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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | RGD:1616587 | 6480464 | ethylene dichloride results in decreased expression of AGO3 mRNA | CTD | PMID:28189721 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1616587 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AGO3 mRNA | CTD | PMID:21354282 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1616587 | 6480464 | Tetrachlorodibenzodioxin affects the expression of AGO3 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of AGO3 mRNA | CTD | PMID:22298810 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1319350 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:1319350 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA | CTD | PMID:28628672 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1616587 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA | CTD | PMID:19191707 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:1616587 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA | CTD | PMID:19191707 | aflatoxin B1 | increases expression | ISO | RGD:1616587 | 6480464 | Aflatoxin B1 results in increased expression of AGO3 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | RGD:1319350 | 6480464 | Aflatoxin B1 results in increased methylation of AGO3 exon | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | RGD:1319350 | 6480464 | Aflatoxin B1 results in decreased methylation of AGO3 gene | CTD | PMID:27153756 | benzo[a]pyrene | multiple interactions | ISO | RGD:1616587 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AGO3 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:1616587 | 6480464 | Benzo(a)pyrene results in increased expression of AGO3 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1319350 | 6480464 | 7 more ... | CTD | PMID:20018196 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of AGO3 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of AGO3 gene | CTD | PMID:28505145 | bisphenol A | multiple interactions | ISO | RGD:1319350 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA | CTD | PMID:28628672 | carbamazepine | affects expression | ISO | RGD:1319350 | 6480464 | Carbamazepine affects the expression of AGO3 mRNA | CTD | PMID:24752500 | cisplatin | multiple interactions | ISO | RGD:1319350 | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of AGO3 mRNA | CTD | PMID:27392435 | cycloheximide | multiple interactions | ISO | RGD:1616587 | 6480464 | Cycloheximide inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] | CTD | PMID:29576526 | cyclosporin A | increases expression | ISO | RGD:1319350 | 6480464 | Cyclosporine results in increased expression of AGO3 mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of AGO3 mRNA | CTD | PMID:23640034 | dexamethasone | multiple interactions | ISO | RGD:1319350 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA | CTD | PMID:28628672 | diclofenac | affects expression | ISO | RGD:1319350 | 6480464 | Diclofenac affects the expression of AGO3 mRNA | CTD | PMID:24752500 | emetine | multiple interactions | ISO | RGD:1616587 | 6480464 | Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] | CTD | PMID:29576526 | indometacin | multiple interactions | ISO | RGD:1319350 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA | CTD | PMID:28628672 | maneb | multiple interactions | ISO | RGD:1616587 | 6480464 | [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA | CTD | PMID:22563483 | methyl methanesulfonate | increases expression | ISO | RGD:1319350 | 6480464 | Methyl Methanesulfonate results in increased expression of AGO3 mRNA | CTD | PMID:23649840 | paraquat | multiple interactions | ISO | RGD:1616587 | 6480464 | [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA | CTD | PMID:22563483 | paraquat | increases expression | ISO | RGD:1616587 | 6480464 | Paraquat results in increased expression of AGO3 mRNA | CTD | PMID:22563483 | phenobarbital | affects expression | ISO | RGD:1616587 | 6480464 | Phenobarbital affects the expression of AGO3 mRNA | CTD | PMID:23091169 | potassium dichromate | decreases expression | ISO | RGD:1319350 | 6480464 | Potassium Dichromate results in decreased expression of AGO3 protein | CTD | PMID:23718831 | pyridaben | increases expression | ISO | RGD:1616587 | 6480464 | pyridaben results in increased expression of AGO3 mRNA | CTD | PMID:22563483 | silver atom | increases expression | ISO | RGD:1616587 | 6480464 | Silver results in increased expression of AGO3 mRNA | CTD | PMID:27131904 | silver atom | affects expression | ISO | RGD:1616587 | 6480464 | Silver affects the expression of AGO3 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | RGD:1616587 | 6480464 | Silver results in increased expression of AGO3 mRNA | CTD | PMID:27131904 | silver(0) | affects expression | ISO | RGD:1616587 | 6480464 | Silver affects the expression of AGO3 mRNA | CTD | PMID:27131904 | sodium arsenate | increases expression | ISO | RGD:1616587 | 6480464 | sodium arsenate results in increased expression of AGO3 mRNA | CTD | PMID:21795629 | sodium fluoride | decreases expression | ISO | RGD:1616587 | 6480464 | Sodium Fluoride results in decreased expression of AGO3 mRNA | CTD | PMID:27862939 | testosterone enanthate | affects expression | ISO | RGD:1319350 | 6480464 | testosterone enanthate affects the expression of AGO3 mRNA | CTD | PMID:17440010 | thapsigargin | affects localization | ISO | RGD:1616587 | 6480464 | Thapsigargin affects the localization of AGO3 mRNA | CTD | PMID:29576526 | thapsigargin | multiple interactions | ISO | RGD:1616587 | 6480464 | Cycloheximide inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA], Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] | CTD | PMID:29576526 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of AGO3 mRNA | CTD | PMID:23411599 | urethane | increases expression | ISO | RGD:1319350 | 6480464 | Urethane results in increased expression of AGO3 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | RGD:1319350 | 6480464 | Valproic Acid results in increased expression of AGO3 mRNA | CTD | PMID:29154799 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of AGO3 mRNA | CTD | PMID:29427782 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of AGO3 mRNA | CTD | PMID:29427782 | |
