Gale (UDP-galactose-4-epimerase) - Rat Genome Database

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Gene: Gale (UDP-galactose-4-epimerase) Rattus norvegicus
Analyze
Symbol: Gale
Name: UDP-galactose-4-epimerase
RGD ID: 621493
Description: Predicted to enable UDP-glucose 4-epimerase activity and protein homodimerization activity. Predicted to be involved in galactose catabolic process via UDP-galactose, Leloir pathway. Predicted to act upstream of or within galactose metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase); PARTICIPATES IN galactokinase deficiency pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: galactose-4-epimerase, UDP; galactowaldenase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-glucose 4-epimerase; UDP-N-acetylglucosamine 4-epimerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,477,420 - 153,481,926 (+)NCBIGRCr8
mRatBN7.25148,193,886 - 148,198,392 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,194,791 - 148,198,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5150,892,892 - 150,897,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,667,161 - 152,671,664 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,649,173 - 152,653,676 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,310,453 - 154,314,959 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,310,453 - 154,314,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,075,304 - 158,079,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,745,853 - 154,750,357 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15154,757,427 - 154,760,391 (+)NCBI
Celera5146,600,743 - 146,605,247 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(-)-lariciresinol  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
dTDP  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
folic acid  (ISO)
folpet  (ISO)
glafenine  (EXP)
inulin  (ISO)
ivermectin  (ISO)
lovastatin  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
UDP-alpha-D-galactose  (ISO)
UDP-alpha-D-glucose  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
UDP-D-galactose  (ISO)
UDP-D-glucose  (ISO)
UDP-N-acetyl-alpha-D-galactosamine  (ISO)
urethane  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. cDNA from rat cells with reconstitutive galactose-epimerase activity in E. coli. Zeschnigk M, etal., Nucleic Acids Res 1990 Sep 11;18(17):5289.
Additional References at PubMed
PMID:12477932   PMID:14741191   PMID:15175331   PMID:16189514   PMID:16302980   PMID:23376485   PMID:25416956   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Gale
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,477,420 - 153,481,926 (+)NCBIGRCr8
mRatBN7.25148,193,886 - 148,198,392 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,194,791 - 148,198,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5150,892,892 - 150,897,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05152,667,161 - 152,671,664 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05152,649,173 - 152,653,676 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,310,453 - 154,314,959 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,310,453 - 154,314,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,075,304 - 158,079,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,745,853 - 154,750,357 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15154,757,427 - 154,760,391 (+)NCBI
Celera5146,600,743 - 146,605,247 (+)NCBICelera
Cytogenetic Map5q36NCBI
GALE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,795,599 - 23,800,754 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,795,599 - 23,800,781 (-)EnsemblGRCh38hg38GRCh38
GRCh37124,122,089 - 24,127,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,994,676 - 23,999,881 (-)NCBINCBI36Build 36hg18NCBI36
Build 34123,867,394 - 23,872,600NCBI
Celera122,451,653 - 22,456,862 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef122,373,666 - 22,378,871 (-)NCBIHuRef
CHM1_1124,234,878 - 24,240,083 (-)NCBICHM1_1
T2T-CHM13v2.0123,630,574 - 23,635,729 (-)NCBIT2T-CHM13v2.0
Gale
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,690,550 - 135,695,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,691,038 - 135,695,489 (+)EnsemblGRCm39 Ensembl
GRCm384135,963,681 - 135,968,178 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,963,727 - 135,968,178 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,521,080 - 135,524,093 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,237,241 - 135,240,254 (+)NCBIMGSCv36mm8
Celera4134,166,296 - 134,169,303 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.29NCBI
Gale
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,713,080 - 3,718,425 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,715,107 - 3,719,288 (-)NCBIChiLan1.0ChiLan1.0
GALE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,140,293 - 203,145,510 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,243,277 - 202,248,475 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,987,218 - 22,992,416 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,971,454 - 23,976,648 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,971,454 - 23,976,500 (-)Ensemblpanpan1.1panPan2
GALE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,704,012 - 75,708,206 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,704,558 - 75,708,169 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,273,414 - 72,278,306 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,262,612 - 76,267,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,263,323 - 76,267,499 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,084,965 - 73,089,857 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,091,618 - 74,096,497 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,097,212 - 75,102,105 (+)NCBIUU_Cfam_GSD_1.0
