RGD Reference Report - Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease. - Rat Genome Database

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Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease.

Authors: Sano, Yusuke  Morimoto, Manabu  Kobayashi, Satoshi  Ueno, Makoto  Fukushima, Taito  Asama, Hiroyuki  Kawano, Kuniyuki  Nagashima, Shuhei  Tanaka, Satoshi  Ohkawa, Shinichi  Maeda, Shin 
Citation: Sano Y, etal., Digestion. 2020 Aug 25:1-9. doi: 10.1159/000509852.
RGD ID: 126925754
Pubmed: PMID:32841939   (View Abstract at PubMed)
DOI: DOI:10.1159/000509852   (Journal Full-text)


BACKGROUND/AIMS: Lusutrombopag, a small-molecule thrombopoietin receptor agonist, is used to treat thrombocytopenia based on the results of a phase 3 trial, including data for single-use administration in patients with chronic liver disease (CLD) undergoing invasive procedures. We aimed to evaluate the efficacy and safety of repeated lusutrombopag use.
METHODS: Lusutrombopag was administered repeatedly in patients undergoing multi-cycle invasive procedures at intervals >1 month.
RESULTS: Data from 8 patients (median platelet count at baseline, 44.0 [range, 35-49] × 109/L) and 25 cycles of invasive procedures, including 2 cycles in 3 patients, 3 cycles in 4 patients, and 7 cycles in 1 patient, were retrospectively evaluated. The procedures included 18 transarterial chemoembolizations, 5 radiofrequency ablations, and 2 liver needle biopsies. Platelet counts increased significantly compared with baseline, and median changes in platelet counts were 46.0 × 109/L (p = 0.012) in cycle 1, 44.0 × 109/L (p = 0.012) in cycle 2, and 42.0 × 109/L (p = 0.008) in cycles 3-7. No severe adverse events, including portal vein thrombus or bleeding, were observed.
CONCLUSIONS: Repeated use of lusutrombopag might be safe and effective against thrombocytopenia in patients with CLD undergoing multi-cycle invasive procedures, although long-term data from more patients are required.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MPLHumanthrombocytopenia amelioratesIMP associated with End Stage Liver DiseaseRGD 
MplRatthrombocytopenia amelioratesISOMPL (Homo sapiens)associated with End Stage Liver DiseaseRGD 
MplMousethrombocytopenia amelioratesISOMPL (Homo sapiens)associated with End Stage Liver DiseaseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mpl  (MPL proto-oncogene, thrombopoietin receptor)

Genes (Mus musculus)
Mpl  (myeloproliferative leukemia virus oncogene)

Genes (Homo sapiens)
MPL  (MPL proto-oncogene, thrombopoietin receptor)


Additional Information