Htr6 (5-hydroxytryptamine receptor 6) - Rat Genome Database

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Gene: Htr6 (5-hydroxytryptamine receptor 6) Rattus norvegicus
Analyze
Symbol: Htr6
Name: 5-hydroxytryptamine receptor 6
RGD ID: 62044
Description: Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; long-term synaptic potentiation; and regulation of amine transport. Located in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-6; 5-HT6; 5-hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; serotonin receptor 6; ST-B17
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25151,295,269 - 151,312,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,296,662 - 151,311,912 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,994,008 - 154,009,139 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05155,768,318 - 155,783,449 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05155,750,238 - 155,765,452 (-)NCBIRnor_WKY
Rnor_6.05157,501,202 - 157,518,870 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,503,040 - 157,518,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,242,331 - 161,257,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5149,681,578 - 149,696,742 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain. Brailov I, etal., Brain Res. 2000 Jul 28;872(1-2):271-5.
2. Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain. Frederick JA and Meador-Woodruff JH, Schizophr Res. 1999 Jul 27;38(1):7-12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Characterization of 5-ht6 receptor and expression of 5-ht6 mRNA in the rat brain during ontogenetic development. Grimaldi B, etal., Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):393-400.
6. Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Hamon M, etal., Neuropsychopharmacology. 1999 Aug;21(2 Suppl):68S-76S.
7. Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1). Kim SH, etal., PLoS One. 2014 Mar 10;9(3):e91402. doi: 10.1371/journal.pone.0091402. eCollection 2014.
8. Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. Kohen R, etal., J Neurochem 1996 Jan;66(1):47-56.
9. Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Marcos B, etal., Eur J Neurosci. 2006 Sep;24(5):1299-306.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning. Mitchell ES, etal., Neuropsychopharmacology. 2007 Jul;32(7):1520-30. Epub 2006 Dec 27.
12. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Monsma FJ Jr, etal., Mol Pharmacol 1993 Mar;43(3):320-7.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Papageorgiou A and Denef C, Endocrinology. 2007 Mar;148(3):1384-95. Epub 2006 Nov 22.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Ruat M, etal., Biochem Biophys Res Commun 1993 May 28;193(1):268-76.
20. Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease. Tsai SJ, etal., Neurosci Lett 1999 Dec 3;276(2):138-9.
21. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. West PJ, etal., Neuroscience. 2009 Dec 1;164(2):692-701. Epub 2009 Aug 4.
Additional References at PubMed
PMID:9225298   PMID:17543469   PMID:17998104   PMID:19549510   PMID:19902184   PMID:20093369   PMID:20514872   PMID:21619890   PMID:21714816   PMID:22179047   PMID:22982249   PMID:23027611  
PMID:24880860   PMID:25078650   PMID:25837696   PMID:25863121   PMID:25934037   PMID:26424380   PMID:26979176   PMID:27032690   PMID:27106213   PMID:28681593   PMID:31412259  


Genomics

Comparative Map Data
Htr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25151,295,269 - 151,312,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,296,662 - 151,311,912 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,994,008 - 154,009,139 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05155,768,318 - 155,783,449 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05155,750,238 - 155,765,452 (-)NCBIRnor_WKY
Rnor_6.05157,501,202 - 157,518,870 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,503,040 - 157,518,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,242,331 - 161,257,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5149,681,578 - 149,696,742 (-)NCBICelera
Cytogenetic Map5q36NCBI
HTR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,664,875 - 19,680,966 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl119,664,875 - 19,680,966 (+)EnsemblGRCh38hg38GRCh38
GRCh37119,991,368 - 20,007,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,864,367 - 19,878,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 34119,737,085 - 19,751,361NCBI
Celera118,318,551 - 18,332,825 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef118,237,853 - 18,251,587 (+)NCBIHuRef
CHM1_1120,101,041 - 20,115,313 (+)NCBICHM1_1
T2T-CHM13v2.0119,488,252 - 19,504,342 (+)NCBIT2T-CHM13v2.0
Htr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,787,017 - 138,802,881 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,788,419 - 138,802,881 (-)EnsemblGRCm39 Ensembl
GRCm384139,059,706 - 139,075,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,061,108 - 139,075,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv374138,617,324 - 138,630,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,333,485 - 138,346,865 (-)NCBIMGSCv36mm8
Celera4140,846,418 - 140,859,919 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.57NCBI
Htr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955452323,641 - 338,312 (+)NCBIChiLan1.0ChiLan1.0
HTR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1119,662,978 - 19,678,680 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,662,978 - 19,678,680 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0118,619,683 - 18,635,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HTR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,022,790 - 79,033,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,022,775 - 79,033,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,536,323 - 75,547,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,589,890 - 79,601,165 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,589,903 - 79,601,165 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,407,980 - 76,419,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,415,288 - 77,426,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,486,607 - 78,497,882 (-)NCBIUU_Cfam_GSD_1.0
Htr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,023,901 - 40,033,703 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364745,848,707 - 5,859,749 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364745,848,719 - 5,858,520 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1678,077,358 - 78,092,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,147,759 - 72,164,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,873,132 - 112,887,533 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,874,734 - 112,887,066 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660333,273,572 - 3,288,466 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,778,657 - 4,791,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247644,778,563 - 4,791,505 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Htr6
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:47
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000070865
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat

Markers in Region
D5Got136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,308,239 - 151,308,356 (+)MAPPERmRatBN7.2
Rnor_6.05157,514,839 - 157,514,955NCBIRnor6.0
Rnor_5.05161,254,035 - 161,254,151UniSTSRnor5.0
Celera5149,693,070 - 149,693,186UniSTS
RH 3.4 Map51033.01RGD
RH 3.4 Map51033.01UniSTS
RH 2.0 Map51005.8RGD
D5Got92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,308,242 - 151,308,369 (+)MAPPERmRatBN7.2
Rnor_6.05157,514,842 - 157,514,968NCBIRnor6.0
Rnor_5.05161,254,038 - 161,254,164UniSTSRnor5.0
Celera5149,693,073 - 149,693,199UniSTS
RH 3.4 Map51033.4RGD
RH 3.4 Map51033.4UniSTS
RH 2.0 Map51021.2RGD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 40
Below cutoff 7 7 20 1 14 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070865   ⟹   ENSRNOP00000064366
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,296,662 - 151,311,912 (-)Ensembl
Rnor_6.0 Ensembl5157,503,040 - 157,518,511 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078028   ⟹   ENSRNOP00000070830
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5157,503,164 - 157,518,631 (-)Ensembl
RefSeq Acc Id: NM_024365   ⟹   NP_077341
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,296,662 - 151,311,912 (-)NCBI
Rnor_6.05157,503,040 - 157,518,511 (-)NCBI
Rnor_5.05161,242,331 - 161,257,707 (-)NCBI
Celera5149,681,578 - 149,696,742 (-)RGD
Sequence:
RefSeq Acc Id: XM_017593608   ⟹   XP_017449097
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,295,269 - 151,312,853 (-)NCBI
Rnor_6.05157,501,202 - 157,518,870 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077341   ⟸   NM_024365
- UniProtKB: A0A8L2QXZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449097   ⟸   XM_017593608
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QXZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064366   ⟸   ENSRNOT00000070865
RefSeq Acc Id: ENSRNOP00000070830   ⟸   ENSRNOT00000078028
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31388-F1-model_v2 AlphaFold P31388 1-436 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694202
Promoter ID:EPDNEW_R4723
Type:single initiation site
Name:Htr6_1
Description:5-hydroxytryptamine receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05157,518,678 - 157,518,738EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62044 AgrOrtholog
BioCyc Gene G2FUF-39432 BioCyc
Ensembl Genes ENSRNOG00000049761 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064366 ENTREZGENE
  ENSRNOP00000064366.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070865 ENTREZGENE
  ENSRNOT00000070865.3 UniProtKB/TrEMBL
InterPro 5HT6_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64354 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HTR6 RGD
PhenoGen Htr6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT6R_RAT UniProtKB/Swiss-Prot
  A0A8L2QXZ5 ENTREZGENE, UniProtKB/TrEMBL
  P31388 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr6  5-hydroxytryptamine receptor 6  Htr6  5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr6  5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled  Htr6  5-hydroxytryptamine (serotonin) receptor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr6  5-hydroxytryptamine (serotonin) receptor 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in striatum, olfactory tubercle, nucleus accumbens and hippocampus 61636
gene_protein 436 amino acids 61636