Cap1 (cyclase associated actin cytoskeleton regulatory protein 1) - Rat Genome Database

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Gene: Cap1 (cyclase associated actin cytoskeleton regulatory protein 1) Rattus norvegicus
Analyze
Symbol: Cap1
Name: cyclase associated actin cytoskeleton regulatory protein 1
RGD ID: 620309
Description: Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in actin filament organization; cAMP-mediated signaling; and cell morphogenesis. Predicted to act upstream of or within actin cytoskeleton organization; ameboidal-type cell migration; and receptor-mediated endocytosis. Predicted to be located in cortical actin cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenylate cyclase associated protein 1; adenylyl cyclase-associated protein 1; CAP 1; CAP, adenylate cyclase-associated protein 1; CAP, adenylate cyclase-associated protein 1 (yeast); cyclase-associated protein homologue; Mch1; MGC108691
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25135,142,108 - 135,168,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,142,112 - 135,168,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,848,892 - 137,875,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,619,408 - 139,645,571 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,625,992 - 139,652,167 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,559,195 - 140,585,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,559,206 - 140,585,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,350,194 - 144,376,587 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,174,441 - 142,201,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,179,669 - 142,206,346 (-)NCBI
Celera5133,680,751 - 133,706,934 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility. Yamazaki K, etal., Lab Invest. 2009 Apr;89(4):425-32. Epub 2009 Feb 2.
10. Molecular cloning and characterization of a rat homolog of CAP, the adenylyl cyclase-associated protein from Saccharomyces cerevisiae. Zelicof A, etal., J Biol Chem 1993 Jun 25;268(18):13448-53.
Additional References at PubMed
PMID:7691848   PMID:12477932   PMID:15004221   PMID:15489334   PMID:19056867   PMID:19199708   PMID:20458337   PMID:21238513   PMID:21423176   PMID:22082260   PMID:23376485   PMID:23533145  
PMID:24006456   PMID:24272071   PMID:25060335   PMID:30682386   PMID:34099549  


Genomics

Comparative Map Data
Cap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25135,142,108 - 135,168,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,142,112 - 135,168,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,848,892 - 137,875,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,619,408 - 139,645,571 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,625,992 - 139,652,167 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,559,195 - 140,585,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,559,206 - 140,585,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,350,194 - 144,376,587 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,174,441 - 142,201,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,179,669 - 142,206,346 (-)NCBI
Celera5133,680,751 - 133,706,934 (-)NCBICelera
Cytogenetic Map5q36NCBI
CAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,040,240 - 40,072,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,040,233 - 40,072,649 (+)EnsemblGRCh38hg38GRCh38
GRCh37140,505,912 - 40,538,320 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,278,842 - 40,310,908 (+)NCBINCBI36Build 36hg18NCBI36
Celera138,788,546 - 38,820,608 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,624,359 - 38,656,372 (+)NCBIHuRef
CHM1_1140,621,882 - 40,653,922 (+)NCBICHM1_1
T2T-CHM13v2.0139,909,560 - 39,942,077 (+)NCBIT2T-CHM13v2.0
Cap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394122,752,841 - 122,779,869 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4122,752,840 - 122,779,849 (-)EnsemblGRCm39 Ensembl
GRCm384122,859,048 - 122,886,076 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4122,859,047 - 122,886,056 (-)EnsemblGRCm38mm10GRCm38
MGSCv374122,536,471 - 122,563,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364122,361,358 - 122,374,759 (-)NCBIMGSCv36mm8
Celera4121,189,663 - 121,215,875 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.27NCBI
Cap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,503,531 - 17,528,049 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545217,503,530 - 17,528,049 (+)NCBIChiLan1.0ChiLan1.0
CAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11185,891,517 - 185,926,819 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,325,715 - 39,358,365 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,651,089 - 40,683,777 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,651,262 - 40,683,777 (+)Ensemblpanpan1.1panPan2
CAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,886,661 - 2,913,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,143,694 - 3,171,063 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,973,496 - 3,000,882 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,973,512 - 3,000,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,880,544 - 2,907,904 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,940,448 - 2,967,801 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,956,849 - 2,984,219 (-)NCBIUU_Cfam_GSD_1.0
Cap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,029,613 - 56,056,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,854,330 - 21,881,622 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647421,854,454 - 21,881,622 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,812,179 - 95,840,570 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1695,811,485 - 95,840,576 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,122,573 - 89,128,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,833,112 - 92,865,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,829,735 - 92,864,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603323,973,782 - 24,006,213 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,517,315 - 22,542,351 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,517,254 - 22,542,356 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cap1
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:212
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000018711
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5134972980138113556Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat

Markers in Region
RH142418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,673 - 135,141,856 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,761 - 140,558,943NCBIRnor6.0
Rnor_5.05144,349,760 - 144,349,942UniSTSRnor5.0
RGSC_v3.45142,173,999 - 142,174,181UniSTSRGSC3.4
Celera5133,680,309 - 133,680,491UniSTS
RH 3.4 Map5890.0UniSTS
Cytogenetic Map5q36UniSTS
RH127550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,141,796 - 135,142,005 (+)MAPPERmRatBN7.2
Rnor_6.05140,558,884 - 140,559,092NCBIRnor6.0
Rnor_5.05144,349,883 - 144,350,091UniSTSRnor5.0
RGSC_v3.45142,174,122 - 142,174,330UniSTSRGSC3.4
Celera5133,680,432 - 133,680,640UniSTS
RH 3.4 Map5876.9UniSTS
Cytogenetic Map5q36UniSTS
AA851880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,142,185 - 135,142,377 (+)MAPPERmRatBN7.2
Rnor_6.05140,559,273 - 140,559,463NCBIRnor6.0
Rnor_5.05144,350,272 - 144,350,462UniSTSRnor5.0
RGSC_v3.45142,174,511 - 142,174,701UniSTSRGSC3.4
Celera5133,680,821 - 133,681,011UniSTS
RH 3.4 Map5900.7UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:237169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,143,159 - 135,144,585 (+)MAPPERmRatBN7.2
Rnor_6.05140,560,246 - 140,561,671NCBIRnor6.0
Rnor_5.05144,351,245 - 144,352,670UniSTSRnor5.0
RGSC_v3.45142,175,484 - 142,176,909UniSTSRGSC3.4
Celera5133,681,794 - 133,683,219UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 7 10 74 35 41 11 7
Low 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018711   ⟹   ENSRNOP00000018711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,142,114 - 135,168,249 (-)Ensembl
Rnor_6.0 Ensembl5140,559,206 - 140,585,408 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105284   ⟹   ENSRNOP00000081879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5135,142,112 - 135,168,769 (-)Ensembl
RefSeq Acc Id: NM_022383   ⟹   NP_071778
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25135,142,116 - 135,168,320 (-)NCBI
Rnor_6.05140,559,203 - 140,585,408 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
RGSC_v3.45142,174,441 - 142,201,120 (-)RGD
Celera5133,680,751 - 133,706,934 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238830   ⟹   XP_006238892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25135,142,108 - 135,168,396 (-)NCBI
Rnor_6.05140,559,195 - 140,585,493 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238831   ⟹   XP_006238893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25135,142,118 - 135,168,401 (-)NCBI
Rnor_6.05140,559,195 - 140,585,493 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238832   ⟹   XP_006238894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25135,142,119 - 135,168,394 (-)NCBI
Rnor_6.05140,559,195 - 140,585,494 (-)NCBI
Rnor_5.05144,350,194 - 144,376,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110702   ⟹   XP_038966630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25135,142,119 - 135,168,885 (-)NCBI
RefSeq Acc Id: XM_039110703   ⟹   XP_038966631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25135,142,119 - 135,160,919 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_071778   ⟸   NM_022383
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238894   ⟸   XM_006238832
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238893   ⟸   XM_006238831
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238892   ⟸   XM_006238830
- Peptide Label: isoform X1
- UniProtKB: Q5FVS8 (UniProtKB/Swiss-Prot),   Q08163 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018711   ⟸   ENSRNOT00000018711
RefSeq Acc Id: XP_038966630   ⟸   XM_039110702
- Peptide Label: isoform X1
- UniProtKB: Q08163 (UniProtKB/Swiss-Prot),   Q5FVS8 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966631   ⟸   XM_039110703
- Peptide Label: isoform X1
- UniProtKB: Q08163 (UniProtKB/Swiss-Prot),   Q5FVS8 (UniProtKB/Swiss-Prot),   A6IS11 (UniProtKB/TrEMBL),   A0A8L2QAE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081879   ⟸   ENSRNOT00000105284
Protein Domains
Adenylate cyclase-associated CAP N-terminal   C-CAP/cofactor C-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08163-F1-model_v2 AlphaFold Q08163 1-474 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620309 AgrOrtholog
BioCyc Gene G2FUF-40028 BioCyc
Ensembl Genes ENSRNOG00000013492 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018711 ENTREZGENE
  ENSRNOP00000018711.4 UniProtKB/TrEMBL
  ENSRNOP00000081879 ENTREZGENE
  ENSRNOP00000081879.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018711 ENTREZGENE
  ENSRNOT00000018711.5 UniProtKB/TrEMBL
  ENSRNOT00000105284 ENTREZGENE
  ENSRNOT00000105284.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.160.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381845 IMAGE-MGC_LOAD
InterPro Adenylate_cyclase-assoc_CAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylate_cyclase-assoc_CAP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylate_cyclase-assoc_CAP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-CAP_CF_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP/MinC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_CS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_CS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARP_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64185 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108691 IMAGE-MGC_LOAD
NCBI Gene 64185 ENTREZGENE
PANTHER PTHR10652 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10652:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CAP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cap1 PhenoGen
PROSITE C_CAP_COFACTOR_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CARP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101278 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G6M3_RAT UniProtKB/TrEMBL
  A0A8L2QAE6 ENTREZGENE, UniProtKB/TrEMBL
  A6IS10_RAT UniProtKB/TrEMBL
  A6IS11 ENTREZGENE, UniProtKB/TrEMBL
  CAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVS8 ENTREZGENE
UniProt Secondary Q5FVS8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-24 Cap1  cyclase associated actin cytoskeleton regulatory protein 1  Cap1  adenylate cyclase associated protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-22 Cap1  adenylate cyclase associated protein 1  Cap1  CAP, adenylate cyclase-associated protein 1 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cap1  CAP, adenylate cyclase-associated protein 1 (yeast)    cyclase-associated protein homologue  Name updated 1299863 APPROVED
2002-08-07 Cap1  cyclase-associated protein homologue      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is constitutively expressed in all tissue types examined 632445
gene_homology protein aa sequence is 36% identical to S. cerevisiae CAP 632445
gene_protein predicted protein contains 474 aa residues 632445