RGD Reference Report - Predicting outcome in minimally invasive (T1a and T1b) urothelial bladder carcinoma using a panel of biomarkers: A high throughput tissue microarray analysis Mhawech-Fauceglia P, Fischer G, Alvarez V Jr, Ahmed A, Herrmann FR, Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY. - Rat Genome Database

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Predicting outcome in minimally invasive (T1a and T1b) urothelial bladder carcinoma using a panel of biomarkers: A high throughput tissue microarray analysis Mhawech-Fauceglia P, Fischer G, Alvarez V Jr, Ahmed A, Herrmann FR, Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY.

Authors:
Citation: See WA Urol Oncol. 2008 May-Jun;26(3):336.
RGD ID: 2299928
Pubmed: PMID:17645415   (View Abstract at PubMed)

OBJECTIVE: To evaluate the protein expression of fibroblast growth factor receptor-3 (FGFR3), hamartin, 14-3-3sigma, Aurora-A, and E-cadherin using immunohistochemistry (IHC) in a series of human bladder carcinomas and to evaluate their value in distinguishing T1a from T1b tumors and in predicting their behavior, as T1 urothelial bladder tumors present great diagnostic and therapeutic challenges to pathologists and clinicians. MATERIALS AND METHODS: Tissue microarrays were constructed from 94 patients (Ta 20, T1a 31, T1b 14, and T2 29 patients) using tissue obtained at first disease presentation. RESULTS: FGFR3 and 14-3-3sigma were the only markers that were significantly associated with tumor grade and 14-3-3sigma was significantly associated with tumor stage. Furthermore, none of these markers could help in distinguishing T1a from T1b tumors. After adjusting for the E-cadherin expression, FGFR3 expression was a significant factor in predicting the time to recurrence in T1a/T1b. Furthermore, among all the clinical variables, grade and depth of invasion were the only ones that had a significant value in predicting T1a/T1b tumor progression. CONCLUSIONS: Even though the staging of T1 to T1a/T1b is not a common practice and it is not included in the Tumor-Node-Metastasis classification, our data clearly confirmed the importance of a proper substaging of T1 tumors whenever feasible.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SFNHumanurinary bladder cancer disease_progressionIEP protein:increased expression:urothelium (human)RGD 
SfnRaturinary bladder cancer disease_progressionISOSFN (Homo sapiens)protein:increased expression:urothelium (human)RGD 
SfnMouseurinary bladder cancer disease_progressionISOSFN (Homo sapiens)protein:increased expression:urothelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sfn  (stratifin)

Genes (Mus musculus)
Sfn  (stratifin)

Genes (Homo sapiens)
SFN  (stratifin)


Additional Information