GJA4 (gap junction protein alpha 4)

Gene: GJA4 (gap junction protein alpha 4) Pan paniscus

Analyze

Symbol:

GJA4

Name:

gap junction protein alpha 4

RGD ID:

11720959

Description:

INVOLVED IN blood vessel development (ortholog); calcium ion transport (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH angiosarcoma (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); coronary artery disease (ortholog); FOUND IN connexin complex (ortholog); gap junction (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	192,050,029 - 192,052,939 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	191,171,197 - 191,174,108 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	34,059,901 - 34,063,181 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	35,241,402 - 35,244,191 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

angiosarcoma (ISO)

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

coronary artery disease (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hemangioma of liver (ISO)

hypertension (ISO)

multiple cutaneous and mucosal venous malformations (ISO)

myocardial infarction (ISO)

skin hemangioma (ISO)

ureteral obstruction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel development (ISO)

calcium ion transport (ISO)

cell-cell signaling (ISO)

endothelium development (ISO)

response to pain (ISO)

Cellular Component

connexin complex (ISO)

gap junction (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

connexin signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GJA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	192,050,029 - 192,052,939 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	191,171,197 - 191,174,108 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	34,059,901 - 34,063,181 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	35,241,402 - 35,244,191 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

GJA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	34,792,999 - 34,795,747 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	34,792,999 - 34,795,747 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	35,258,600 - 35,261,348 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	35,031,186 - 35,033,935 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	34,927,714 - 34,930,439	NCBI
Celera	1	33,532,323 - 33,535,072 (+)	NCBI		Celera
Cytogenetic Map	1	p34.3	NCBI
HuRef	1	33,376,201 - 33,378,950 (+)	NCBI		HuRef
CHM1_1	1	35,374,168 - 35,376,917 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	34,655,628 - 34,658,374 (+)	NCBI		T2T-CHM13v2.0

Gja4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	127,205,213 - 127,207,832 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	127,205,214 - 127,207,832 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	127,311,420 - 127,314,039 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	127,311,421 - 127,314,039 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	126,988,665 - 126,991,222 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	126,813,725 - 126,816,282 (-)	NCBI		MGSCv36	mm8
Celera	4	125,645,767 - 125,648,324 (-)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	61.47	NCBI

Gja4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	144,917,791 - 144,920,324 (-)	NCBI		GRCr8
mRatBN7.2	5	139,633,324 - 139,635,857 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	139,633,287 - 139,635,925 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	142,328,532 - 142,331,068 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	144,098,526 - 144,101,062 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	144,099,313 - 144,101,849 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	145,374,688 - 145,377,221 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	145,374,690 - 145,377,221 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	149,142,702 - 149,145,235 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	146,755,061 - 146,757,594 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	146,765,101 - 146,767,633 (-)	NCBI
Celera	5	138,127,254 - 138,129,787 (-)	NCBI		Celera
RH 3.4 Map	5	934.8	RGD
Cytogenetic Map	5	q36	NCBI

Gja4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	12,902,773 - 12,905,337 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	12,902,764 - 12,905,337 (+)	NCBI	ChiLan1.0	ChiLan1.0

GJA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	7,167,665 - 7,170,388 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gja4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	51,613,628 - 51,616,047 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	17,439,327 - 17,440,331 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	17,439,250 - 17,440,829 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GJA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	91,045,394 - 91,048,162 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	91,045,430 - 91,048,161 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GJA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	98,092,282 - 98,095,036 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	98,092,785 - 98,093,786 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	18,746,427 - 18,749,170 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gja4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	17,836,180 - 17,845,011 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	17,842,566 - 17,845,011 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014344447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003812551 ⟹ XP_003812599

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	192,050,030 - 192,052,926 (-)	NCBI
NHGRI_mPanPan1	1	191,171,197 - 191,174,095 (-)	NCBI
Mhudiblu_PPA_v0	1	34,059,911 - 34,062,667 (+)	NCBI
PanPan1.1	1	35,241,438 - 35,244,191 (+)	NCBI

