Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Rattus norvegicus
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
Description: Predicted to have thrombopoietin receptor activity; involved in several processes, including cellular response to hypoxia, leukocyte homeostasis, and platelet aggregation; localizes to several cellular components, including the cell surface, neuron projection, and neuronal cell body; used to study myelofibrosis; biomarker of thrombocytopenia; orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; 3-methylcholanthrene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC366455; myeloproliferative leukemia virus oncogene; thrombopoietin receptor
Homo sapiens (human) : MPL (MPL proto-oncogene, thrombopoietin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Mpl (myeloproliferative leukemia virus oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Canis lupus familiaris (dog) : MPL (MPL proto-oncogene, thrombopoietin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mpl (MPL proto-oncogene, thrombopoietin receptor)
Sus scrofa (pig) : MPL (MPL proto-oncogene, thrombopoietin receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mpl
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.