Sfn (stratifin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Sfn (stratifin) Mus musculus
Analyze
Symbol: Sfn
Name: stratifin
RGD ID: 1312342
MGI Page MGI
Description: Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including cAMP/PKA signal transduction; establishment of skin barrier; and protein export from nucleus. Acts upstream of or within keratinocyte differentiation; negative regulation of cell population proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14-3-3; 14-3-3 protein sigma; 14-3-3 sigma protein; E; Er; Mme1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide; Ywh; Ywhas
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ywhaq-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,327,867 - 133,329,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,327,867 - 133,329,479 (-)EnsemblGRCm39 Ensembl
GRCm384133,600,556 - 133,602,168 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,600,556 - 133,602,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,156,471 - 133,158,083 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,872,632 - 132,873,884 (-)NCBIMGSCv36mm8
Celera4131,765,686 - 131,767,298 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitrophenol  (EXP)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methylcytosine  (ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-phellandrene  (EXP)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (EXP)
chrysin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
Ethyl maltol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
GW 4064  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
nickel atom  (ISO)
nickel sulfate  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (ISO,ISS,TAS)
extracellular region  (IEA)
nucleus  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal body wall morphology  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal embryonic autopod plate morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal epidermis stratum spinosum morphology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal esophagus development  (IAGP)
abnormal external auditory canal morphology  (IAGP)
abnormal eyelid aperture  (IAGP)
abnormal eyelid fusion  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal head morphology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mouth morphology  (IAGP)
abnormal nasal cavity morphology  (IAGP)
abnormal nasopharynx morphology  (IAGP)
abnormal oral cavity morphology  (IAGP)
abnormal oral epithelium morphology  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal pharynx morphology  (IAGP)
abnormal radius morphology  (IAGP)
abnormal skin morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tongue morphology  (IAGP)
absent epidermis stratum corneum  (IAGP)
absent epidermis stratum granulosum  (IAGP)
absent spleen marginal zone  (IAGP)
anal atresia  (IAGP)
brachyphalangia  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
decreased B cell number  (IAGP)
decreased B-1a cell number  (IAGP)
decreased caudal vertebrae number  (IAGP)
decreased follicular B cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased marginal zone B cell number  (IAGP)
distorted hair follicle pattern  (IAGP)
epidermal hyperplasia  (IAGP)
flat face  (IAGP)
flattened snout  (IAGP)
fused lips  (IAGP)
herniated intestine  (IAGP)
impaired skin barrier function  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell proliferation  (IAGP)
increased cell proliferation  (IAGP)
increased skin papilloma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
kinked tail  (IAGP)
kyphosis  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
median cleft palate  (IAGP)
microcephaly  (IAGP)
microphthalmia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oral atresia  (IAGP)
palatal shelf fusion with tongue or mandible  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
premature hair loss  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
shiny skin  (IAGP)
short limbs  (IAGP)
short snout  (IAGP)
short tail  (IAGP)
small ears  (IAGP)
small external nares  (IAGP)
small limb buds  (IAGP)
sparse hair  (IEA)
syndactyly  (IAGP)
thick epidermis  (IAGP)
thick epidermis stratum spinosum  (IAGP)
thin epidermis  (IAGP)
thin lip  (IAGP)
thin skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation. Akahira J, etal., Clin Cancer Res. 2004 Apr 15;10(8):2687-93.
2. Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia. Gasco M, etal., Oncogene. 2002 Mar 14;21(12):1876-81.
3. Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas. Kunze E, etal., Int J Mol Med. 2006 Oct;18(4):547-57.
4. Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors. L'Esperance S, etal., Int J Oncol. 2006 Jul;29(1):5-24.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. Nakayama H, etal., Pathol Int. 2005 Nov;55(11):707-15.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Predicting outcome in minimally invasive (T1a and T1b) urothelial bladder carcinoma using a panel of biomarkers: A high throughput tissue microarray analysis Mhawech-Fauceglia P, Fischer G, Alvarez V Jr, Ahmed A, Herrmann FR, Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, NY. See WA Urol Oncol. 2008 May-Jun;26(3):336.
Additional References at PubMed
PMID:479550   PMID:1613075   PMID:1613076   PMID:1909952   PMID:2443312   PMID:2632240   PMID:2989601   PMID:6174530   PMID:6374282   PMID:6643653   PMID:6746880   PMID:9328433  
PMID:10349636   PMID:10767298   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11203384   PMID:11217851   PMID:11845283   PMID:11864996   PMID:12075357   PMID:12077355   PMID:12466851  
PMID:14517281   PMID:14613977   PMID:14681479   PMID:15286034   PMID:15648052   PMID:16141072   PMID:16141073   PMID:16200063   PMID:16239341   PMID:16532026   PMID:16602821   PMID:16613846  
PMID:16710422   PMID:17041601   PMID:17041603   PMID:17177285   PMID:17643371   PMID:17938205   PMID:18184563   PMID:18332103   PMID:18606808   PMID:19014373   PMID:19626033   PMID:20082218  
PMID:20100467   PMID:20105280   PMID:20237493   PMID:20439433   PMID:20729863   PMID:21093383   PMID:21205887   PMID:21228373   PMID:21267068   PMID:21327095   PMID:21565611   PMID:21574244  
PMID:21677750   PMID:21743007   PMID:21873635   PMID:21926108   PMID:22173065   PMID:22354994   PMID:22366192   PMID:22377760   PMID:22560297   PMID:22585169   PMID:22768254   PMID:22794259  
PMID:23375543   PMID:23906066   PMID:24055172   PMID:24067649   PMID:24075906   PMID:24478334   PMID:24862038   PMID:25133425   PMID:25668240   PMID:26334721   PMID:26527653   PMID:26542370  
PMID:26902285   PMID:27034005   PMID:27184845   PMID:27302476   PMID:27409835   PMID:28378742   PMID:29632206   PMID:30188892   PMID:30457570   PMID:30595499   PMID:30704515   PMID:30858352  
PMID:31040226   PMID:31144406   PMID:32325033   PMID:32369015   PMID:33495819   PMID:33833407   PMID:34224368   PMID:34294877   PMID:36418889   PMID:37048108   PMID:37524711  


