertens. 1998 May;20(4):417-37.
5. Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia. de Andrade CR, etal., Br J Pharmacol. 2009 Jun;157(4):568-80. Epub 2009 Apr 9.
6. Linkage mapping of the endothelin-converting enzyme gene (Ednce) to rat chromosome 5. Deng AY and Rapp JP, Mamm Genome 1995 Oct;6(10):759-60.
7. Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta. Doi Y, etal., Histol Histopathol 2002 Jan;17(1):97-105.
8. Enhancement of immunoreactivity for endothelin-1 and endothelin-converting enzyme-1 in the cadmium-treated rat thoracic aorta. Doi Y, etal., Virchows Arch. 2002 Aug;441(2):179-86. Epub 2002 Jan 31.
9. Selective upregulation of endothelin converting enzyme-1a in the human failing heart. Ergul A, etal., J Card Fail. 2000 Dec;6(4):314-20.
10. Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation. Feldman DL, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S255-9.
11. Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease. Funalot B, etal., Mol Psychiatry. 2004 Dec;9(12):1122-8, 1059.
12. Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5. Funke-Kaiser H, etal., FASEB J 2003 Aug;17(11):1487-9.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Up-regulation of endothelin-converting-enzyme mRNA expression following cardioplegic arrest. Goodwin AT, etal., Clin Sci (Lond). 2002 Aug;103 Suppl 48:206S-209S.
16. Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis. Gupta A, etal., J Mol Cell Cardiol. 2005 Mar;38(3):527-37.
17. A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. Hofstra RM, etal., Am J Hum Genet 1999 Jan;64(1):304-8.
18. Increased renal medullary endothelin-1 synthesis in prehypertensive DOCA- and salt-treated rats. Hsieh TJ, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F112-21.
19. Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. Ikebe M, etal., Nephron Exp Nephrol. 2003;94(4):e137-45.
20. Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein. Jackson CD, etal., Exp Biol Med (Maywood). 2006 Jun;231(6):794-801.
21. Diabetes and radiocontrast media increase endothelin converting enzyme-1 in the kidney. Khamaisi M, etal., Kidney Int. 2008 Jul;74(1):91-100. doi: 10.1038/ki.2008.112. Epub 2008 Apr 2.
22. Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme-1. Kilic E, etal., J Pineal Res. 2004 Nov;37(4):247-51.
23. Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Kwan AL, etal., Neuroreport. 2002 Feb 11;13(2):197-9.
24. Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Matsumura Y, etal., Jpn J Pharmacol. 2000 Sep;84(1):16-24.
25. Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. McNeish AJ, etal., Br J Pharmacol. 2012 Dec;167(8):1679-90. doi: 10.1111/j.1476-5381.2012.02129.x.
26. Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis. Minamino T, etal., Circulation. 1997 Jan 7;95(1):221-30.
27. Increased immunoreactivities against endothelin-converting enzyme-1 and monocyte chemotactic protein-1 in hepatic stellate cells of rat fibrous liver induced by thioacetamide. Nagata T, etal., Med Mol Morphol. 2005 Sep;38(3):161-72.
28. Intranephron distribution and regulation of endothelin-converting enzyme-1 in cyclosporin A-induced acute renal failure in rats. Nakayama Y, etal., J Am Soc Nephrol. 1999 Mar;10(3):562-71.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. Pelayo JC, etal., J Physiol. 2011 Nov 1;589(Pt 21):5213-30. doi: 10.1113/jphysiol.2011.214452. Epub 2011 Aug 30.
32. Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load. Pikkarainen S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1639-45. Epub 2006 Jan 12.
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Endothelin-converting enzyme inhibition in the rat model of acute heart failure: heart function and neurohormonal activation. Rufanova VA, etal., Exp Biol Med (Maywood). 2009 Oct;234(10):1201-11. doi: 10.3181/0902-RM-62. Epub 2009 Jul 13.
36. Tissue endothelin-converting enzyme activity correlates with cardiovascular risk factors in coronary artery disease. Ruschitzka F, etal., Circulation. 2000 Sep 5;102(10):1086-92.
37. Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11. Shimada K, etal., Biochem J. 1996 May 1;315 ( Pt 3):863-7.
38. Identification and characterization of two isoforms of an endothelin-converting enzyme-1. Shimada K, etal., FEBS Lett 1995 Sep 4;371(2):140-4.
39. Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. Shimada K, etal., J Biol Chem 1994 Jul 15;269(28):18275-8.
40. [Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat]. Simonova AI, etal., Ross Fiziol Zh Im I M Sechenova. 2008 Jul;94(7):777-84.
41. Inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts. Simonson MS, etal., Transplantation. 1999 Jun 27;67(12):1542-7.
42. Role of endothelin-converting enzyme-1 in the suppression of constitutive nitric oxide synthase in rat gastric mucosal injury by indomethacin. Slomiany BL and Slomiany A, Scand J Gastroenterol. 2000 Nov;35(11):1131-6.
43. Rosmarinic acid administration attenuates diabetes-induced vascular dysfunction of the rat aorta. Sotnikova R, etal., J Pharm Pharmacol. 2013 May;65(5):713-23. doi: 10.1111/jphp.12037. Epub 2013 Feb 27.
44. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
45. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
46. A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization. Valdenaire O, etal., Eur J Biochem 1999 Sep;264(2):341-9.
47. Expression of endothelin-1, endothelin-3, endothelin-converting enzyme-1, and endothelin-A and endothelin-B receptor mRNA after angioplasty-induced neointimal formation in the rat. Wang X, etal., Circ Res. 1996 Feb;78(2):322-8.
48. Inhibition of endothelin converting enzyme-1 activity or expression ameliorates angiotensin II-induced myocardial hypertrophy in cultured cardiomyocytes. Wang Z, etal., Pharmazie. 2009 Nov;64(11):755-9.
49. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Yanagisawa H, etal., Development 1998 Mar;125(5):825-36.
50. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
51. Alteration of endothelin system and calcium handling protein in left ventricles following drug treatment in dilated cardiomyopathy rats. Zhang JN, etal., Acta Pharmacol Sin. 2003 Nov;24(11):1099-102.
Additional References at PubMed
PMID:7805846   PMID:7864876   PMID:9710124   PMID:12950083   PMID:14519446   PMID:14969349   PMID:15344879   PMID:15838257   PMID:15838282   PMID:17897319   PMID:18039931   PMID:18992253  
PMID:19056867   PMID:19222484   PMID:19531493   PMID:19847761   PMID:19946888   PMID:20414044   PMID:21801596   PMID:29948551  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85155,361,031 - 155,462,723 (+)NCBIGRCr8
mRatBN7.25150,077,679 - 150,179,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,077,644 - 150,179,371 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,773,465 - 152,873,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,547,754 - 154,648,239 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,529,783 - 154,630,269 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,215,469 - 156,318,652 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,215,417 - 156,318,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,968,604 - 160,075,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,635,656 - 156,735,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,645,659 - 156,747,472 (+)NCBI
Celera5148,472,086 - 148,571,980 (+)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38121,217,250 - 21,345,504 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,217,247 - 21,345,572 (-)EnsemblGRCh38hg38GRCh38
GRCh37121,543,743 - 21,671,997 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,418,939 - 21,489,494 (-)NCBINCBI36Build 36hg18NCBI36
Build 34121,291,657 - 21,362,213NCBI
Celera119,868,639 - 19,996,910 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,789,436 - 19,917,657 (-)NCBIHuRef
CHM1_1121,655,386 - 21,783,707 (-)NCBICHM1_1
T2T-CHM13v2.0121,044,316 - 21,172,559 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394137,589,548 - 137,692,540 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,589,548 - 137,692,540 (+)EnsemblGRCm39 Ensembl
GRCm384137,862,237 - 137,965,229 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,862,237 - 137,965,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv374137,418,152 - 137,521,144 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,134,373 - 137,237,305 (+)NCBIMGSCv36mm8
Celera4136,126,032 - 136,196,612 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554521,651,316 - 1,751,489 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,653,783 - 1,704,619 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21205,783,201 - 205,910,343 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,895,167 - 205,022,339 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0120,166,019 - 20,290,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,206,199 - 21,278,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,206,199 - 21,278,909 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1277,732,645 - 77,793,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,678,686 - 77,792,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,191,949 - 74,307,168 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,248,131 - 78,362,573 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,248,163 - 78,362,572 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,065,942 - 75,181,163 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,130,913 - 76,192,255 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,133,728 - 77,195,129 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505841,209,358 - 41,258,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,034,134 - 7,083,005 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,034,134 - 7,083,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl679,408,326 - 79,466,152 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,408,322 - 79,465,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,659,673 - 73,781,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120111,212,567 - 111,342,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,212,594 - 111,342,821 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660334,933,846 - 5,063,084 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247646,221,867 - 6,318,477 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,222,301 - 6,318,423 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ece1
434 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:427
Count of miRNA genes:217
Interacting mature miRNAs:275
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,175,116 - 150,175,316 (+)MAPPERmRatBN7.2
Rnor_6.05156,314,394 - 156,314,593NCBIRnor6.0
Rnor_5.05160,066,056 - 160,066,255UniSTSRnor5.0
RGSC_v3.45156,733,178 - 156,733,378RGDRGSC3.4
RGSC_v3.45156,733,179 - 156,733,378UniSTSRGSC3.4
RGSC_v3.15156,743,217 - 156,743,417RGD
Celera5148,569,376 - 148,569,575UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,105,801 - 150,105,937 (+)MAPPERmRatBN7.2
Rnor_6.05156,243,687 - 156,243,822NCBIRnor6.0
Rnor_5.05159,996,822 - 159,996,957UniSTSRnor5.0
RGSC_v3.45156,663,716 - 156,663,851UniSTSRGSC3.4
Celera5148,500,081 - 148,500,216UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,174,419 - 150,174,580 (+)MAPPERmRatBN7.2
Rnor_6.05156,313,697 - 156,313,857NCBIRnor6.0
Rnor_5.05160,065,359 - 160,065,519UniSTSRnor5.0
RGSC_v3.45156,732,482 - 156,732,642UniSTSRGSC3.4
Celera5148,568,679 - 148,568,839UniSTS
RH 3.4 Map51023.7UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,161,129 - 150,161,238 (+)MAPPERmRatBN7.2
Rnor_6.05156,300,318 - 156,300,426NCBIRnor6.0
Rnor_5.05160,051,980 - 160,052,088UniSTSRnor5.0
RGSC_v3.45156,719,193 - 156,719,301UniSTSRGSC3.4
Celera5148,555,390 - 148,555,498UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 38 11 8
Low 3
Below cutoff


RefSeq Acc Id: ENSRNOT00000067616   ⟹   ENSRNOP00000062928
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,077,678 - 150,179,371 (+)Ensembl
Rnor_6.0 Ensembl5156,215,417 - 156,318,671 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077742   ⟹   ENSRNOP00000072923
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,077,644 - 150,179,371 (+)Ensembl
Rnor_6.0 Ensembl5156,215,434 - 156,318,648 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096331   ⟹   ENSRNOP00000095338