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1. | Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23. |
2. | RGD automated import pipeline for gene-chemical interactions |
3. | RGD comprehensive gene curation |
PubMed | 15260970 18771919 19536157 19946888 19966796 22658674 22681889 22795694 22863743 23064648 25931508 26764146 29040713 |
Ago3 (Rattus norvegicus - Norway rat) |
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AGO3 (Homo sapiens - human) |
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Ago3 (Mus musculus - house mouse) |
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Ago3 (Chinchilla lanigera - long-tailed chinchilla) |
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AGO3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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AGO3 (Canis lupus familiaris - dog) |
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AGO3 (Sus scrofa - pig) |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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High | ||||||||||||||||
Medium | 2 | 8 | 4 | 8 | 2 | 3 | 5 | 6 | ||||||||
Low | 20 | 41 | 15 | 15 | 1 | 3 | 8 | 26 | 25 | 3 | 9 | 41 | 32 | 3 | 2 | |
Below cutoff | 2 | 2 |
RefSeq Transcripts | NM_001271193 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_008764024 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017593400 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AAHX01039695 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AAHX01039696 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AAHX01039697 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AAHX01039698 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AAHX01039699 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AC125765 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001271193 ⟹ NP_001258122 | |||||||||||||||||||
RefSeq Status: | VALIDATED | |||||||||||||||||||
Type: | CODING | |||||||||||||||||||
Position: |
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Sequence: |
GACCCGGGAGAGCGAAAAGCGGCGGCGGCGGGGCGGCTGGAGGGTCCCGGAGGTGCGCGCGTCAhide sequence |
RefSeq Acc Id: | XM_008764024 ⟹ XP_008762246 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
AAAAATAAAAAAATAAAATAAATAAATTTTCACCGATTTCGTCATATGCTTTGCCATTTTTCAGhide sequence |
RefSeq Acc Id: | XM_017593400 ⟹ XP_017448889 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
ATGAATAATTAGAAGCTCAGAGGACTGGAAGTGAAGTTTCTGCCACTGCCTTTTACAAAGCACAhide sequence |
Protein RefSeqs | NP_001258122 | (Get FASTA) | NCBI Sequence Viewer |
XP_008762246 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017448889 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001258122 ⟸ NM_001271193 |
- UniProtKB: | F1LUS2 (UniProtKB/TrEMBL) |
- Sequence: |
MEIGSAGPIGAQPLLIVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNRhide sequence |
RefSeq Acc Id: | XP_008762246 ⟸ XM_008764024 |
- Peptide Label: | isoform X1 |
- Sequence: |
MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQhide sequence |
RefSeq Acc Id: | XP_017448889 ⟸ XM_017593400 |
- Peptide Label: | isoform X1 |
- Sequence: |
MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQhide sequence |
RGD ID: | 13694036 | |||||||||
Promoter ID: | EPDNEW_R4561 | |||||||||
Type: | single initiation site | |||||||||
Name: | Ago3_1 | |||||||||
Description: | argonaute 3, RISC catalytic component | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
5 | 144386012 | 144386013 | G | C | snv | MR/N (MCW) |
5 | 144386013 | 144386014 | C | G | snv | MR/N (MCW) |
Database | Acc Id | Source(s) |
AGR Gene | RGD:1309163 | AgrOrtholog |
Ensembl Genes | ENSRNOG00000034269 | ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000050518 | ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000042371 | ENTREZGENE, UniProtKB/TrEMBL |
Gene3D-CATH | 3.30.420.10 | UniProtKB/TrEMBL |
InterPro | AGO3 | UniProtKB/TrEMBL |
ArgoL2 | UniProtKB/TrEMBL | |
Argonaute_Mid_dom | UniProtKB/TrEMBL | |
Argonaute_N | UniProtKB/TrEMBL | |
DUF1785 | UniProtKB/TrEMBL | |
PAZ | UniProtKB/TrEMBL | |
PAZ_dom_sf | UniProtKB/TrEMBL | |
Piwi | UniProtKB/TrEMBL | |
RNaseH-like_dom | UniProtKB/TrEMBL | |
RNaseH_sf | UniProtKB/TrEMBL | |
KEGG Report | rno:313593 | UniProtKB/TrEMBL |
NCBI Gene | 313593 | ENTREZGENE |
Pfam | ArgoL2 | UniProtKB/TrEMBL |
ArgoMid | UniProtKB/TrEMBL | |
ArgoN | UniProtKB/TrEMBL | |
DUF1785 | UniProtKB/TrEMBL | |
PAZ | UniProtKB/TrEMBL | |
Piwi | UniProtKB/TrEMBL | |
PhenoGen | Ago3 | PhenoGen |
PROSITE | PAZ | UniProtKB/TrEMBL |
PIWI | UniProtKB/TrEMBL | |
SMART | DUF1785 | UniProtKB/TrEMBL |
PAZ | UniProtKB/TrEMBL | |
Piwi | UniProtKB/TrEMBL | |
Superfamily-SCOP | PAZ | UniProtKB/TrEMBL |
RNaseH_fold | UniProtKB/TrEMBL | |
UniGene | Rn.92025 | ENTREZGENE |
UniProt | F1LUS2 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2018-12-04 | Ago3 | argonaute RISC catalytic component 3 | Ago3 | argonaute 3, RISC catalytic component | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2015-12-02 | Ago3 | argonaute 3, RISC catalytic component | Ago3 | argonaute RISC catalytic component 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2013-02-22 | Ago3 | argonaute RISC catalytic component 3 | Eif2c3 | eukaryotic translation initiation factor 2C, 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-04-30 | Eif2c3 | eukaryotic translation initiation factor 2C, 3 | Eif2c3_predicted | eukaryotic translation initiation factor 2C, 3 (predicted) | 'predicted' is removed | 2292626 | APPROVED |
2005-01-12 | Eif2c3_predicted | eukaryotic translation initiation factor 2C, 3 (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |
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More on Ago3 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
RGD Object Information | |
RGD ID: | 1309163 |
Created: | 2005-01-12 |
Species: | Rattus norvegicus |
Last Modified: | 2019-11-27 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.