Mpl (MPL proto-oncogene, thrombopoietin receptor) - Rat Genome Database

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Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Heterocephalus glaber
Analyze
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
RGD ID: 18918593
Description: ENCODES a protein that exhibits cytokine receptor activity (inferred); thrombopoietin receptor activity (inferred); INVOLVED IN basophil homeostasis (ortholog); cellular response to hypoxia (ortholog); definitive hemopoiesis (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Chronic Hepatitis B (ortholog); congenital amegakaryocytic thrombocytopenia (ortholog); FOUND IN cell surface (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myeloproliferative leukemia virus oncogene; Thrombopoietin receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,656,260 - 2,669,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,656,260 - 2,671,455 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,656,260 - 2,669,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,656,260 - 2,671,455 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38143,337,818 - 43,354,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl143,337,818 - 43,354,466 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,803,489 - 43,820,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,576,062 - 43,592,722 (+)NCBINCBI36Build 36hg18NCBI36
Build 34143,472,567 - 43,489,228NCBI
Celera142,085,625 - 42,102,280 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,923,380 - 41,939,975 (+)NCBIHuRef
CHM1_1143,919,946 - 43,936,585 (+)NCBICHM1_1
T2T-CHM13v2.0143,208,365 - 43,225,013 (+)NCBIT2T-CHM13v2.0
Mpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,299,609 - 118,314,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,299,612 - 118,314,710 (-)EnsemblGRCm39 Ensembl
GRCm384118,442,412 - 118,457,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4118,442,415 - 118,457,513 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,115,022 - 118,130,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364117,940,347 - 117,955,403 (-)NCBIMGSCv36mm8
Celera4117,167,633 - 117,182,859 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map454.61NCBI
Mpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,259,288 - 137,281,540 (-)NCBIGRCr8
mRatBN7.25131,973,895 - 131,987,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5131,973,895 - 131,986,797 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05137,268,412 - 137,282,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,269,480 - 137,281,298 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,532,972 (-)NCBICelera
Cytogenetic Map5q36NCBI
Mpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,922,156 - 2,937,223 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,922,156 - 2,937,223 (+)NCBIChiLan1.0ChiLan1.0
MPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,455,594 - 183,472,256 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,596,971 - 182,613,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,639,191 - 42,654,738 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1144,018,395 - 44,034,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl144,018,395 - 44,034,492 (+)Ensemblpanpan1.1panPan2
MPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11516,815,102 - 16,825,321 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1516,815,294 - 16,825,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1516,937,406 - 16,953,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01516,977,122 - 16,993,028 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1516,978,816 - 16,993,003 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11516,769,591 - 16,785,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01516,838,589 - 16,854,485 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01516,912,170 - 16,928,047 (-)NCBIUU_Cfam_GSD_1.0
Mpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,919,891 - 58,932,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,744,673 - 24,757,085 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,744,673 - 24,757,189 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6167,896,287 - 167,908,625 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16167,896,191 - 167,908,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26155,334,350 - 155,335,846 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,457,549 - 89,474,756 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2089,459,493 - 89,474,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603327,447,284 - 27,462,737 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006464   ⟹   ENSHGLP00000006383
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248922,656,260 - 2,669,946 (+)Ensembl
RefSeq Acc Id: XM_004871861   ⟹   XP_004871918
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248922,656,260 - 2,671,455 (+)NCBI
RefSeq Acc Id: XM_013068191   ⟹   XP_012923645
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248922,656,260 - 2,671,454 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004871918 (Get FASTA)   NCBI Sequence Viewer  
  XP_012923645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA99272 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006383
  ENSHGLP00100023665
RefSeq Acc Id: XP_004871918   ⟸   XM_004871861
- Peptide Label: isoform X1
- UniProtKB: G5AQG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923645   ⟸   XM_013068191
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000006383   ⟸   ENSHGLT00000006464


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004663 Ensembl, ENTREZGENE
  ENSHGLG00100017391 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000006464 ENTREZGENE
  ENSHGLT00100023907 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Growth/epo_recpt_lig-bind UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Long_hematopoietin_rcpt_CS UniProtKB/TrEMBL
KEGG Report hgl:101707597 UniProtKB/TrEMBL
NCBI Gene Mpl ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam EpoR_lig-bind UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_L_F1 UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt G5AQG2 ENTREZGENE, UniProtKB/TrEMBL