Sfn (stratifin) - Rat Genome Database

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Gene: Sfn (stratifin) Rattus norvegicus
Analyze
Symbol: Sfn
Name: stratifin
RGD ID: 1304729
Description: Predicted to enable several functions, including identical protein binding activity; phosphoserine residue binding activity; and protein sequestering activity. Predicted to be involved in several processes, including apoptotic signaling pathway; cAMP/PKA signal transduction; and establishment of skin barrier. Predicted to act upstream of or within keratinocyte differentiation; negative regulation of cell population proliferation; and regulation of cell cycle. Predicted to be located in nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2-acetamidofluorene; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14-3-3 protein sigma; LOC313017
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,110,582 - 151,111,854 (-)NCBIGRCr8
mRatBN7.25145,826,722 - 145,827,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05151,823,422 - 151,824,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,512,802 - 155,514,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,475,395 - 151,479,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,485,433 - 151,490,434 (+)NCBI
Celera5144,247,261 - 144,248,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
5-methylcytosine  (ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chrysin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
Ethyl maltol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
GW 4064  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation. Akahira J, etal., Clin Cancer Res. 2004 Apr 15;10(8):2687-93.
2. Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia. Gasco M, etal., Oncogene. 2002 Mar 14;21(12):1876-81.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Epigenetic and proteolytic inactivation of 14-3-3sigma in breast and prostate cancers. Horie-Inoue K and Inoue S, Semin Cancer Biol. 2006 Jun;16(3):235-9. Epub 2006 Apr 1.
6. Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas. Kunze E, etal., Int J Mol Med. 2006 Oct;18(4):547-57.
7. Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. L'Esperance S, etal., Int J Oncol. 2006 Jul;29(1):5-24.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. Nakayama H, etal., Pathol Int. 2005 Nov;55(11):707-15.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Predicting outcome in minimally invasive (T1a and T1b) urothelial bladder carcinoma using a panel of biomarkers: A high throughput tissue microarray analysis Mhawech-Fauceglia P, Fischer G, Alvarez V Jr, Ahmed A, Herrmann FR, Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY. See WA Urol Oncol. 2008 May-Jun;26(3):336.
Additional References at PubMed
PMID:6174530   PMID:10767298   PMID:11574543   PMID:15778465   PMID:16239341   PMID:16532026   PMID:16710422   PMID:17041603   PMID:17938205   PMID:19056867   PMID:23533145   PMID:24075906  
PMID:25468996  


Genomics

Comparative Map Data
Sfn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,110,582 - 151,111,854 (-)NCBIGRCr8
mRatBN7.25145,826,722 - 145,827,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05151,823,422 - 151,824,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,512,802 - 155,514,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,475,395 - 151,479,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,485,433 - 151,490,434 (+)NCBI
Celera5144,247,261 - 144,248,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
SFN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,863,149 - 26,864,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,863,149 - 26,864,456 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,189,640 - 27,190,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,062,220 - 27,063,534 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,873,774 - 26,875,089NCBI
Celera125,586,728 - 25,588,042 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,443,317 - 25,444,639 (+)NCBIHuRef
CHM1_1127,302,848 - 27,304,162 (+)NCBICHM1_1
T2T-CHM13v2.0126,701,224 - 26,702,527 (+)NCBIT2T-CHM13v2.0
Sfn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,327,867 - 133,329,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,327,867 - 133,329,479 (-)EnsemblGRCm39 Ensembl
GRCm384133,600,556 - 133,602,168 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,600,556 - 133,602,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,156,471 - 133,158,083 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,872,632 - 132,873,884 (-)NCBIMGSCv36mm8
Celera4131,765,686 - 131,767,298 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Sfn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,217,698 - 6,218,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,217,519 - 6,218,481 (+)NCBIChiLan1.0ChiLan1.0
SFN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21200,004,931 - 200,006,544 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,109,040 - 199,110,562 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,126,212 - 26,127,761 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,182,629 - 27,184,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,182,834 - 27,183,580 (+)Ensemblpanpan1.1panPan2
SFN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,268,289 - 73,269,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,268,791 - 73,269,537 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,846,343 - 69,847,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,832,085 - 73,833,433 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1270,657,031 - 70,658,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,662,570 - 71,663,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,665,732 - 72,667,080 (-)NCBIUU_Cfam_GSD_1.0
Sfn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,450,127 - 45,454,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,246,534 - 11,279,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,274,927 - 11,279,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,188,445 - 84,189,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,188,521 - 84,189,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,750,656 - 77,760,032 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,902,481 - 105,904,313 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,902,974 - 105,903,720 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603310,524,809 - 10,527,364 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476410,859,667 - 10,860,413 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476410,859,556 - 10,860,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sfn
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:125
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000005553, ENSRNOT00000043959
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH135032  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q13UniSTS
Cytogenetic Map5q36UniSTS
AW433686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,833,256 - 145,833,469 (+)MAPPERmRatBN7.2
Rnor_6.05151,829,957 - 151,830,169NCBIRnor6.0
Rnor_5.05155,519,337 - 155,519,549UniSTSRnor5.0
RGSC_v3.45151,473,648 - 151,473,860UniSTSRGSC3.4
Celera5144,253,796 - 144,254,008UniSTS
RH 3.4 Map5966.11UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 1 6 1
Low 33 21 10 18 10 1 1 48 29 31 11 1
Below cutoff 8 32 27 27 5 7 24 6 5

Sequence


Ensembl Acc Id: ENSRNOT00000043959   ⟹   ENSRNOP00000040819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)Ensembl
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)Ensembl
RefSeq Acc Id: NM_001416777   ⟹   NP_001403706
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,110,582 - 151,111,854 (-)NCBI
mRatBN7.25145,826,722 - 145,827,994 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001403706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80680 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040819.3
Ensembl Acc Id: ENSRNOP00000040819   ⟸   ENSRNOT00000043959
RefSeq Acc Id: NP_001403706   ⟸   NM_001416777
- UniProtKB: G3V9A3 (UniProtKB/TrEMBL),   Q68FS0 (UniProtKB/TrEMBL),   A6ISX9 (UniProtKB/TrEMBL)
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9A3-F1-model_v2 AlphaFold G3V9A3 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694125
Promoter ID:EPDNEW_R4645
Type:single initiation site
Name:Sfn_1
Description:stratifin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,824,696 - 151,824,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304729 AgrOrtholog
Ensembl Genes ENSRNOG00000033153 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043959.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.190.20 UniProtKB/TrEMBL
InterPro 14-3-3 UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/TrEMBL
  14-3-3_sigma UniProtKB/TrEMBL
NCBI Gene 313017 ENTREZGENE
PANTHER 14-3-3 PROTEIN SIGMA UniProtKB/TrEMBL
  PTHR18860 UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/TrEMBL
PhenoGen Sfn PhenoGen
PIRSF 14-3-3 UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/TrEMBL
  1433_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033153 RatGTEx
SMART 14_3_3 UniProtKB/TrEMBL
Superfamily-SCOP 14-3-3 UniProtKB/TrEMBL
UniProt A6ISX9 ENTREZGENE, UniProtKB/TrEMBL
  G3V9A3 ENTREZGENE, UniProtKB/TrEMBL
  Q68FS0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sfn  stratifin   Sfn_predicted  stratifin (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sfn_predicted  stratifin (predicted)      Symbol and Name status set to approved 70820 APPROVED