Gene: Ece1 (endothelin converting enzyme 1) Rattus norvegicus
Analyze
Symbol:
Ece1
Name:
endothelin converting enzyme 1
Description:
Exhibits identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Localizes to the early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Ece; ECE-1; Endothelin-converting enzyme; endothelin-converting enzyme 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ECE1 (endothelin converting enzyme 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Ece1 (endothelin converting enzyme 1) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ece1 (endothelin converting enzyme 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ECE1 (endothelin converting enzyme 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ECE1 (endothelin converting enzyme 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ece1 (endothelin converting enzyme 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ECE1 (endothelin converting enzyme 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
ECE2 (endothelin converting enzyme 2) HGNC
OrthoDB
Homo sapiens (human):
EEF1AKMT4-ECE2 (EEF1AKMT4-ECE2 readthrough) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
ECE1 (endothelin converting enzyme 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Ece1 (endothelin converting enzyme 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
ece1 (endothelin converting enzyme 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Nep3
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Caenorhabditis elegans (roundworm):
nep-1
Alliance
DIOPT (InParanoid, OrthoInspector, PANTHER)
Caenorhabditis elegans (roundworm):
nep-11
Alliance
DIOPT (InParanoid, OrthoInspector, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 156,215,469 - 156,318,652 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 156,215,417 - 156,318,671 (+) Ensembl Rnor_5.0 5 159,968,604 - 160,075,347 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 156,635,656 - 156,735,783 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 156,645,659 - 156,747,472 (+) NCBI Celera 5 148,472,086 - 148,571,980 (+) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Hirschsprung Disease, Cardiac Defects, and Autonomic Dysfunction ISO RGD:731823 8554872 ClinVar Annotator: match by OMIM:613870 ClinVar PMID:8530372 , PMID:9915973 Hirschsprung's disease ISO RGD:731823 8554872 ClinVar Annotator: match by term: Hirschsprung disease ClinVar
Imported Annotations - CTD
autonomic nervous system disease ISO RGD:731823 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9915973 congenital heart disease ISO RGD:731823 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9449665 , PMID:9915973 Craniofacial Abnormalities ISO RGD:731823 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9449665 Hirschsprung's disease ISO RGD:731823 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9915973 hypertension ISO RGD:731823 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12566389 type 2 diabetes mellitus ISO RGD:731823 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16387788 Imported Annotations - MGI
double outlet right ventricle ISS RGD:1552140 13592920 OMIM:217095 MouseDO Imported Annotations - OMIM
essential hypertension ISO RGD:731823 7240710 OMIM Hirschsprung Disease, Cardiac Defects, and Autonomic Dysfunction ISO RGD:731823 7240710 OMIM
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:731823 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ECE1 mRNA CTD PMID:22079256 1-methylphenanthrene multiple interactions ISO RGD:731823 6480464 [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ECE1 mRNA CTD PMID:17690111 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Testosterone] results in increased expression of ECE1 mRNA CTD PMID:11375906 17beta-estradiol increases expression ISO RGD:731823 6480464 Estradiol results in increased expression of ECE1 mRNA CTD PMID:19943105 , PMID:23019147 17beta-estradiol multiple interactions ISO RGD:731823 6480464 Tamoxifen inhibits the reaction [Estradiol results in increased expression of ECE1 mRNA] CTD PMID:19943105 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1552140 6480464 Tetrachlorodibenzodioxin results in increased expression of ECE1 mRNA CTD PMID:20819909 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ECE1 mRNA CTD PMID:18796159 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552140 6480464 Tetrachlorodibenzodioxin affects the expression of