PRDX1 (peroxiredoxin 1) - Rat Genome Database
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Gene: PRDX1 (peroxiredoxin 1) Homo sapiens
Analyze
Symbol: PRDX1
Name: peroxiredoxin 1
RGD ID: 733744
HGNC Page HGNC
Description: Exhibits thioredoxin peroxidase activity. Involved in hydrogen peroxide catabolic process and natural killer cell activation. Localizes to cytoplasm and nucleus. Implicated in methylmalonic aciduria and homocystinuria type cblC.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MSP23; natural killer cell-enhancing factor A; natural killer-enhancing factor A; NKEF-A; NKEFA; PAG; PAGA; PAGB; peroxiredoxin-1; proliferation-associated gene A; proliferation-associated gene protein; PRX1; PRXI; TDPX2; thioredoxin peroxidase 2; thioredoxin-dependent peroxide reductase 2; thioredoxin-dependent peroxiredoxin 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PRDX1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl145,510,914 - 45,542,732 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl145,511,036 - 45,523,047 (-)EnsemblGRCh38hg38GRCh38
GRCh38145,511,051 - 45,522,890 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37145,976,707 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37145,976,723 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,749,294 - 45,760,196 (-)NCBINCBI36hg18NCBI36
Build 34145,645,800 - 45,656,702NCBI
Celera144,260,797 - 44,271,582 (-)NCBI
Cytogenetic Map1p34.1NCBI
HuRef144,088,373 - 44,099,940 (-)NCBIHuRef
CHM1_1146,093,972 - 46,105,688 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(S)-naringenin  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
acetamide  (ISO)
acrolein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite ion  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
astaxanthin  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
calycosin  (EXP)
capsaicin  (ISO)
captan  (ISO)
carbon nanotube  (EXP)
cerium trichloride  (EXP)
chloramine T  (ISO)
chlordecone  (ISO)
chloropicrin  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (EXP)
cylindrospermopsin  (ISO)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dicrotophos  (EXP)
diethyl maleate  (EXP,ISO)
dihydroartemisinin  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
etoposide  (ISO)
finasteride  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
frenolicin B  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hypochlorous acid  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (EXP)
menadione  (ISO)
mercury dibromide  (EXP)
metam  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nimesulide  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (EXP)
oleanolic acid  (EXP)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phlorizin  (ISO)
picloram  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
Propiverine  (ISO)
Pyridostigmine bromide  (ISO)
pyrogallol  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP)
rotenone  (ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sulindac  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
Tomentosin  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichlopyr  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triphenylstannane  (EXP)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
zinc atom  (EXP)
zinc pyrithione  (EXP)
zinc(0)  (EXP)

References

Additional References at PubMed
PMID:7702627   PMID:8026862   PMID:8089076   PMID:8123050   PMID:8188254   PMID:8462106   PMID:8496166   PMID:9334312   PMID:9388242   PMID:10419887   PMID:10514471   PMID:10530780  
PMID:10751410   PMID:10843682   PMID:11497302   PMID:11752456   PMID:11771746   PMID:11904290   PMID:11986303   PMID:12059788   PMID:12080185   PMID:12161445   PMID:12196529   PMID:12421812  
PMID:12477932   PMID:12517450   PMID:12650976   PMID:12714748   PMID:12853451   PMID:14703116   PMID:14744259   PMID:15105503   PMID:15161933   PMID:15448164   PMID:15489334   PMID:15592455  
