Cdc42 (cell division cycle 42) - Rat Genome Database

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Gene: Cdc42 (cell division cycle 42) Rattus norvegicus
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Symbol: Cdc42
Name: cell division cycle 42
RGD ID: 71043
Description: Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including Cdc42 protein signal transduction; actin filament branching; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog; cell division cycle 42 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,555,069 - 149,593,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,553,724 - 149,593,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,253,400 - 152,289,928 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05154,027,699 - 154,064,227 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05154,009,694 - 154,046,226 (-)NCBIRnor_WKY
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Celera5147,953,334 - 147,989,998 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
1,8-cineole  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bazedoxifene  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
casticin  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
disodium selenite  (ISO)
ethanol  (EXP,ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
GTP  (EXP,ISO)
haloperidol  (EXP)
hexaconazole  (ISO)
hydralazine  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lovastatin  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
NSC 23766  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
Risedronate sodium  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toosendanin  (ISO)
tremolite asbestos  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
warfarin  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IBA,ISO)
actin filament branching  (IMP)
actin filament organization  (IMP,ISO,ISS)
adherens junction organization  (ISO)
anatomical structure morphogenesis  (IEA)
cardiac conduction system development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
Cdc42 protein signal transduction  (IBA,IDA)
cell division  (IEA)
cell junction assembly  (ISO,ISS)
cellular response to type II interferon  (ISO)
dendritic cell migration  (ISO)
dendritic spine morphogenesis  (ISO,ISS)
embryonic heart tube development  (ISO)
endocytosis  (IBA,ISO)
endothelin receptor signaling pathway involved in heart process  (ISO)
establishment of cell polarity  (TAS)
establishment of epithelial cell apical/basal polarity  (ISO,ISS)
establishment of Golgi localization  (IMP)
establishment of localization in cell  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
establishment or maintenance of cell polarity  (IBA,IEA)
filopodium assembly  (ISO)
Golgi organization  (IMP)
heart contraction  (ISO)
integrin-mediated signaling pathway  (ISO)
modification of synaptic structure  (IBA,IMP)
modulation by host of viral process  (IEA)
negative regulation of protein-containing complex assembly  (ISO)
neuron fate determination  (ISO)
neuropilin signaling pathway  (ISO)
nuclear migration  (ISO)
nucleus localization  (ISO)
organelle transport along microtubule  (IMP)
phagocytosis, engulfment  (ISO,ISS)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of catalytic activity  (IMP)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cellular component organization  (IEA)
positive regulation of cytokinesis  (ISO,ISS)
positive regulation of DNA replication  (IMP)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of filopodium assembly  (ISO,ISS)
positive regulation of intracellular protein transport  (IMP)
positive regulation of JNK cascade  (IDA)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of pinocytosis  (ISO,ISS)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO,ISS)
positive regulation of synapse structural plasticity  (IMP)
protein localization  (ISO)
protein phosphorylation  (ISO)
protein ubiquitination  (IEA)
regulation of attachment of spindle microtubules to kinetochore  (ISO,ISS)
regulation of exocytosis  (TAS)
regulation of filopodium assembly  (ISO,ISS)
regulation of lamellipodium assembly  (ISO)
regulation of mitotic nuclear division  (ISO)
regulation of modification of postsynaptic structure  (IDA,IMP)
regulation of postsynapse organization  (IEA,ISO)
regulation of protein binding  (ISO)
regulation of stress fiber assembly  (ISO)
response to glucose  (TAS)
small GTPase mediated signal transduction  (IEA)
sprouting angiogenesis  (IMP)
submandibular salivary gland formation  (IEP)
substantia nigra development  (ISO)
viral RNA genome replication  (ISO)

References

References - curated
# Reference Title Reference Citation
1. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
2. Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis. Cardell LO, etal., Allergy. 2009 Sep;64(9):1301-8. Epub 2009 Apr 27.
3. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6.
4. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Chockalingam PS, etal., Am J Physiol Cell Physiol 2002 Aug;283(2):C500-11.
