Khdrbs1 (KH RNA binding domain containing, signal transduction associated 1) - Rat Genome Database

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Gene: Khdrbs1 (KH RNA binding domain containing, signal transduction associated 1) Rattus norvegicus
Analyze
Symbol: Khdrbs1
Name: KH RNA binding domain containing, signal transduction associated 1
RGD ID: 621459
Description: Enables SH3 domain binding activity and identical protein binding activity. Involved in cell surface receptor signaling pathway; regulation of alternative mRNA splicing, via spliceosome; and spermatogenesis. Located in nucleus. Part of Grb2-Sos complex. Orthologous to human KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GAP-associated tyrosine phosphoprotein p62; KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1-like; LOC100361306; p21 Ras GTPase-activating protein-associated p62; P62; p68; Sam68; src associated in mitosis, 68 kDa; src-associated in mitosis 68 kDa protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,337,048 - 147,374,604 (-)NCBIGRCr8
mRatBN7.25142,051,844 - 142,089,175 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,063,570 - 142,089,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,764,372 - 144,790,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,534,194 - 146,560,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,530,842 - 146,557,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,927,145 - 147,953,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,927,152 - 147,953,093 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,655,530 - 151,680,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,801,685 - 148,802,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,882,113 - 148,909,264 (-)NCBI
Celera5140,536,987 - 140,562,345 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
astragaloside IV  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
hexane  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
Grb2-Sos complex  (IDA)
membrane  (ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO,ISS)
protein-containing complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn). Hartmann AM, etal., Mol Biol Cell 1999 Nov;10(11):3909-26.
4. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. Heinrich B, etal., J Biol Chem. 2009 May 22;284(21):14303-15. Epub 2009 Mar 12.
5. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Moran MF, etal., Mol Cell Biol. 1991 Apr;11(4):1804-12.
8. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. Najib S and Sanchez-Margalet V, J Cell Biochem 2002;86(1):99-106.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K. Sanchez-Margalet V and Najib S, FEBS Lett. 1999 Jul 23;455(3):307-10.
13. Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling. Song Z, etal., Toxicol Appl Pharmacol. 2019 Feb 1;364:45-54. doi: 10.1016/j.taap.2018.12.002. Epub 2018 Dec 5.
14. p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1. Stoss O, etal., Mol Cell Neurosci 2004 Sep;27(1):8-21.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Venables JP, etal., Hum Mol Genet. 1999 Jun;8(6):959-69.
Additional References at PubMed
PMID:1374686   PMID:7799925   PMID:9045636   PMID:9315629   PMID:10749975   PMID:11118435   PMID:12496368   PMID:12833144   PMID:14693677   PMID:14991841   PMID:14996936   PMID:15062979  
PMID:15489334   PMID:16079148   PMID:16179349   PMID:19946888   PMID:20186123   PMID:21613532   PMID:21923101   PMID:21984414   PMID:22196734   PMID:22365833   PMID:22658674   PMID:22681889  
PMID:23782269   PMID:24514149   PMID:24625528   PMID:24715058   PMID:25145264   PMID:26350037   PMID:27059137   PMID:27105917   PMID:27236696   PMID:29496907   PMID:31413325  


