Gja4 (gap junction protein alpha 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gja4 (gap junction protein alpha 4) Heterocephalus glaber
Analyze
Symbol: Gja4
Name: gap junction protein alpha 4
RGD ID: 18925301
Description: ENCODES a protein that exhibits gap junction channel activity (inferred); INVOLVED IN blood vessel development (ortholog); calcium ion transport (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH angiosarcoma (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); coronary artery disease (ortholog); FOUND IN connexin complex (ortholog); gap junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Gap junction alpha-4 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476417,836,180 - 17,845,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476417,842,566 - 17,845,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
connexin complex  (IEA,ISO)
gap junction  (IEA,ISO)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gja4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476417,836,180 - 17,845,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476417,842,566 - 17,845,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GJA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,792,999 - 34,795,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,792,999 - 34,795,747 (+)EnsemblGRCh38hg38GRCh38
GRCh37135,258,600 - 35,261,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36135,031,186 - 35,033,935 (+)NCBINCBI36Build 36hg18NCBI36
Build 34134,927,714 - 34,930,439NCBI
Celera133,532,323 - 33,535,072 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,376,201 - 33,378,950 (+)NCBIHuRef
CHM1_1135,374,168 - 35,376,917 (+)NCBICHM1_1
T2T-CHM13v2.0134,655,628 - 34,658,374 (+)NCBIT2T-CHM13v2.0
Gja4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,205,213 - 127,207,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,205,214 - 127,207,832 (-)EnsemblGRCm39 Ensembl
GRCm384127,311,420 - 127,314,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,311,421 - 127,314,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,988,665 - 126,991,222 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,813,725 - 126,816,282 (-)NCBIMGSCv36mm8
Celera4125,645,767 - 125,648,324 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.47NCBI
Gja4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,917,791 - 144,920,324 (-)NCBIGRCr8
mRatBN7.25139,633,324 - 139,635,857 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,633,287 - 139,635,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,328,532 - 142,331,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05144,098,526 - 144,101,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05144,099,313 - 144,101,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,374,688 - 145,377,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,374,690 - 145,377,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05149,142,702 - 149,145,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,755,061 - 146,757,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15146,765,101 - 146,767,633 (-)NCBI
Celera5138,127,254 - 138,129,787 (-)NCBICelera
RH 3.4 Map5934.8RGD
Cytogenetic Map5q36NCBI
Gja4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545212,902,773 - 12,905,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545212,902,764 - 12,905,337 (+)NCBIChiLan1.0ChiLan1.0
GJA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,050,029 - 192,052,939 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,171,197 - 191,174,108 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,059,901 - 34,063,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,241,402 - 35,244,191 (+)NCBIpanpan1.1PanPan1.1panPan2
GJA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,167,665 - 7,170,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gja4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,613,628 - 51,616,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,439,327 - 17,440,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,439,250 - 17,440,829 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,045,394 - 91,048,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,045,430 - 91,048,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12098,092,282 - 98,095,036 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2098,092,785 - 98,093,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603318,746,427 - 18,749,170 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018093   ⟹   ENSHGLP00000017916
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476417,836,180 - 17,845,011 (+)Ensembl
RefSeq Acc Id: XM_004850913   ⟹   XP_004850970
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476417,842,566 - 17,845,011 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004850970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09493 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017916
  ENSHGLP00000033453
  ENSHGLP00000034646
RefSeq Acc Id: XP_004850970   ⟸   XM_004850913
- UniProtKB: G5BJN2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017916   ⟸   ENSHGLT00000018093


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000018093 ENTREZGENE
  ENSHGLT00000043003 UniProtKB/TrEMBL
  ENSHGLT00000064348 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
InterPro Connexin UniProtKB/TrEMBL
  Connexin37 UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
KEGG Report hgl:101705539 UniProtKB/TrEMBL
NCBI Gene Gja4 ENTREZGENE
PANTHER GAP JUNCTION ALPHA-4 PROTEIN UniProtKB/TrEMBL
  PTHR11984 UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
PRINTS CONNEXIN UniProtKB/TrEMBL
  CONNEXINA4 UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
UniProt G5BJN2 ENTREZGENE, UniProtKB/TrEMBL