RGD Reference Report - Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions. - Rat Genome Database

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Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions.

Authors: Tran, PK  Agardh, HE  Tran-Lundmark, K  Ekstrand, J  Roy, J  Henderson, B  Gabrielsen, A  Hansson, GK  Swedenborg, J  Paulsson-Berne, G  Hedin, U 
Citation: Tran PK, etal., Atherosclerosis. 2007 Feb;190(2):264-70. Epub 2006 Apr 18.
RGD ID: 1624254
Pubmed: PMID:16620836   (View Abstract at PubMed)
DOI: DOI:10.1016/j.atherosclerosis.2006.03.010   (Journal Full-text)

Heparan sulfate in the extracellular matrix of the artery wall has been proposed to possess anti-atherogenic properties by interfering with lipoprotein retention, suppression of inflammation, and inhibition of smooth muscle cell growth. Previously, the amount of heparan sulfate in atherosclerotic lesions from humans and animals has been shown to be reduced but the identity or identities of the heparan sulfate molecules being down regulated in this disease are not known. In this study, atherosclerotic lesions were retrieved from 44 patients undergoing surgery for symptomatic carotid stenosis. Normal iliac arteries from organ donors were used as controls. Analysis of the specimens by gene microarray showed a selective reduction in perlecan gene expression, whereas, expression of the other heparan sulfate proteoglycans in the artery wall, agrin and collagen XVIII, remained unchanged. Expression of the large chondroitin sulfate proteoglycan, versican, also remained unchanged. Real-time PCR confirmed the decrease in perlecan gene expression and the unchanged expression of versican. The findings were supported by immunohistochemical analysis demonstrating a reduced accumulation of both perlecan core protein and heparan sulfate in carotid lesions. The study demonstrates a reduction of perlecan mRNA-expression and protein deposition in human atherosclerosis, which in part explains the low levels of heparan sulfate in this disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
carotid artery disease  IEP 1624254mRNA and protein:decreased expression:carotid arteryRGD 
carotid artery disease  ISOHSPG2 (Homo sapiens)1624254; 1624254mRNA and protein:decreased expression:carotid arteryRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspg2  (heparan sulfate proteoglycan 2)

Genes (Mus musculus)
Hspg2  (perlecan (heparan sulfate proteoglycan 2))

Genes (Homo sapiens)
HSPG2  (heparan sulfate proteoglycan 2)


Additional Information