ECE1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ECE1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1552140 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ECE1 gene] CTD PMID:20819909 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of ECE1 mRNA CTD PMID:21346803 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP 6480464 Puromycin Aminonucleoside results in increased expression of ECE1 mRNA, Puromycin Aminonucleoside results in increased expression of ECE1 protein CTD PMID:12972712 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1552140 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of ECE1 mRNA CTD PMID:26251327 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1552140 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of ECE1 mRNA CTD PMID:18648102 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of ECE1 mRNA CTD PMID:24780913 , PMID:25825206 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of ECE1 mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO RGD:731823 6480464 Aflatoxin B1 results in decreased methylation of ECE1 gene CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:731823 6480464 Aflatoxin B1 results in increased methylation of ECE1 intron CTD PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:731823 6480464 aflatoxin B2 results in decreased methylation of ECE1 intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:731823 6480464 Tretinoin results in increased expression of ECE1 mRNA CTD PMID:23830798 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ECE1 mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of ECE1 mRNA CTD PMID:30779732 Aroclor 1254 decreases expression ISO RGD:1552140 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of ECE1 mRNA CTD PMID:25270620 asbestos increases expression ISO RGD:731823 6480464 Asbestos results in increased expression of ECE1 mRNA CTD PMID:22398240 benzene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ECE1 mRNA CTD PMID:17905399 benzo[a]pyrene increases expression ISO RGD:1552140 6480464 Benzo(a)pyrene results in increased expression of ECE1 mRNA CTD PMID:20127859 benzo[a]pyrene affects methylation ISO RGD:731823 6480464 Benzo(a)pyrene affects the methylation of ECE1 intron CTD PMID:30157460 benzo[a]pyrene multiple interactions ISO RGD:731823 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 benzo[a]pyrene decreases expression ISO RGD:1552140 6480464 Benzo(a)pyrene results in decreased expression of ECE1 mRNA CTD PMID:19770486 benzo[b]fluoranthene multiple interactions ISO RGD:731823 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ECE1 mRNA CTD PMID:17690111 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ECE1 mRNA CTD PMID:25181051 choline multiple interactions ISO RGD:1552140 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ECE1, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ECE1 gene CTD PMID:20938992 cobalt dichloride increases expression ISO RGD:731823 6480464 cobaltous chloride results in increased expression of ECE1 mRNA CTD PMID:25469848 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of ECE1 mRNA, cobaltous chloride results in increased expression of ECE1 protein CTD PMID:25469848 dibenz[a,h]anthracene multiple interactions ISO RGD:731823 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 dibenzo[a,l]pyrene multiple interactions ISO RGD:731823 6480464 [Benzo(a)pyrene co-treated with dibenzo(a, l)pyrene] affects the expression of ECE1 mRNA CTD PMID:17690111 dicrotophos increases expression ISO RGD:731823 6480464 dicrotophos results in increased expression of ECE1 mRNA CTD PMID:28302478 dioxygen increases expression ISO RGD:1552140 6480464 Oxygen deficiency results in increased expression of ECE1 mRNA, Oxygen deficiency results in increased expression of ECE1 protein CTD PMID:21926265 dioxygen multiple interactions ISO RGD:731823 6480464 Oxygen deficiency promotes the reaction [HIF1A protein binds to ECE1 intron], Oxygen deficiency promotes the reaction [HIF1A protein binds to ECE1 promoter] CTD PMID:25469848 dioxygen increases expression ISO RGD:731823 6480464 Oxygen deficiency results in increased expression of ECE1 mRNA CTD PMID:25469848 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of ECE1 mRNA CTD PMID:25469848 dioxygen multiple interactions ISO RGD:1552140 6480464 Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of ECE1 mRNA], Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of ECE1 protein] CTD PMID:21926265 dorsomorphin multiple