PMID:15635413   PMID:15840729   PMID:15864612   PMID:15955662   PMID:16009940   PMID:16169070   PMID:16189514   PMID:16278420   PMID:16341674   PMID:16376335   PMID:16583711   PMID:16611982  
PMID:16677601   PMID:16710414   PMID:16815975   PMID:17081065   PMID:17141802   PMID:17176052   PMID:17234762   PMID:17352427   PMID:17519234   PMID:17540176   PMID:17601350   PMID:17603937  
PMID:17606720   PMID:17676665   PMID:17707450   PMID:17761673   PMID:17786348   PMID:17893145   PMID:17909037   PMID:18029348   PMID:18172504   PMID:18271526   PMID:18281480   PMID:18303054  
PMID:18413821   PMID:18501712   PMID:18549262   PMID:18606987   PMID:18624398   PMID:18977241   PMID:18992915   PMID:19016754   PMID:19135121   PMID:19167051   PMID:19199708   PMID:19286652  
PMID:19298244   PMID:19338310   PMID:19369943   PMID:19380743   PMID:19406930   PMID:19558833   PMID:19737972   PMID:19738201   PMID:19766572   PMID:19812042   PMID:19902980   PMID:20237496  
PMID:20301503   PMID:20381070   PMID:20458337   PMID:20589759   PMID:20610706   PMID:20631257   PMID:20647304   PMID:20877624   PMID:21044950   PMID:21081503   PMID:21145461   PMID:21159870  
PMID:21273562   PMID:21280222   PMID:21319273   PMID:21343392   PMID:21401077   PMID:21415862   PMID:21516123   PMID:21565611   PMID:21630459   PMID:21800051   PMID:21873635   PMID:21969592  
PMID:21980378   PMID:21988832   PMID:22158042   PMID:22215146   PMID:22234250   PMID:22236188   PMID:22323290   PMID:22446018   PMID:22475482   PMID:22492841   PMID:22537621   PMID:22623428  
PMID:22658674   PMID:22664934   PMID:22681889   PMID:22810585   PMID:22863883   PMID:22877757   PMID:22902630   PMID:22939629   PMID:22944692   PMID:22985558   PMID:23060010   PMID:23065574  
PMID:23084401   PMID:23113308   PMID:23241402   PMID:23246001   PMID:23277276   PMID:23334324   PMID:23376485   PMID:23386615   PMID:23421996   PMID:23455922   PMID:23479738   PMID:23533145  
PMID:23537643   PMID:23580065   PMID:23615915   PMID:23723070   PMID:23737084   PMID:23824729   PMID:23914992   PMID:23956138   PMID:23971998   PMID:23979707   PMID:24009050   PMID:24062305  
PMID:24152995   PMID:24244333   PMID:24297309   PMID:24316730   PMID:24332808   PMID:24412244   PMID:24457600   PMID:24480440   PMID:24711643   PMID:25011585   PMID:25082442   PMID:25162226  
PMID:25192599   PMID:25324306   PMID:25426613   PMID:25468996   PMID:25484280   PMID:25579166   PMID:25670202   PMID:25756610   PMID:25798074   PMID:25865307   PMID:25921289   PMID:25959826  
PMID:25963833   PMID:26117319   PMID:26150388   PMID:26159854   PMID:26170166   PMID:26209609   PMID:26301632   PMID:26344197   PMID:26460568   PMID:26478675   PMID:26496610   PMID:26524401  
PMID:26548861   PMID:26549023   PMID:26561776   PMID:26617696   PMID:26618866   PMID:26636537   PMID:26641092   PMID:26689287   PMID:26752685   PMID:26777405   PMID:26816005   PMID:26831064  
PMID:26972000   PMID:27025967   PMID:27142532   PMID:27158335   PMID:27177495   PMID:27182664   PMID:27259998   PMID:27342126   PMID:27388124   PMID:27462432   PMID:27503926   PMID:27517622  
PMID:27545878   PMID:27591049   PMID:27607350   PMID:27612662   PMID:27684187   PMID:27756681   PMID:27924073   PMID:28009281   PMID:28027390   PMID:28082197   PMID:28219939   PMID:28225217  
PMID:28242625   PMID:28298427   PMID:28314261   PMID:28348082   PMID:28398822   PMID:28515276   PMID:28581483   PMID:28671123   PMID:28685749   PMID:28712289   PMID:28902428   PMID:28927264  
PMID:29063384   PMID:29117863   PMID:29212245   PMID:29229926   PMID:29298432   PMID:29302025   PMID:29331416   PMID:29339092   PMID:29377617   PMID:29449217   PMID:29467282   PMID:29478914  
PMID:29491746   PMID:29507755   PMID:29582423   PMID:29656298   PMID:29669786   PMID:29673884   PMID:29676528   PMID:29687844   PMID:29735542   PMID:29773556   PMID:29777862   PMID:29844126  