5. Distribution of small Rho GTPases in the developing rat submandibular gland. Crema VO, etal., J Mol Histol. 2008 Oct;39(5):519-25. Epub 2008 Sep 11.
6. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
7. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. Dovas A, etal., J Biol Chem. 2010 Jul 23;285(30):23296-308. doi: 10.1074/jbc.M109.098129. Epub 2010 May 15.
8. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. El-Sibai M, etal., J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74. Epub 2007 Sep 12.
9. RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury. Erschbamer MK, etal., J Comp Neurol. 2005 Apr 4;484(2):224-33.
10. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville S and Hall A, Nature 2003 Feb 13;421(6924):753-6.
11. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
12. Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain. Fournes B, etal., Mol Cell Biol 2003 Oct;23(20):7291-304.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. Hahn A, etal., Biochem J 2002 Feb 15;362(Pt 1):33-40.
15. Molecular cloning and sequencing of rat Cdc42 GTPase cDNA. Han JS, etal., Exp Mol Med 2000 Sep 30;32(3):115-9.
16. Cdc42 regulates microtubule-dependent Golgi positioning. Hehnly H, etal., Traffic. 2010 Aug;11(8):1067-78. doi: 10.1111/j.1600-0854.2010.01082.x. Epub 2010 May 26.
17. Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation. Ispanovic E, etal., Am J Physiol Cell Physiol. 2008 Sep;295(3):C600-10. Epub 2008 Jun 18.
18. Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. Khan OM, etal., J Clin Invest. 2011 Feb;121(2):628-39. doi: 10.1172/JCI43758. Epub 2011 Jan 25.
19. The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics. Lim KB, etal., J Biol Chem. 2008 Jul 18;283(29):20454-72. doi: 10.1074/jbc.M710185200. Epub 2008 Apr 29.
20. An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression. Marques CA, etal., Blood. 2008 Feb 1;111(3):1413-9. Epub 2007 Oct 30.
21. Gene Data Set MGD Curation, June 12, 2002
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Murakoshi H, etal., Nature. 2011 Apr 7;472(7341):100-4. Epub 2011 Mar 20.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. Nevins AK and Thurmond DC, J Biol Chem. 2005 Jan 21;280(3):1944-52. Epub 2004 Nov 9.
26. Distribution of Rho family GTPases in the adult rat hippocampus and cerebellum. O'Kane EM, etal., Brain Res Mol Brain Res 2003 May 26;114(1):1-8.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Padmos RC, etal., Arch Gen Psychiatry. 2008 Apr;65(4):395-407.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways. Sharma AK, etal., Toxicol Pathol. 2009 Oct;37(6):776-89. Epub 2009 Aug 21.
35. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. Teramoto H, etal., J Biol Chem. 1996 Nov 1;271(44):27225-8.
36. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
37. The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner. Xie C, etal., J Biol Chem. 2011 Oct 14;286(41):35933-42. Epub 2011 Aug 15.
38. High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients. Yang D, etal., Dig Dis Sci. 2017 Apr;62(4):958-967. doi: 10.1007/s10620-017-4451-z. Epub 2017 Feb 8.
39. Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Zhao J, etal., Cell Signal. 2007 Apr;19(4):831-43. Epub 2006 Dec 8.
40. Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells. Zhu X, etal., Exp Cell Res. 2011 Oct 1;317(16):2384-9. Epub 2011 Jul 7.
41. Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Zhu X, etal., Int J Dev Neurosci. 2000 Jul-Aug;18(4-5):433-7.