interactions ISO RGD:731823 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases response to substance ISO RGD:1552140 6480464 ECE1 protein results in increased susceptibility to Doxorubicin CTD PMID:20101000 doxorubicin decreases expression ISO RGD:731823 6480464 Doxorubicin results in decreased expression of ECE1 mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of ECE1 mRNA CTD PMID:29391264 entinostat increases expression ISO RGD:731823 6480464 entinostat results in increased expression of ECE1 mRNA CTD PMID:27188386 ethanol affects splicing ISO RGD:1552140 6480464 Ethanol affects the splicing of ECE1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1552140 6480464 Ethanol results in increased expression of ECE1 mRNA CTD PMID:30319688 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of ECE1 mRNA CTD PMID:18035473 fluoranthene multiple interactions ISO RGD:731823 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ECE1 mRNA CTD PMID:17690111 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of ECE1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1552140 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ECE1, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ECE1 gene CTD PMID:20938992 fulvestrant multiple interactions ISO RGD:731823 6480464 [fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA CTD PMID:19943105 genistein decreases expression ISO RGD:731823 6480464 Genistein results in decreased expression of ECE1 mRNA CTD PMID:16399490 genistein increases expression EXP 6480464 Genistein results in increased expression of ECE1 mRNA CTD PMID:21782745 genistein multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of ECE1 mRNA CTD PMID:21782745 glycidol affects expression EXP 6480464 glycidol affects the expression of ECE1 mRNA CTD PMID:24915197 hydroquinone O-beta-D-glucopyranoside increases expression ISO RGD:731823 6480464 Arbutin results in increased expression of ECE1 mRNA CTD PMID:17103032 indometacin increases activity EXP 6480464 Indomethacin results in increased activity of ECE1 protein CTD PMID:16280098 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of ECE1 protein CTD PMID:11145282 indometacin multiple interactions EXP 6480464 EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]] more ... CTD PMID:11145282 , PMID:16280098 L-methionine multiple interactions ISO RGD:1552140 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ECE1, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ECE1 gene CTD PMID:20938992 L-mimosine increases expression EXP 6480464 Mimosine results in increased expression of ECE1 mRNA, Mimosine results in increased expression of ECE1 protein CTD PMID:25469848 L-mimosine increases expression ISO RGD:731823 6480464 Mimosine results in increased expression of ECE1 mRNA CTD PMID:25469848 lipopolysaccharide multiple interactions EXP 6480464 5 more ... CTD PMID:26694894 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of ECE1 mRNA, Lipopolysaccharides results in increased expression of ECE1 protein CTD PMID:26694894 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of ECE1 mRNA CTD PMID:30467583 methoxychlor multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of ECE1 mRNA CTD PMID:21782745 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of ECE1 mRNA CTD PMID:21782745 methylmercury(1+) multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ECE1 mRNA CTD PMID:17905399 metoprolol decreases expression ISO RGD:731823 6480464 Metoprolol results in decreased expression of ECE1 mRNA CTD PMID:9607404 nickel sulfate increases expression ISO RGD:731823 6480464 nickel sulfate results in increased expression of ECE1 mRNA CTD PMID:16780908 oroxylin A multiple interactions EXP 6480464 5 more ... CTD PMID:26694894 ouabain increases expression ISO RGD:731823 6480464 Ouabain results in increased expression of ECE1 protein CTD PMID:18247327 ozone increases expression EXP 6480464 Ozone results in increased expression of ECE1 mRNA CTD PMID:16081523 , PMID:17662977 paracetamol increases expression ISO RGD:731823 6480464 Acetaminophen results in increased expression of ECE1 mRNA CTD PMID:22230336 , PMID:29067470 perfluorooctanoic acid decreases expression ISO RGD:731823 6480464 perfluorooctanoic acid results in decreased expression of ECE1 protein CTD PMID:26879310 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of ECE1 mRNA CTD PMID:19162173 phenobarbital decreases expression ISO RGD:1552140 6480464 Phenobarbital results in