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Gene: Ece1 (endothelin converting enzyme 1) Rattus norvegicus
Symbol: Ece1
Name: endothelin converting enzyme 1
RGD ID: 620293
Description: Exhibits identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Localizes to early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: Ece; ECE-1; Endothelin-converting enzyme; endothelin-converting enzyme 1
Homo sapiens (human) : ECE1 (endothelin converting enzyme 1)  HGNC  Alliance
Mus musculus (house mouse) : Ece1 (endothelin converting enzyme 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ece1 (endothelin converting enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ECE1 (endothelin converting enzyme 1)
Canis lupus familiaris (dog) : ECE1 (endothelin converting enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ece1 (endothelin converting enzyme 1)
Sus scrofa (pig) : ECE1 (endothelin converting enzyme 1)
Chlorocebus sabaeus (African green monkey) : ECE1 (endothelin converting enzyme 1)
Heterocephalus glaber (naked mole-rat) : Ece1 (endothelin converting enzyme 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05156,215,469 - 156,318,652 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,215,417 - 156,318,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,968,604 - 160,075,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,635,656 - 156,735,783 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,645,659 - 156,747,472 (+)NCBI
Celera5148,472,086 - 148,571,980 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ece1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620293
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.