Epha2 (Eph receptor A2) - Rat Genome Database

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Gene: Epha2 (Eph receptor A2) Rattus norvegicus
Analyze
Symbol: Epha2
Name: Eph receptor A2
RGD ID: 1307204
Description: Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; mammary gland epithelium development; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Predicted to be located in several cellular components, including focal adhesion; lamellipodium; and tight junction. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ephrin receptor EphA2; ephrin type-A receptor 2; LOC366492
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,888,629 - 158,917,100 (+)NCBIGRCr8
mRatBN7.25153,605,644 - 153,634,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,605,644 - 153,634,117 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,294,648 - 156,322,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,067,931 - 158,096,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,057,120 - 158,085,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,845,773 - 159,874,203 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,558,669 - 163,586,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,185,143 - 160,214,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,190,327 - 160,224,048 (+)NCBI
Celera5151,971,932 - 152,000,092 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antimonite  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cholanic acid  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
fenamidone  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
propiconazole  (EXP)
prothioconazole  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axial mesoderm formation  (ISO)
axon guidance  (IEA)
blood vessel development  (ISO)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
blood vessel morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
cAMP metabolic process  (ISO)
cell chemotaxis  (ISO)
cell migration  (ISO)
cell motility  (ISO)
defense response to Gram-positive bacterium  (ISO)
ephrin receptor signaling pathway  (ISO)
inflammatory response  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
keratinocyte differentiation  (ISO)
lens fiber cell morphogenesis  (ISO)
mammary gland epithelial cell proliferation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of lymphangiogenesis  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
neural tube development  (ISO)
neuron differentiation  (ISO)
notochord cell development  (ISO)
notochord formation  (ISO)
notochord morphogenesis  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
pericyte cell differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of bicellular tight junction assembly  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
post-anal tail morphogenesis  (ISO)
protein localization to plasma membrane  (ISO)
regulation of angiogenesis  (ISO)
regulation of blood vessel endothelial cell migration  (ISO)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of lamellipodium assembly  (ISO)
response to growth factor  (ISO)
skeletal system development  (ISO)
vasculogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases. Balwin C, etal., Am J Physiol Renal Physiol. 2006 May 30;.
2. Semiquantitative expression analysis of ephrine-receptor tyrosine kinase mRNA's in a rat model of traumatic brain injury. Biervert C, etal., Neurosci Lett. 2001 Nov 23;315(1-2):25-8.
3. Inhibition of retinal neovascularization by soluble EphA2 receptor. Chen J, etal., Exp Eye Res. 2006 Apr;82(4):664-73. Epub 2005 Dec 15.
4. Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist. Dobrzanski P, etal., Cancer Res. 2004 Feb 1;64(3):910-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. PTIP Inhibits Cell Invasion in Esophageal Squamous Cell Carcinoma via Modulation of EphA2 Expression. Han X, etal., Front Oncol. 2021 Mar 23;11:629916. doi: 10.3389/fonc.2021.629916. eCollection 2021.
8. Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats. Ivanov AI, etal., Physiol Genomics. 2005 Apr 14;21(2):152-60. Epub 2005 Jan 25.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo. Xu H, etal., Am J Physiol Renal Physiol. 2005 Apr;288(4):F855-66. Epub 2004 Nov 23.
Additional References at PubMed
PMID:10655584   PMID:11287184   PMID:14988728   PMID:15145949   PMID:16782872   PMID:18339848   PMID:18387945   PMID:18794797   PMID:18948590   PMID:19299512   PMID:19321667   PMID:19443703  
PMID:19573808   PMID:19581412   PMID:19684201   PMID:20679435   PMID:20861311   PMID:21423176   PMID:23358419   PMID:25063885   PMID:25468996   PMID:26158630   PMID:27385333   PMID:27733379  
PMID:27815408   PMID:29901110   PMID:30986645   PMID:32721428   PMID:37904187  


Genomics

Comparative Map Data
Epha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,888,629 - 158,917,100 (+)NCBIGRCr8
mRatBN7.25153,605,644 - 153,634,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,605,644 - 153,634,117 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,294,648 - 156,322,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,067,931 - 158,096,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,057,120 - 158,085,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,845,773 - 159,874,203 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,558,669 - 163,586,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,185,143 - 160,214,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,190,327 - 160,224,048 (+)NCBI
Celera5151,971,932 - 152,000,092 (+)NCBICelera
Cytogenetic Map5q36NCBI
EPHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,124,337 - 16,156,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,124,337 - 16,156,069 (-)EnsemblGRCh38hg38GRCh38
GRCh37116,450,832 - 16,482,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,323,419 - 16,355,151 (-)NCBINCBI36Build 36hg18NCBI36
Build 34116,196,138 - 16,227,870NCBI
Celera114,930,817 - 14,962,560 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,968,749 - 15,000,153 (-)NCBIHuRef
CHM1_1116,249,454 - 16,281,203 (-)NCBICHM1_1
T2T-CHM13v2.0115,565,745 - 15,597,465 (-)NCBIT2T-CHM13v2.0
Epha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,028,532 - 141,056,695 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,028,551 - 141,056,695 (+)EnsemblGRCm39 Ensembl
GRCm384141,301,221 - 141,329,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,301,240 - 141,329,384 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,857,155 - 140,885,293 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,573,316 - 140,601,454 (+)NCBIMGSCv36mm8
Celera4143,116,872 - 143,145,199 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.67NCBI
Epha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,120,266 - 2,152,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,120,447 - 2,151,932 (+)NCBIChiLan1.0ChiLan1.0
EPHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,765,451 - 210,798,549 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,014,072 - 210,047,154 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,259,915 - 15,292,983 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,253,509 - 16,284,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,253,513 - 16,284,787 (-)Ensemblpanpan1.1panPan2
EPHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,534,130 - 81,561,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,070,108 - 78,097,636 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,179,960 - 82,207,481 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,179,892 - 82,207,484 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,933,025 - 78,960,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,950,185 - 79,977,704 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,018,093 - 81,045,632 (+)NCBIUU_Cfam_GSD_1.0
Epha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,823,596 - 37,849,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,648,550 - 3,673,861 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,648,395 - 3,673,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,251,467 - 75,279,314 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,251,465 - 75,279,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,567,147 - 69,595,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,147,077 - 116,178,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,147,040 - 116,178,644 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605419,643,306 - 19,675,426 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,264,945 - 2,296,197 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,265,114 - 2,296,032 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epha2
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:117
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000012328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat

Markers in Region
D5Got100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,620,771 - 153,621,110 (+)MAPPERmRatBN7.2
Rnor_6.05159,860,901 - 159,861,239NCBIRnor6.0
Rnor_5.05163,572,796 - 163,573,134UniSTSRnor5.0
RGSC_v3.45160,200,553 - 160,200,892RGDRGSC3.4
RGSC_v3.45160,200,554 - 160,200,892UniSTSRGSC3.4
RGSC_v3.15160,210,742 - 160,211,080RGD
Celera5151,987,032 - 151,987,370UniSTS
RH 3.4 Map51056.0RGD
RH 3.4 Map51056.0UniSTS
Cytogenetic Map5q36UniSTS
D5Uwm47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,632,528 - 153,632,741 (+)MAPPERmRatBN7.2
Rnor_6.05159,872,617 - 159,872,829NCBIRnor6.0
Rnor_5.05163,584,623 - 163,584,832UniSTSRnor5.0
Celera5151,998,494 - 151,998,718UniSTS
Cytogenetic Map5q36UniSTS
D5Got263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,628,841 - 153,629,082 (+)MAPPERmRatBN7.2
Rnor_6.05159,868,930 - 159,869,170NCBIRnor6.0
Rnor_5.05163,580,928 - 163,581,168UniSTSRnor5.0
RGSC_v3.45160,208,526 - 160,208,766UniSTSRGSC3.4
Celera5151,994,909 - 151,995,149UniSTS
Cytogenetic Map5q36UniSTS
AW545284  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,633,602 - 153,633,734 (+)MAPPERmRatBN7.2
Rnor_6.05159,873,691 - 159,873,822NCBIRnor6.0
Rnor_5.05163,585,694 - 163,585,825UniSTSRnor5.0
RGSC_v3.45160,214,215 - 160,214,346UniSTSRGSC3.4
Celera5151,999,580 - 151,999,711UniSTS
Cytogenetic Map5q36UniSTS
RH133479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,633,913 - 153,634,108 (+)MAPPERmRatBN7.2
Rnor_6.05159,874,002 - 159,874,196NCBIRnor6.0
Rnor_5.05163,586,005 - 163,586,199UniSTSRnor5.0
RGSC_v3.45160,214,526 - 160,214,720UniSTSRGSC3.4
Celera5151,999,891 - 152,000,085UniSTS
RH 3.4 Map51056.1UniSTS
Cytogenetic Map5q36UniSTS
BQ200164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,624,363 - 153,624,577 (+)MAPPERmRatBN7.2
Rnor_6.05159,864,452 - 159,864,665NCBIRnor6.0
Rnor_5.05163,576,450 - 163,576,663UniSTSRnor5.0
RGSC_v3.45160,204,048 - 160,204,261UniSTSRGSC3.4
Celera5151,990,431 - 151,990,644UniSTS
RH 3.4 Map51056.1UniSTS
Cytogenetic Map5q36UniSTS
Epha2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,633,275 - 153,633,989 (+)MAPPERmRatBN7.2
Rnor_6.05159,873,364 - 159,874,077NCBIRnor6.0
Rnor_5.05163,585,367 - 163,586,080UniSTSRnor5.0
RGSC_v3.45160,213,888 - 160,214,601UniSTSRGSC3.4
Celera5151,999,253 - 151,999,966UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 10 16 8 8 2 22 25 11
Low 2 33 41 33 19 33 8 11 72 13 14 8
Below cutoff 2

Sequence


RefSeq Acc Id: ENSRNOT00000012328   ⟹   ENSRNOP00000012328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,605,644 - 153,634,115 (+)Ensembl
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106486   ⟹   ENSRNOP00000092464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,611,087 - 153,634,117 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109692   ⟹   ENSRNOP00000079148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,606,610 - 153,634,117 (+)Ensembl
RefSeq Acc Id: NM_001108977   ⟹   NP_001102447
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,888,629 - 158,917,100 (+)NCBI
mRatBN7.25153,605,644 - 153,634,115 (+)NCBI
Rnor_6.05159,845,773 - 159,874,203 (+)NCBI
Rnor_5.05163,558,669 - 163,586,206 (+)NCBI
RGSC_v3.45160,185,143 - 160,214,727 (+)RGD
Celera5151,971,932 - 152,000,092 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102447 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80978 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012328
  ENSRNOP00000012328.5
  ENSRNOP00000079148.1
  ENSRNOP00000092464.1
RefSeq Acc Id: NP_001102447   ⟸   NM_001108977
- Peptide Label: precursor
- UniProtKB: D3ZBN3 (UniProtKB/TrEMBL),   A6ITS7 (UniProtKB/TrEMBL),   A0A8I6ADQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012328   ⟸   ENSRNOT00000012328
RefSeq Acc Id: ENSRNOP00000092464   ⟸   ENSRNOT00000106486
RefSeq Acc Id: ENSRNOP00000079148   ⟸   ENSRNOT00000109692
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBN3-F1-model_v2 AlphaFold D3ZBN3 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694223
Promoter ID:EPDNEW_R4748
Type:single initiation site
Name:Epha2_1
Description:Eph receptor A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05159,845,773 - 159,845,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307204 AgrOrtholog
BioCyc Gene G2FUF-39354 BioCyc
Ensembl Genes ENSRNOG00000009222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012328 ENTREZGENE
  ENSRNOT00000012328.7 UniProtKB/TrEMBL
  ENSRNOT00000106486.1 UniProtKB/TrEMBL
  ENSRNOT00000109692.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphA2_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  Growth_fac_rcpt UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
  Tyr_prot_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_prot_kinase_rcpt_V_CS UniProtKB/TrEMBL
KEGG Report rno:366492 UniProtKB/TrEMBL
NCBI Gene 366492 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 3 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PhenoGen Epha2 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009222 RatGTEx
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
  Grow_fac_recept UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A8I5ZQ88_RAT UniProtKB/TrEMBL
  A0A8I6ADQ0 ENTREZGENE, UniProtKB/TrEMBL
  A6ITS7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Epha2  Eph receptor A2   Epha2_predicted  Eph receptor A2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Epha2_predicted  Eph receptor A2 (predicted)      Symbol and Name status set to approved 70820 APPROVED