Gja4 (gap junction protein, alpha 4) - Rat Genome Database

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Gene: Gja4 (gap junction protein, alpha 4) Rattus norvegicus
Analyze
Symbol: Gja4
Name: gap junction protein, alpha 4
RGD ID: 2691
Description: Predicted to enable gap junction channel activity. Involved in several processes, including calcium ion transport; endothelium development; and response to pain. Located in gap junction. Part of connexin complex. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human GJA4 (gap junction protein alpha 4); PARTICIPATES IN connexin signaling pathway; INTERACTS WITH (S)-nicotine; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: connexin h1; connexin-37; cx37; CXN37; Cxnh1; gap junction alpha-4 protein; gap junction membrane channel protein alpha 4; Gap junction membrane channel protein alpha 4 (connexin 37); Gap junction membrane channel, protein alpha 4 (connexin 37)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,917,791 - 144,920,324 (-)NCBIGRCr8
mRatBN7.25139,633,324 - 139,635,857 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,633,287 - 139,635,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,328,532 - 142,331,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05144,098,526 - 144,101,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05144,099,313 - 144,101,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,374,688 - 145,377,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,374,690 - 145,377,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05149,142,702 - 149,145,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,755,061 - 146,757,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15146,765,101 - 146,767,633 (-)NCBI
Celera5138,127,254 - 138,129,787 (-)NCBICelera
RH 3.4 Map5934.8RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-carnitine  (ISO)
(S)-nicotine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
astragaloside IV  (ISO)
atenolol  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cyclophosphamide  (ISO)
diarsenic trioxide  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
fonofos  (ISO)
gentamycin  (EXP)
lycopene  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
resveratrol  (EXP,ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
connexin complex  (IBA,IDA)
gap junction  (IDA,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries. Earley S, etal., Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2677-86. Epub 2004 Aug 19.
2. Connexins: gaps in our knowledge of vascular function. Figueroa XF, etal., Physiology (Bethesda). 2004 Oct;19:277-84.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Induction of connexin 37 expression in a rat model of neuropathic pain. Lin SH, etal., Brain Res Mol Brain Res 2002 Mar 28;99(2):134-40.
8. Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily. Listi F, etal., Int J Cardiol. 2005 Jul 10;102(2):269-71.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Connexin37 is the major connexin expressed in the media of caudal artery. Rummery NM, etal., Arterioscler Thromb Vasc Biol 2002 Sep 1;22(9):1427-32.
15. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions. Vrionis FD, etal., Gene Ther. 1997 Jun;4(6):577-85.
19. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
20. Multiple connexin expression in regenerating arterial endothelial gap junctions. Yeh HI, etal., Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1753-62.
21. Individual gap junction plaques contain multiple connexins in arterial endothelium. Yeh HI, etal., Circ Res. 1998 Dec 14-28;83(12):1248-63.
22. Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. Yeh HI, etal., J Histochem Cytochem. 2000 Oct;48(10):1377-89.
Additional References at PubMed
PMID:12435353   PMID:15016632   PMID:15489334   PMID:17928514   PMID:19129462   PMID:19828678   PMID:20805582   PMID:24133065   PMID:24269759   PMID:25217644   PMID:28818996   PMID:29049831  
PMID:32350069  


Genomics

Comparative Map Data
Gja4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,917,791 - 144,920,324 (-)NCBIGRCr8
mRatBN7.25139,633,324 - 139,635,857 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,633,287 - 139,635,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,328,532 - 142,331,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05144,098,526 - 144,101,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05144,099,313 - 144,101,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,374,688 - 145,377,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,374,690 - 145,377,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05149,142,702 - 149,145,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,755,061 - 146,757,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15146,765,101 - 146,767,633 (-)NCBI
Celera5138,127,254 - 138,129,787 (-)NCBICelera
RH 3.4 Map5934.8RGD
Cytogenetic Map5q36NCBI
GJA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,792,999 - 34,795,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,792,999 - 34,795,747 (+)EnsemblGRCh38hg38GRCh38
GRCh37135,258,600 - 35,261,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36135,031,186 - 35,033,935 (+)NCBINCBI36Build 36hg18NCBI36
Build 34134,927,714 - 34,930,439NCBI
Celera133,532,323 - 33,535,072 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,376,201 - 33,378,950 (+)NCBIHuRef
CHM1_1135,374,168 - 35,376,917 (+)NCBICHM1_1
T2T-CHM13v2.0134,655,628 - 34,658,374 (+)NCBIT2T-CHM13v2.0
Gja4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,205,213 - 127,207,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,205,214 - 127,207,832 (-)EnsemblGRCm39 Ensembl
GRCm384127,311,420 - 127,314,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,311,421 - 127,314,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,988,665 - 126,991,222 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,813,725 - 126,816,282 (-)NCBIMGSCv36mm8
Celera4125,645,767 - 125,648,324 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.47NCBI
Gja4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545212,902,773 - 12,905,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545212,902,764 - 12,905,337 (+)NCBIChiLan1.0ChiLan1.0
GJA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,050,029 - 192,052,939 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,171,197 - 191,174,108 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,059,901 - 34,063,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,241,402 - 35,244,191 (+)NCBIpanpan1.1PanPan1.1panPan2
GJA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,167,665 - 7,170,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gja4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,613,628 - 51,616,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,439,327 - 17,440,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,439,250 - 17,440,829 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,045,394 - 91,048,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,045,430 - 91,048,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12098,092,282 - 98,095,036 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2098,092,785 - 98,093,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603318,746,427 - 18,749,170 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476417,836,180 - 17,845,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476417,842,566 - 17,845,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gja4
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:189
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000019246
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH94392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,633,329 - 139,633,503 (+)MAPPERmRatBN7.2
Rnor_6.05145,374,694 - 145,374,867NCBIRnor6.0
Rnor_5.05149,142,708 - 149,142,881UniSTSRnor5.0
RGSC_v3.45146,755,067 - 146,755,240UniSTSRGSC3.4
Celera5138,127,260 - 138,127,433UniSTS
RH 3.4 Map5934.8UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:226049  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,633,824 - 139,634,191 (+)MAPPERmRatBN7.2
Rnor_6.05145,375,189 - 145,375,555NCBIRnor6.0
Rnor_5.05149,143,203 - 149,143,569UniSTSRnor5.0
RGSC_v3.45146,755,562 - 146,755,928UniSTSRGSC3.4
Celera5138,127,755 - 138,128,121UniSTS
Cytogenetic Map5q36UniSTS
RH134065  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,633,369 - 139,634,557 (+)MAPPERmRatBN7.2
Rnor_6.05145,374,734 - 145,375,921NCBIRnor6.0
Rnor_5.05149,142,748 - 149,143,935UniSTSRnor5.0
RGSC_v3.45146,755,107 - 146,756,294UniSTSRGSC3.4
Celera5138,127,300 - 138,128,487UniSTS
Cytogenetic Map5q36UniSTS
PMC197251P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,634,422 - 139,634,748 (+)MAPPERmRatBN7.2
Rnor_6.05145,375,787 - 145,376,112NCBIRnor6.0
Rnor_5.05149,143,801 - 149,144,126UniSTSRnor5.0
RGSC_v3.45146,756,160 - 146,756,485UniSTSRGSC3.4
Celera5138,128,353 - 138,128,678UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 1 1 1 18 20 30 11 1
Low 3 10 57 41 18 41 7 10 56 15 11 7
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000019246   ⟹   ENSRNOP00000019246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5139,633,287 - 139,635,925 (-)Ensembl
Rnor_6.0 Ensembl5145,374,690 - 145,377,221 (-)Ensembl
RefSeq Acc Id: NM_021654   ⟹   NP_067686
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,917,791 - 144,920,324 (-)NCBI
mRatBN7.25139,633,324 - 139,635,857 (-)NCBI
Rnor_6.05145,374,688 - 145,377,221 (-)NCBI
Rnor_5.05149,142,702 - 149,145,235 (-)NCBI
RGSC_v3.45146,755,061 - 146,757,594 (-)RGD
Celera5138,127,254 - 138,129,787 (-)RGD
Sequence:
RefSeq Acc Id: NP_067686   ⟸   NM_021654
- UniProtKB: Q03190 (UniProtKB/Swiss-Prot),   A0A654IEV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019246   ⟸   ENSRNOT00000019246
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03190-F1-model_v2 AlphaFold Q03190 1-333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694049
Promoter ID:EPDNEW_R4574
Type:single initiation site
Name:Gja4_1
Description:gap junction protein, alpha 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05145,377,231 - 145,377,291EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2691 AgrOrtholog
BioCyc Gene G2FUF-39853 BioCyc
Ensembl Genes ENSRNOG00000014357 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028461 UniProtKB/Swiss-Prot
  ENSRNOG00060015995 UniProtKB/Swiss-Prot
  ENSRNOG00065031226 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019246.6 UniProtKB/Swiss-Prot
  ENSRNOT00055049260 UniProtKB/Swiss-Prot
  ENSRNOT00060027384 UniProtKB/Swiss-Prot
  ENSRNOT00065053850 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128770 IMAGE-MGC_LOAD
  IMAGE:7306623 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin37 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105441 IMAGE-MGC_LOAD
  MGC:93465 IMAGE-MGC_LOAD
NCBI Gene 25655 ENTREZGENE
PANTHER GAP JUNCTION ALPHA-4 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gja4 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014357 RatGTEx
  ENSRNOG00055028461 RatGTEx
  ENSRNOG00060015995 RatGTEx
  ENSRNOG00065031226 RatGTEx
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230030
UniProt A0A654IEV1 ENTREZGENE, UniProtKB/TrEMBL
  CXA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 Gja4  gap junction protein, alpha 4  Gja4  gap junction membrane channel protein alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gja4  gap junction membrane channel protein alpha 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression increases in response to sciatic nerve injury 728686