Sequence:

show sequence

GGTCCAGCAGGGCTCCCGCGGGCGTCACTCCGGCCATCGTCCCCACCTCCACCTGGGCCGCCCG
GCAGGCAGGCGACGGAGGCCCGGGAGCCATGGGTGACTGGGGCTTCCTGGAGAAGTTGCTGGAC
CAGGTCCAGGAGCACTCGACCGTGGTGGGTAAGATCTGGCTGACGGTGCTCTTCATCTTCCGCA
TCCTCATCCTGGGCCTGGCCGGCGAGTCAGTGTGGGGTGACGAGCAGTCAGATTTCGAGTGTAA
CACGGCCCAGCCAGGCTGCACCAACGTCTGCTATGACCAGGCCTTCCCCATCTCCCACATCCGC
TACTGGGTGCTGCAGTTCCTCTTCGTCAGCACGCCCACCCTGGTCTACCTGGGCCATGTCATTT
ACCTGTCTCGGCGAGAAGAGCGGCTGCGGCAGAAGGAGGGGGAGCTGCGGGCACTGCCGGCCAA
GGACCCACAGGTGGAGCGGGCGCTGGCGGCCGTAGAGCGTCAGATGGCCAAGATCTCGGTGGCA
GAAGATGGTCGCCTGCGCATCCGCGGAGCACTGATGGGCACCTATGTCGCCAGTGTGCTCTGCA
AGAGTGTGCTAGAGGCAGGCTTCCTCTATGGCCAGTGGCGCCTGTACGGCTGGACCATGGAGCC
CGTGTTTGTGTGCCAGCGAGCACCCTGCCCCTACCTCGTGGACTGCTTTGTCTCTCGCCCCACG
GAGAAGACCATCTTCATCATCTTCATGTTGGTGGTTGGACTCATCTCCCTGGTGCTTAACCTGC
TGGAGTTGGTGCACCTGCTGTGTCGCTGCCTCAGCCGGGGGATGAGGGCACGGCAAGGCCAGGA
CGCACCCCCGACCCAGGGCACCTCCTCAGACCCTTACACGGACCAGGTCTTCTTCTACCTCCCC
GTGGGCCAGGGGCCCTCATCCCCACCATGCCCCACCTACAATGGGCTCTCATCCAGTGAGCAGA
ACTGGGCCAACCTGACCACAGAGGAGAGGCTGGCGTCTTCCAGGCCCCCTCTCTTCCTGGACCC
ACCCCCTCAGAATGGCCAAAAATCCCCCAGTCGTCCCAGCAGCTCTGCTTCTAAGAAGCAGTAT
GTATAGAGGCCTGTGGCTTATGTCACCCAACAGAGGGGTCCTGAGAAGTCTGGCTGCCTGGGAT
GCCCCCTGCCCCCTCCTGGAAGGCTCTGCAGAGATGACTGGGCTGGGGAAGCAGATGCTTGCTG
GCCATGGAACCTCATTGCAAGTTGTTCTTGAACACCTGAGGCCTTCCTGGTGCCCACCAGGCAC
TACGGCTTCCTCTCCAGAATGTGGCTTTGCCTGAGCACAGACAGAGTCAGCATGGAATGCTCTT
GGCCAAGGGTACTGGGGGCCCTCTGGCCTTTTGCAGCTGATCCAGAGGAACCCAGAGCCAACTT
ACCCCAACCTCACCCTATGGAACAGTCACCTGTGCGCAGGTTGTCCTCAAACCCTCTCCTCACA
GGAAAAGGCGGATTGAGGCTGCTGGGTCAGCCTTGATCGCACAGACAGAGCTTGTGCCGGATTT
GGCCCTGTCAAGGGGACTGGTGCCTTGTTTTCATCACTCCTTCCTAGTTCTACTGTTCATGCTT
CTGAAATAAACAGGACTTGATCACAA

hide sequence

RefSeq Acc Id:

XM_014344447 ⟹ XP_014199933

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	192,050,029 - 192,052,939 (-)	NCBI
NHGRI_mPanPan1	1	191,171,197 - 191,174,108 (-)	NCBI
Mhudiblu_PPA_v0	1	34,059,901 - 34,063,181 (+)	NCBI
PanPan1.1	1	35,241,402 - 35,244,191 (+)	NCBI