decreased expression of ECE1 mRNA CTD PMID:25270620 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of ECE1 mRNA CTD PMID:15007106 phenylmercury acetate increases expression ISO RGD:731823 6480464 Phenylmercuric Acetate results in increased expression of ECE1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:731823 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA CTD PMID:27188386 phosphoramidon multiple interactions EXP 6480464 EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]] more ... CTD PMID:11145282 , PMID:16280098 pirinixic acid decreases expression ISO RGD:1552140 6480464 pirinixic acid results in decreased expression of ECE1 mRNA CTD PMID:17426115 , PMID:23811191 potassium chromate increases expression ISO RGD:731823 6480464 potassium chromate(VI) results in increased expression of ECE1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:731823 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ECE1 mRNA CTD PMID:22079256 potassium dichromate increases expression ISO RGD:731823 6480464 Potassium Dichromate results in increased expression of ECE1 protein CTD PMID:23718831 quartz decreases expression ISO RGD:731823 6480464 Quartz results in decreased expression of ECE1 mRNA CTD PMID:27917503 resveratrol decreases expression ISO RGD:731823 6480464 resveratrol results in decreased expression of ECE1 mRNA CTD PMID:21554123 resveratrol decreases activity ISO RGD:731823 6480464 resveratrol results in decreased activity of ECE1 protein CTD PMID:21554123 SB 203580 affects expression EXP 6480464 SB 203580 affects the expression of ECE1 mRNA CTD PMID:21084678 SB 431542 multiple interactions ISO RGD:731823 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos decreases methylation ISO RGD:731823 6480464 Asbestos, Serpentine results in decreased methylation of ECE1 gene CTD PMID:29523930 sodium arsenate decreases expression ISO RGD:1552140 6480464 sodium arsenate results in decreased expression of ECE1 mRNA CTD PMID:21795629 stilbene-4,4'-diol decreases expression ISO RGD:731823 6480464 4, 4'-dihydroxystilbene results in decreased expression of ECE1 mRNA CTD PMID:21554123 stilbene-4,4'-diol decreases activity ISO RGD:731823 6480464 4, 4'-dihydroxystilbene results in decreased activity of ECE1 protein CTD PMID:21554123 tamoxifen multiple interactions ISO RGD:731823 6480464 [fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA, Tamoxifen inhibits the reaction [Estradiol results in increased expression of ECE1 mRNA] CTD PMID:19943105 tamoxifen increases expression ISO RGD:731823 6480464 Tamoxifen results in increased expression of ECE1 mRNA CTD PMID:19943105 testosterone multiple interactions EXP 6480464 [Estradiol co-treated with Testosterone] results in increased expression of ECE1 mRNA CTD PMID:11375906 testosterone affects expression EXP 6480464 Testosterone affects the expression of ECE1 mRNA CTD PMID:12122504 , PMID:14616470 tetrachloromethane decreases expression ISO RGD:1552140 6480464 Carbon Tetrachloride results in decreased expression of ECE1 mRNA CTD PMID:17484886 torcetrapib increases expression ISO RGD:731823 6480464 torcetrapib results in increased expression of ECE1 mRNA CTD PMID:23228038 trans-stilbene-4,4'-diol decreases expression ISO RGD:731823 6480464 4, 4'-dihydroxystilbene results in decreased expression of ECE1 mRNA CTD PMID:21554123 trans-stilbene-4,4'-diol decreases activity ISO RGD:731823 6480464 4, 4'-dihydroxystilbene results in decreased activity of ECE1 protein CTD PMID:21554123 trichloroethene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ECE1 mRNA CTD PMID:17905399 trichostatin A affects expression ISO RGD:731823 6480464 trichostatin A affects the expression of ECE1 mRNA CTD PMID:28542535 troglitazone decreases expression ISO RGD:1552140 6480464 troglitazone results in decreased expression of ECE1 mRNA CTD PMID:28973697 urethane increases expression ISO RGD:731823 6480464 Urethane results in increased expression of ECE1 mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:731823 6480464 Valproic Acid results in increased methylation of ECE1 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:731823 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:731823 6480464 Valproic Acid results in increased expression of ECE1 mRNA CTD PMID:23179753 more ... zoledronic acid increases expression ISO RGD:731823 6480464 zoledronic acid results in increased expression of ECE1 mRNA CTD PMID:24714768
