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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2691
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja4
Name: gap junction protein, alpha 4
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja4decreases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA4 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA4 proteinPMID:24269759
Gja4increases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of GJA4 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of GJA4 proteinPMID:24269759
Gja4multiple interactionsISOGja4 (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene affects the reaction [A gene mutant form results in decreased expression of GJA4 protein]; [A gene mutant form co-treated with 9,10-Dimethyl-1,2-benzanthracene] affects the expression of GJA4 proteinPMID:25447408
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