Genomics

Comparative Map Data
Khdrbs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,337,048 - 147,374,604 (-)NCBIGRCr8
mRatBN7.25142,051,844 - 142,089,175 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,063,570 - 142,089,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,764,372 - 144,790,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,534,194 - 146,560,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,530,842 - 146,557,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,927,145 - 147,953,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,927,152 - 147,953,093 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,655,530 - 151,680,547 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,801,685 - 148,802,351 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,882,113 - 148,909,264 (-)NCBI
Celera5140,536,987 - 140,562,345 (-)NCBICelera
Cytogenetic Map5q36NCBI
KHDRBS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,013,868 - 32,060,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,013,868 - 32,060,850 (+)EnsemblGRCh38hg38GRCh38
GRCh37132,479,469 - 32,526,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,252,078 - 32,282,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 34132,148,583 - 32,178,565NCBI
Celera130,749,379 - 30,779,362 (+)NCBICelera
Cytogenetic Map1p35.2NCBI
HuRef130,595,973 - 30,643,133 (+)NCBIHuRef
CHM1_1132,594,894 - 32,642,040 (+)NCBICHM1_1
T2T-CHM13v2.0131,871,794 - 31,918,779 (+)NCBIT2T-CHM13v2.0
Khdrbs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,596,143 - 129,637,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,596,957 - 129,636,096 (-)EnsemblGRCm39 Ensembl
GRCm384129,702,380 - 129,743,878 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,703,164 - 129,742,303 (-)EnsemblGRCm38mm10GRCm38
MGSCv374129,392,103 - 129,419,526 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,218,078 - 129,244,570 (-)NCBIMGSCv36mm8
Celera4128,049,339 - 128,077,091 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.34NCBI
Khdrbs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,413,883 - 10,440,678 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,413,883 - 10,458,518 (+)NCBIChiLan1.0ChiLan1.0
KHDRBS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,768,104 - 194,817,464 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,889,907 - 193,939,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,297,843 - 31,345,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1132,312,598 - 32,342,587 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,312,598 - 32,342,582 (+)Ensemblpanpan1.1panPan2
KHDRBS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,108,822 - 69,148,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,123,663 - 69,148,073 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,689,332 - 65,728,750 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,675,445 - 69,714,910 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,689,360 - 69,714,870 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,511,546 - 66,550,990 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,507,703 - 67,547,145 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,506,957 - 68,546,417 (-)NCBIUU_Cfam_GSD_1.0
Khdrbs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,264,153 - 49,292,459 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,088,816 - 15,118,310 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,088,815 - 15,131,048 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KHDRBS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl688,530,385 - 88,572,463 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,530,364 - 88,572,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,393,560 - 82,435,657 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KHDRBS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,831,307 - 100,859,609 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,832,461 - 100,859,630 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603315,832,445 - 15,860,835 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Khdrbs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,244,390 - 15,275,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,244,521 - 15,292,901 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Khdrbs1
207 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:275
Interacting mature miRNAs:320
Transcripts:ENSRNOT00000075270
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
BF396566  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25142,083,316 - 142,083,446 (+)MAPPERmRatBN7.2
Rnor_6.05147,947,305 - 147,947,434NCBIRnor6.0
Rnor_5.05151,674,759 - 151,674,888UniSTSRnor5.0
Celera5140,556,557 - 140,556,686UniSTS
RH 3.4 Map5960.31UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000075270   ⟹   ENSRNOP00000066894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5142,063,570 - 142,089,180 (-)Ensembl
Rnor_6.0 Ensembl5147,927,152 - 147,953,093 (-)Ensembl
RefSeq Acc Id: NM_130405   ⟹   NP_569089
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85147,347,904 - 147,373,448 (-)NCBI
mRatBN7.25142,063,559 - 142,089,106 (-)NCBI
Rnor_6.05147,927,145 - 147,953,093 (-)NCBI
Rnor_5.05151,655,530 - 151,680,547 (-)NCBI
RGSC_v3.45148,801,685 - 148,802,351 (+)RGD
Celera5140,536,987 - 140,562,345 (-)RGD
Sequence:
RefSeq Acc Id: XR_005504357
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85147,337,048 - 147,374,604 (-)NCBI
mRatBN7.25142,051,844 - 142,089,175 (-)NCBI
Protein Sequences
Protein RefSeqs NP_569089 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61987 (Get FASTA)   NCBI Sequence Viewer  
  AAK77001 (Get FASTA)   NCBI Sequence Viewer  
  AAL09361 (Get FASTA)   NCBI Sequence Viewer  
  EDL80569 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066894.1
  ENSRNOP00055039938
  ENSRNOP00060035158
  ENSRNOP00065035080
GenBank Protein Q91V33 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_569089   ⟸   NM_130405
- UniProtKB: Q91V33 (UniProtKB/Swiss-Prot),   A6ISL8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066894   ⟸   ENSRNOT00000075270
Protein Domains
K Homology   KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91V33-F1-model_v2 AlphaFold Q91V33 1-443 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694076
Promoter ID:EPDNEW_R4601
Type:initiation region
Name:Khdrbs1_1
Description:KH RNA binding domain containing, signal transduction associated1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,953,141 - 147,953,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621459 AgrOrtholog
BioCyc Gene G2FUF-39779 BioCyc
Ensembl Genes ENSRNOG00000046794 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028072 UniProtKB/Swiss-Prot
  ENSRNOG00060024486 UniProtKB/Swiss-Prot
  ENSRNOG00065024942 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075270.2 UniProtKB/Swiss-Prot
  ENSRNOT00055048583 UniProtKB/Swiss-Prot
  ENSRNOT00060042435 UniProtKB/Swiss-Prot
  ENSRNOT00065042864 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599491 IMAGE-MGC_LOAD
InterPro BBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Qua1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sam68-YY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72326 IMAGE-MGC_LOAD
NCBI Gene 117268 ENTREZGENE
PANTHER KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Qua1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sam68-YY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Khdrbs1 PhenoGen
PROSITE KH_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046794 RatGTEx
  ENSRNOG00055028072 RatGTEx
  ENSRNOG00060024486 RatGTEx
  ENSRNOG00065024942 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Eukaryotic type KH-domain (KH-domain type I) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6ISL8 ENTREZGENE, UniProtKB/TrEMBL
  KHDR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Khdrbs1  KH RNA binding domain containing, signal transduction associated 1  Khdrbs1  KH domain containing, RNA binding, signal transduction associated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Khdrbs1  KH domain containing, RNA binding, signal transduction associated 1  LOC100361306  KH domain-containing, RNA-binding, signal transduction-associated protein 1-like  Data merged from RGD:2320359 737654 PROVISIONAL
2010-05-05 LOC100361306  KH domain-containing, RNA-binding, signal transduction-associated protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Khdrbs1  KH domain containing, RNA binding, signal transduction associated 1    src associated in mitosis, 68 kDa  Name updated 1299863 APPROVED
2004-09-10 Khdrbs1  src associated in mitosis, 68 kDa  Sam68    Symbol and Name updated 1299863 APPROVED
2002-08-07 Sam68  src associated in mitosis, 68 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocates from the nucleus to the cytoplasm 634064
gene_domains contains Src homology (SH) 2 and 3 domain binding sites 634064
gene_physical_interaction interacts with Grb2 via SH3 domains 634064