Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

4 Annotations Found.

An association has been curated linking Mpl and essential thrombocythemia in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Ding J, etal., Blood. 2004 Jun 1;103(11):4198-200. Epub 2004 Feb 5.
  • The annotation has been inferred from sequence orthology with MPL (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 4 additional annotations were made from Ding J, etal., Blood. 2004 Jun 1;103(11):4198-200. Epub 2004 Feb 5.
  • 22 RGD objects have been annotated to essential thrombocythemia  (DOID:2224)
  • 25 papers in RGD have been used to annotate Mpl
  • Curation Notes: DNA:missense mutation:cds:pS505N (human)


    • An association has been curated linking Mpl and essential thrombocythemia in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Li J, etal., Br J Haematol. 2000 Dec;111(3):943-53.
  • The annotation has been inferred from sequence orthology with MPL (Homo sapiens) [(IEP) inferred from expression pattern]
  • 2 additional annotations were made from Li J, etal., Br J Haematol. 2000 Dec;111(3):943-53.
  • 22 RGD objects have been annotated to essential thrombocythemia  (DOID:2224)
  • 25 papers in RGD have been used to annotate Mpl
  • Curation Notes: mRNA, protein:decreased expression:blood, platelet (human)


    • An association has been curated linking Mpl and essential thrombocythemia in Rattus norvegicus.        

  • The association was inferred from sequence or structural similarity (ISS)
    		•  
  • The annotation was made from RGD automated import pipeline for MGI gene-to-disease annotations
  • The annotation has been inferred from sequence or structural similarity with MPL (Homo sapiens) [(IEA) inferred from electronic annotation]
  • 22 RGD objects have been annotated to essential thrombocythemia  (DOID:2224)
  • 25 papers in RGD have been used to annotate Mpl
  • Curation Notes: OMIM:187950 | OMIM:300331 | OMIM:601977 | OMIM:614521


    • An association has been curated linking Mpl and essential thrombocythemia in Rattus norvegicus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with MPL (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 22 RGD objects have been annotated to essential thrombocythemia  (DOID:2224)
  • 25 papers in RGD have been used to annotate Mpl
  • Curation Notes: ClinVar Annotator: match by term: Essential thrombocythemia | ClinVar Annotator: match by term: Thrombocythemia 1
  • Original References(s): PMID:11133753 PMID:14764528 PMID:15269348 PMID:15531462 PMID:16199547 PMID:16470591 PMID:17054430 PMID:17666371 PMID:18451306 PMID:18528423 PMID:19483125 PMID:19608689 PMID:20151976 PMID:21489838 PMID:23970983 PMID:24033266 PMID:24728327 PMID:25741868 PMID:27069254 PMID:28492532 PMID:28697167 PMID:31064749 PMID:8073287


    • Go Back to source page   Continue to Ontology report