RGD Reference Report - Expression of connexins in the normal and obstructed developing kidney. - Rat Genome Database

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Expression of connexins in the normal and obstructed developing kidney.

Authors: Silverstein, DM  Thornhill, BA  Leung, JC  Vehaskari, VM  Craver, RD  Trachtman, HA  Chevalier, RL 
Citation: Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
RGD ID: 7207847
Pubmed: PMID:12644912   (View Abstract at PubMed)
DOI: DOI:10.1007/s00467-002-1065-1   (Journal Full-text)

Connections between cells are achieved by proteins called connexins that comprise the gap junction. Connexins play a major role in organ development. Our reverse transcription-polymerase chain reaction (RT-PCR) studies demonstrate that Cx30, Cx36, Cx37, Cx40, Cx45, Cx46, and Cx50 are expressed in the kidney. Quantitative RT-PCR indicates that Cx37, Cx45, and Cx46 are preferentially expressed during early renal development. We also explored the expression of connexins in neonatal unilateral ureteral obstruction (UUO). After 12 days of neonatal UUO, the renal mRNA expression of Cx30, Cx37, and Cx40 was significantly elevated. In contrast, there was no change in connexin renal mRNA levels in adult UUO. We conclude that multiple connexins are expressed in the rat kidney and several are aberrantly expressed in neonatal UUO.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ureteral obstruction  ISOGja4 (Rattus norvegicus)7207847; 7207847mRNA:increased expression:kidney:RGD 
ureteral obstruction  ISOGja5 (Rattus norvegicus)7207847; 7207847mRNA:increased expression:kidneyRGD 
ureteral obstruction  ISOGjb6 (Rattus norvegicus)7207847; 7207847mRNA:increased expression:kidney:RGD 
ureteral obstruction  IEP 7207847; 7207847mRNA:increased expression:kidney:RGD 
ureteral obstruction  IEP 7207847mRNA:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gja4  (gap junction protein, alpha 4)
Gja5  (gap junction protein, alpha 5)
Gjb6  (gap junction protein, beta 6)

Genes (Mus musculus)
Gja4  (gap junction protein, alpha 4)
Gja5  (gap junction protein, alpha 5)
Gjb6  (gap junction protein, beta 6)

Genes (Homo sapiens)
GJA4  (gap junction protein alpha 4)
GJA5  (gap junction protein alpha 5)
GJB6  (gap junction protein beta 6)


Additional Information