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,118,576 - 150,179,371 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102078   ⟹   ENSRNOP00000095315
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,132,844 - 150,179,371 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108805   ⟹   ENSRNOP00000093768
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,125,952 - 150,179,371 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111435   ⟹   ENSRNOP00000096436
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,132,258 - 150,179,371 (+)Ensembl
RefSeq Acc Id: NM_053596   ⟹   NP_446048
Rat AssemblyChrPosition (strand)Source
GRCr85155,361,031 - 155,461,069 (+)NCBI
mRatBN7.25150,077,679 - 150,177,721 (+)NCBI
Rnor_6.05156,215,469 - 156,316,998 (+)NCBI
Rnor_5.05159,968,604 - 160,075,347 (+)NCBI
RGSC_v3.45156,635,656 - 156,735,783 (+)RGD
Celera5148,472,086 - 148,571,980 (+)RGD
RefSeq Acc Id: XM_006239275   ⟹   XP_006239337
Rat AssemblyChrPosition (strand)Source
GRCr85155,408,524 - 155,462,723 (+)NCBI
mRatBN7.25150,125,860 - 150,179,375 (+)NCBI
Rnor_6.05156,263,820 - 156,318,652 (+)NCBI
Rnor_5.05159,968,604 - 160,075,347 (+)NCBI
RefSeq Acc Id: XM_006239276   ⟹   XP_006239338
Rat AssemblyChrPosition (strand)Source
GRCr85155,416,461 - 155,462,723 (+)NCBI
mRatBN7.25150,133,115 - 150,179,375 (+)NCBI
Rnor_6.05156,270,405 - 156,318,652 (+)NCBI
Rnor_5.05159,968,604 - 160,075,347 (+)NCBI
RefSeq Acc Id: XM_063288516   ⟹   XP_063144586
Rat AssemblyChrPosition (strand)Source
GRCr85155,402,207 - 155,462,723 (+)NCBI
RefSeq Acc Id: NP_446048   ⟸   NM_053596
- UniProtKB: Q6IN10 (UniProtKB/TrEMBL),   F7EP67 (UniProtKB/TrEMBL),   A6ITF1 (UniProtKB/TrEMBL),   A0A8I6AMF9 (UniProtKB/TrEMBL),   A0A0G2K465 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239337   ⟸   XM_006239275
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL15 (UniProtKB/TrEMBL),   A0A8I6AMF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239338   ⟸   XM_006239276
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AJE5 (UniProtKB/TrEMBL),   A0A8J8Y3G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062928   ⟸   ENSRNOT00000067616
RefSeq Acc Id: ENSRNOP00000072923   ⟸   ENSRNOT00000077742
RefSeq Acc Id: ENSRNOP00000093768   ⟸   ENSRNOT00000108805
RefSeq Acc Id: ENSRNOP00000095315   ⟸   ENSRNOT00000102078
RefSeq Acc Id: ENSRNOP00000096436   ⟸   ENSRNOT00000111435
RefSeq Acc Id: ENSRNOP00000095338   ⟸   ENSRNOT00000096331
RefSeq Acc Id: XP_063144586   ⟸   XM_063288516
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42893-F1-model_v2 AlphaFold P42893 1-762 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694186
Promoter ID:EPDNEW_R4708
Type:initiation region
Description:endothelin converting enzyme 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05156,215,431 - 156,215,491EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620293 AgrOrtholog
BioCyc Gene G2FUF-39468 BioCyc
Ensembl Genes ENSRNOG00000014241 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067616.3 UniProtKB/TrEMBL
  ENSRNOT00000077742.2 UniProtKB/TrEMBL
  ENSRNOT00000096331.1 UniProtKB/TrEMBL
  ENSRNOT00000102078.1 UniProtKB/TrEMBL
  ENSRNOT00000108805.1 UniProtKB/TrEMBL
  ENSRNOT00000111435.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94204 UniProtKB/TrEMBL
PANTHER PTHR11733 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11733:SF130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ece1 PhenoGen
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014241 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ECE1_RAT UniProtKB/Swiss-Prot
UniProt Secondary F7EP67 UniProtKB/TrEMBL
  Q6IN10 UniProtKB/TrEMBL
  Q9WUY8 UniProtKB/Swiss-Prot
  Q9WUY9 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ece1  endothelin converting enzyme 1      Symbol and Name updated 629477 APPROVED
2003-03-07 Ece1  endothelin converting enzyme 1  Ece  Endothelin-converting enzyme  Data merged from RGD:2530 628472 PROVISIONAL
2002-08-07 Ece1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ece  Endothelin-converting enzyme      Symbol and Name status set to approved 70586 APPROVED