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Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Rattus norvegicus
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
RGD ID: 1311069
Description: Predicted to have thrombopoietin receptor activity. Involved in several processes, including myeloid cell homeostasis; platelet aggregation; and positive regulation of platelet formation. Localizes to several cellular components, including cell surface; neuron projection; and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC366455; myeloproliferative leukemia virus oncogene; thrombopoietin receptor
Homo sapiens (human) : MPL (MPL proto-oncogene, thrombopoietin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Mpl (myeloproliferative leukemia virus oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Canis lupus familiaris (dog) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
Sus scrofa (pig) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Chlorocebus sabaeus (African green monkey) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Heterocephalus glaber (naked mole-rat) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mpl
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.