Biological Process apoptotic process IMP 1581735 RGD bradykinin catabolic process ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 bradykinin catabolic process IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcitonin catabolic process ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 calcitonin catabolic process IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 ear development ISO RGD:731823 1624291 (PMID:9915973) RGD PMID:9915973 ear development IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic digit morphogenesis ISO RGD:731823 1624291 (PMID:9915973) RGD PMID:9915973 embryonic digit morphogenesis IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 endothelin maturation ISO RGD:731823 1624291 (PMID:7805846) RGD PMID:7805846 endothelin maturation IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart development ISO RGD:731823 1624291 (PMID:9915973) RGD PMID:9915973 heart development IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 hormone catabolic process ISO RGD:731823 1624291 (PMID:7864876) RGD PMID:7864876 peptide hormone processing ISO RGD:731823 1624291 (PMID:7864876) RGD PMID:7864876 pharyngeal system development ISO RGD:1552140 1624291 MGI:MGI:2158947 (MGI:MGI:2675516 , PMID:12950083) RGD MGI:MGI:2675516 , PMID:12950083 pharyngeal system development IEA UniProtKB:Q4PZA2 , ensembl:ENSMUSP000000995761600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cAMP-mediated signaling IMP 7243859 RGD positive regulation of cardiac muscle hypertrophy IMP 7243873 RGD positive regulation of G protein-coupled receptor signaling pathway IMP 1581735 RGD positive regulation of receptor recycling IMP 7243869 RGD positive regulation of receptor recycling IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of receptor recycling ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 protein processing IDA 728596 RGD protein processing ISO RGD:731823 1624291 (PMID:7805846) RGD PMID:7805846 proteolysis IDA 728596 RGD regulation of blood pressure IMP 7243876 RGD regulation of blood vessel diameter IMP 7243859 RGD regulation of ERK1 and ERK2 cascade IMP 7243869 RGD response to cadmium ion IEP 7244161 RGD response to drug IEP 7244163 RGD response to hypoxia IDA 728806 RGD response to muscle stretch IEP 7243951 RGD substance P catabolic process ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 substance P catabolic process IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasmic vesicle IDA 7243859 RGD early endosome ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 early endosome IDA 7243859 RGD endosome ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 endosome IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane ISO RGD:731823 1624291 (PMID:9449382), (PMID:9710124) RGD PMID:9449382 , PMID:9710124 external side of plasma membrane IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane IDA 8553464 PMID:9449382 BHF-UCL integral component of membrane ISO RGD:731823 1624291 (PMID:7805846) RGD PMID:7805846 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 integral component of membrane IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane IDA 728596 RGD perinuclear region of cytoplasm ISO RGD:731823 1624291 (PMID:9710124) RGD PMID:9710124 perinuclear region of cytoplasm IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISO RGD:731823 1624291 (PMID:18039931) RGD PMID:18039931 plasma membrane IDA 7244169 RGD secretory granule IDA 728806 RGD vesicle IDA 8553464 PMID:9449382 BHF-UCL Weibel-Palade body ISO RGD:731823 1624291 (PMID:9710124) RGD PMID:9710124 Weibel-Palade body IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function endopeptidase activity ISO RGD:731823 1624291 (PMID:18039931), (PMID:7805846) RGD PMID:18039931 , PMID:7805846 identical protein binding IMP 7244169 homodimerization RGD metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProt GO_REF:0000037 metalloendopeptidase activity IEA InterPro:IPR000718 , InterPro:IPR018497 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein binding ISO RGD:731823 1624291 UniProtKB:P49760 , UniProtKB:P60370 (PMID:25416956) RGD PMID:25416956 protein homodimerization activity ISO RGD:731823 1624291 UniProtKB:P42892 (PMID:7805846) RGD PMID:7805846 protein homodimerization activity IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107 zinc ion binding ISO RGD:731823 1624291 (PMID:18992253) RGD PMID:18992253 zinc ion binding IEA UniProtKB:P42892 , ensembl:ENSP000003640281600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
