PRDX1 (peroxiredoxin 1) - Rat Genome Database

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Gene: PRDX1 (peroxiredoxin 1) Canis lupus familiaris
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Symbol: PRDX1
Name: peroxiredoxin 1
RGD ID: 12141544
Description: ENCODES a protein that exhibits heme binding (ortholog); identical protein binding (ortholog); peroxiredoxin activity (ortholog); INVOLVED IN canonical NF-kappaB signal transduction (ortholog); erythrocyte homeostasis (ortholog); fibroblast proliferation (ortholog); ASSOCIATED WITH asbestosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: peroxiredoxin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC475156  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,834,009 - 14,855,665 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,838,652 - 14,862,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,959,792 - 14,976,803 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,988,879 - 15,010,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,993,508 - 15,018,355 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,790,828 - 14,808,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,858,579 - 14,875,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,930,831 - 14,947,857 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202   PMID:37756605  


Genomics

Comparative Map Data
PRDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,834,009 - 14,855,665 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,838,652 - 14,862,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,959,792 - 14,976,803 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,988,879 - 15,010,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,993,508 - 15,018,355 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,790,828 - 14,808,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,858,579 - 14,875,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,930,831 - 14,947,857 (+)NCBIUU_Cfam_GSD_1.0
PRDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,511,051 - 45,522,890 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,510,914 - 45,542,732 (-)EnsemblGRCh38hg38GRCh38
GRCh37145,976,723 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,749,294 - 45,760,196 (-)NCBINCBI36Build 36hg18NCBI36
Build 34145,645,800 - 45,656,702NCBI
Celera144,260,797 - 44,271,582 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,088,373 - 44,099,940 (-)NCBIHuRef
CHM1_1146,093,972 - 46,105,688 (-)NCBICHM1_1
T2T-CHM13v2.0145,383,419 - 45,395,258 (-)NCBIT2T-CHM13v2.0
Prdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,542,796 - 116,557,196 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,542,741 - 116,558,019 (+)EnsemblGRCm39 Ensembl
GRCm384116,685,599 - 116,700,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,685,544 - 116,700,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv374116,358,204 - 116,372,605 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,183,531 - 116,197,932 (+)NCBIMGSCv36mm8
Celera4115,419,593 - 115,433,994 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.28NCBI
Prdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,383,906 - 135,399,504 (+)NCBIGRCr8
mRatBN7.25130,147,258 - 130,162,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,772,005 - 132,788,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,526,605 - 134,543,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,549,011 - 134,565,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,536,413 - 135,551,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,332,556 - 139,348,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,975,780 - 136,991,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,981,005 - 136,996,856 (+)NCBI
Celera5128,674,439 - 128,690,018 (+)NCBICelera
Cytogenetic Map5q35NCBI
Prdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,761,401 - 12,773,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,761,390 - 12,773,413 (+)NCBIChiLan1.0ChiLan1.0
PRDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,286,968 - 181,297,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,428,500 - 180,439,413 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,813,508 - 44,824,430 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,171,453 - 46,182,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,171,453 - 46,182,018 (-)Ensemblpanpan1.1panPan2
Prdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,816,994 - 60,828,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,639,259 - 26,653,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,641,776 - 26,653,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,824,395 - 165,861,442 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,847,390 - 165,859,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,253,841 - 153,265,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,267,026 - 87,277,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,267,044 - 87,279,978 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,683,931 - 29,694,719 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,405,253 - 1,414,926 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,405,253 - 1,414,980 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRDX1
373 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 4 4
