Zfp683 (zinc finger protein 683) - Rat Genome Database

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Gene: Zfp683 (zinc finger protein 683) Rattus norvegicus
Analyze
Symbol: Zfp683
Name: zinc finger protein 683
RGD ID: 2323855
Description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including cellular response to ionomycin; regulation of gene expression; and regulation of lymphocyte differentiation. Predicted to act upstream of or within NK T cell differentiation and natural killer cell differentiation. Predicted to be located in nucleus. Orthologous to human ZNF683 (zinc finger protein 683); INTERACTS WITH amphetamine; tetrachloromethane; aldehydo-D-glucose (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100359438; novel zinc finger protein-like; tissue-resident T-cell transcription regulator protein ZNF683
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,558,880 - 151,569,937 (+)NCBIGRCr8
mRatBN7.25146,277,972 - 146,285,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5146,278,978 - 146,285,000 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05152,280,982 - 152,288,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05155,967,579 - 155,974,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,801,039 - 152,806,811 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5144,696,953 - 144,704,148 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22885984   PMID:26179882   PMID:27102484  


Genomics

Comparative Map Data
Zfp683
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,558,880 - 151,569,937 (+)NCBIGRCr8
mRatBN7.25146,277,972 - 146,285,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5146,278,978 - 146,285,000 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05152,280,982 - 152,288,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05155,967,579 - 155,974,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,801,039 - 152,806,811 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5144,696,953 - 144,704,148 (+)NCBICelera
Cytogenetic Map5q36NCBI
ZNF683
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,361,634 - 26,374,518 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,361,634 - 26,374,522 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,688,125 - 26,699,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,560,712 - 26,571,853 (-)NCBINCBI36Build 36hg18NCBI36
Celera125,084,470 - 25,095,611 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef124,942,150 - 24,953,290 (-)NCBIHuRef
CHM1_1126,801,286 - 26,812,426 (-)NCBICHM1_1
T2T-CHM13v2.0126,199,081 - 26,211,983 (-)NCBIT2T-CHM13v2.0
Zfp683
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,778,506 - 133,786,252 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,781,149 - 133,786,307 (+)EnsemblGRCm39 Ensembl
GRCm384134,051,195 - 134,058,941 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4134,053,838 - 134,058,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv374133,607,109 - 133,614,855 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera4132,226,715 - 132,244,549 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.5NCBI
Znf683
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554525,748,639 - 5,754,911 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554525,748,569 - 5,758,389 (-)NCBIChiLan1.0ChiLan1.0
ZNF683
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21200,487,226 - 200,510,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,585,427 - 199,608,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,622,548 - 25,636,106 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,690,359 - 26,703,755 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,690,359 - 26,703,755 (-)Ensemblpanpan1.1panPan2
ZNF683
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,656,842 - 73,667,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,658,525 - 73,667,605 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha270,233,501 - 70,244,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,219,802 - 74,230,587 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1271,044,851 - 71,055,565 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,050,469 - 72,061,255 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,054,013 - 73,065,017 (+)NCBIUU_Cfam_GSD_1.0
Znf683
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,026,456 - 45,034,310 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647410,851,249 - 10,859,092 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF683
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,758,979 - 83,765,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,756,865 - 83,765,905 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,434,849 - 77,443,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF683
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120106,336,441 - 106,411,217 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603310,011,743 - 10,019,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf683
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476410,382,733 - 10,388,608 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp683
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000029799
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000114582   ⟹   ENSRNOP00000084431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,278,978 - 146,285,000 (+)Ensembl
RefSeq Acc Id: XM_002729549   ⟹   XP_002729595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,558,880 - 151,569,937 (+)NCBI
mRatBN7.25146,277,972 - 146,285,856 (+)NCBI
Rnor_6.05152,280,982 - 152,288,208 (+)NCBI
Rnor_5.05155,967,579 - 155,974,205 (+)NCBI
RGSC_v3.45152,801,039 - 152,806,811 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_002729595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084431.1
Reference Protein Sequences
RefSeq Acc Id: XP_002729595   ⟸   XM_002729549
- Sequence:
RefSeq Acc Id: ENSRNOP00000084431   ⟸   ENSRNOT00000114582
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323855 AgrOrtholog
BioCyc Gene G2FUF-39600 BioCyc
Ensembl Genes ENSRNOG00000065788 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114582.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 100359438 ENTREZGENE
PANTHER PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN 1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp683 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065788 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6A1Z3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-01 Zfp683  zinc finger protein 683  Zfp683  zinc finger protein 683  Data merged from RGD:149736173 737654 PROVISIONAL
2021-08-09 Zfp683  zinc finger protein 683      Symbol and Name status set to provisional 45752 PROVISIONAL
2014-07-09 Zfp683  zinc finger protein 683  LOC100359438  novel zinc finger protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100359438  novel zinc finger protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL