Epha2 (Eph receptor A2) - Rat Genome Database

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Gene: Epha2 (Eph receptor A2) Rattus norvegicus
Analyze
Symbol: Epha2
Name: Eph receptor A2
RGD ID: 1307204
Description: Predicted to have transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including animal organ development; blood vessel morphogenesis; and intracellular signal transduction. Predicted to localize to several cellular components, including focal adhesion; lamellipodium; and tight junction. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ephrin receptor EphA2; ephrin type-A receptor 2; LOC366492
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25153,605,644 - 153,634,115 (+)NCBI
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05159,845,773 - 159,874,203 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05163,558,669 - 163,586,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,185,143 - 160,214,727 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15160,190,327 - 160,224,048 (+)NCBI
Celera5151,971,932 - 152,000,092 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cholanic acid  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenamidone  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
orphenadrine  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
axial mesoderm formation  (ISO)
axon guidance  (IBA)
blood vessel development  (ISO)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
blood vessel morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
cAMP metabolic process  (ISO)
cell chemotaxis  (ISO)
cell migration  (ISO)
cell motility  (ISO)
defense response to Gram-positive bacterium  (ISO)
ephrin receptor signaling pathway  (ISO)
inflammatory response  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
keratinocyte differentiation  (ISO)
lens fiber cell morphogenesis  (ISO)
mammary gland epithelial cell proliferation  (ISO)
multicellular organism development  (IBA)
negative regulation of angiogenesis  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of lymphangiogenesis  (ISO)
negative regulation of protein kinase B signaling  (ISO)
neural tube development  (ISO)
neuron differentiation  (ISO)
notochord cell development  (ISO)
notochord formation  (ISO)
notochord morphogenesis  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
peptidyl-tyrosine phosphorylation  (IEA)
pericyte cell differentiation  (ISO)
positive regulation of bicellular tight junction assembly  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of protein localization to plasma membrane  (ISO)
post-anal tail morphogenesis  (ISO)
protein kinase B signaling  (ISO)
protein localization to plasma membrane  (ISO)
regulation of angiogenesis  (ISO)
regulation of blood vessel endothelial cell migration  (ISO)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of lamellipodium assembly  (ISO)
response to growth factor  (ISO)
skeletal system development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vasculogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10655584   PMID:11287184   PMID:14988728   PMID:15145949   PMID:16782872   PMID:18339848   PMID:18387945   PMID:18794797   PMID:18948590   PMID:19299512   PMID:19321667   PMID:19443703  
PMID:19573808   PMID:19581412   PMID:19684201   PMID:20679435   PMID:20861311   PMID:21423176   PMID:23358419   PMID:25063885   PMID:25468996   PMID:26158630   PMID:27385333   PMID:27733379  
PMID:27815408   PMID:29901110   PMID:30986645  


Genomics

Comparative Map Data
Epha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25153,605,644 - 153,634,115 (+)NCBI
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05159,845,773 - 159,874,203 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05163,558,669 - 163,586,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,185,143 - 160,214,727 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15160,190,327 - 160,224,048 (+)NCBI
Celera5151,971,932 - 152,000,092 (+)NCBICelera
Cytogenetic Map5q36NCBI
EPHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl116,124,337 - 16,156,069 (-)EnsemblGRCh38hg38GRCh38
GRCh38116,124,337 - 16,156,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,450,832 - 16,482,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,323,419 - 16,355,151 (-)NCBINCBI36hg18NCBI36
Build 34116,196,138 - 16,227,870NCBI
Celera114,930,817 - 14,962,560 (-)NCBI
Cytogenetic Map1p36.13NCBI
HuRef114,968,749 - 15,000,153 (-)NCBIHuRef
CHM1_1116,249,454 - 16,281,203 (-)NCBICHM1_1
Epha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,028,532 - 141,056,695 (+)NCBIGRCm39mm39
GRCm39 Ensembl4141,028,551 - 141,056,695 (+)Ensembl
GRCm384141,301,221 - 141,329,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,301,240 - 141,329,384 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,857,155 - 140,885,293 (+)NCBIGRCm37mm9NCBIm37
MGSCv364140,573,316 - 140,601,454 (+)NCBImm8
Celera4143,116,872 - 143,145,199 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.67NCBI
Epha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,120,266 - 2,152,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,120,447 - 2,151,932 (+)NCBIChiLan1.0ChiLan1.0
EPHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,253,509 - 16,284,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,253,513 - 16,284,787 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0115,259,915 - 15,292,983 (-)NCBIMhudiblu_PPA_v0panPan3
EPHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,534,130 - 81,561,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,534,125 - 81,561,725 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,070,108 - 78,097,636 (+)NCBI
ROS_Cfam_1.0282,179,960 - 82,207,481 (+)NCBI
UMICH_Zoey_3.1278,933,025 - 78,960,551 (+)NCBI
UNSW_CanFamBas_1.0279,950,185 - 79,977,704 (+)NCBI
UU_Cfam_GSD_1.0281,018,093 - 81,045,632 (+)NCBI
Epha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,823,596 - 37,849,129 (-)NCBI
SpeTri2.0NW_0049364743,648,395 - 3,673,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,251,467 - 75,279,314 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,251,465 - 75,279,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,567,147 - 69,595,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,147,077 - 116,178,647 (+)NCBI
ChlSab1.1 Ensembl20116,147,040 - 116,178,644 (+)Ensembl
Epha2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,265,114 - 2,296,032 (-)NCBI

