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Gene: Hspg2 (perlecan (heparan sulfate proteoglycan 2)) Mus musculus
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Symbol: Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Description: Exhibits protease binding activity. Involved in several processes, including animal organ development; extracellular matrix organization; and skeletal system development. Localizes to the basement membrane. Used to study Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; dextro-looped transposition of the great arteries 1; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Is expressed in several structures, including alimentary system; cardiovascular system; early conceptus; genitourinary system; and nervous system. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2); PARTICIPATES IN Hedgehog signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI852380; basement membrane-specific heparan sulfate proteoglycan core protein; HSPG; Pcn; per; Plc
Orthologs:
Homo sapiens (human) : HSPG2 (heparan sulfate proteoglycan 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspg2 (heparan sulfate proteoglycan 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspg2 (heparan sulfate proteoglycan 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPG2 (heparan sulfate proteoglycan 2)
Canis lupus familiaris (dog) : HSPG2 (heparan sulfate proteoglycan 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspg2 (heparan sulfate proteoglycan 2)
Sus scrofa (pig) : HSPG2 (heparan sulfate proteoglycan 2)
Chlorocebus sabaeus (African green monkey) : HSPG2 (heparan sulfate proteoglycan 2)
Heterocephalus glaber (naked mole-rat) : Hspg2 (heparan sulfate proteoglycan 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl4137,468,769 - 137,570,630 (+)EnsemblGRCm38mm10GRCm38
GRCm384137,468,751 - 137,570,630 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374137,024,718 - 137,126,545 (+)NCBIGRCm37mm9NCBIm37
MGSCv364137,024,724 - 137,126,545 (+)NCBImm8
Celera4135,720,332 - 135,778,896 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hspg2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558001
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.