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Gene: PRDX2 (peroxiredoxin 2) Homo sapiens
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Symbol: PRDX2
Name: peroxiredoxin 2
Description: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory sperm binding protein Li 2a; HEL-S-2a; MGC4104; natural killer cell-enhancing factor B; natural killer-enhancing factor B; NKEF-B; NKEFB; peroxiredoxin-2; PRP; PRX2; PRXII; PTX1; TDPX1; thiol-specific antioxidant 1; thiol-specific antioxidant protein; thioredoxin peroxidase 1; thioredoxin-dependent peroxide reductase 1; torin; TPX1; TSA
Orthologs:
Mus musculus (house mouse) : Prdx2 (peroxiredoxin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prdx2 (peroxiredoxin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prdx2 (peroxiredoxin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PRDX2 (peroxiredoxin 2)
Canis lupus familiaris (dog) : PRDX2 (peroxiredoxin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prdx2 (peroxiredoxin 2)
Sus scrofa (pig) : PRDX2 (peroxiredoxin 2)
more info ...
Related Pseudogenes: PRDX2P1   PRDX2P2   PRDX2P3   PRDX2P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,796,823 - 12,801,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,907,634 - 12,912,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,768,634 - 12,773,694 (-)NCBINCBI36hg18NCBI36
Build 341912,772,426 - 12,773,694NCBI
Celera1912,797,342 - 12,802,402 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,479,370 - 12,484,460 (-)NCBIHuRef
CHM1_11912,908,110 - 12,913,203 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PRDX2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733019
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.