Position Markers
D5Got100  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,620,771 - 153,621,110 (+)MAPPER
Rnor_6.05159,860,901 - 159,861,239NCBIRnor6.0
Rnor_5.05163,572,796 - 163,573,134UniSTSRnor5.0
RGSC_v3.45160,200,553 - 160,200,892RGDRGSC3.4
RGSC_v3.45160,200,554 - 160,200,892UniSTSRGSC3.4
RGSC_v3.15160,210,742 - 160,211,080RGD
Celera5151,987,032 - 151,987,370UniSTS
RH 3.4 Map51056.0RGD
RH 3.4 Map51056.0UniSTS
Cytogenetic Map5q36UniSTS
D5Uwm47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,632,528 - 153,632,741 (+)MAPPER
Rnor_6.05159,872,617 - 159,872,829NCBIRnor6.0
Rnor_5.05163,584,623 - 163,584,832UniSTSRnor5.0
Celera5151,998,494 - 151,998,718UniSTS
Cytogenetic Map5q36UniSTS
D5Got263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,628,841 - 153,629,082 (+)MAPPER
Rnor_6.05159,868,930 - 159,869,170NCBIRnor6.0
Rnor_5.05163,580,928 - 163,581,168UniSTSRnor5.0
RGSC_v3.45160,208,526 - 160,208,766UniSTSRGSC3.4
Celera5151,994,909 - 151,995,149UniSTS
Cytogenetic Map5q36UniSTS
AW545284  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,633,602 - 153,633,734 (+)MAPPER
Rnor_6.05159,873,691 - 159,873,822NCBIRnor6.0
Rnor_5.05163,585,694 - 163,585,825UniSTSRnor5.0
RGSC_v3.45160,214,215 - 160,214,346UniSTSRGSC3.4
Celera5151,999,580 - 151,999,711UniSTS
Cytogenetic Map5q36UniSTS
RH133479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,633,913 - 153,634,108 (+)MAPPER
Rnor_6.05159,874,002 - 159,874,196NCBIRnor6.0
Rnor_5.05163,586,005 - 163,586,199UniSTSRnor5.0
RGSC_v3.45160,214,526 - 160,214,720UniSTSRGSC3.4
Celera5151,999,891 - 152,000,085UniSTS
RH 3.4 Map51056.1UniSTS
Cytogenetic Map5q36UniSTS
BQ200164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,624,363 - 153,624,577 (+)MAPPER
Rnor_6.05159,864,452 - 159,864,665NCBIRnor6.0
Rnor_5.05163,576,450 - 163,576,663UniSTSRnor5.0
RGSC_v3.45160,204,048 - 160,204,261UniSTSRGSC3.4
Celera5151,990,431 - 151,990,644UniSTS
RH 3.4 Map51056.1UniSTS
Cytogenetic Map5q36UniSTS
Epha2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,633,275 - 153,633,989 (+)MAPPER
Rnor_6.05159,873,364 - 159,874,077NCBIRnor6.0
Rnor_5.05163,585,367 - 163,586,080UniSTSRnor5.0
RGSC_v3.45160,213,888 - 160,214,601UniSTSRGSC3.4
Celera5151,999,253 - 151,999,966UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116767924161767924Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116767924161767924Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116767924161767924Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116767924161767924Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5149568588167739697Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149832180164807402Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5150340838164298744Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5150360936167946134Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5157212422167739539Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5157319671171194163Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5157319671173707219Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:117
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000012328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 10 16 8 8 2 22 25 11
Low 2 33 41 33 19 33 8 11 72 13 14 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012328   ⟹   ENSRNOP00000012328
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5159,845,774 - 159,874,206 (+)Ensembl
RefSeq Acc Id: NM_001108977   ⟹   NP_001102447
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25153,605,644 - 153,634,115 (+)NCBI
Rnor_6.05159,845,773 - 159,874,203 (+)NCBI
Rnor_5.05163,558,669 - 163,586,206 (+)NCBI
RGSC_v3.45160,185,143 - 160,214,727 (+)RGD
Celera5151,971,932 - 152,000,092 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102447 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80978 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102447   ⟸   NM_001108977
- Peptide Label: precursor
- UniProtKB: D3ZBN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012328   ⟸   ENSRNOT00000012328
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694223
Promoter ID:EPDNEW_R4748
Type:single initiation site
Name:Epha2_1
Description:Eph receptor A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05159,845,773 - 159,845,833EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307204 AgrOrtholog
Ensembl Genes ENSRNOG00000009222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012328 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012328 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.120.260 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphA2_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  Growth_fac_rcpt UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
  Tyr_prot_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_prot_kinase_rcpt_V_CS UniProtKB/TrEMBL
KEGG Report rno:366492 UniProtKB/TrEMBL
NCBI Gene 366492 ENTREZGENE
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PhenoGen Epha2 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
  Grow_fac_recept UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt D3ZBN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Epha2  Eph receptor A2   Epha2_predicted  Eph receptor A2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Epha2_predicted  Eph receptor A2 (predicted)      Symbol and Name status set to approved 70820 APPROVED