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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
Acc ID: CHEBI:85010
Term: eltrombopag
Definition: A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).
Chemical ID: MESH:C520809
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mplmultiple interactionsISORGD:13223306480464CTDeltrombopag binds to and results in increased activity of MPL proteinPMID:21646437
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