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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | increases expression | ISO | RGD:733307 | 6480464 | vinylidene chloride results in increased expression of LAPTM5 mRNA | CTD | PMID:26682919 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of LAPTM5 mRNA | CTD | PMID:25380136 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:733307 | 6480464 | Ethinyl Estradiol affects the expression of LAPTM5 mRNA | CTD | PMID:17555576 | 17beta-estradiol | multiple interactions | ISO | RGD:1354375 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of LAPTM5 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1354375 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LAPTM5 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:733307 | 6480464 | Tetrachlorodibenzodioxin affects the expression of LAPTM5 mRNA | CTD | PMID:26377647, PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LAPTM5 mRNA | CTD | PMID:21215274 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 6-dinitrotoluene affects the expression of LAPTM5 mRNA | CTD | PMID:21346803 | 2-butoxyethanol | decreases expression | ISO | RGD:733307 | 6480464 | n-butoxyethanol results in decreased expression of LAPTM5 mRNA | CTD | PMID:19812364 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:733307 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of LAPTM5 mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | RGD:733307 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of LAPTM5 promoter | CTD | PMID:26251327 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of LAPTM5 mRNA | CTD | PMID:25380136 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:733307 | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of LAPTM5 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:733307 | 6480464 | [bis(4-hydroxyphenyl)sulfone co-treated with LIF protein] results in decreased expression of LAPTM5 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:733307 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of LAPTM5 mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | decreases expression | ISO | RGD:733307 | 6480464 | Fenretinide results in decreased expression of LAPTM5 mRNA | CTD | PMID:28973697 | aflatoxin B1 | affects expression | ISO | RGD:1354375 | 6480464 | Aflatoxin B1 affects the expression of LAPTM5 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:1354375 | 6480464 | Aflatoxin B1 results in increased expression of LAPTM5 mRNA | CTD | PMID:21632981, PMID:21641981 | all-trans-retinoic acid | decreases expression | ISO | RGD:1354375 | 6480464 | Tretinoin results in decreased expression of LAPTM5 mRNA | CTD | PMID:16249480 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1354375 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in increased expression of LAPTM5 mRNA | CTD | PMID:15894607 | all-trans-retinoic acid | increases expression | ISO | RGD:1354375 | 6480464 | Tretinoin results in increased expression of LAPTM5 mRNA | CTD | PMID:15894607, PMID:17218384 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of LAPTM5 mRNA | CTD | PMID:16483693 | antirheumatic drug | decreases expression | ISO | RGD:1354375 | 6480464 | Antirheumatic Agents results in decreased expression of LAPTM5 mRNA | CTD | PMID:24449571 | arsane | affects methylation | ISO | RGD:1354375 | 6480464 | Arsenic affects the methylation of LAPTM5 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:1354375 | 6480464 | Arsenic affects the methylation of LAPTM5 gene | CTD | PMID:25304211 | arsenous acid | increases expression | ISO | RGD:1354375 | 6480464 | Arsenic Trioxide results in increased expression of LAPTM5 mRNA | CTD | PMID:15894607, PMID:20458559 | arsenous acid | multiple interactions | ISO | RGD:1354375 | 6480464 | [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of LAPTM5 mRNA | CTD | PMID:15894607 | benzo[a]pyrene | affects expression | ISO | RGD:1354375 | 6480464 | Benzo(a)pyrene affects the expression of LAPTM5 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:1354375 | 6480464 | Benzo(a)pyrene results in increased expression of LAPTM5 mRNA | CTD | PMID:21632981 | benzo[a]pyrene | increases expression | ISO | RGD:733307 | 6480464 | Benzo(a)pyrene results in increased expression of LAPTM5 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LAPTM5 mRNA | CTD | PMID:18180321 | bisphenol A | increases expression | ISO | RGD:1354375 | 6480464 | bisphenol A results in increased expression of LAPTM5 mRNA | CTD | PMID:29718440 | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of LAPTM5 promoter | CTD | PMID:27415467 | bisphenol A | decreases expression | ISO | RGD:733307 | 6480464 | bisphenol A results in decreased expression of LAPTM5 mRNA | CTD | PMID:25594700 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of LAPTM5 mRNA | CTD | PMID:25181051 | bisphenol F | increases expression | ISO | RGD:733307 | 6480464 | bisphenol F results in increased expression of LAPTM5 mRNA | CTD | PMID:30951980 | cadmium dichloride | increases expression | ISO | RGD:733307 | 6480464 | Cadmium Chloride results in increased expression of LAPTM5 mRNA | CTD | PMID:24982889 | carbon nanotube | decreases expression | ISO | RGD:733307 | 6480464 | Nanotubes, Carbon analog results in decreased expression of LAPTM5 mRNA, Nanotubes, Carbon results in decreased expression of LAPTM5 mRNA | CTD | PMID:25554681 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of LAPTM5 mRNA | CTD | PMID:30556269 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of LAPTM5 mRNA | CTD | PMID:30556269 | cyclosporin A | decreases expression | ISO | RGD:1354375 | 6480464 | Cyclosporine results in decreased expression of LAPTM5 mRNA | CTD | PMID:20106945, PMID:27989131 | dextran sulfate | increases expression | ISO | RGD:733307 | 6480464 | Dextran Sulfate results in increased expression of LAPTM5 mRNA | CTD | PMID:23894361 | diarsenic trioxide | increases expression | ISO | RGD:1354375 | 6480464 | Arsenic Trioxide results in increased expression of LAPTM5 mRNA | CTD | PMID:15894607, PMID:20458559 | diarsenic trioxide | multiple interactions | ISO | RGD:1354375 | 6480464 | [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of LAPTM5 mRNA | CTD | PMID:15894607 | doxorubicin | decreases expression | ISO | RGD:1354375 | 6480464 | Doxorubicin results in decreased expression of LAPTM5 mRNA | CTD | PMID:29803840 | emodin | increases expression | ISO | RGD:733307 | 6480464 | Emodin results in increased expression of LAPTM5 mRNA | CTD | PMID:15612046 | ethanol | increases expression | ISO | RGD:733307 | 6480464 | Ethanol results in increased expression of LAPTM5 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | RGD:1354375 | 6480464 | Ethyl Methanesulfonate results in increased expression of LAPTM5 mRNA | CTD | PMID:23649840 | flavonoids | increases expression | EXP | | 6480464 | Flavonoids results in increased expression of LAPTM5 mRNA | CTD | PMID:18035473 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of LAPTM5 mRNA | CTD | PMID:24136188 | fonofos | decreases methylation | ISO | RGD:1354375 | 6480464 | Fonofos results in decreased methylation of LAPTM5 promoter | CTD | PMID:22847954 | formaldehyde | decreases expression | EXP | | 6480464 | Formaldehyde results in decreased expression of LAPTM5 mRNA | CTD | PMID:17285311 | formaldehyde | decreases expression | ISO | RGD:1354375 | 6480464 | Formaldehyde results in decreased expression of LAPTM5 mRNA | CTD | PMID:28937961 | formaldehyde | increases expression | ISO | RGD:1354375 | 6480464 | Formaldehyde results in increased expression of LAPTM5 mRNA | CTD | PMID:23649840 | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of LAPTM5 gene, furan results in decreased methylation of LAPTM5 promoter | CTD | PMID:22079235 | Genipin | multiple interactions | ISO | RGD:733307 | 6480464 | genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of LAPTM5 mRNA] | CTD | PMID:22687549 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of LAPTM5 mRNA | CTD | PMID:22061828 | hydrogen peroxide | decreases secretion | ISO | RGD:733307 | 6480464 | Hydrogen Peroxide results in decreased secretion of LAPTM5 mRNA | CTD | PMID:21179422 | isotretinoin | increases expression | ISO | RGD:1354375 | 6480464 | Isotretinoin results in increased expression of LAPTM5 mRNA | CTD | PMID:20436886 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of LAPTM5 mRNA | CTD | PMID:20080153 | lipopolysaccharide | multiple interactions | ISO | RGD:733307 | 6480464 | genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of LAPTM5 mRNA] | CTD | PMID:22687549 | lipopolysaccharide | increases expression | ISO | RGD:733307 | 6480464 | Lipopolysaccharides results in increased