Sequence:

show sequence

CCTCTGCGCTATTTAAGGCGCCCCCGCCGCCCGTGCGGTCCAGCAGGGCTCCCGCGGGCGTCAC
TCCGGCCATCGTCCCCACCTCCACCTGGGCCGCCCGGCAGGCAGGCGGTAGAACGGGCGTGGCA
GACCTCCCTGCAGGCTTGTTGCTGGGCGAACGAGAAGGATGCCATGCTGACACACTGACGTGCT
CTGTCTCCTTGCAGACGGAGGCCCGGGAGCCATGGGTGACTGGGGCTTCCTGGAGAAGTTGCTG
GACCAGGTCCAGGAGCACTCGACCGTGGTGGGTAAGATCTGGCTGACGGTGCTCTTCATCTTCC
GCATCCTCATCCTGGGCCTGGCCGGCGAGTCAGTGTGGGGTGACGAGCAGTCAGATTTCGAGTG
TAACACGGCCCAGCCAGGCTGCACCAACGTCTGCTATGACCAGGCCTTCCCCATCTCCCACATC
CGCTACTGGGTGCTGCAGTTCCTCTTCGTCAGCACGCCCACCCTGGTCTACCTGGGCCATGTCA
TTTACCTGTCTCGGCGAGAAGAGCGGCTGCGGCAGAAGGAGGGGGAGCTGCGGGCACTGCCGGC
CAAGGACCCACAGGTGGAGCGGGCGCTGGCGGCCGTAGAGCGTCAGATGGCCAAGATCTCGGTG
GCAGAAGATGGTCGCCTGCGCATCCGCGGAGCACTGATGGGCACCTATGTCGCCAGTGTGCTCT
GCAAGAGTGTGCTAGAGGCAGGCTTCCTCTATGGCCAGTGGCGCCTGTACGGCTGGACCATGGA
GCCCGTGTTTGTGTGCCAGCGAGCACCCTGCCCCTACCTCGTGGACTGCTTTGTCTCTCGCCCC
ACGGAGAAGACCATCTTCATCATCTTCATGTTGGTGGTTGGACTCATCTCCCTGGTGCTTAACC
TGCTGGAGTTGGTGCACCTGCTGTGTCGCTGCCTCAGCCGGGGGATGAGGGCACGGCAAGGCCA
GGACGCACCCCCGACCCAGGGCACCTCCTCAGACCCTTACACGGACCAGGTCTTCTTCTACCTC
CCCGTGGGCCAGGGGCCCTCATCCCCACCATGCCCCACCTACAATGGGCTCTCATCCAGTGAGC
AGAACTGGGCCAACCTGACCACAGAGGAGAGGCTGGCGTCTTCCAGGCCCCCTCTCTTCCTGGA
CCCACCCCCTCAGAATGGCCAAAAATCCCCCAGTCGTCCCAGCAGCTCTGCTTCTAAGAAGCAG
TATGTATAGAGGCCTGTGGCTTATGTCACCCAACAGAGGGGTCCTGAGAAGTCTGGCTGCCTGG
GATGCCCCCTGCCCCCTCCTGGAAGGCTCTGCAGAGATGACTGGGCTGGGGAAGCAGATGCTTG
CTGGCCATGGAACCTCATTGCAAGTTGTTCTTGAACACCTGAGGCCTTCCTGGTGCCCACCAGG
CACTACGGCTTCCTCTCCAGAATGTGGCTTTGCCTGAGCACAGACAGAGTCAGCATGGAATGCT
CTTGGCCAAGGGTACTGGGGGCCCTCTGGCCTTTTGCAGCTGATCCAGAGGAACCCAGAGCCAA
CTTACCCCAACCTCACCCTATGGAACAGTCACCTGTGCGCAGGTTGTCCTCAAACCCTCTCCTC
ACAGGAAAAGGCGGATTGAGGCTGCTGGGTCAGCCTTGATCGCACAGACAGAGCTTGTGCCGGA
TTTGGCCCTGTCAAGGGGACTGGTGCCTTGTTTTCATCACTCCTTCCTAGTTCTACTGTTCATG
CTTCTGAAATAAACAGGACTTGATCACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003812599	(Get FASTA)	NCBI Sequence Viewer
	XP_014199933	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_014199933 ⟸ XM_014344447

- Sequence:

show sequence

MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNV
CYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPQVERALA
AVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPC
PYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS
DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQKSP
SRPSSSASKKQYV

hide sequence

RefSeq Acc Id:

XP_003812599 ⟸ XM_003812551

- Sequence:

show sequence

MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNV
CYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPQVERALA
AVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPC
PYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSS
DPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQKSP
SRPSSSASKKQYV

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	GJA4	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations