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Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Rattus norvegicus
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Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
RGD ID: 1311069
Description: Predicted to have thrombopoietin receptor activity. Involved in several processes, including myeloid cell homeostasis; platelet aggregation; and positive regulation of platelet formation. Localizes to several cellular components, including cell surface; neuron projection; and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; 2,3',4,4',5-Pentachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC366455; myeloproliferative leukemia virus oncogene; thrombopoietin receptor
Orthologs:
Homo sapiens (human) : MPL (MPL proto-oncogene, thrombopoietin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Mpl (myeloproliferative leukemia virus oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Canis lupus familiaris (dog) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
Sus scrofa (pig) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Chlorocebus sabaeus (African green monkey) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Heterocephalus glaber (naked mole-rat) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mpl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.