Ephb2 (Eph receptor B2) - Rat Genome Database

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Gene: Ephb2 (Eph receptor B2) Rattus norvegicus
Symbol: Ephb2
Name: Eph receptor B2
RGD ID: 1564232
Description: Predicted to enable several functions, including amyloid-beta binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cell junction assembly; positive regulation of nervous system development; and positive regulation of protein localization. Located in cell surface; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse. Used to study irritable bowel syndrome and ulcerative colitis. Biomarker of irritable bowel syndrome and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; syndecan signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ephrin type-B receptor 2; ephrin type-B receptor 2-like; LOC103689967; LOC313633; RGD1564232; similar to Ephb2 protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85154,179,065 - 154,360,459 (-)NCBIGRCr8
mRatBN7.25148,889,574 - 149,077,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,897,246 - 149,077,059 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,593,352 - 151,774,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,367,634 - 153,548,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,349,643 - 153,530,963 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
columbamine  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
diethyl malate  (ISO)
dorsomorphin  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nitrogen dioxide  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propofol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
triazines  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
axon guidance  (IBA,ISO)
axonal fasciculation  (ISO)
axonogenesis  (ISO)
B cell activation  (ISO)
camera-type eye morphogenesis  (ISO)
cell morphogenesis  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO)
cellular response to amyloid-beta  (IEP)
cellular response to lipopolysaccharide  (IEP)
central nervous system projection neuron axonogenesis  (ISO)
commissural neuron axon guidance  (ISO)
corpus callosum development  (ISO)
dendritic spine development  (ISO)
dendritic spine morphogenesis  (ISO)
ephrin receptor signaling pathway  (IBA,ISO)
hindbrain tangential cell migration  (IMP)
inner ear morphogenesis  (ISO)
learning  (ISO)
learning or memory  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cytokine production involved in inflammatory response  (IDA)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
neuron projection retraction  (ISO)
optic nerve morphogenesis  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of immunoglobulin production  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of protein localization to cell surface  (IDA)
positive regulation of protein localization to plasma membrane  (IMP)
positive regulation of synapse assembly  (IMP,ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
postsynaptic membrane assembly  (IDA,IEP,IMP)
regulation of autophagosome assembly  (ISO)
regulation of axonogenesis  (ISO)
regulation of behavioral fear response  (IMP)
regulation of blood coagulation  (ISO)
regulation of body fluid levels  (ISO)
regulation of filopodium assembly  (IMP)
regulation of neuronal synaptic plasticity  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (IDA)
regulation of synapse assembly  (ISO)
regulation of T-helper 17 type immune response  (IDA)
retinal ganglion cell axon guidance  (ISO)
roof of mouth development  (ISO)
tight junction assembly  (IDA)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  (ISO)
urogenital system development  (ISO)
vesicle-mediated intercellular transport  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. Bundesen LQ, etal., J Neurosci. 2003 Aug 27;23(21):7789-800.
2. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Cissé M, etal., Nature. 2011 Jan 6;469(7328):47-52. doi: 10.1038/nature09635. Epub 2010 Nov 28.
3. Infralimbic EphB2 Modulates Fear Extinction in Adolescent Rats. Cruz E, etal., J Neurosci. 2015 Sep 9;35(36):12394-403. doi: 10.1523/JNEUROSCI.4254-14.2015.
4. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Dalva MB, etal., Cell. 2000 Dec 8;103(6):945-56.
5. Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Essmann CL, etal., Nat Neurosci. 2008 Sep;11(9):1035-43. doi: 10.1038/nn.2171.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons. Geng D, etal., Neurochem Int. 2013 Oct;63(4):283-90. doi: 10.1016/j.neuint.2013.06.016. Epub 2013 Jul 2.
8. [EphB2-Fc promotes activation of endogenous neural stem cells after cerebral cortex infarction: experimental with hypertensive rats] He YD, etal., Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2395-9.
9. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Hoogenraad CC, etal., Nat Neurosci. 2005 Jul;8(7):906-15. doi: 10.1038/nn1487.
10. Preferential control of basal dendritic protrusions by EphB2. Kayser MS, etal., PLoS One. 2011 Feb 25;6(2):e17417. doi: 10.1371/journal.pone.0017417.
11. Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Liu YH, etal., Sci Rep. 2017 Mar 9;7:42895. doi: 10.1038/srep42895.
12. Activation of EphB receptors contributes to primary sensory neuron excitability by facilitating Ca2+ influx directly or through Src kinase-mediated N-methyl-D-aspartate receptor phosphorylation. Ma P, etal., Pain. 2020 Jul;161(7):1584-1596. doi: 10.1097/j.pain.0000000000001855.
13. The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Mimche PN, etal., Hepatology. 2015 Sep;62(3):900-14. doi: 10.1002/hep.27792. Epub 2015 Apr 22.
14. Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Nishimura T, etal., Mol Biol Cell. 2006 Mar;17(3):1273-85. Epub 2006 Jan 4.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Blockade of Erythropoietin-Producing Human Hepatocellular Carcinoma Receptor B1 in Spinal Dorsal Horn Alleviates Visceral Pain in Rats. Sun CL, etal., Pain Res Manag. 2021 Apr 7;2021:7582494. doi: 10.1155/2021/7582494. eCollection 2021.
22. Cutting Edge: EPHB2 Is a Coreceptor for Fungal Recognition and Phosphorylation of Syk in the Dectin-1 Signaling Pathway. Sun W, etal., J Immunol. 2021 Apr 1;206(7):1419-1423. doi: 10.4049/jimmunol.2001373. Epub 2021 Mar 8.
23. Expression of EphB2 in the development of anorectal malformations in fetal rats. Wang DJ, etal., J Pediatr Surg. 2009 Mar;44(3):592-9. doi: 10.1016/j.jpedsurg.2008.08.017.
24. EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats. Wu J, etal., CNS Neurosci Ther. 2021 Jun;27(6):714-724. doi: 10.1111/cns.13641. Epub 2021 Apr 1.
25. Blockade of EphB2 enhances neurogenesis in the subventricular zone and improves neurological function after cerebral cortical infarction in hypertensive rats. Xing S, etal., Brain Res. 2008 Sep 16;1230:237-46. doi: 10.1016/j.brainres.2008.06.097. Epub 2008 Jul 2.
26. Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance. Yu T, etal., Stem Cell Res Ther. 2021 Mar 15;12(1):181. doi: 10.1186/s13287-021-02232-w.
27. Expression of ephrin receptors and ligands in postmortem brains of HIV-infected subjects with and without cognitive impairment. Yuferov V, etal., J Neuroimmune Pharmacol. 2013 Mar;8(1):333-44. doi: 10.1007/s11481-012-9429-1. Epub 2013 Jan 12.
28. EphrinB2/ephB2-mediated myenteric synaptic plasticity: mechanisms underlying the persistent muscle hypercontractility and pain in postinfectious IBS. Zhang L, etal., FASEB J. 2019 Dec;33(12):13644-13659. doi: 10.1096/fj.201901192R. Epub 2019 Oct 25.
Additional References at PubMed
PMID:8689685   PMID:8947026   PMID:9883737   PMID:9990854   PMID:10839360   PMID:11532925   PMID:11585923   PMID:11754835   PMID:11754836   PMID:11780069   PMID:12052960   PMID:12971893  
PMID:14691139   PMID:14988728   PMID:15223334   PMID:16977320   PMID:17122040   PMID:17310244   PMID:17440041   PMID:17686994   PMID:18410519   PMID:21029865   PMID:21471370   PMID:21608225  
PMID:21746865   PMID:23881165   PMID:25834064   PMID:25922200   PMID:28358367   PMID:29731254   PMID:30213874   PMID:34648765   PMID:38353051  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85154,179,065 - 154,360,459 (-)NCBIGRCr8
mRatBN7.25148,889,574 - 149,077,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,897,246 - 149,077,059 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,593,352 - 151,774,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,367,634 - 153,548,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,349,643 - 153,530,963 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38122,710,838 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36Build 36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
T2T-CHM13v2.0122,535,722 - 22,747,006 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)EnsemblGRCm39 Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBIMGSCv36mm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21204,032,188 - 204,237,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,128,354 - 203,340,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,985,696 - 77,172,430 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,109,031 - 8,203,106 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl680,650,740 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120109,747,883 - 109,954,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247647,421,862 - 7,593,482 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ephb2
1249 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:60
Interacting mature miRNAs:60
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,924,708 - 148,924,837 (+)MAPPERmRatBN7.2
Rnor_6.05155,051,873 - 155,052,001NCBIRnor6.0
Rnor_5.05158,816,587 - 158,816,715UniSTSRnor5.0
RGSC_v3.45155,450,540 - 155,450,798RGDRGSC3.4
RGSC_v3.45155,450,641 - 155,450,769UniSTSRGSC3.4
RGSC_v3.15155,460,680 - 155,460,808RGD
Celera5147,324,795 - 147,324,923UniSTS
RH 3.4 Map51008.9UniSTS
RH 3.4 Map51008.9RGD
FHH x ACI Map584.23UniSTS
FHH x ACI Map584.23RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05155,136,406 - 155,136,543NCBIRnor6.0
Rnor_5.05158,900,115 - 158,900,252UniSTSRnor5.0
RGSC_v3.45155,536,222 - 155,536,392RGDRGSC3.4
RGSC_v3.45155,536,223 - 155,536,392UniSTSRGSC3.4
RGSC_v3.15155,546,261 - 155,546,431RGD