Genomics

Comparative Map Data
Sfn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,327,867 - 133,329,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,327,867 - 133,329,479 (-)EnsemblGRCm39 Ensembl
GRCm384133,600,556 - 133,602,168 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,600,556 - 133,602,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,156,471 - 133,158,083 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,872,632 - 132,873,884 (-)NCBIMGSCv36mm8
Celera4131,765,686 - 131,767,298 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
SFN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,863,149 - 26,864,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,863,149 - 26,864,456 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,189,640 - 27,190,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,062,220 - 27,063,534 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,873,774 - 26,875,089NCBI
Celera125,586,728 - 25,588,042 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,443,317 - 25,444,639 (+)NCBIHuRef
CHM1_1127,302,848 - 27,304,162 (+)NCBICHM1_1
T2T-CHM13v2.0126,701,224 - 26,702,527 (+)NCBIT2T-CHM13v2.0
Sfn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,110,582 - 151,111,854 (-)NCBIGRCr8
mRatBN7.25145,826,722 - 145,827,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,826,201 - 145,831,314 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05151,823,422 - 151,824,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,823,887 - 151,824,633 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,512,802 - 155,514,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,475,395 - 151,479,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,485,433 - 151,490,434 (+)NCBI
Celera5144,247,261 - 144,248,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
Sfn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,217,698 - 6,218,444 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,217,519 - 6,218,481 (+)NCBIChiLan1.0ChiLan1.0
SFN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21200,004,931 - 200,006,544 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,109,040 - 199,110,562 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,126,212 - 26,127,761 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,182,629 - 27,184,075 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,182,834 - 27,183,580 (+)Ensemblpanpan1.1panPan2
SFN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,268,289 - 73,269,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,268,791 - 73,269,537 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,846,343 - 69,847,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,832,085 - 73,833,433 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1270,657,031 - 70,658,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,662,570 - 71,663,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,665,732 - 72,667,080 (-)NCBIUU_Cfam_GSD_1.0
Sfn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,450,127 - 45,454,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,246,534 - 11,279,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,274,927 - 11,279,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,188,445 - 84,189,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,188,521 - 84,189,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,750,656 - 77,760,032 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,902,481 - 105,904,313 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,902,974 - 105,903,720 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603310,524,809 - 10,527,364 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476410,859,667 - 10,860,413 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476410,859,556 - 10,860,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:304
Count of miRNA genes:228
Interacting mature miRNAs:262
Transcripts:ENSMUST00000057311
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
25394567Skmw55_mskeletal muscle weight 55, gastroc (mouse)4131437804133710576Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
14696808Rbcn1_mrod bipolar cell number 1 (mouse)4131947311134047311Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
25394568Skmw56_mskeletal muscle weight 56, EDL (mouse)4129859344133710576Mouse
12904009Cfq9_mconditioned fear QTL 9 (mouse)4130036287133772722Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129465811136864536Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
4142082Psds2_mpsoriasis-like skin disease severity 2 (mouse)Not determined4133154678137617995Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131650724140879275Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
Sfn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
cM Map462.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000057311   ⟹   ENSMUSP00000050374
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4133,327,867 - 133,329,479 (-)Ensembl
GRCm38.p6 Ensembl4133,600,556 - 133,602,168 (-)Ensembl
RefSeq Acc Id: NM_018754   ⟹   NP_061224
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394133,327,867 - 133,329,163 (-)NCBI
GRCm384133,600,556 - 133,602,168 (-)ENTREZGENE
MGSCv374133,156,471 - 133,158,083 (-)RGD
Celera4131,765,686 - 131,767,298 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_061224 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC14344 (Get FASTA)   NCBI Sequence Viewer  
  AAF36093 (Get FASTA)   NCBI Sequence Viewer  
  BAE27209 (Get FASTA)   NCBI Sequence Viewer  
  BAE41107 (Get FASTA)   NCBI Sequence Viewer  
  EDL30056 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000050374
  ENSMUSP00000050374.4
GenBank Protein O70456 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_061224   ⟸   NM_018754
- UniProtKB: Q3TEZ1 (UniProtKB/Swiss-Prot),   O70456 (UniProtKB/Swiss-Prot),   Q9JJ20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000050374   ⟸   ENSMUST00000057311
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70456-F1-model_v2 AlphaFold O70456 1-248 view protein structure

Promoters
RGD ID:6836368
Promoter ID:MM_KWN:40027
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung,   Spleen
Transcripts:NM_018754
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364133,157,711 - 133,159,082 (-)MPROMDB
RGD ID:6884964
Promoter ID:EPDNEW_M5933
Type:initiation region
Name:Sfn_1
Description:Mus musculus stratifin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384133,601,832 - 133,601,892EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891831 AgrOrtholog
Ensembl Genes ENSMUSG00000047281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057311 ENTREZGENE
  ENSMUST00000057311.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_sigma UniProtKB/Swiss-Prot
KEGG Report mmu:55948 UniProtKB/Swiss-Prot
MGD MGI:1891831 ENTREZGENE
NCBI Gene 55948 ENTREZGENE
PANTHER 14-3-3 PROTEIN SIGMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sfn PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1433_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 14_3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 1433S_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TEZ1 ENTREZGENE
  Q9JJ20 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3TEZ1 UniProtKB/Swiss-Prot