Gale
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,125,032 - 43,129,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,949,798 - 8,954,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,949,814 - 8,954,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GALE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,605,968 - 81,610,473 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1681,605,968 - 81,610,535 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,416,319 - 75,420,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GALE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,883,796 - 108,889,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20108,886,161 - 108,892,562 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660337,445,136 - 7,450,240 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gale
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,344,179 - 8,348,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247648,344,180 - 8,348,549 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gale
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:113
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000013322
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013322   ⟹   ENSRNOP00000013322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,194,791 - 148,198,388 (+)Ensembl
Rnor_6.0 Ensembl5154,310,453 - 154,314,955 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084085   ⟹   ENSRNOP00000069728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5154,311,998 - 154,314,627 (+)Ensembl
RefSeq Acc Id: NM_080783   ⟹   NP_542961
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,477,420 - 153,481,924 (+)NCBI
mRatBN7.25148,193,886 - 148,198,390 (+)NCBI
Rnor_6.05154,310,453 - 154,314,957 (+)NCBI
Rnor_5.05158,075,304 - 158,079,822 (+)NCBI
RGSC_v3.45154,745,853 - 154,750,357 (+)RGD
Celera5146,600,743 - 146,605,247 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239134   ⟹   XP_006239196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,478,100 - 153,481,926 (+)NCBI
mRatBN7.25148,194,518 - 148,198,392 (+)NCBI
Rnor_6.05154,310,503 - 154,314,959 (+)NCBI
Rnor_5.05158,075,304 - 158,079,822 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109133   ⟹   XP_038965061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,478,563 - 153,481,926 (+)NCBI
mRatBN7.25148,195,025 - 148,198,392 (+)NCBI
RefSeq Acc Id: XM_039109134   ⟹   XP_038965062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,479,789 - 153,481,926 (+)NCBI
mRatBN7.25148,195,741 - 148,198,392 (+)NCBI
RefSeq Acc Id: XM_063287063   ⟹   XP_063143133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85153,477,495 - 153,480,298 (+)NCBI
RefSeq Acc Id: NP_542961   ⟸   NM_080783
- UniProtKB: P18645 (UniProtKB/Swiss-Prot),   Q4QRB0 (UniProtKB/TrEMBL),   F7EKL8 (UniProtKB/TrEMBL),   A0A9K3Y6V3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239196   ⟸   XM_006239134
- Peptide Label: isoform X2
- UniProtKB: P18645 (UniProtKB/Swiss-Prot),   Q4QRB0 (UniProtKB/TrEMBL),   F7EKL8 (UniProtKB/TrEMBL),   A0A9K3Y6V3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013322   ⟸   ENSRNOT00000013322
Ensembl Acc Id: ENSRNOP00000069728   ⟸   ENSRNOT00000084085
RefSeq Acc Id: XP_038965061   ⟸   XM_039109133
- Peptide Label: isoform X1
- UniProtKB: P18645 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038965062   ⟸   XM_039109134
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143133   ⟸   XM_063287063
- Peptide Label: isoform X4
Protein Domains
NAD(P)-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18645-F1-model_v2 AlphaFold P18645 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694163
Promoter ID:EPDNEW_R4687
Type:multiple initiation site
Name:Gale_1
Description:UDP-galactose-4-epimerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05154,310,444 - 154,310,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621493 AgrOrtholog
BioCyc Gene G2FUF-39522 BioCyc
BioCyc Pathway PWY-7344 [UDP-alpha-D-galactose biosynthesis] BioCyc
BioCyc Pathway Image PWY-7344 BioCyc
Ensembl Genes ENSRNOG00000009712 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013322 ENTREZGENE
  ENSRNOT00000131247 ENTREZGENE
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
  UDP-galactose 4-epimerase, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7443707 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  UDP_G4E UniProtKB/Swiss-Prot
MGC_CLONE MGC:114277 IMAGE-MGC_LOAD
NCBI Gene 114860 ENTREZGENE
PANTHER UDP-GLUCOSE 4-EPIMERASE UniProtKB/Swiss-Prot
  UDP-GLUCOSE 4-EPIMERASE UniProtKB/Swiss-Prot
Pfam GDP_Man_Dehyd UniProtKB/Swiss-Prot
PhenoGen Gale PhenoGen
PRINTS NUCEPIMERASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009712 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A9K3Y6V3 ENTREZGENE, UniProtKB/TrEMBL
  A6IT84_RAT UniProtKB/TrEMBL
  A6IT85_RAT UniProtKB/TrEMBL
  F7EKL8 ENTREZGENE
  GALE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRB0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Gale  UDP-galactose-4-epimerase  Gale  galactose-4-epimerase, UDP  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gale  galactose-4-epimerase, UDP      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Gale        Symbol and Name status set to provisional 70820 PROVISIONAL