Celera5147,408,299 - 147,408,436UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,895,646 - 148,895,847 (+)MAPPERmRatBN7.2
Rnor_6.05155,022,880 - 155,023,080NCBIRnor6.0
Rnor_5.05158,787,594 - 158,787,794UniSTSRnor5.0
RGSC_v3.45155,421,437 - 155,421,637UniSTSRGSC3.4
Celera5147,295,755 - 147,295,955UniSTS
RH 3.4 Map51007.9UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,988,625 - 148,989,167 (+)MAPPERmRatBN7.2
Rnor_6.05155,115,890 - 155,116,431NCBIRnor6.0
Rnor_5.05158,879,599 - 158,880,140UniSTSRnor5.0
RGSC_v3.45155,516,031 - 155,516,572UniSTSRGSC3.4
Celera5147,388,128 - 147,388,669UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 6 10 4 6 4 59 20 28
Low 1 23 20 10 13 10 5 5 15 15 10 11 5
Below cutoff 14 25 25 25 3 6 3 3


RefSeq Acc Id: ENSRNOT00000016983   ⟹   ENSRNOP00000016983
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,897,246 - 149,077,059 (-)Ensembl
Rnor_6.0 Ensembl5155,023,006 - 155,143,539 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089574   ⟹   ENSRNOP00000070517
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,897,246 - 149,016,900 (-)Ensembl
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)Ensembl
RefSeq Acc Id: NM_001127319   ⟹   NP_001120791
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr85154,179,065 - 154,360,424 (-)NCBI
mRatBN7.25148,895,614 - 149,076,989 (-)NCBI
Rnor_6.05155,024,478 - 155,143,539 (-)NCBI
Rnor_5.05158,789,192 - 158,907,248 (-)NCBI
RGSC_v3.45155,423,035 - 155,605,384 (-)RGD
Celera5147,297,353 - 147,415,432 (-)RGD
RefSeq Acc Id: XM_039110055   ⟹   XP_038965983
Rat AssemblyChrPosition (strand)Source
GRCr85154,179,065 - 154,360,455 (-)NCBI
mRatBN7.25148,889,574 - 149,077,027 (-)NCBI
RefSeq Acc Id: XM_039110056   ⟹   XP_038965984
Rat AssemblyChrPosition (strand)Source
GRCr85154,179,065 - 154,360,454 (-)NCBI
mRatBN7.25148,889,574 - 149,077,025 (-)NCBI
RefSeq Acc Id: XM_039110057   ⟹   XP_038965985
Rat AssemblyChrPosition (strand)Source
GRCr85154,179,065 - 154,360,454 (-)NCBI
mRatBN7.25148,889,574 - 149,077,026 (-)NCBI
RefSeq Acc Id: XM_039110058   ⟹   XP_038965986
Rat AssemblyChrPosition (strand)Source
GRCr85154,179,065 - 154,360,456 (-)NCBI
mRatBN7.25148,889,574 - 149,077,027 (-)NCBI
RefSeq Acc Id: XR_010066401
Rat AssemblyChrPosition (strand)Source
GRCr85154,179,065 - 154,360,459 (-)NCBI
RefSeq Acc Id: NP_001120791   ⟸   NM_001127319
- Peptide Label: precursor
- UniProtKB: B2B9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070517   ⟸   ENSRNOT00000089574
RefSeq Acc Id: ENSRNOP00000016983   ⟸   ENSRNOT00000016983
RefSeq Acc Id: XP_038965986   ⟸   XM_039110058
- Peptide Label: isoform X4
- UniProtKB: B2B9B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965983   ⟸   XM_039110055
- Peptide Label: isoform X1
- UniProtKB: B2B9B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965985   ⟸   XM_039110057
- Peptide Label: isoform X3
- UniProtKB: B2B9B0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965984   ⟸   XM_039110056
- Peptide Label: isoform X2
- UniProtKB: F1MAJ0 (UniProtKB/TrEMBL),   B2B9B0 (UniProtKB/TrEMBL)
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JY48-F1-model_v2 AlphaFold A0A0G2JY48 1-986 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564232 AgrOrtholog
BioCyc Gene G2FUF-39490 BioCyc
Ensembl Genes ENSRNOG00000012531 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016983.8 UniProtKB/TrEMBL
  ENSRNOT00000089574.2 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphB2_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  Growth_fac_rcpt UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
KEGG Report rno:313633 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PhenoGen Ephb2 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012531 RatGTEx
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
  Grow_fac_recept UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A0G2JY48_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ephb2  Eph receptor B2  LOC103689967  ephrin type-B receptor 2-like  Data merged from RGD:9190068 737654 PROVISIONAL
2014-08-25 LOC103689967  ephrin type-B receptor 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Ephb2  Eph receptor B2   Ephb2_predicted  Eph receptor B2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ephb2_predicted  Eph receptor B2 (predicted)  RGD1564232_predicted  similar to Ephb2 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1564232_predicted  similar to Ephb2 protein (predicted)  LOC313633  similar to Ephb2 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313633  similar to Ephb2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL