Mpl (MPL proto-oncogene, thrombopoietin receptor) - Rat Genome Database

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Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Rattus norvegicus
Analyze
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
RGD ID: 1311069
Description: Predicted to enable thrombopoietin receptor activity. Involved in several processes, including basophil homeostasis; eosinophil homeostasis; and monocyte homeostasis. Located in cell surface and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC366455; myeloproliferative leukemia virus oncogene; thrombopoietin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,259,288 - 137,281,540 (-)NCBIGRCr8
mRatBN7.25131,973,895 - 131,987,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5131,973,895 - 131,986,797 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Alexander WS, etal., Blood. 1996 Mar 15;87(6):2162-70.
2. Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration. de Serres M, etal., Stem Cells. 1999;17(6):316-26.
3. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Ding J, etal., Blood. 2004 Jun 1;103(11):4198-200. Epub 2004 Feb 5.
4. Molecular detection of c-mpl thrombopoietin receptor gene expression in chronic myeloproliferative disorders. Duensing S, etal., Mol Pathol. 1999 Jun;52(3):146-50.
5. A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Ehrenreich H, etal., Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):862-7. Epub 2005 Jan 10.
6. Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene. El-Harith el-HA, etal., Br J Haematol. 2009 Jan;144(2):185-94. doi: 10.1111/j.1365-2141.2008.07430.x. Epub 2008 Nov 19.
7. Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gao W, etal., Gastroenterology. 2013 Sep;145(3):636-46.e5. doi: 10.1053/j.gastro.2013.05.049. Epub 2013 Jun 5.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Ihara K, etal., Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3132-6.
11. Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim. Kuter DJ, etal., Blood. 2009 Oct 29;114(18):3748-56. doi: 10.1182/blood-2009-05-224766. Epub 2009 Aug 11.
12. Autoantibody to c-Mpl (thrombopoietin receptor) in systemic lupus erythematosus: relationship to thrombocytopenia with megakaryocytic hypoplasia. Kuwana M, etal., Arthritis Rheum. 2002 Aug;46(8):2148-59.
13. The platelet thrombopoietin receptor number and function are markedly decreased in patients with essential thrombocythaemia. Li J, etal., Br J Haematol. 2000 Dec;111(3):943-53.
14. Thrombopoietin modulates cardiac contractility in vitro and contributes to myocardial depressing activity of septic shock serum. Lupia E, etal., Basic Res Cardiol. 2010 Sep;105(5):609-20. doi: 10.1007/s00395-010-0103-6. Epub 2010 May 14.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Decreased prothrombotic effects of pegylated recombinant human megakaryocyte growth and development factor in thrombocytopenic state in a rat thrombosis model. Nishiyama U, etal., J Thromb Haemost. 2005 Feb;3(2):355-60.
17. Effects of thrombopoietin on growth of hepatocellular carcinoma: Is thrombopoietin therapy for liver disease safe or not? Nozaki R, etal., Hepatol Res. 2013 Jun;43(6):610-20. doi: 10.1111/hepr.12006. Epub 2012 Nov 16.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease. Sano Y, etal., Digestion. 2020 Aug 25:1-9. doi: 10.1159/000509852.
25. CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis. Yan Z, etal., J Cancer Res Clin Oncol. 2019 May;145(5):1147-1164. doi: 10.1007/s00432-019-02860-z. Epub 2019 Feb 15.
Additional References at PubMed
PMID:16484588   PMID:18684867   PMID:20643340   PMID:20711984   PMID:25468569   PMID:25538044  


Genomics

Comparative Map Data
Mpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,259,288 - 137,281,540 (-)NCBIGRCr8
mRatBN7.25131,973,895 - 131,987,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5131,973,895 - 131,986,797 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
MPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38143,337,818 - 43,354,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl143,337,818 - 43,354,466 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,803,489 - 43,820,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,576,062 - 43,592,722 (+)NCBINCBI36Build 36hg18NCBI36
Build 34143,472,567 - 43,489,228NCBI
Celera142,085,625 - 42,102,280 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,923,380 - 41,939,975 (+)NCBIHuRef
CHM1_1143,919,946 - 43,936,585 (+)NCBICHM1_1
T2T-CHM13v2.0143,208,365 - 43,225,013 (+)NCBIT2T-CHM13v2.0
Mpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,299,609 - 118,314,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,299,612 - 118,314,710 (-)EnsemblGRCm39 Ensembl
GRCm384118,442,412 - 118,457,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4118,442,415 - 118,457,513 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,115,022 - 118,130,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364117,940,347 - 117,955,403 (-)NCBIMGSCv36mm8
Celera4117,167,633 - 117,182,859 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map454.61NCBI
Mpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,922,156 - 2,937,223 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,922,156 - 2,937,223 (+)NCBIChiLan1.0ChiLan1.0
MPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,455,594 - 183,472,256 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,596,971 - 182,613,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,639,191 - 42,654,738 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1144,018,395 - 44,034,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl144,018,395 - 44,034,492 (+)Ensemblpanpan1.1panPan2
MPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11516,815,102 - 16,825,321 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1516,815,294 - 16,825,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1516,937,406 - 16,953,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01516,977,122 - 16,993,028 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1516,978,816 - 16,993,003 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11516,769,591 - 16,785,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01516,838,589 - 16,854,485 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01516,912,170 - 16,928,047 (-)NCBIUU_Cfam_GSD_1.0
Mpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,919,891 - 58,932,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,744,673 - 24,757,085 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,744,673 - 24,757,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6167,896,287 - 167,908,625 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16167,896,191 - 167,908,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26155,334,350 - 155,335,846 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,457,549 - 89,474,756 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2089,459,493 - 89,474,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603327,447,284 - 27,462,737 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,656,260 - 2,669,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,656,260 - 2,671,455 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpl
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:33
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000034762
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat

Markers in Region
Mpl  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25131,985,255 - 131,986,117 (+)MAPPERmRatBN7.2
Rnor_6.05137,279,787 - 137,280,648NCBIRnor6.0
Rnor_5.05141,069,251 - 141,070,112UniSTSRnor5.0
RGSC_v3.45138,930,479 - 138,931,340UniSTSRGSC3.4
Celera5130,530,727 - 130,531,588UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 6
Low 16 16 16 10 16 4 3 13 7
Below cutoff 3 23 7 5 2 5 2 3 36 32 26 4 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001072502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005504959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB235197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ013343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ013344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ013345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000034762   ⟹   ENSRNOP00000035474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5137,269,504 - 137,281,298 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093301   ⟹   ENSRNOP00000076315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5131,973,895 - 131,986,797 (-)Ensembl
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093502   ⟹   ENSRNOP00000076196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093708   ⟹   ENSRNOP00000076155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5131,975,572 - 131,986,797 (-)Ensembl
Rnor_6.0 Ensembl5137,269,480 - 137,281,297 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093752   ⟹   ENSRNOP00000076263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5137,269,501 - 137,281,277 (-)Ensembl
RefSeq Acc Id: NM_001419844   ⟹   NP_001406773
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,288 - 137,272,177 (-)NCBI
mRatBN7.25131,973,895 - 131,986,784 (-)NCBI
RefSeq Acc Id: XM_006238749   ⟹   XP_006238811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,272,850 (-)NCBI
mRatBN7.25131,973,897 - 131,987,455 (-)NCBI
Rnor_6.05137,268,412 - 137,282,032 (-)NCBI
Rnor_5.05141,057,876 - 141,070,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593804   ⟹   XP_017449293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,272,854 (-)NCBI
mRatBN7.25131,973,897 - 131,987,459 (-)NCBI
Rnor_6.05137,268,412 - 137,282,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593805   ⟹   XP_017449294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,272,859 (-)NCBI
mRatBN7.25131,973,897 - 131,987,468 (-)NCBI
Rnor_6.05137,268,412 - 137,282,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593806   ⟹   XP_017449295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,272,861 (-)NCBI
mRatBN7.25131,973,897 - 131,987,472 (-)NCBI
Rnor_6.05137,269,515 - 137,282,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111192   ⟹   XP_038967120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,260,484 - 137,272,862 (-)NCBI
mRatBN7.25131,975,091 - 131,987,472 (-)NCBI
RefSeq Acc Id: XM_063288116   ⟹   XP_063144186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,272,851 (-)NCBI
RefSeq Acc Id: XM_063288117   ⟹   XP_063144187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,281,540 (-)NCBI
RefSeq Acc Id: XM_063288118   ⟹   XP_063144188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,259,290 - 137,272,856 (-)NCBI
RefSeq Acc Id: XR_005504959
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,260,597 - 137,272,862 (-)NCBI
mRatBN7.25131,975,194 - 131,987,472 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006238811   ⟸   XM_006238749
- Peptide Label: isoform X5
- UniProtKB: A6JZI5 (UniProtKB/TrEMBL),   A6JZI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449294   ⟸   XM_017593805
- Peptide Label: isoform X2
- UniProtKB: A6JZI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449293   ⟸   XM_017593804
- Peptide Label: isoform X1
- UniProtKB: A6JZI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449295   ⟸   XM_017593806
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000076263   ⟸   ENSRNOT00000093752
RefSeq Acc Id: ENSRNOP00000076155   ⟸   ENSRNOT00000093708
RefSeq Acc Id: ENSRNOP00000076315   ⟸   ENSRNOT00000093301
RefSeq Acc Id: ENSRNOP00000076196   ⟸   ENSRNOT00000093502
RefSeq Acc Id: ENSRNOP00000035474   ⟸   ENSRNOT00000034762
RefSeq Acc Id: XP_038967120   ⟸   XM_039111192
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001406773   ⟸   NM_001419844
- Peptide Label: precursor
- UniProtKB: A0A1W2Q6N1 (UniProtKB/TrEMBL),   A6JZI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144187   ⟸   XM_063288117
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063144188   ⟸   XM_063288118
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063144186   ⟸   XM_063288116
- Peptide Label: isoform X6
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1W2Q6N1-F1-model_v2 AlphaFold A0A1W2Q6N1 1-644 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311069 AgrOrtholog
BioCyc Gene G2FUF-40152 BioCyc
Ensembl Genes ENSRNOG00000028377 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093301 ENTREZGENE
  ENSRNOT00000093301.2 UniProtKB/TrEMBL
  ENSRNOT00000093708.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Growth/epo_recpt_lig-bind UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Long_hematopoietin_rcpt_CS UniProtKB/TrEMBL
KEGG Report rno:366455 UniProtKB/TrEMBL
NCBI Gene 366455 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  THROMBOPOIETIN RECEPTOR UniProtKB/TrEMBL
Pfam EpoR_lig-bind UniProtKB/TrEMBL
PhenoGen Mpl PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_L_F1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028377 RatGTEx
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0A1W2Q670_RAT UniProtKB/TrEMBL
  A0A1W2Q6N1 ENTREZGENE, UniProtKB/TrEMBL
  A6JZI5 ENTREZGENE, UniProtKB/TrEMBL
  A6JZI6 ENTREZGENE, UniProtKB/TrEMBL
  A6JZI7 ENTREZGENE, UniProtKB/TrEMBL
  Q1ERS7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Mpl  MPL proto-oncogene, thrombopoietin receptor  Mpl  myeloproliferative leukemia virus oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mpl  myeloproliferative leukemia virus oncogene   Mpl_predicted  myeloproliferative leukemia virus oncogene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mpl_predicted  myeloproliferative leukemia virus oncogene (predicted)      Symbol and Name status set to approved 70820 APPROVED