Additional References at PubMed
PMID:7592896   PMID:8625410   PMID:9748241   PMID:10618719   PMID:10699171   PMID:10724160   PMID:10954424   PMID:11035016   PMID:11260256   PMID:11584266   PMID:11807099   PMID:12477932  
PMID:12612085   PMID:14570905   PMID:14662747   PMID:14978216   PMID:15121898   PMID:15226395   PMID:15249579   PMID:15263019   PMID:15389538   PMID:15489334   PMID:15504731   PMID:15601624  
PMID:15642749   PMID:15723051   PMID:15728722   PMID:15775979   PMID:15797550   PMID:15866890   PMID:15882626   PMID:16195887   PMID:16328953   PMID:16336220   PMID:16380373   PMID:16443932  
PMID:16510873   PMID:16616186   PMID:16621792   PMID:16842757   PMID:16892058   PMID:17081755   PMID:17515837   PMID:17537723   PMID:17634366   PMID:18316075   PMID:18838382   PMID:19039103  
PMID:19056867   PMID:19144319   PMID:19161392   PMID:19199708   PMID:19244314   PMID:19289122   PMID:19376974   PMID:19542631   PMID:19787194   PMID:19796622   PMID:19943951   PMID:19946888  
PMID:20458337   PMID:20530489   PMID:20534521   PMID:20873783   PMID:21048939   PMID:21173111   PMID:21423176   PMID:21435037   PMID:21546274   PMID:21690310   PMID:21828338   PMID:21956892  
PMID:22426478   PMID:22461490   PMID:22494997   PMID:22871113   PMID:22891260   PMID:22926577   PMID:23219958   PMID:23325254   PMID:23358418   PMID:23376485   PMID:23533145   PMID:23620790  
PMID:23750457   PMID:23793062   PMID:24352656   PMID:24792215   PMID:25217619   PMID:25595978   PMID:25753037   PMID:25851601   PMID:26051942   PMID:26204446   PMID:26465210   PMID:27355516  
PMID:27412363   PMID:27482713   PMID:27917469   PMID:28031329   PMID:28161375   PMID:28432079   PMID:28838336   PMID:29321558   PMID:30358011   PMID:31144461   PMID:31397884   PMID:34634536  
PMID:34753065  


Genomics

Comparative Map Data
Cdc42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,555,069 - 149,593,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,553,724 - 149,593,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,253,400 - 152,289,928 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05154,027,699 - 154,064,227 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05154,009,694 - 154,046,226 (-)NCBIRnor_WKY
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Celera5147,953,334 - 147,989,998 (-)NCBICelera
Cytogenetic Map5q36NCBI
CDC42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,052,709 - 22,101,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl122,052,627 - 22,101,360 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,379,202 - 22,427,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
T2T-CHM13v2.0121,876,517 - 21,925,101 (+)NCBIT2T-CHM13v2.0
Cdc42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,047,007 - 137,085,070 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,047,007 - 137,085,031 (-)EnsemblGRCm39 Ensembl
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBIMGSCv36mm8
Celera4135,540,002 - 135,577,854 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
Cdc42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
CDC42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,188,722 - 22,228,351 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0121,245,970 - 21,286,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC403934
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBIUU_Cfam_GSD_1.0
Cdc42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,731,950 - 41,773,901 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364747,556,765 - 7,598,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,123 - 80,089,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC42
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,568,004 - 110,608,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,569,352 - 110,582,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,689,907 - 5,730,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc42
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Cdc42  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.45156,117,344 - 156,117,531UniSTSRGSC3.4
RGSC_v3.45156,105,066 - 156,105,248UniSTSRGSC3.4
Celera5147,964,527 - 147,964,714UniSTS
Celera5147,952,277 - 147,952,459UniSTS
RH137463  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,555,701 - 149,555,890 (+)MAPPERmRatBN7.2
Rnor_6.05155,690,900 - 155,691,088NCBIRnor6.0
Rnor_5.05159,446,787 - 159,446,975UniSTSRnor5.0
RGSC_v3.45156,105,638 - 156,105,826UniSTSRGSC3.4
Celera5147,952,849 - 147,953,037UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:224478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,557,684 - 149,557,838 (+)MAPPERmRatBN7.2
Rnor_6.05155,692,883 - 155,693,036NCBIRnor6.0
Rnor_5.05159,448,770 - 159,448,923UniSTSRnor5.0
RGSC_v3.45156,107,621 - 156,107,774UniSTSRGSC3.4
Celera5147,954,832 - 147,954,985UniSTS
Cytogenetic Map5q36UniSTS
Cdc42  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05159,458,806 - 159,458,993UniSTSRnor5.0
RGSC_v3.45156,117,344 - 156,117,531UniSTSRGSC3.4
Celera5147,964,527 - 147,964,714UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:167
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000018118, ENSRNOT00000029025
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_171994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF491841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018118   ⟹   ENSRNOP00000018118
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,557,150 - 149,593,111 (-)Ensembl
Rnor_6.0 Ensembl5155,693,116 - 155,709,215 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000029025   ⟹   ENSRNOP00000030928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,553,724 - 149,574,069 (-)Ensembl
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)Ensembl
RefSeq Acc Id: NM_171994   ⟹   NP_741991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,556,187 - 149,593,108 (-)NCBI
Rnor_6.05155,691,385 - 155,728,300 (-)NCBI
Rnor_5.05159,446,154 - 159,485,163 (-)NCBI
RGSC_v3.45156,106,123 - 156,143,040 (-)RGD
Celera5147,953,334 - 147,989,998 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764286   ⟹   XP_008762508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,555,069 - 149,589,791 (-)NCBI
Rnor_6.05155,690,267 - 155,725,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764287   ⟹   XP_008762509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,557,145 - 149,593,239 (-)NCBI
Rnor_6.05155,692,343 - 155,728,385 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110709   ⟹   XP_038966637
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,555,069 - 149,588,827 (-)NCBI
RefSeq Acc Id: XM_039110710   ⟹   XP_038966638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,555,069 - 149,592,180 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_741991   ⟸   NM_171994
- UniProtKB: Q71TW5 (UniProtKB/Swiss-Prot),   Q8CFN2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762508   ⟸   XM_008764286
- Peptide Label: isoform X1
- UniProtKB: Q71TW5 (UniProtKB/Swiss-Prot),   Q8CFN2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762509   ⟸   XM_008764287
- Peptide Label: isoform X2
- UniProtKB: Q8CFN2 (UniProtKB/Swiss-Prot),   A0A0G2JSM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018118   ⟸   ENSRNOT00000018118
RefSeq Acc Id: ENSRNOP00000030928   ⟸   ENSRNOT00000029025
RefSeq Acc Id: XP_038966638   ⟸   XM_039110710
- Peptide Label: isoform X1
- UniProtKB: Q71TW5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038966637   ⟸   XM_039110709
- Peptide Label: isoform X1
- UniProtKB: Q71TW5 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFN2-F1-model_v2 AlphaFold Q8CFN2 1-191 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694177
Promoter ID:EPDNEW_R4702
Type:initiation region
Name:Cdc42_1
Description:cell division cycle 42
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05155,728,312 - 155,728,372EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 156120637 156120638 A T snv DA/BklArbNsi (ICAHN)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71043 AgrOrtholog
BioCyc Gene G2FUF-39479 BioCyc
Ensembl Genes ENSRNOG00000013536 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018118 ENTREZGENE
  ENSRNOP00000018118.2 UniProtKB/TrEMBL
  ENSRNOP00000030928 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018118 ENTREZGENE
  ENSRNOT00000018118.6 UniProtKB/TrEMBL
  ENSRNOT00000029025 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920523 IMAGE-MGC_LOAD
InterPro Cdc42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64465 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72646 IMAGE-MGC_LOAD
NCBI Gene 64465 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdc42 PhenoGen
PROSITE RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot
SMART RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSM8 ENTREZGENE, UniProtKB/TrEMBL
  CDC42_RAT UniProtKB/Swiss-Prot
  Q71TW5 ENTREZGENE
  Q8CFN2 ENTREZGENE
UniProt Secondary Q6P9Y3 UniProtKB/Swiss-Prot
  Q71TW5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-01-14 Cdc42  cell division cycle 42  Cdc42  cell division cycle 42 (GTP binding protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cdc42  cell division cycle 42 (GTP binding protein)  Cdc42  cell division cycle 42 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cdc42  cell division cycle 42 homolog (S. cerevisiae)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process regulates cell polarity through the spatial regulation of GSK-3beta and Apc 632398
gene_process involved in reduction of the expression of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642