RGD Reference Report - Induction of connexin 37 expression in a rat model of neuropathic pain. - Rat Genome Database

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Induction of connexin 37 expression in a rat model of neuropathic pain.

Authors: Lin, SH  Lu, CY  Muhammad, R  Chou, WY  Lin, FC  Wu, PC  Lin, CR  Yang, LC 
Citation: Lin SH, etal., Brain Res Mol Brain Res 2002 Mar 28;99(2):134-40.
RGD ID: 728686
Pubmed: PMID:11978404   (View Abstract at PubMed)

Activation of cutaneous C-fibers by capsaicin or sciatic nerve transection increases the number of astrocytic gap junctions as well as the levels of connexin 43 in the dorsal horn on the stimulated side. Changes in connexin 37 mRNA expression following nerve injury have not been previously documented. We examined the role of gap junction protein connexin 37 in neuropathic hypersensitivity following peripheral nerve injury. Study results showed ipsilaterally increased connexin 37 mRNA levels proximally and distally in rat sciatic nerves after injury and behavioral thermal hyperalgesia at 7 and 14 days. Proximal and distal connexin 37 mRNA levels returned to baseline by 21 days. Sciatic nerve connexin 37 mRNA increases were proportional to the extent of thermal hyperalgesia, but skin, muscle, and lumbar spinal cord connexin 37 mRNA showed no significant changes. Neuropathic pain relief correlated with downregulation of connexin 37 mRNA. Results indicate that upregulation of connexin 37 mRNA following sciatic nerve injury correlates with subsequent thermal hyperalgesia, which suggests that gap junctions (connexin 37) are responsible for the hyperexcitability following peripheral nerve injury.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gja4Ratresponse to pain  IEP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gja4Ratgap junction  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gja4  (gap junction protein, alpha 4)


Additional Information