PMID:29845934   PMID:29859926   PMID:29884768   PMID:29908016   PMID:29929436   PMID:30209976   PMID:30232004   PMID:30284335   PMID:30287919   PMID:30320910   PMID:30455355   PMID:30463901  
PMID:30567989   PMID:30575818   PMID:30585266   PMID:30690837   PMID:30693924   PMID:30737378   PMID:30833792   PMID:30862546   PMID:30886505   PMID:30942445   PMID:30948266   PMID:30981892  
PMID:30997501   PMID:31046837   PMID:31091453   PMID:31158443   PMID:31180492   PMID:31239290   PMID:31248990   PMID:31253590   PMID:31267705   PMID:31300519   PMID:31366734   PMID:31429766  
PMID:31436131   PMID:31470801   PMID:31477836   PMID:31536960   PMID:31580947   PMID:31586073   PMID:31613423   PMID:31796584   PMID:31952546   PMID:31980649   PMID:32357862   PMID:32457219  
PMID:32529326   PMID:32694731   PMID:32814053   PMID:33011678  


Genomics

Comparative Map Data
PRDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl145,510,914 - 45,542,732 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl145,511,036 - 45,523,047 (-)EnsemblGRCh38hg38GRCh38
GRCh38145,511,051 - 45,522,890 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37145,976,707 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37145,976,723 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,749,294 - 45,760,196 (-)NCBINCBI36hg18NCBI36
Build 34145,645,800 - 45,656,702NCBI
Celera144,260,797 - 44,271,582 (-)NCBI
Cytogenetic Map1p34.1NCBI
HuRef144,088,373 - 44,099,940 (-)NCBIHuRef
CHM1_1146,093,972 - 46,105,688 (-)NCBICHM1_1
Prdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,542,796 - 116,557,197 (+)NCBIGRCm39mm39
GRCm384116,685,599 - 116,700,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,685,544 - 116,700,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv374116,358,204 - 116,372,605 (+)NCBIGRCm37mm9NCBIm37
MGSCv364116,183,531 - 116,197,932 (+)NCBImm8
Celera4115,419,593 - 115,433,994 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.28NCBI
Prdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25130,147,276 - 130,162,850 (+)NCBI
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05135,536,413 - 135,551,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05139,332,556 - 139,348,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,975,780 - 136,991,630 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15136,981,005 - 136,996,856 (+)NCBI
Celera5128,674,439 - 128,690,018 (+)NCBICelera
Cytogenetic Map5q35NCBI
Prdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,761,401 - 12,773,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,761,390 - 12,773,413 (+)NCBIChiLan1.0ChiLan1.0
PRDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1146,171,453 - 46,182,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,171,453 - 46,182,018 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0144,813,508 - 44,824,430 (-)NCBIMhudiblu_PPA_v0panPan3
PRDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1514,838,652 - 14,862,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11514,834,009 - 14,855,665 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647426,641,776 - 26,653,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,824,520 - 165,861,442 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,847,390 - 165,859,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,253,841 - 153,265,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,267,026 - 87,277,634 (+)NCBI
ChlSab1.1 Ensembl2087,267,044 - 87,279,978 (+)Ensembl
Prdx1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249061,405,253 - 1,414,980 (-)NCBI

Position Markers
A007G24  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,976,765 - 45,976,924UniSTSGRCh37
Build 36145,749,352 - 45,749,511RGDNCBI36
Celera144,260,855 - 44,261,014RGD
Cytogenetic Map1p34.1UniSTS
HuRef144,088,431 - 44,088,590UniSTS
GeneMap99-GB4 RH Map1130.49UniSTS
NCBI RH Map1294.0UniSTS
D1S2391  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,976,743 - 45,976,996UniSTSGRCh37
Build 36145,749,330 - 45,749,583RGDNCBI36
Celera144,260,833 - 44,261,086RGD
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map9p22UniSTS
HuRef912,936,819 - 12,937,078UniSTS
HuRef144,088,409 - 44,088,662UniSTS
Whitehead-YAC Contig Map1 UniSTS
GeneMap99-G3 RH Map12438.0UniSTS
G62947  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,987,875 - 45,988,150UniSTSGRCh37
Build 36145,760,462 - 45,760,737RGDNCBI36
Celera144,271,848 - 44,272,123RGD
Cytogenetic Map1p34.1UniSTS
HuRef144,099,253 - 44,099,528UniSTS
TNG Radiation Hybrid Map125305.0UniSTS
SHGC-132089  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,976,776 - 45,976,966UniSTSGRCh37
Build 36145,749,363 - 45,749,553RGDNCBI36
Celera144,260,866 - 44,261,056RGD
Cytogenetic Map1p34.1UniSTS
HuRef144,088,442 - 44,088,632UniSTS
TNG Radiation Hybrid Map125317.0UniSTS
SHGC-146777  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,976,211 - 45,976,536UniSTSGRCh37
Build 36145,748,798 - 45,749,123RGDNCBI36
Celera144,260,300 - 44,260,626RGD
Cytogenetic Map1p34.1UniSTS
HuRef144,087,876 - 44,088,202UniSTS
TNG Radiation Hybrid Map125320.0UniSTS
RH69651  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37145,976,416 - 45,976,625UniSTSGRCh37
Build 36145,749,003 - 45,749,212RGDNCBI36
Celera144,260,506 - 44,260,715RGD
Cytogenetic Map1p34.1UniSTS
HuRef144,088,082 - 44,088,291UniSTS
GeneMap99-GB4 RH Map1130.39UniSTS
NCBI RH Map1294.0UniSTS
RH70158  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p34.1UniSTS
GeneMap99-GB4 RH Map953.75UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:959
Count of miRNA genes:425
Interacting mature miRNAs:463
Transcripts:ENST00000262746, ENST00000319248, ENST00000372079, ENST00000424390, ENST00000447184, ENST00000483583
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 59 1 171 42 135 40 197 17 28 41 169 282 8 1
Medium 2378 2976 1555 582 1805 425 4157 2173 3706 378 1291 1331 167 1 1204 2788 5 2
Low 1 14 11 3 7
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001202431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI912389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL451136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV691526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM740381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM762399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM787105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM827394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU564066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD638470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ877459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ297142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262746   ⟹   ENSP00000262746
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,511,036 - 45,521,938 (-)Ensembl
RefSeq Acc Id: ENST00000319248   ⟹   ENSP00000361152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,511,051 - 45,521,884 (-)Ensembl
RefSeq Acc Id: ENST00000372079   ⟹   ENSP00000361150
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,511,051 - 45,521,854 (-)Ensembl
RefSeq Acc Id: ENST00000424390   ⟹   ENSP00000389047
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,514,507 - 45,523,047 (-)Ensembl
RefSeq Acc Id: ENST00000447184   ⟹   ENSP00000407034
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,514,507 - 45,521,938 (-)Ensembl
RefSeq Acc Id: ENST00000483583
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,515,654 - 45,521,867 (-)Ensembl
RefSeq Acc Id: ENST00000676549   ⟹   ENSP00000503140
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl145,510,914 - 45,542,732 (-)Ensembl
RefSeq Acc Id: NM_001202431   ⟹   NP_001189360
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38145,511,051 - 45,522,890 (-)NCBI
GRCh37145,976,707 - 45,988,562 (-)ENTREZGENE
