Prdx1 (peroxiredoxin 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Prdx1 (peroxiredoxin 1) Rattus norvegicus
Analyze
Symbol: Prdx1
Name: peroxiredoxin 1
RGD ID: 620039
Description: Enables heme binding activity; identical protein binding activity; and peroxiredoxin activity. Involved in response to oxidative stress. Located in euchromatin; mitochondrial matrix; and peroxisomal matrix. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hbp23; heme-binding 23 kDa protein; MGC108617; peroxiredoxin-1; thioredoxin peroxidase 2; thioredoxin-dependent peroxide reductase 2; thioredoxin-dependent peroxiredoxin 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,383,906 - 135,399,504 (+)NCBIGRCr8
mRatBN7.25130,147,258 - 130,162,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,772,005 - 132,788,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,526,605 - 134,543,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,549,011 - 134,565,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,536,413 - 135,551,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,332,556 - 139,348,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,975,780 - 136,991,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,981,005 - 136,996,856 (+)NCBI
Celera5128,674,439 - 128,690,018 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
antimonite  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite ion  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calycosin  (ISO)
capsaicin  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloramine T  (EXP)
chlordecone  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP,ISO)
dihydroartemisinin  (ISO)
dioscin  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
etoposide  (ISO)
fenthion  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
frenolicin B  (ISO)
furan  (EXP)
Gastrodin  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
indole-3-methanol  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metam  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
oleanolic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
picloram  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
Propiverine  (EXP)
Pyridostigmine bromide  (EXP)
pyrogallol  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
Siomycin A  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
styrene  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
Tributyltin oxide  (ISO)
trichlopyr  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. In-depth identification of pathways related to cisplatin-induced hepatotoxicity through an integrative method based on an informatics-assisted label-free protein quantitation and microarray gene expression approach. Cho YE, etal., Mol Cell Proteomics. 2012 Jan;11(1):M111.010884. doi: 10.1074/mcp.M111.010884. Epub 2011 Oct 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. Hirotsu S, etal., Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12333-8.
5. Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells. Immenschuh S, etal., Biochemistry 1995 Oct 17;34(41):13407-11.
6. Differential cellular and subcellular localization of heme-binding protein 23/peroxiredoxin I and heme oxygenase-1 in rat liver. Immenschuh S, etal., J Histochem Cytochem. 2003 Dec;51(12):1621-31.
7. Inhibition of the thiol-specific antioxidant activity of rat liver MSP23 protein by hemin. Ishii T, etal., Biochem Biophys Res Commun. 1995 Nov 22;216(3):970-5.
8. Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. Iwahara S, etal., Biochemistry 1995 Oct 17;34(41):13398-406.
9. Rat lung peroxiredoxins I and II are differentially regulated during development and by hyperoxia. Kim HS, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1212-7.
10. Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle. Lee CK, etal., Biochim Biophys Acta. 2007 Jul;1774(7):848-55. Epub 2007 May 10.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cold acclimation reduces hepatic protein Kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in Rats. Sepa-Kishi DM, etal., Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13592.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8360158   PMID:8462106   PMID:10514471   PMID:10751410   PMID:11986303   PMID:12891360   PMID:12960165   PMID:15448164   PMID:15489334   PMID:15858817   PMID:16170382   PMID:16297875  
PMID:16309569   PMID:16880205   PMID:17519234   PMID:17603937   PMID:17634366   PMID:17761673   PMID:17974571   PMID:18250162   PMID:18606987   PMID:18614015   PMID:19182904   PMID:19199708  
PMID:20458337   PMID:21516123   PMID:21630459   PMID:22166015   PMID:22658674   PMID:22664934   PMID:22681889   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23580065  
PMID:23979707   PMID:24625528   PMID:25468996   PMID:25989822   PMID:26003307   PMID:26316108   PMID:26945066   PMID:27756681   PMID:27922677   PMID:29410271   PMID:29476059   PMID:31904090  
PMID:32292063   PMID:33682513   PMID:35352799  


Genomics

Comparative Map Data
Prdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,383,906 - 135,399,504 (+)NCBIGRCr8
mRatBN7.25130,147,258 - 130,162,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,772,005 - 132,788,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,526,605 - 134,543,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,549,011 - 134,565,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,536,413 - 135,551,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,332,556 - 139,348,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,975,780 - 136,991,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,981,005 - 136,996,856 (+)NCBI
Celera5128,674,439 - 128,690,018 (+)NCBICelera
Cytogenetic Map5q35NCBI
PRDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,511,051 - 45,522,890 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,510,914 - 45,542,732 (-)EnsemblGRCh38hg38GRCh38
GRCh37145,976,723 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,749,294 - 45,760,196 (-)NCBINCBI36Build 36hg18NCBI36
Build 34145,645,800 - 45,656,702NCBI
Celera144,260,797 - 44,271,582 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,088,373 - 44,099,940 (-)NCBIHuRef
CHM1_1146,093,972 - 46,105,688 (-)NCBICHM1_1
T2T-CHM13v2.0145,383,419 - 45,395,258 (-)NCBIT2T-CHM13v2.0
Prdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,542,796 - 116,557,196 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,542,741 - 116,558,019 (+)EnsemblGRCm39 Ensembl
GRCm384116,685,599 - 116,700,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,685,544 - 116,700,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv374116,358,204 - 116,372,605 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,183,531 - 116,197,932 (+)NCBIMGSCv36mm8
