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GENE - TERM ANNOTATION REPORT

RGD ID: 1311069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
Acc ID: DOID:4971
Term: myelofibrosis
Definition: A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Myelofibrosis "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpl IMP 10449004RGD  
Mpl ISOMPL (Homo sapiens)7240710OMIM  
Mpl ISOMPL (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Mpl ISOMPL (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Myelofibrosis with myeloid metaplasia | ClinVar Annotator: match by term: Myelofibrosis, somatic | ClinVar Annotator: match by term: Primary myelofibrosisPMID:10971406 PMID:11071383 PMID:11133753 PMID:14764528 PMID:16199547 PMID:16470591 PMID:16834459 PMID:16868251 PMID:17666371 PMID:18090929 PMID:18451306 PMID:18528423 PMID:18769448 PMID:19036112 PMID:19388932 PMID:19483125 PMID:19608689 PMID:20113333 PMID:20151976 PMID:20188141 PMID:21326037 PMID:21489838 PMID:23625800 PMID:23970983 PMID:24033266 PMID:24438083 PMID:24728327 PMID:25023898 PMID:25538044 PMID:25741868 PMID:26316487 PMID:28492532 PMID:28823277 PMID:31064749 PMID:31294534 PMID:32703794 PMID:35477182 PMID:8073287
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