Sfn (stratifin) - Rat Genome Database

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Gene: Sfn (stratifin) Rattus norvegicus
Analyze
Symbol: Sfn
Name: stratifin
RGD ID: 1304729
Description: Predicted to enable identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; establishment of skin barrier; and regulation of epidermal cell division. Predicted to act upstream of or within keratinocyte differentiation; negative regulation of keratinocyte proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2-acetamidofluorene; 5-aza-2'-deoxycytidine.
Type: protein-coding
Previously known as: 14-3-3 protein sigma; LOC313017
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)Ensembl
Rnor_6.05151,823,422 - 151,824,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,512,802 - 155,514,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,475,395 - 151,479,996 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,485,433 - 151,490,434 (+)NCBI
Celera5144,247,261 - 144,248,776 (-)NCBICelera
Cytogenetic Map5q36NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
5-methylcytosine  (ISO)
6-O-methylguanine  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chrysin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
GW 4064  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
luteolin  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

Additional References at PubMed
PMID:6174530   PMID:10767298   PMID:11574543   PMID:15778465   PMID:16239341   PMID:16532026   PMID:16710422   PMID:17041603   PMID:17938205   PMID:19056867   PMID:23533145   PMID:24075906  
PMID:25468996  


Genomics

Comparative Map Data
Sfn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)Ensembl
Rnor_6.05151,823,422 - 151,824,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,512,802 - 155,514,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,475,395 - 151,479,996 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,485,433 - 151,490,434 (+)NCBI
Celera5144,247,261 - 144,248,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
SFN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,863,149 - 26,864,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl126,863,149 - 26,864,456 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,189,640 - 27,190,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,062,220 - 27,063,534 (+)NCBINCBI36hg18NCBI36
Build 34126,873,774 - 26,875,089NCBI
Celera125,586,728 - 25,588,042 (+)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,443,317 - 25,444,639 (+)NCBIHuRef
CHM1_1127,302,848 - 27,304,162 (+)NCBICHM1_1
T2T-CHM13v2.0126,701,224 - 26,702,527 (+)NCBI
Sfn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,327,867 - 133,329,479 (-)NCBIGRCm39mm39
GRCm39 Ensembl4133,327,867 - 133,329,479 (-)Ensembl
GRCm384133,600,556 - 133,602,168 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,600,556 - 133,602,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,156,471 - 133,158,083 (-)NCBIGRCm37mm9NCBIm37
MGSCv364132,872,632 - 132,873,884 (-)NCBImm8
Celera4131,765,686 - 131,767,298 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Sfn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,217,698 - 6,218,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,217,519 - 6,218,481 (+)NCBIChiLan1.0ChiLan1.0
SFN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,182,629 - 27,184,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,182,834 - 27,183,580 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,126,212 - 26,127,761 (+)NCBIMhudiblu_PPA_v0panPan3
SFN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,268,289 - 73,269,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,268,791 - 73,269,537 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,846,343 - 69,847,691 (-)NCBI
ROS_Cfam_1.0273,832,085 - 73,833,433 (-)NCBI
UMICH_Zoey_3.1270,657,031 - 70,658,379 (-)NCBI
UNSW_CanFamBas_1.0271,662,570 - 71,663,918 (-)NCBI
UU_Cfam_GSD_1.0272,665,732 - 72,667,080 (-)NCBI
Sfn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,450,127 - 45,454,645 (+)NCBI
SpeTri2.0NW_00493647411,274,927 - 11,279,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,902,481 - 105,904,313 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,902,974 - 105,903,720 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603310,524,809 - 10,527,364 (+)NCBIVero_WHO_p1.0
Sfn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476410,859,667 - 10,860,413 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476410,859,556 - 10,860,876 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH135032  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q13UniSTS
Cytogenetic Map5q36UniSTS
AW433686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,833,256 - 145,833,469 (+)MAPPERmRatBN7.2
Rnor_6.05151,829,957 - 151,830,169NCBIRnor6.0
Rnor_5.05155,519,337 - 155,519,549UniSTSRnor5.0
RGSC_v3.45151,473,648 - 151,473,860UniSTSRGSC3.4
Celera5144,253,796 - 144,254,008UniSTS
RH 3.4 Map5966.11UniSTS
Cytogenetic Map5q36UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:125
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000005553, ENSRNOT00000043959
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 1 6 1
Low 33 21 10 18 10 1 1 48 29 31 11 1
Below cutoff 8 32 27 27 5 7 24 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000043959   ⟹   ENSRNOP00000040819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)Ensembl
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)Ensembl
RefSeq Acc Id: XM_001065560   ⟹   XP_001065560
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera5144,247,261 - 144,248,776 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003750048   ⟹   XP_003750096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,823,422 - 151,824,937 (-)NCBI
Rnor_5.05155,512,802 - 155,514,320 (-)NCBI
Sequence:
Protein Sequences
GenBank Protein EDL80680 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001065560   ⟸   XM_001065560
- Sequence:
RefSeq Acc Id: XP_003750096   ⟸   XM_003750048
- Sequence:
RefSeq Acc Id: ENSRNOP00000040819   ⟸   ENSRNOT00000043959
Protein Domains
14_3_3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9A3-F1-model_v2 AlphaFold G3V9A3 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694125
Promoter ID:EPDNEW_R4645
Type:single initiation site
Name:Sfn_1
Description:stratifin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,824,696 - 151,824,756EPDNEW
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 151823957 151823958 T G snv CDR, ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), ACI/EurMcwi (2019), ACI/N (2020), MR/N (2020)
5 151824090 151824091 C G snv CDR, ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), ACI/EurMcwi (2019), ACI/N (2020)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 155513337 155513338 T G snv ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), SDLEF7/Barth (UDEL), Crl:SD (UDEL), ZF (KyushuU)
5 155513470 155513471 C G snv ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), Crl:SD (UDEL), ZF (KyushuU), ZFDM (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304729 AgrOrtholog
Ensembl Genes ENSRNOG00000033153 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040819 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043959 UniProtKB/TrEMBL
Gene3D-CATH 1.20.190.20 UniProtKB/TrEMBL
InterPro 14-3-3 UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/TrEMBL
  14-3-3_sigma UniProtKB/TrEMBL
NCBI Gene 313017 ENTREZGENE
PANTHER PTHR18860 UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/TrEMBL
PhenoGen Sfn PhenoGen
PIRSF 14-3-3 UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/TrEMBL
  1433_2 UniProtKB/TrEMBL
SMART 14_3_3 UniProtKB/TrEMBL
Superfamily-SCOP 14-3-3 UniProtKB/TrEMBL
UniProt G3V9A3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sfn  stratifin   Sfn_predicted  stratifin (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sfn_predicted  stratifin (predicted)      Symbol and Name status set to approved 70820 APPROVED