Medium 5 5 18 6 6 6 6 6 12 8 6 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000007369   ⟹   ENSCAFP00000006827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1514,838,652 - 14,862,971 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000072270   ⟹   ENSCAFP00000052280
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1514,838,667 - 14,855,662 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000091627   ⟹   ENSCAFP00000044218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1514,841,373 - 14,855,669 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092555   ⟹   ENSCAFP00000057261
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1514,843,988 - 14,855,669 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039900   ⟹   ENSCAFP00845031244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1514,993,508 - 15,018,355 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845039966   ⟹   ENSCAFP00845031296
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1514,993,508 - 15,018,309 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040036   ⟹   ENSCAFP00845031350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1514,993,955 - 15,010,841 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040109   ⟹   ENSCAFP00845031410
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1514,996,228 - 15,010,848 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040132   ⟹   ENSCAFP00845031430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1514,998,856 - 15,010,848 (+)Ensembl
RefSeq Acc Id: NM_001252165   ⟹   NP_001239094
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11514,838,667 - 14,855,665 (+)NCBI
Dog10K_Boxer_Tasha1514,959,792 - 14,976,803 (+)NCBI
ROS_Cfam_1.01514,993,523 - 15,010,844 (+)NCBI
UMICH_Zoey_3.11514,790,828 - 14,808,277 (+)NCBI
UNSW_CanFamBas_1.01514,858,579 - 14,875,829 (+)NCBI
UU_Cfam_GSD_1.01514,930,831 - 14,947,857 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038687183   ⟹   XP_038543111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01514,993,952 - 15,010,844 (+)NCBI
RefSeq Acc Id: XM_038687184   ⟹   XP_038543112
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01514,988,879 - 15,010,844 (+)NCBI
RefSeq Acc Id: NP_001239094   ⟸   NM_001252165
- UniProtKB: A0A8C0SYI9 (UniProtKB/TrEMBL),   A0A8C0KVJ8 (UniProtKB/TrEMBL),   A0A8P0T4S3 (UniProtKB/TrEMBL),   A0A8I3S380 (UniProtKB/TrEMBL),   A0A8P0N7B2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000057261   ⟸   ENSCAFT00000092555
RefSeq Acc Id: ENSCAFP00000044218   ⟸   ENSCAFT00000091627
RefSeq Acc Id: ENSCAFP00000052280   ⟸   ENSCAFT00000072270
RefSeq Acc Id: ENSCAFP00000006827   ⟸   ENSCAFT00000007369
RefSeq Acc Id: XP_038543112   ⟸   XM_038687184
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SYI9 (UniProtKB/TrEMBL),   A0A8C0KVJ8 (UniProtKB/TrEMBL),   A0A8P0T4S3 (UniProtKB/TrEMBL),   A0A8I3S380 (UniProtKB/TrEMBL),   A0A8P0N7B2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543111   ⟸   XM_038687183
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PG86 (UniProtKB/TrEMBL),   A0A8I3S380 (UniProtKB/TrEMBL),   A0A8P0N7B2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845031410   ⟸   ENSCAFT00845040109
RefSeq Acc Id: ENSCAFP00845031350   ⟸   ENSCAFT00845040036
RefSeq Acc Id: ENSCAFP00845031430   ⟸   ENSCAFT00845040132
RefSeq Acc Id: ENSCAFP00845031244   ⟸   ENSCAFT00845039900
RefSeq Acc Id: ENSCAFP00845031296   ⟸   ENSCAFT00845039966
Promoters
RGD ID:13685903
Promoter ID:EPDNEW_C3973
Type:single initiation site
Name:PRDX1_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11514,841,400 - 14,841,460EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004567 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017158 UniProtKB/TrEMBL
  ENSCAFG00040017967 UniProtKB/TrEMBL
  ENSCAFG00845022593 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007369.5 UniProtKB/TrEMBL
  ENSCAFT00000072270.2 UniProtKB/TrEMBL
  ENSCAFT00000091627.2 UniProtKB/TrEMBL
  ENSCAFT00000092555.2 UniProtKB/TrEMBL
  ENSCAFT00000104434.1 UniProtKB/TrEMBL
  ENSCAFT00030031711.1 UniProtKB/TrEMBL
  ENSCAFT00030031757.1 UniProtKB/TrEMBL
  ENSCAFT00040033148.1 UniProtKB/TrEMBL
  ENSCAFT00040033241.1 UniProtKB/TrEMBL
  ENSCAFT00040033263.1 UniProtKB/TrEMBL
  ENSCAFT00845039900.1 UniProtKB/TrEMBL
  ENSCAFT00845039966 ENTREZGENE
  ENSCAFT00845039966.1 UniProtKB/TrEMBL
  ENSCAFT00845040036 ENTREZGENE
  ENSCAFT00845040036.1 UniProtKB/TrEMBL
  ENSCAFT00845040109.1 UniProtKB/TrEMBL
  ENSCAFT00845040132.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro AhpC/TSA UniProtKB/TrEMBL
  Peroxiredoxin_AhpC-typ UniProtKB/TrEMBL
  Peroxiredoxin_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report cfa:475375 UniProtKB/TrEMBL
NCBI Gene PRDX1 ENTREZGENE
PANTHER PEROXIREDOXIN-1 UniProtKB/TrEMBL
  THIOREDOXIN PEROXIDASE UniProtKB/TrEMBL
Pfam 1-cysPrx_C UniProtKB/TrEMBL
  AhpC-TSA UniProtKB/TrEMBL
PIRSF AHPC UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0KVJ8 ENTREZGENE
  A0A8C0NZU8_CANLF UniProtKB/TrEMBL
  A0A8C0SYI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SZV7_CANLF UniProtKB/TrEMBL
  A0A8I3PG86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PGE1_CANLF UniProtKB/TrEMBL
  A0A8I3PJ75_CANLF UniProtKB/TrEMBL
  A0A8I3S380 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S3A0_CANLF UniProtKB/TrEMBL
  A0A8P0N7B2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PJA8_CANLF UniProtKB/TrEMBL
  A0A8P0T4S3 ENTREZGENE
  A0A8P0T9C4_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0T4S3 UniProtKB/TrEMBL