expression of LAPTM5 mRNA | CTD | PMID:27339419 | lipopolysaccharide | decreases expression | ISO | RGD:733307 | 6480464 | Lipopolysaccharides results in decreased expression of LAPTM5 mRNA | CTD | PMID:22687549 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of LAPTM5 mRNA | CTD | PMID:25380136 | nickel atom | increases expression | ISO | RGD:1354375 | 6480464 | Nickel results in increased expression of LAPTM5 mRNA | CTD | PMID:24768652, PMID:25583101 | paracetamol | affects expression | ISO | RGD:733307 | 6480464 | Acetaminophen affects the expression of LAPTM5 mRNA | CTD | PMID:17562736 | parathion | decreases methylation | ISO | RGD:1354375 | 6480464 | Parathion results in decreased methylation of LAPTM5 promoter | CTD | PMID:22847954 | phenobarbital | increases expression | ISO | RGD:733307 | 6480464 | Phenobarbital results in increased expression of LAPTM5 mRNA | CTD | PMID:23091169 | pirinixic acid | decreases expression | ISO | RGD:733307 | 6480464 | pirinixic acid results in decreased expression of LAPTM5 mRNA | CTD | PMID:17426115 | quercetin | increases expression | ISO | RGD:1354375 | 6480464 | Quercetin results in increased expression of LAPTM5 mRNA | CTD | PMID:21632981 | quinolin-8-ol | increases expression | ISO | RGD:733307 | 6480464 | Oxyquinoline results in increased expression of LAPTM5 mRNA | CTD | PMID:15612046 | resveratrol | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in increased expression of LAPTM5 mRNA | CTD | PMID:25905778 | resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of LAPTM5 mRNA | CTD | PMID:25905778 | rotenone | increases expression | ISO | RGD:733307 | 6480464 | Rotenone results in increased expression of LAPTM5 mRNA | CTD | PMID:23186747 | sodium arsenite | affects expression | ISO | RGD:1354375 | 6480464 | sodium arsenite affects the expression of LAPTM5 mRNA | CTD | PMID:20816728 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of LAPTM5 mRNA | CTD | PMID:19281266 | streptozocin | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in increased expression of LAPTM5 mRNA | CTD | PMID:25905778 | terbufos | decreases methylation | ISO | RGD:1354375 | 6480464 | terbufos results in decreased methylation of LAPTM5 promoter | CTD | PMID:22847954 | tert-butyl hydroperoxide | increases expression | ISO | RGD:1354375 | 6480464 | tert-Butylhydroperoxide results in increased expression of LAPTM5 mRNA | CTD | PMID:15336504 | testosterone enanthate | affects expression | ISO | RGD:1354375 | 6480464 | testosterone enanthate affects the expression of LAPTM5 mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | ISO | RGD:733307 | 6480464 | Carbon Tetrachloride results in increased expression of LAPTM5 mRNA | CTD | PMID:27339419 | valproic acid | affects expression | ISO | RGD:1354375 | 6480464 | Valproic Acid affects the expression of LAPTM5 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | RGD:1354375 | 6480464 | Valproic Acid results in decreased expression of LAPTM5 mRNA | CTD | PMID:29154799 | valproic acid | increases methylation | ISO | RGD:1354375 | 6480464 | Valproic Acid results in increased methylation of LAPTM5 gene | CTD | PMID:29154799 | vancomycin | decreases expression | ISO | RGD:733307 | 6480464 | Vancomycin results in decreased expression of LAPTM5 mRNA | CTD | PMID:18930951 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of LAPTM5 mRNA | CTD | PMID:19015723 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of LAPTM5 mRNA | CTD | PMID:23034163 | |
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1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | GOA data from the GO Consortium |
3. | MGD data from the GO Consortium |
4. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
5. | Origasa M, etal., Brain Res Mol Brain Res 2001 Mar 31;88(1-2):1-13. |
6. | RGD automated data pipeline |
7. | RGD automated import pipeline for gene-chemical interactions |
8. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
PubMed | 20439489 |
Laptm5 (Rattus norvegicus - Norway rat) |
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LAPTM5 (Homo sapiens - human) |
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Laptm5 (Mus musculus - house mouse) |
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Laptm5 (Chinchilla lanigera - long-tailed chinchilla) |
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LAPTM5 (Pan paniscus - bonobo/pygmy chimpanzee) |
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LAPTM5 (Canis lupus familiaris - dog) |
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Laptm5 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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LAPTM5 (Sus scrofa - pig) |
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RH131904 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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High | ||||||||||||||||
Medium | 5 | 8 | 5 | 9 | 4 | 3 | 8 | 10 | 11 | 11 | 31 | 11 | 2 | 8 | ||
Low | 17 | 31 | 18 | 6 | 3 | 8 | 18 | 15 | 10 | 24 | 6 | |||||
Below cutoff | 4 |
RefSeq Transcripts | NM_053538 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_017593668 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AABR07050048 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AAHX01039961 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AB046592 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC060517 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473968 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ225663 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_053538 ⟹ NP_445990 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
GTGCACCATGGCCTCCCGTGCAGTGCCAGTCAGGCAGACATGCTGTTGTTTCAATGTCCGAGTThide sequence |
RefSeq Acc Id: | XM_017593668 ⟹ XP_017449157 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
ATAGACCCTAGGTCGGCAAAGCCACTGTGAACTTGTTACTTCCAGTGACGTGGAGAATTTCTCChide sequence |
Protein RefSeqs | NP_445990 | (Get FASTA) | NCBI Sequence Viewer |
XP_017449157 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAH60517 | (Get FASTA) | NCBI Sequence Viewer |
BAB03459 | (Get FASTA) | NCBI Sequence Viewer | |
EDL80601 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_445990 ⟸ NM_053538 |
- UniProtKB: | Q6P9Z7 (UniProtKB/TrEMBL) |
- Sequence: |
MASRAVPVRQTCCCFNVRVATVALAIYHIVMSVLLFIEHVVEVARGKVSCRFSKMPYLRLADLLhide sequence |
RefSeq Acc Id: | XP_017449157 ⟸ XM_017593668 |
- Peptide Label: | isoform X1 |
- Sequence: |
MCLPRPLHLGPGSCNGHILLLAQVSAVCTIDGVMSVLLFIEHVVEVARGKVSCRFSKMPYLRLAhide sequence |
RGD ID: | 13694087 | |||||||||
Promoter ID: | EPDNEW_R4611 | |||||||||
Type: | initiation region | |||||||||
Name: | Laptm5_1 | |||||||||
Description: | lysosomal protein transmembrane 5 | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:621838 | AgrOrtholog |
Ensembl Genes | ENSRNOG00000011054 | ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000015198 | ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOP00000071739 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000015198 | ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOT00000083028 | UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:5597893 | IMAGE-MGC_LOAD |
InterPro | LAPTM4/5 | UniProtKB/TrEMBL |
LAPTM_4A/5 | UniProtKB/TrEMBL | |
Lysosomal-assoc_TM_prot5 | UniProtKB/TrEMBL | |
KEGG Report | rno:89783 | UniProtKB/TrEMBL |
MGC_CLONE | MGC:72357 | IMAGE-MGC_LOAD |
NCBI Gene | 89783 | ENTREZGENE |
PANTHER | PTHR12479:SF2 | UniProtKB/TrEMBL |
Pfam | Mtp | UniProtKB/TrEMBL |
PhenoGen | Laptm5 | PhenoGen |
TIGRFAMs | mtp | UniProtKB/TrEMBL |
UniGene | Rn.24799 | ENTREZGENE |
UniProt | A0A0G2K184_RAT | UniProtKB/TrEMBL |
Q6P9Z7 | ENTREZGENE, UniProtKB/TrEMBL | |
UniProt Secondary | F1LN25 | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2009-10-22 | Laptm5 | lysosomal protein transmembrane 5 | Laptm5 | lysosomal multispanning membrane protein 5 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-11-11 | Laptm5 | lysosomal multispanning membrane protein 5 | Laptm5 | lysosomal-associated protein transmembrane 5 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-09-10 | Laptm5 | lysosomal-associated protein transmembrane 5 | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2002-08-07 | Laptm5 | lysosomal-associated protein transmembrane 5 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_cellular_localization | localized to the perinuclear area of cultured microglia | 633121 |
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More on Laptm5 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
RGD Object Information | |
RGD ID: | 621838 |
Created: | 2002-08-06 |
Species: | Rattus norvegicus |
Last Modified: | 2019-11-27 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.