Celera4115,419,593 - 115,433,994 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.28NCBI
Prdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,761,401 - 12,773,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,761,390 - 12,773,413 (+)NCBIChiLan1.0ChiLan1.0
PRDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,286,968 - 181,297,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,428,500 - 180,439,413 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,813,508 - 44,824,430 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,171,453 - 46,182,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,171,453 - 46,182,018 (-)Ensemblpanpan1.1panPan2
PRDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,834,009 - 14,855,665 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,838,652 - 14,862,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,959,792 - 14,976,803 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,988,879 - 15,010,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,993,508 - 15,018,355 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,790,828 - 14,808,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,858,579 - 14,875,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,930,831 - 14,947,857 (+)NCBIUU_Cfam_GSD_1.0
Prdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,816,994 - 60,828,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,639,259 - 26,653,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,641,776 - 26,653,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,824,395 - 165,861,442 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,847,390 - 165,859,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,253,841 - 153,265,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,267,026 - 87,277,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,267,044 - 87,279,978 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,683,931 - 29,694,719 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,405,253 - 1,414,926 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,405,253 - 1,414,980 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prdx1
127 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:120
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000023132
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH127925  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q36UniSTS
Prdx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,602,573 - 193,602,643 (+)MAPPERmRatBN7.2
mRatBN7.25130,154,646 - 130,156,228 (+)MAPPERmRatBN7.2
mRatBN7.25130,156,177 - 130,156,228 (+)MAPPERmRatBN7.2
Rnor_6.02208,738,546 - 208,738,615NCBIRnor6.0
Rnor_6.05135,543,785 - 135,545,366NCBIRnor6.0
Rnor_5.02228,162,502 - 228,162,571UniSTSRnor5.0
Rnor_5.05139,340,009 - 139,341,590UniSTSRnor5.0
RGSC_v3.45136,983,429 - 136,985,010UniSTSRGSC3.4
RGSC_v3.42201,373,781 - 201,373,850UniSTSRGSC3.4
Celera2186,293,818 - 186,293,887UniSTS
Celera5128,681,817 - 128,683,398UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:470676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,602,443 - 193,602,900 (+)MAPPERmRatBN7.2
mRatBN7.2647,072,314 - 47,072,784 (+)MAPPERmRatBN7.2
Rnor_6.0649,393,315 - 49,393,784NCBIRnor6.0
Rnor_6.02208,738,416 - 208,738,872NCBIRnor6.0
Rnor_5.0658,073,558 - 58,074,027UniSTSRnor5.0
Rnor_5.02228,162,372 - 228,162,828UniSTSRnor5.0
RGSC_v3.42201,373,651 - 201,374,107UniSTSRGSC3.4
RGSC_v3.4648,332,780 - 48,333,249UniSTSRGSC3.4
Celera646,276,343 - 46,276,812UniSTS
Celera2186,293,688 - 186,294,144UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023132   ⟹   ENSRNOP00000023132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)Ensembl
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)Ensembl
RefSeq Acc Id: NM_057114   ⟹   NP_476455
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,383,906 - 135,399,504 (+)NCBI
mRatBN7.25130,147,258 - 130,162,856 (+)NCBI
Rnor_6.05135,536,413 - 135,551,986 (+)NCBI
Rnor_5.05139,332,556 - 139,348,210 (+)NCBI
RGSC_v3.45136,975,780 - 136,991,630 (+)RGD
Celera5128,674,439 - 128,690,018 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476455 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH58450 (Get FASTA)   NCBI Sequence Viewer  
  AAH88118 (Get FASTA)   NCBI Sequence Viewer  
  BAA06275 (Get FASTA)   NCBI Sequence Viewer  
  EDL90264 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023132.2
  ENSRNOP00055018456
  ENSRNOP00060042039
  ENSRNOP00065021904
GenBank Protein Q63716 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476455   ⟸   NM_057114
- UniProtKB: Q63716 (UniProtKB/Swiss-Prot),   A6JZ89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023132   ⟸   ENSRNOT00000023132
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63716-F1-model_v2 AlphaFold Q63716 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693938
Promoter ID:EPDNEW_R4463
Type:multiple initiation site
Name:Prdx1_1
Description:peroxiredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,536,393 - 135,536,453EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620039 AgrOrtholog
BioCyc Gene G2FUF-40242 BioCyc
Ensembl Genes ENSRNOG00000017194 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055013251 UniProtKB/Swiss-Prot
  ENSRNOG00060029088 UniProtKB/Swiss-Prot
  ENSRNOG00065016670 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023132.6 UniProtKB/Swiss-Prot
  ENSRNOT00055022725 UniProtKB/Swiss-Prot
  ENSRNOT00060050497 UniProtKB/Swiss-Prot
  ENSRNOT00065027783 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920987 IMAGE-MGC_LOAD
  IMAGE:7324630 IMAGE-MGC_LOAD
InterPro AhpC/TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_AhpC-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108617 IMAGE-MGC_LOAD
  MGC:72725 IMAGE-MGC_LOAD
NCBI Gene 117254 ENTREZGENE
PANTHER PEROXIREDOXIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN PEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AhpC-TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prdx1 PhenoGen
PIRSF AHPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017194 RatGTEx
  ENSRNOG00055013251 RatGTEx
  ENSRNOG00060029088 RatGTEx
  ENSRNOG00065016670 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JZ89 ENTREZGENE, UniProtKB/TrEMBL
  PRDX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prdx1  peroxiredoxin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Prdx1  peroxiredoxin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is induced by heavy metals CdCl2 and CoCl2 729465