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Gene: Hspg2 (heparan sulfate proteoglycan 2) Rattus norvegicus
Symbol: Hspg2
Name: heparan sulfate proteoglycan 2
RGD ID: 621770
Description: Exhibits collagen V binding activity. Involved in several processes, including animal organ regeneration; embryo implantation; and positive regulation of endothelial cell proliferation. Localizes to collagen-containing extracellular matrix. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2,2-tetramine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: basement membrane-specific heparan sulfate proteoglycan core protein; LOC313641; Per; perlecan; perlecan (heparan sulfate proteoglycan 2)
Homo sapiens (human) : HSPG2 (heparan sulfate proteoglycan 2)  HGNC  Alliance
Mus musculus (house mouse) : Hspg2 (perlecan (heparan sulfate proteoglycan 2))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspg2 (heparan sulfate proteoglycan 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPG2 (heparan sulfate proteoglycan 2)
Canis lupus familiaris (dog) : HSPG2 (heparan sulfate proteoglycan 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspg2 (heparan sulfate proteoglycan 2)
Sus scrofa (pig) : HSPG2 (heparan sulfate proteoglycan 2)
Chlorocebus sabaeus (African green monkey) : HSPG2 (heparan sulfate proteoglycan 2)
Heterocephalus glaber (naked mole-rat) : Hspg2 (heparan sulfate proteoglycan 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05155,812,096 - 155,913,751 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05159,568,612 - 159,669,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5148,073,391 - 148,174,691 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspg2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621770
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.