HuRef144,088,373 - 44,099,940 (-)ENTREZGENE
CHM1_1146,093,972 - 46,105,688 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002574   ⟹   NP_002565
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38145,511,051 - 45,521,884 (-)NCBI
GRCh37145,976,707 - 45,988,562 (-)ENTREZGENE
Build 36145,749,294 - 45,760,196 (-)NCBI Archive
HuRef144,088,373 - 44,099,940 (-)ENTREZGENE
CHM1_1146,093,972 - 46,104,736 (-)NCBI
Sequence:
RefSeq Acc Id: NM_181696   ⟹   NP_859047
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38145,511,051 - 45,521,884 (-)NCBI
GRCh37145,976,707 - 45,988,562 (-)ENTREZGENE
Build 36145,749,294 - 45,760,196 (-)NCBI Archive
HuRef144,088,373 - 44,099,940 (-)ENTREZGENE
CHM1_1146,093,972 - 46,104,736 (-)NCBI
Sequence:
RefSeq Acc Id: NM_181697   ⟹   NP_859048
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38145,511,051 - 45,521,884 (-)NCBI
GRCh37145,976,707 - 45,988,562 (-)ENTREZGENE
Build 36145,749,294 - 45,760,196 (-)NCBI Archive
HuRef144,088,373 - 44,099,940 (-)ENTREZGENE
CHM1_1146,093,972 - 46,104,736 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001189360   ⟸   NM_001202431
- UniProtKB: Q06830 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_859048   ⟸   NM_181697
- UniProtKB: Q06830 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_859047   ⟸   NM_181696
- UniProtKB: Q06830 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_002565   ⟸   NM_002574
- UniProtKB: Q06830 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000389047   ⟸   ENST00000424390
RefSeq Acc Id: ENSP00000361150   ⟸   ENST00000372079
RefSeq Acc Id: ENSP00000407034   ⟸   ENST00000447184
RefSeq Acc Id: ENSP00000262746   ⟸   ENST00000262746
RefSeq Acc Id: ENSP00000361152   ⟸   ENST00000319248
RefSeq Acc Id: ENSP00000503140   ⟸   ENST00000676549
Protein Domains
1-cysPrx_C   Thioredoxin

Promoters
RGD ID:6855360
Promoter ID:EPDNEW_H845
Type:initiation region
Name:PRDX1_1
Description:peroxiredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38145,521,884 - 45,521,944EPDNEW
RGD ID:6786307
Promoter ID:HG_KWN:2495
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC001CNZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36145,757,206 - 45,757,706 (-)MPROMDB
RGD ID:6785188
Promoter ID:HG_KWN:2496
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000372079,   NM_002574,   NM_181696,   OTTHUMT00000020845,   OTTHUMT00000020846,   OTTHUMT00000090852
Position:
Human AssemblyChrPosition (strand)Source
Build 36145,760,086 - 45,761,017 (-)MPROMDB
RGD ID:6851784
Promoter ID:EP73697
Type:single initiation site
Name:HS_PRDX1
Description:Peroxiredoxin 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36145,760,143 - 45,760,203EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.1(chr1:45402871-45603348)x3 copy number gain See cases [RCV000051494] Chr1:45402871..45603348 [GRCh38]
Chr1:45868543..46069020 [GRCh37]
Chr1:45641130..45841607 [NCBI36]
Chr1:1p34.1
uncertain significance
GRCh38/hg38 1p34.1(chr1:45440264-45869574)x3 copy number gain See cases [RCV000051078] Chr1:45440264..45869574 [GRCh38]
Chr1:45905936..46335246 [GRCh37]
Chr1:45678523..46107833 [NCBI36]
Chr1:1p34.1
uncertain significance
GRCh38/hg38 1p34.3-33(chr1:39479787-47688131)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|See cases [RCV000051817] Chr1:39479787..47688131 [GRCh38]
Chr1:39945459..48153803 [GRCh37]
Chr1:39718046..47926390 [NCBI36]
Chr1:1p34.3-33
pathogenic
GRCh38/hg38 1p34.3-34.1(chr1:38222737-45636176)x3 copy number gain See cases [RCV000051803] Chr1:38222737..45636176 [GRCh38]
Chr1:38688409..46101848 [GRCh37]
Chr1:38460996..45874435 [NCBI36]
Chr1:1p34.3-34.1
pathogenic
GRCh38/hg38 1p34.1(chr1:44962358-45585262)x3 copy number gain See cases [RCV000134906] Chr1:44962358..45585262 [GRCh38]
Chr1:45428030..46050934 [GRCh37]
Chr1:45200617..45823521 [NCBI36]
Chr1:1p34.1
uncertain significance
GRCh38/hg38 1p34.1(chr1:45488251-46220805)x3 copy number gain See cases [RCV000137659] Chr1:45488251..46220805 [GRCh38]
Chr1:45953923..46686477 [GRCh37]
Chr1:45726510..46459064 [NCBI36]
Chr1:1p34.1
uncertain significance
GRCh38/hg38 1p34.1(chr1:45469848-46220805)x3 copy number gain See cases [RCV000141255] Chr1:45469848..46220805 [GRCh38]
Chr1:45935520..46686477 [GRCh37]
Chr1:45708107..46459064 [NCBI36]
Chr1:1p34.1
likely benign|uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p34.1(chr1:45953923-46126722)x3 copy number gain See cases [RCV000240537] Chr1:45953923..46126722 [GRCh37]
Chr1:1p34.1
uncertain significance
GRCh37/hg19 1p34.1-32.3(chr1:45303358-52157856)x1 copy number loss See cases [RCV000448358] Chr1:45303358..52157856 [GRCh37]
Chr1:1p34.1-32.3
likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p34.1(chr1:45715667-46501705)x3 copy number gain See cases [RCV000510158] Chr1:45715667..46501705 [GRCh37]
Chr1:1p34.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_181697.3(PRDX1):c.515-2A>T AND METHYLMALONIC ACIDURIA single nucleotide variant METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE, DIGENIC [RCV000585793] Chr1:45511416 [GRCh38]
Chr1:45977088 [GRCh37]
Chr1:1p34.1
pathogenic|association
NM_181697.3(PRDX1):c.515-1G>T AND METHYLMALONIC ACIDURIA single nucleotide variant METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE, DIGENIC [RCV000585802] Chr1:45511415 [GRCh38]
Chr1:45977087 [GRCh37]
Chr1:1p34.1
pathogenic|association
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease, dominant intermediate C [RCV000708276] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance
GRCh37/hg19 1p34.1(chr1:45923445-46017520)x1 copy number loss not provided [RCV000681440] Chr1:45923445..46017520 [GRCh37]
Chr1:1p34.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p34.1(chr1:45819489-46245645)x3 copy number gain not provided [RCV000748974] Chr1:45819489..46245645 [GRCh37]
Chr1:1p34.1
benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_181697.3(PRDX1):c.383+9T>A single nucleotide variant not provided [RCV000931344] Chr1:45514864 [GRCh38]
Chr1:45980536 [GRCh37]
Chr1:1p34.1
likely benign
GRCh37/hg19 1p34.1(chr1:45386263-45982314)x1 copy number loss not provided [RCV001005083] Chr1:45386263..45982314 [GRCh37]
Chr1:1p34.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9352 AgrOrtholog
COSMIC PRDX1 COSMIC
Ensembl Genes ENSG00000117450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000262746 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000361150 UniProtKB/TrEMBL
  ENSP00000361152 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000389047 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000407034 UniProtKB/TrEMBL
Ensembl Transcript ENST00000262746 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000319248 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000372079 UniProtKB/TrEMBL
  ENST00000424390 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000447184 UniProtKB/TrEMBL
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000117450 GTEx
HGNC ID HGNC:9352 ENTREZGENE
Human Proteome Map PRDX1 Human Proteome Map
InterPro AhpC/TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_AhpC-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peroxiredoxin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5052 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5052 ENTREZGENE
OMIM 176763 OMIM
  277400 OMIM
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AhpC-TSA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33722 PharmGKB
PIRSF AHPC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MRQ5_HUMAN UniProtKB/TrEMBL
  A0A0A0MSI0_HUMAN UniProtKB/TrEMBL
  A0A384NPQ2_HUMAN UniProtKB/TrEMBL
  PRDX1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B5BU26 UniProtKB/Swiss-Prot
  D3DPZ8 UniProtKB/Swiss-Prot
  P35703 UniProtKB/Swiss-Prot
  Q2V576 UniProtKB/Swiss-Prot
  Q5T154 UniProtKB/Swiss-Prot
  Q5T155 UniProtKB/Swiss-Prot